4ajh A 1.93 BS01 88S A 1 G28 D51 V52 A95 G96 I115 G24 D47 V48 A91 G92 I111 R105 D165 R168 H192 R101 D161 R164 H188 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1334 ALKDQLIVNLLKVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF 4ajh B 1.93 BS01 88S B 1 D51 V52 T94 A95 G96 R98 I115 I119 D50 V51 T93 A94 G95 R97 I114 I118 R105 D165 R168 H192 R104 D164 R167 H191 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1333 ALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF 4ajh C 1.93 BS01 88S C 1 G28 D51 V52 A95 G96 I119 G27 D50 V51 A94 G95 I118 R105 D165 R168 H192 R104 D164 R167 H191 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1335 ALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF 4ajh D 1.93 BS01 88S D 1 G28 D51 V52 T94 A95 G96 I115 G27 D50 V51 T93 A94 G95 I114 R105 D165 R168 H192 R104 D164 R167 H191 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1335 ALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF 4ajj A 1.75 BS01 88S A 1 D51 V52 T94 A95 G96 I115 I119 D50 V51 T93 A94 G95 I114 I118 R105 D165 R168 H192 R104 D164 R167 H191 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1332 ALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF 4ajj B 1.75 BS01 88S B 1 D51 V52 A95 G96 I115 I119 D50 V51 A94 G95 I114 I118 R105 D165 R168 H192 R104 D164 R167 H191 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1332 ALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF 4ajj C 1.75 BS01 88S C 1 D51 V52 A95 G96 I119 D50 V51 A94 G95 I118 R105 D165 R168 H192 R104 D164 R167 H191 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1334 ALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF 4ajj D 1.75 BS01 88S D 1 D51 V52 T94 A95 G96 I115 I119 D50 V51 T93 A94 G95 I114 I118 R105 D165 R168 H192 R104 D164 R167 H191 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1332 ALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF 4ajk A 2.03 BS01 88S A 1 G28 D51 V52 T94 A95 G96 I115 I119 G27 D50 V51 T93 A94 G95 I114 I118 R105 D165 R168 H192 R104 D164 R167 H191 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM -logKd/Ki=3.11, Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1332 AALKDQLIVNLLKEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF 4ajk B 2.03 BS01 88S B 1 D51 V52 T94 A95 G96 R98 I115 I119 D49 V50 T92 A93 G94 R96 I113 I117 R105 D165 R168 H192 R103 D163 R166 H190 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1333 ALKDQLIVNLLKEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF 4ajk C 2.03 BS01 88S C 1 G28 D51 V52 T94 A95 G96 I115 I119 G26 D49 V50 T92 A93 G94 I113 I117 R105 D165 R168 H192 R103 D163 R166 H190 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1333 AALKDQLIVNLLKQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF 4ajk D 2.03 BS01 88S D 1 G28 D51 V52 T94 A95 G96 I115 G27 D50 V51 T93 A94 G95 I114 R105 D165 R168 H192 R104 D164 R167 H191 1.1.1.27 0001666,0001889,0003824,0004457,0004459,0005515,0005737,0005739,0005829,0006089,0006090,0007519,0007584,0009410,0009749,0014070,0016491,0016616,0019661,0019674,0019752,0019900,0035686,0042542,0042802,0042867,0043065,0043627,0051287,0051591,1990204 Kd=770uM Kd=7.70e+5nM, IC50=>5.00e+5nM P04642 22417091 1333 ALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF