5mja A 2.14 BS01 7O3 A 1 I625 V633 A649 K651 E668 T697 M700 G703 L751 S761 D762 I17 V25 A41 K43 E60 T89 M92 G95 L143 S153 D154 D744 A746 R748 N749 D762 S781 D136 A138 R140 N141 D154 S167 2.7.10.1 0004672,0004713,0005524,0006468 ic50=220nM -logKd/Ki=6.66, IC50=220nM P54762 28459525 901 EFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLPTYTSSPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVA 5mja B 2.14 BS01 7O3 B 1 V633 A649 K651 E668 T697 M700 G703 L751 D762 V25 A41 K43 E60 T89 M92 G95 L143 D154 D744 A746 R748 N749 D762 S781 K785 D136 A138 R140 N141 D154 S167 K171 2.7.10.1 0004672,0004713,0005524,0006468 ic50=220nM P54762 28459525 901 EFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKT 5mjb A 2.23 BS01 7O3 A 1 I625 V633 A649 K651 E668 T697 M700 C703 L751 D762 I18 V26 A42 K44 E61 T90 M93 C96 L144 D155 D744 A746 R748 N749 D762 S781 K785 D137 A139 R141 N142 D155 S168 K172 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=8.52, IC50=3.0nM P54762 28459525 901 REFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTV 5mjb B 2.23 BS01 7O3 B 1 I625 V633 A649 K651 E668 T697 M700 C703 L751 D762 I18 V26 A42 K44 E61 T90 M93 C96 L144 D155 D744 A746 R748 N749 D762 S781 K785 D137 A139 R141 N142 D155 S171 K175 2.7.10.1 0004672,0004713,0005524,0006468 P54762 28459525 901 REFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKT