5ll9 A 1.45 BS02 6YQ A 1 H91 H117 V119 S133 L197 T198 T199 P201 W208 H89 H115 V117 S131 L195 T196 T197 P199 W206 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 -logKd/Ki=6.08, Kd=833nM Kd=833nM, kon=380000M-1-s-1, koff=0.17s-1 O43570 302 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5ll9 B 1.45 BS02 6YQ B 1 H91 H93 H117 S130 L197 T198 T199 P201 H89 H91 H115 S128 L195 T196 T197 P199 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=833nM, kon=380000M-1-s-1, koff=0.17s-1 O43570 302 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5ll9 C 1.45 BS02 6YQ C 1 H91 H117 V119 S130 S133 L197 T198 T199 P201 W208 H89 H115 V117 S128 S131 L195 T196 T197 P199 W206 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=833nM, kon=380000M-1-s-1, koff=0.17s-1 O43570 302 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5ll9 D 1.45 BS02 6YQ D 1 H91 H117 S130 L197 T198 T199 P201 W208 H89 H115 S128 L195 T196 T197 P199 W206 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=833nM, kon=380000M-1-s-1, koff=0.17s-1 O43570 302 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5lla A 1.5 BS02 6YQ A 1 H96 H98 H121 V123 F133 L200 T201 V202 P204 H91 H93 H116 V118 F128 L195 T196 V197 P199 H66 H96 H98 E108 H121 T201 H61 H91 H93 E103 H116 T196 4.2.1.1 0004089,0005515,0005737,0005829,0006730,0008270,0016829,0043209,0043231,0046872 kon=630000M-1-s-1, koff=0.0020s-1, Kd=19nM Q8N1Q1 302 SWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH 5lla B 1.5 BS02 6YQ B 1 H96 H98 H121 V123 F133 L200 T201 V202 H91 H93 H116 V118 F128 L195 T196 V197 H66 H96 H98 E108 H121 T201 H61 H91 H93 E103 H116 T196 4.2.1.1 0004089,0005515,0005737,0005829,0006730,0008270,0016829,0043209,0043231,0046872 -logKd/Ki=7.72, Kd=18.9nM kon=630000M-1-s-1, koff=0.0020s-1, Kd=19nM Q8N1Q1 302 SWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH