5in4 A 1.6 BS03 6CK A 1 F60 T62 Y69 H75 E77 L82 Y84 F43 T45 Y52 H58 E60 L65 Y67 T155 S156 E157 Y179 K183 T138 S139 E140 Y162 K166 4.2.1.47 0005515,0005737,0005829,0007219,0008446,0016829,0019673,0042350,0042351,0042802,0070062,0070401 Kd=11uM O60547 27434622 1003 LYFQGRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA 5in4 A 1.6 BS04 6CK B 1 A216 N217 K222 R225 Y323 A199 N200 K205 R208 Y306 T155 S156 E157 Y179 K183 T138 S139 E140 Y162 K166 4.2.1.47 0005515,0005737,0005829,0007219,0008446,0016829,0019673,0042350,0042351,0042802,0070062,0070401 Kd=11uM O60547 27434622 401 LYFQGRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA 5in4 B 1.6 BS02 6CK A 1 A216 N217 K222 R225 Y323 A195 N196 K201 R204 Y302 T155 S156 E157 Y179 K183 T134 S135 E136 Y158 K162 4.2.1.47 0005515,0005737,0005829,0007219,0008446,0016829,0019673,0042350,0042351,0042802,0070062,0070401 Kd=11uM O60547 27434622 1003 GRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA 5in4 B 1.6 BS03 6CK B 1 F60 T62 Y69 H75 E77 L82 Y84 F39 T41 Y48 H54 E56 L61 Y63 T155 S156 E157 Y179 K183 T134 S135 E136 Y158 K162 4.2.1.47 0005515,0005737,0005829,0007219,0008446,0016829,0019673,0042350,0042351,0042802,0070062,0070401 Kd=11uM O60547 27434622 401 GRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA 5in4 C 1.6 BS03 6CK C 1 F60 T62 Y69 H75 E77 L82 Y84 F39 T41 Y48 H54 E56 L61 Y63 T155 S156 E157 Y179 K183 T134 S135 E136 Y158 K162 4.2.1.47 0005515,0005737,0005829,0007219,0008446,0016829,0019673,0042350,0042351,0042802,0070062,0070401 Kd=11uM O60547 27434622 1003 GRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA 5in4 C 1.6 BS04 6CK D 1 A216 N217 K222 R225 Y323 A195 N196 K201 R204 Y302 T155 S156 E157 Y179 K183 T134 S135 E136 Y158 K162 4.2.1.47 0005515,0005737,0005829,0007219,0008446,0016829,0019673,0042350,0042351,0042802,0070062,0070401 Kd=11uM O60547 27434622 401 GRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA 5in4 D 1.6 BS02 6CK C 1 A216 N217 K222 R225 Y323 A372 A195 N196 K201 R204 Y302 A351 T155 S156 E157 Y179 K183 T134 S135 E136 Y158 K162 4.2.1.47 0005515,0005737,0005829,0007219,0008446,0016829,0019673,0042350,0042351,0042802,0070062,0070401 Kd=11uM O60547 27434622 1003 GRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA 5in4 D 1.6 BS03 6CK D 1 F60 T62 Y69 H75 E77 L82 Y84 F39 T41 Y48 H54 E56 L61 Y63 T155 S156 E157 Y179 K183 T134 S135 E136 Y158 K162 4.2.1.47 0005515,0005737,0005829,0007219,0008446,0016829,0019673,0042350,0042351,0042802,0070062,0070401 Kd=11uM O60547 27434622 401 GRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA 8d0q A 1.39 BS03 6CK A 1 E137 Y168 V192 V193 S194 N195 R202 Y225 V226 D228 N246 Y252 T254 E255 K256 E75 Y106 V130 V131 S132 N133 R140 Y163 V164 D166 N184 Y190 T192 E193 K194 2.4.1.152 0006486,0008417,0016020 Q9Y231 37202521 401 ETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTNPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNDKNLIPTISACKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDYNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN