4gtr B 2.2 BS02 7TR B 1 L96 W102 Y105 W106 D297 D359 Y361 H362 Y365 L76 W82 Y85 W86 D277 D339 Y341 H342 Y345 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H228 R271 K274 D277 C279 Y280 D332 D339 H342 2.5.1.58 0003824,0004311,0004659,0004660,0005515,0005875,0005965,0006629,0008270,0008283,0008284,0008285,0008318,0014070,0018343,0034097,0042060,0042277,0045787,0046872,0048144,0048145,0048146,0051770 -logKd/Ki=8.30, IC50<5nM Q02293 22963166 502 EPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGF 4gtv B 1.95 BS03 7TR B 1 Y44 L45 C196 D238 W244 F289 H290 Y37 L38 C189 D231 W237 F282 H283 H190 R232 K235 D238 C240 Y241 D280 D287 H290 H183 R225 K228 D231 C233 Y234 D273 D280 H283 2.5.1.60 0003824,0004659,0004661,0004663,0005515,0005968,0008270,0008318,0018344,0019840,0031267,0046872 ic50=38nM -logKd/Ki=7.42, IC50=38nM Q08603 22963166 403 QKDVTIKSDAPDTLLLEKHADYIASYGSDYEYCMSEYLRMSGVYWGLTVMDLMGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLYDSIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLQRVNVQPELVS