4rwj A 2.489 BS01 66T A 1 L484 G485 F489 A512 K514 E531 M535 I545 V561 A564 S565 G567 L630 D641 L28 G29 F33 A56 K58 E75 M79 I89 V105 A108 S109 G111 L174 D185 D623 A625 R627 N628 D641 D167 A169 R171 N172 D185 2.7.10.1 0004672,0004713,0005007,0005524,0006468 Kd=2nM -logKd/Ki=8.70, Kd=2nM P11362 25686244 801 MAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 4rwj B 2.489 BS01 66T B 1 L484 A512 K514 E531 M535 I545 V561 A564 S565 G567 L630 D641 F642 L26 A54 K56 E73 M77 I87 V103 A106 S107 G109 L159 D170 F171 D623 A625 R627 N628 D641 D152 A154 R156 N157 D170 2.7.10.1 0004672,0004713,0005007,0005524,0006468 Kd=2nM P11362 25686244 801 GVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLYKKTTGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSN 4rwk A 2.982 BS01 66T A 1 L484 V492 A512 A564 S565 G567 L630 D641 L28 V36 A56 A108 S109 G111 L174 D185 D623 A625 R627 N628 D641 D167 A169 R171 N172 D185 2.7.10.1 0004672,0004713,0005007,0005524,0006468 -logKd/Ki=7.19, Kd=64nM P11362 25686244 801 MAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIMEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 4rwk B 2.982 BS01 66T B 1 L484 G485 A512 K514 E531 M535 M561 A564 S565 G567 L630 A640 D641 F642 L26 G27 A54 K56 E73 M77 M103 A106 S107 G109 L156 A166 D167 F168 D623 A625 R627 N628 D641 D149 A151 R153 N154 D167 2.7.10.1 0004672,0004713,0005007,0005524,0006468 P11362 25686244 801 GVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIMEYASKGNLREYLQARRQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAIDYYKKTGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSN 4v05 A 2.57 BS01 66T A 1 L484 F489 A512 K514 E531 V561 Y563 A564 S565 G567 L630 D641 L21 F26 A49 K51 E68 V98 Y100 A101 S102 G104 L156 D167 D623 A625 R627 N628 D641 D149 A151 R153 N154 D167 0004672,0004713,0005007,0005524,0006468 -logKd/Ki=9.70, Kd=0.2nM 25465127 1769 ELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE 4v05 B 2.57 BS01 66T B 1 A512 K514 I545 V561 Y563 A564 S565 G567 L630 A640 D641 F642 A51 K53 I84 V100 Y102 A103 S104 G106 L156 A166 D167 F168 D623 A625 R627 N628 D641 D149 A151 R153 N154 D167 0004672,0004713,0005007,0005524,0006468 25465127 1767 GVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 4wun A 1.65 BS01 66T A 1 L484 G485 F489 A512 K514 E531 M535 I545 V561 Y563 A564 S565 G567 L630 A640 D641 L20 G21 F25 A48 K50 E67 M71 I81 V97 Y99 A100 S101 G103 L165 A175 D176 D623 A625 R627 N628 D641 D158 A160 R162 N163 D176 2.7.10.1 0004672,0004713,0005007,0005524,0006468 P11362 25760602 801 LPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE 4wun B 1.65 BS01 66T B 1 L484 G485 F489 A512 K514 E531 M535 I545 V561 Y563 A564 S565 G567 L630 D641 L24 G25 F29 A49 K51 E68 M72 I82 V98 Y100 A101 S102 G104 L153 D164 D623 A625 R627 N628 D641 D146 A148 R150 N151 D164 2.7.10.1 0004672,0004713,0005007,0005524,0006468 P11362 25760602 801 SEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS