5f32 A 2.05 BS03 5V7 A 1 Y132 Y177 F185 H188 E190 K206 W208 H276 Y122 Y167 F175 H178 E180 K196 W198 H266 G170 Y177 H188 E190 H276 S288 G160 Y167 H178 E180 H266 S278 1.14.11.66,1.14.11.69 ic50=11.5uM -logKd/Ki=4.94, IC50=11.5uM IC50=11500nM O75164 26741168 403 SARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 5f32 B 2.05 BS03 5V7 B 1 Y132 Y177 F185 H188 E190 K206 W208 H276 Y122 Y167 F175 H178 E180 K196 W198 H266 G170 Y177 H188 E190 H276 S288 G160 Y167 H178 E180 H266 S278 1.14.11.66,1.14.11.69 ic50=11.5uM IC50=11500nM O75164 26741168 403 SARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL 5f32 C 2.05 BS03 5V7 C 1 Y132 Y177 F185 H188 E190 K206 W208 K241 H276 Y127 Y172 F180 H183 E185 K201 W203 K236 H271 G170 Y177 H188 E190 H276 S288 G165 Y172 H183 E185 H271 S283 1.14.11.66,1.14.11.69 ic50=11.5uM IC50=11500nM O75164 26741168 403 ETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLK 5f32 D 2.05 BS03 5V7 D 1 Y132 Y177 F185 H188 E190 K206 W208 K241 H276 Y127 Y172 F180 H183 E185 K201 W203 K236 H271 G170 Y177 H188 E190 H276 S288 G165 Y172 H183 E185 H271 S283 1.14.11.66,1.14.11.69 ic50=11.5uM IC50=11500nM O75164 26741168 403 ETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEF