5izq A 3.6 BS01 83A A 1 D81 Y85 W102 W134 H135 K136 G137 W138 W140 W171 S174 Y175 D74 Y78 W95 W127 H128 K129 G130 W131 W133 W164 S167 Y168 ? -logKd/Ki=8.52, IC50=3.04nM IC50=3.0nM P15328 27458733 300 RTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGT 5izq B 3.6 BS01 83A B 1 Y60 D81 Y85 W102 H135 K136 G137 W138 W140 W171 S174 Y175 Y51 D72 Y76 W93 H126 K127 G128 W129 W131 W162 S165 Y166 ? IC50=3.0nM P15328 27458733 300 ELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMS 5izq C 3.6 BS01 83A C 1 Y60 F62 D81 Y85 W102 R103 W134 H135 K136 G137 W138 W140 W171 S174 Y52 F54 D73 Y77 W94 R95 W126 H127 K128 G129 W130 W132 W163 S166 ? IC50=3.0nM P15328 27458733 300 TELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGTLV 5izq E 3.6 BS01 83A E 1 F62 D81 R106 H135 K136 G137 W140 W171 S174 Y175 F56 D75 R100 H129 K130 G131 W134 W165 S168 Y169 ? IC50=3.0nM P15328 27458733 300 ARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMS 5izq F 3.6 BS01 83A F 1 Y60 D81 Y85 W102 R103 H135 K136 G137 W138 W140 W171 S174 Y175 Y53 D74 Y78 W95 R96 H128 K129 G130 W131 W133 W164 S167 Y168 ? IC50=3.0nM P15328 27458733 300 RTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGTL 5izq G 3.6 BS01 83A G 1 Y60 D81 Y85 W102 R103 H135 K136 G137 W138 W140 W171 S174 Y53 D74 Y78 W95 R96 H128 K129 G130 W131 W133 W164 S167 ? IC50=3.0nM P15328 27458733 300 RTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMS 5izq H 3.6 BS01 83A H 1 Y60 D81 Y85 W134 H135 K136 G137 W138 W140 W171 S174 Y175 Y52 D73 Y77 W126 H127 K128 G129 W130 W132 W163 S166 Y167 ? IC50=3.0nM P15328 27458733 300 TELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAM 5j9f A 2.1 BS02 83A A 1 F895 M896 R897 I898 L899 V946 A947 V950 D951 F88 M89 R90 I91 L92 V139 A140 V143 D144 N913 H915 T942 D951 N106 H108 T135 D144 2.1.2.2,6.3.3.1,6.3.4.13 0004644,0006189,0009058 Ki=59nM -logKd/Ki=7.23, Ki=59nM IC50=666nM, Ki=59nM P22102 27458733 1102 ARVAVLISGTGSNLQALIDSTREPNSSAQIDIVISNKAAVAGLDKAERAGIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVAKWNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICWV