5ts0 a 2.8468 BS01 7J1 Z 1 L91 D124 G128 W129 L91 D124 G128 W129 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 a 2.8468 BS02 7J1 a 1 S20 T21 Q22 S27 V31 K33 I45 G47 T48 A49 S20 T21 Q22 S27 V31 K33 I45 G47 T48 A49 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 b 2.8468 BS01 7J1 a 1 L91 M95 D124 A126 G128 W129 L91 M95 D124 A126 G128 W129 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 b 2.8468 BS02 7J1 b 1 S20 T21 Q22 S27 V31 K33 I45 G47 T48 A49 L98 S20 T21 Q22 S27 V31 K33 I45 G47 T48 A49 L98 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 H 2.8468 BS01 7J1 H 1 T1 S20 T21 Q22 S27 V31 K33 I45 G47 A49 T1 S20 T21 Q22 S27 V31 K33 I45 G47 A49 3.4.25.1 0004298,0005839,0010498,0051603 -logKd/Ki=7.80, IC50=0.016uM P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS 5ts0 H 2.8468 BS02 7J1 N 1 D124 W129 N130 D124 W129 N130 3.4.25.1 0004298,0005839,0010498,0051603 -logKd/Ki=7.80, IC50=0.016uM P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS 5ts0 I 2.8468 BS01 7J1 H 1 L91 D124 G128 W129 L91 D124 G128 W129 3.4.25.1 0004298,0005839,0010498,0051603 -logKd/Ki=7.80, IC50=0.016uM P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS 5ts0 I 2.8468 BS02 7J1 I 1 S20 T21 Q22 S27 V31 K33 I45 G47 A49 L98 S20 T21 Q22 S27 V31 K33 I45 G47 A49 L98 3.4.25.1 0004298,0005839,0010498,0051603 -logKd/Ki=7.80, IC50=0.016uM P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS 5ts0 J 2.8468 BS01 7J1 I 1 L91 M95 D124 G128 W129 L91 M95 D124 G128 W129 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS 5ts0 J 2.8468 BS02 7J1 J 1 S20 T21 Q22 S27 V31 K33 I45 G47 A49 S20 T21 Q22 S27 V31 K33 I45 G47 A49 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS 5ts0 K 2.8468 BS01 7J1 J 1 L91 D124 G128 W129 L91 D124 G128 W129 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 K 2.8468 BS02 7J1 K 1 S20 T21 S27 V31 K33 I45 G47 A49 S20 T21 S27 V31 K33 I45 G47 A49 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 L 2.8468 BS01 7J1 K 1 M95 S122 F123 D124 A125 G128 W129 M95 S122 F123 D124 A125 G128 W129 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 L 2.8468 BS02 7J1 L 1 S20 T21 Q22 S27 V31 K33 I45 G47 T48 A49 S20 T21 Q22 S27 V31 K33 I45 G47 T48 A49 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 M 2.8468 BS01 7J1 L 1 L91 M95 S122 D124 W129 N130 L91 M95 S122 D124 W129 N130 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS 5ts0 M 2.8468 BS02 7J1 M 1 S20 T21 Q22 S27 V31 K33 I45 G47 A49 S20 T21 Q22 S27 V31 K33 I45 G47 A49 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS 5ts0 N 2.8468 BS01 7J1 M 1 L91 D124 G128 W129 L91 D124 G128 W129 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 N 2.8468 BS02 7J1 N 1 S20 T21 S27 V31 K33 I45 G47 A49 S20 T21 S27 V31 K33 I45 G47 A49 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 V 2.8468 BS01 7J1 V 1 S20 T21 Q22 S27 V31 K33 I45 G47 A49 L98 S20 T21 Q22 S27 V31 K33 I45 G47 A49 L98 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 V 2.8468 BS02 7J1 b 1 L91 D124 G128 W129 L91 D124 G128 W129 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 W 2.8468 BS01 7J1 V 1 D124 G128 W129 D124 G128 W129 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 W 2.8468 BS02 7J1 W 1 S20 T21 Q22 S27 V31 K33 I45 G47 A49 L98 S20 T21 Q22 S27 V31 K33 I45 G47 A49 L98 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 X 2.8468 BS01 7J1 W 1 D124 A125 G128 W129 D124 A125 G128 W129 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS 5ts0 X 2.8468 BS02 7J1 X 1 S20 T21 Q22 S27 V31 K33 I45 G47 A49 S20 T21 Q22 S27 V31 K33 I45 G47 A49 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS 5ts0 Y 2.8468 BS01 7J1 X 1 D124 W129 D124 W129 3.4.25.1 0004298,0005839,0010498,0051603 -logKd/Ki=7.80, IC50=0.016uM P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 Y 2.8468 BS02 7J1 Y 1 S20 T21 S27 V31 K33 I45 G47 T48 A49 L98 S20 T21 S27 V31 K33 I45 G47 T48 A49 L98 3.4.25.1 0004298,0005839,0010498,0051603 -logKd/Ki=7.80, IC50=0.016uM P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSG 5ts0 Z 2.8468 BS01 7J1 Y 1 D124 A125 G128 W129 D124 A125 G128 W129 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS 5ts0 Z 2.8468 BS02 7J1 Z 1 S20 T21 Q22 S27 V31 K33 I45 G47 A49 V53 S20 T21 Q22 S27 V31 K33 I45 G47 A49 V53 3.4.25.1 0004298,0005839,0010498,0051603 P9WHT9 27976853 301 TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRS