5mju A 3.71 BS02 7O9 A 1 I100 I223 S345 S346 A375 T376 M379 T382 G419 A426 G427 D456 R459 N463 I64 I148 S262 S263 A292 T293 M296 T299 G329 A336 G337 D366 R369 N373 ? 0015293,0016020 P43003,Q15758 28424515 602 TKEDVKSFLRRNALLLLTVLAVILGVVLGFLLRPYPLSPREVKYFAFPGELLMRMLKMLILPLIVSSLITGLASLDAKASGRLGMRAVVYYMSTTIIAVVLGIILVLIIHEVLDCFLDLARNIFPSNLVSAAFRSYSTTGQEVEGMNILGLVVFSMVFGFALGKMGEQGQLLVDFFNSLNEATMKLVAIIMWYAPLGILFLIAGKIVEGQLGMYMVTVIVGLVIHGLIVLPLIYFLITRKNPFVFIAGILQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEAVAAIFIAQVNQIITISITATAASIGAAGIPQAGLVTMVIVLTAVGLPTDDITLIIAVDWLLDRFRTMVNVLGDALGAGIVEHLSRKELEKQDA 6s3q A 3.34 BS01 7O9 A 1 S332 S333 T370 A404 G407 V411 A414 T418 D444 R447 T448 N451 S286 S287 T324 A358 G361 V365 A368 T372 D398 R401 T402 N405 ? 0001662,0001975,0002027,0005253,0005313,0005314,0005515,0005737,0005768,0005783,0005886,0006749,0006750,0006801,0006811,0006836,0006865,0006882,0007212,0007215,0007268,0007420,0007611,0007613,0007625,0007626,0009410,0009897,0009986,0010460,0010467,0010842,0015108,0015179,0015183,0015293,0015501,0015813,0016020,0016324,0016595,0019221,0022008,0030424,0030425,0030534,0031901,0031902,0031982,0032279,0033229,0034599,0035633,0036293,0042417,0042802,0042883,0043005,0043025,0043083,0043197,0043198,0043204,0043278,0043524,0043679,0045121,0045184,0045202,0046872,0048514,0048678,0050808,0051402,0051938,0055037,0055038,0060013,0060041,0060047,0060291,0061744,0070062,0070633,0070777,0070778,0070779,0071242,0071288,0071314,0071407,0071577,0071944,0072347,0090313,0090461,0097049,0097386,0097440,0098685,0098712,0098793,0098877,0099170,0099544,0140009,0140010,0150002,0150104,1902476,1903712,1903926,1990635,1990708 IC50=300nM P43005 601 EWKRFLKNNWVLLSTVAAVVLGITTGVLVREHRNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGVRAVVYYFCTTLIAVILGIVLVVSIKPGVTQVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVS 6s3q B 3.34 BS01 7O9 B 1 S332 S333 T370 A404 G407 V411 A414 T418 D444 R447 T448 N451 S286 S287 T324 A358 G361 V365 A368 T372 D398 R401 T402 N405 ? 0001662,0001975,0002027,0005253,0005313,0005314,0005515,0005737,0005768,0005783,0005886,0006749,0006750,0006801,0006811,0006836,0006865,0006882,0007212,0007215,0007268,0007420,0007611,0007613,0007625,0007626,0009410,0009897,0009986,0010460,0010467,0010842,0015108,0015179,0015183,0015293,0015501,0015813,0016020,0016324,0016595,0019221,0022008,0030424,0030425,0030534,0031901,0031902,0031982,0032279,0033229,0034599,0035633,0036293,0042417,0042802,0042883,0043005,0043025,0043083,0043197,0043198,0043204,0043278,0043524,0043679,0045121,0045184,0045202,0046872,0048514,0048678,0050808,0051402,0051938,0055037,0055038,0060013,0060041,0060047,0060291,0061744,0070062,0070633,0070777,0070778,0070779,0071242,0071288,0071314,0071407,0071577,0071944,0072347,0090313,0090461,0097049,0097386,0097440,0098685,0098712,0098793,0098877,0099170,0099544,0140009,0140010,0150002,0150104,1902476,1903712,1903926,1990635,1990708 IC50=300nM P43005 502 EWKRFLKNNWVLLSTVAAVVLGITTGVLVREHRNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGVRAVVYYFCTTLIAVILGIVLVVSIKPGVTQVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVS 6s3q C 3.34 BS01 7O9 C 1 S332 S333 T370 A404 G407 V411 A414 T418 D444 R447 T448 N451 S286 S287 T324 A358 G361 V365 A368 T372 D398 R401 T402 N405 ? 0001662,0001975,0002027,0005253,0005313,0005314,0005515,0005737,0005768,0005783,0005886,0006749,0006750,0006801,0006811,0006836,0006865,0006882,0007212,0007215,0007268,0007420,0007611,0007613,0007625,0007626,0009410,0009897,0009986,0010460,0010467,0010842,0015108,0015179,0015183,0015293,0015501,0015813,0016020,0016324,0016595,0019221,0022008,0030424,0030425,0030534,0031901,0031902,0031982,0032279,0033229,0034599,0035633,0036293,0042417,0042802,0042883,0043005,0043025,0043083,0043197,0043198,0043204,0043278,0043524,0043679,0045121,0045184,0045202,0046872,0048514,0048678,0050808,0051402,0051938,0055037,0055038,0060013,0060041,0060047,0060291,0061744,0070062,0070633,0070777,0070778,0070779,0071242,0071288,0071314,0071407,0071577,0071944,0072347,0090313,0090461,0097049,0097386,0097440,0098685,0098712,0098793,0098877,0099170,0099544,0140009,0140010,0150002,0150104,1902476,1903712,1903926,1990635,1990708 IC50=300nM P43005 502 EWKRFLKNNWVLLSTVAAVVLGITTGVLVREHRNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGVRAVVYYFCTTLIAVILGIVLVVSIKPGVTQVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVS 6x14 A 3.71 BS01 7O9 A 1 I16 M202 S278 T314 G359 L387 D394 R397 I13 M199 S275 T311 G356 L384 D391 R394 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33155546 501 YRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6x14 B 3.71 BS02 7O9 B 1 I16 M202 S278 T314 G359 L387 D394 R397 I13 M199 S275 T311 G356 L384 D391 R394 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33155546 501 YRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6x14 C 3.71 BS02 7O9 C 1 I16 M202 S278 T314 G359 L387 D394 R397 I13 M199 S275 T311 G356 L384 D391 R394 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33155546 501 YRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE