1rxc J 2.35 BS04 5UD J 1 I69 T94 T95 G96 F162 Q166 E196 M197 E198 I220 I66 T91 T92 G93 F159 Q163 E193 M194 E195 I217 H8 G26 R30 R48 E80 R91 T94 R168 I220 V221 R223 M234 H5 G23 R27 R45 E77 R88 T91 R165 I217 V218 R220 M231 2.4.2.3 0003824,0004850,0005524,0005737,0005829,0006218,0006974,0009116,0009164,0009166,0016757,0016763,0030955,0032991,0042802,0044206,0046050,0047847 P12758 15003451 2051 SDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPVKLASHREFTTWRAELDGKPVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGASLHFAPLEFPAVADFECTTALVEAAKSIGATTHVGVTASSDTFYPGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESATLLTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESHAVKIVVEAARRLL 1tgv A 2.2 BS01 5UD A 1 T94 T95 G96 F162 Q166 E196 M197 E198 I220 T91 T92 G93 F159 Q163 E193 M194 E195 I217 H8 G26 R30 R48 E80 R91 T94 R168 I220 V221 R223 M234 H5 G23 R27 R45 E77 R88 T91 R165 I217 V218 R220 M231 2.4.2.3 0003824,0004850,0005524,0005737,0005829,0006218,0006974,0009116,0009164,0009166,0016757,0016763,0030955,0032991,0042802,0044206,0046050,0047847 P12758 3001 SDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPVKLASHREFTTWRAELDGKPVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGASLHFAPLEFPAVADFECTTALVEAAKSIGATTHVGVTASSDTFYPGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESATLLTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESHAVKIVVEAARRLL 1tgv B 2.2 BS01 5UD B 1 T94 T95 G96 F162 Q166 E196 M197 E198 I220 T91 T92 G93 F159 Q163 E193 M194 E195 I217 H8 G26 R30 R48 E80 R91 T94 R168 I220 V221 R223 M234 H5 G23 R27 R45 E77 R88 T91 R165 I217 V218 R220 M223 2.4.2.3 0003824,0004850,0005524,0005737,0005829,0006218,0006974,0009116,0009164,0009166,0016757,0016763,0030955,0032991,0042802,0044206,0046050,0047847 P12758 5002 SDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPVKLASHREFTTWRAELDGKPVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGASLHFAPLEFPAVADFECTTALVEAAKSIGATTHVGVTASSDTFYPGQERYDTYSGRVVRHFKGSMEEWQAMGVMNYEMESATLLTMCASQGLRAGMVAGVIVNRTQMKQTESHAVKIVVEAARRLL 4a7s A 1.06 BS03 5UD A 1 K30 W32 S98 K30 W32 S98 H46 H48 H63 H71 H80 D83 H120 R143 H46 H48 H63 H71 H80 D83 H120 R143 1.15.1.1 0000302,0000303,0001541,0001819,0001890,0001895,0002262,0004784,0005507,0005515,0005576,0005615,0005634,0005654,0005737,0005739,0005758,0005759,0005777,0005829,0005886,0006749,0006801,0006879,0006915,0006979,0007283,0007566,0007605,0007626,0008089,0008090,0008217,0008270,0008340,0009408,0009410,0010467,0016209,0016491,0019226,0019228,0019430,0030346,0031267,0031410,0032287,0032839,0032930,0032991,0033081,0035234,0040014,0042542,0042554,0042802,0042803,0043025,0043065,0043066,0043087,0043410,0043524,0045471,0046620,0046716,0046872,0048538,0048678,0050665,0050728,0050766,0051087,0051093,0051881,0060047,0060052,0060087,0060088,0070062,0072593,0099610,1902177,1904115,2000242 P00441 23612299 1159 ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCITGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 4a7s F 1.06 BS03 5UD F 1 E21 W32 S98 E21 W32 S98 1.15.1.1 0000302,0000303,0001541,0001819,0001890,0001895,0002262,0004784,0005507,0005515,0005576,0005615,0005634,0005654,0005737,0005739,0005758,0005759,0005777,0005829,0005886,0006749,0006801,0006879,0006915,0006979,0007283,0007566,0007605,0007626,0008089,0008090,0008217,0008270,0008340,0009408,0009410,0010467,0016209,0016491,0019226,0019228,0019430,0030346,0031267,0031410,0032287,0032839,0032930,0032991,0033081,0035234,0040014,0042542,0042554,0042802,0042803,0043025,0043065,0043066,0043087,0043410,0043524,0045471,0046620,0046716,0046872,0048538,0048678,0050665,0050728,0050766,0051087,0051093,0051881,0060047,0060052,0060087,0060088,0070062,0072593,0099610,1902177,1904115,2000242 P00441 23612299 1160 ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCITGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 4pb2 A 2.302 BS01 5UD A 1 Q154 E332 F366 S371 Q153 E320 F354 S359 ? 0005337,0005886,0015293,0016020,0042802,1901642 Kd=16uM -logKd/Ki=4.80, Kd=16uM Q9KPL5 25082345 501 SLFMSCCGMAVLLGIAVLLSSNRKAINLRTVGGAFAIQFSLGAFILYVPWGQELLRGFSDAVSNVINYGNDGTSFLFGGLVSGKMFEVFGGGGFIFAFRVLPTLIFFSALISVLYYLGVMQWVIRILGGGLQKALGTSRAESMSAAANIFVGQTEAPLVVRPFVPKMTQSELFAVMCGGLASIAGGVLAGYASMGVKIEYLVAASFMAAPGGLLFAKLMMPETEKPQDKPANVIDAAAGGASAGLQLALNVGAMLIAFIGLIALINGMLGGIGGWFGMPELKLEMLLGWLFAPLAFLIGVPWNEATVAGEFIGLKTVANEFVAYSQFAPYLTEAAPVVLSEKTKAIISFALCGFANLSSIAILLGGLGSLAPKRRGDIARMGVKAVIAGTLSNLMAATIAGFFL