5hx6 A 2.23 BS01 65U A 1 V31 K45 V76 L78 L90 M92 H136 D156 L157 F162 V19 K33 V64 L66 L78 M80 H124 D144 L145 F150 D138 K140 E142 N143 D156 T189 D126 K128 E130 N131 D144 T159 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.00, IC50=10nM IC50=1.6nM, Ki=0.800000nM Q13546 26854747 301 IKMKSSDFLESAELDSGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE 5hx6 B 2.23 BS01 65U B 1 M44 K45 L70 V76 L78 L90 M92 L129 H136 A155 D156 L157 L159 S161 M26 K27 L52 V58 L60 L72 M74 L111 H118 A137 D138 L139 L141 S143 D138 K140 E142 N143 D156 T189 D120 K122 E124 N125 D138 T159 2.7.11.1 0004672,0005524,0006468 IC50=1.6nM, Ki=0.800000nM Q13546 26854747 301 VIKMKSSDFLESVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE