4gtq B 2.6 BS03 7TQ B 1 L96 A98 S99 W102 A151 P152 D297 D359 Y361 H362 L78 A80 S81 W84 A133 P134 D279 D341 Y343 H344 H248 R291 K294 D297 C299 Y300 D352 D359 H362 H230 R273 K276 D279 C281 Y282 D334 D341 H344 2.5.1.58 0003824,0004311,0004659,0004660,0005515,0005875,0005965,0006629,0008270,0008283,0008284,0008285,0008318,0014070,0018343,0034097,0042060,0042277,0045787,0046872,0048144,0048145,0048146,0051770 -logKd/Ki=8.30, IC50<5nM Q02293 22963166 503 WSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGF 4gtt B 2.05 BS03 7TQ B 1 Y44 L96 Q103 F147 Y195 D287 F289 Y37 L89 Q96 F140 Y188 D280 F282 H190 R232 K235 D238 C240 Y241 D280 D287 H290 H183 R225 K228 D231 C233 Y234 D273 D280 H283 2.5.1.60 0003824,0004659,0004661,0004663,0005515,0005968,0008270,0008318,0018344,0019840,0031267,0046872 ic50=6nM -logKd/Ki=8.22, IC50=6nM Q08603 22963166 403 QKDVTIKSDAPDTLLLEKHADYIASYGSDYEYCMSEYLRMSGVYWGLTVMDLMGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLYDSIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLQRVNVQPELVS