5t1s A 2.3 BS01 76Q A 1 M192 A211 K213 V246 Y262 Y264 M265 P266 N267 G268 D272 L318 S328 D329 M25 A44 K46 V73 Y89 Y91 M92 P93 N94 G95 D99 L145 S155 D156 D311 K313 A315 N316 D329 T351 D138 K140 A142 N143 D156 T175 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=84nM -logKd/Ki=7.08, IC50=84nM Q9NWZ3 28501511 9901 TRFHSFSFYELKNVTNNFDERPIKMGEGGFGVVYKGYVNNTTVAVKKLTTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 5t1s B 2.3 BS01 76Q B 1 M192 A211 K213 V246 Y262 Y264 M265 P266 G268 D272 L318 S328 D329 M32 A51 K53 V77 Y93 Y95 M96 P97 G99 D103 L149 S159 D160 D311 K313 A315 N316 D329 T351 D142 K144 A146 N147 D160 T177 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=84nM Q9NWZ3 28501511 9901 SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLALKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 5t1s C 2.3 BS01 76Q C 1 M192 A211 K213 Y262 Y264 M265 P266 N267 G268 D272 L318 D329 M29 A48 K50 Y94 Y96 M97 P98 N99 G100 D104 L150 D161 D311 K313 A315 N316 D329 T351 D143 K145 A147 N148 D161 T178 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=84nM Q9NWZ3 28501511 9901 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 5t1s D 2.3 BS01 76Q D 1 M192 A211 K213 Y262 Y264 M265 P266 G268 D272 L318 S328 D329 M29 A48 K50 Y92 Y94 M95 P96 G98 D102 L148 S158 D159 D311 K313 A315 N316 D329 T351 D141 K143 A145 N146 D159 T176 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=84nM Q9NWZ3 28501511 9901 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA