5lxd A 2.58 BS01 7A7 A 1 G156 V163 F228 L231 L282 I294 D295 G77 V84 F149 L152 L203 I215 D216 D275 K277 N280 D295 S312 D196 K198 N201 D216 S233 2.7.12.1 0004672,0004712,0005524,0006468 -logKd/Ki=8.50, IC50=3.16nM Q92630 27766861 501 PMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 5lxd B 2.58 BS01 7A7 B 1 G156 V163 F228 L231 L282 I294 D295 G77 V84 F149 L152 L203 I215 D216 D275 K277 N280 D295 S312 D196 K198 N201 D216 S233 2.7.12.1 0004672,0004712,0005524,0006468 Q92630 27766861 501 PMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 6yti A 2.4 BS01 7A7 A 1 F172 A189 K191 F241 L244 S247 D250 E292 L295 V324 F22 A39 K41 F91 L94 S97 D100 E142 L145 V171 D288 K290 N293 D325 T342 D138 K140 N143 D172 T189 2.7.12.1 0004672,0005524,0006468 P49759 32787076 605 ICQSGDVLSARYEIVDLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK