5tx3 A 2.9 BS01 7MY A 1 V25 K40 Y88 C89 E93 L139 I149 V25 K40 Y80 C81 E85 L131 I141 D132 K134 E136 N137 D150 S171 D124 K126 E128 N129 D142 S147 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=8.85, IC50~1.4nM Q14680 28926338 1000 SGSMKDYDELLKYYELHETIGTAKVKLACHILTGEMVAIKIMDKNIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLGSLAYAAPELIQGKGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 5tx3 A 2.9 BS02 7MY B 1 E15 T16 E18 T19 D132 K134 E136 N137 D150 S171 D124 K126 E128 N129 D142 S147 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=8.85, IC50~1.4nM Q14680 28926338 1001 SGSMKDYDELLKYYELHETIGTAKVKLACHILTGEMVAIKIMDKNIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLGSLAYAAPELIQGKGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 5tx3 B 2.9 BS01 7MY B 1 V25 K40 L86 Y88 C89 G92 E93 I149 V23 K38 L74 Y76 C77 G80 E81 I137 D132 K134 E136 N137 D150 S171 D120 K122 E124 N125 D138 S140 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 Q14680 28926338 1001 SGSMKDYDELLKYYELHETIGKVKLACHILTGEMVAIKIMDKKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDGSLAYAAPELIQGLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRL