3ii5 A 2.79 BS01 831 A 1 I462 A480 K482 E500 L504 L513 T528 G592 D593 F594 I16 A34 K36 E54 L58 L67 T82 G146 D147 F148 D575 K577 N579 N580 D593 S615 D129 K131 N133 N134 D147 S158 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=7.62, IC50=0.024uM IC50=24nM P15056 19864136 1 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS 3ii5 B 2.79 BS01 831 B 1 I462 K482 E500 L504 I526 T528 G592 D593 F594 I15 K35 E53 L57 I79 T81 G145 D146 F147 D575 K577 N579 N580 D593 S615 D128 K130 N132 N133 D146 S152 2.7.11.1 0004672,0005524,0006468 IC50=24nM P15056 19864136 1 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL