2j4z A 2.0 BS01 626 A 1 A160 Y212 A213 P214 G216 R220 E260 L263 A273 H280 A35 Y87 A88 P89 G91 R95 E135 L138 A148 H155 D256 K258 E260 N261 D274 T292 D131 K133 E135 N136 D149 T167 2.7.11.1 0000212,0000226,0000278,0004672,0005524,0006468,0007052,0007098,0007100,0051321 ic50=65nM -logKd/Ki=7.19, IC50=65nM O14965 17125279 1389 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSS 2j4z B 2.0 BS01 626 B 1 A160 L210 E211 Y212 A213 P214 G216 R220 E260 L263 A273 H280 A35 L85 E86 Y87 A88 P89 G91 R95 E135 L138 A148 H155 D256 K258 E260 N261 D274 T292 D131 K133 E135 N136 D149 T167 2.7.11.1 0000212,0000226,0000278,0004672,0005524,0006468,0007052,0007098,0007100,0051321 ic50=65nM O14965 17125279 1395 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQ 2owb A 2.1 BS02 626 A 1 L59 G62 A65 K66 C67 A80 K82 E131 C133 R136 F183 L23 G26 A29 K30 C31 A44 K46 E95 C97 R100 F147 D176 K178 G180 N181 D194 T214 D140 K142 G144 N145 D158 T178 2.7.11.21 0004672,0005524,0006468 ic50=0.44uM -logKd/Ki=6.36, IC50=0.44uM P53350 17461553 500 AKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPS