5ehr A 1.7 BS01 5OD A 1 E110 R111 F113 T219 E249 E250 T253 L254 Q257 P491 K492 Q495 E96 R97 F99 T192 E216 E217 T220 L221 Q224 P451 K452 Q455 D425 C459 R465 T466 Q506 D385 C419 R425 T426 Q466 3.1.3.48 0004725,0006470,0016311 Kd=73nM -logKd/Ki=7.14, Kd=73nM IC50=70.0nM Q06124 27362227 601 RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESGDFVLSVRTGDSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 5ehr B 1.7 BS01 5OD B 1 E110 R111 F113 T219 E250 T253 L254 Q257 P491 K492 Q495 E95 R96 F98 T192 E214 T217 L218 Q221 P436 K437 Q440 D425 C459 R465 T466 Q506 D370 C404 R410 T411 Q451 3.1.3.48 0004725,0006470,0016311 Kd=73nM IC50=70.0nM Q06124 27362227 601 RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESSHPGDFVLSVRTSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHVSDYINANIIMPKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 6bmu A 2.12 BS01 5OD A 1 R111 F113 H114 T219 E249 E250 T253 L254 Q257 P491 K492 Q495 R104 F106 H107 T194 E216 E217 T220 L221 Q224 P446 K447 Q450 D425 C459 R465 T466 Q506 D380 C414 R420 T421 Q461 3.1.3.48 0004725,0006470,0016311 IC50=70.0nM Q06124 29304282 601 SRRWFHPNITGVEAENLLLTRGVDGSFLARPSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKGDVIELKYPLNCADPTSERWFHGHLEKLLTEKGKHGSFLVRESPGDFVLSVRTGSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPPVSDYINANIIMPPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 6bmu B 2.12 BS01 5OD B 1 E110 R111 F113 T219 E249 E250 T253 L254 Q257 P491 K492 Q495 E102 R103 F105 T194 E215 E216 T219 L220 Q223 P440 K441 Q444 D425 C459 R465 T466 Q506 D374 C408 R414 T415 Q455 3.1.3.48 0004725,0006470,0016311 IC50=70.0nM Q06124 29304282 601 RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLDVIELKYPLNCADPTSERWFHGHLSGAEKLLTEKGKHGSFLVREPGDFVLSVRTSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHVSDYINANIIMPPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 6bmw A 2.1 BS01 5OD A 1 E110 R111 F113 H114 T219 E249 E250 T253 L254 Q257 P491 K492 Q495 E102 R103 F105 H106 T195 E217 E218 T221 L222 Q225 P441 K442 Q445 D425 C459 R465 T466 Q506 D375 C409 R415 T416 Q456 3.1.3.48 0004725,0006470,0016311 IC50=70.0nM Q06124 29304282 601 SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKDVIELKYPLNCADPTSERWFHGHLEAEKLLTEKGKHGSFLVRESPGDFVLSVRTGSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHPVSDYINANIIMPKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 6bmw B 2.1 BS01 5OD B 1 E110 R111 F113 T219 E249 T253 L254 Q257 P491 K492 Q495 E103 R104 F106 T193 E214 T218 L219 Q222 P439 K440 Q443 D425 C459 R465 T466 Q506 D373 C407 R413 T414 Q454 3.1.3.48 0004725,0006470,0016311 IC50=70.0nM Q06124 29304282 601 RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKDVIELKYPLNCADPTSERWFHGHLAEKLLTEKGKHGSFLVREPGDFVLSVRTSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHVSDYINANIIMPPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 6bmy A 2.09 BS01 5OD A 1 E110 R111 F113 H114 T219 E250 T253 L254 Q257 P491 K492 Q495 E103 R104 F106 H107 T194 E217 T220 L221 Q224 P446 K447 Q450 D425 C459 R465 T466 Q506 D380 C414 R420 T421 Q461 3.1.3.48 0004725,0006470,0016311 IC50=70.0nM Q06124 29304282 601 SRRWFHPNITGVEAENLLLTRGVDGSFLARPSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKGDVIELKYPLNCADPTSERWFHGHLEKLLTEKGKHGSFLVRESPGDFVLSVRTGSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPPVSDYINANIIMPPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 6bmy B 2.09 BS01 5OD B 1 E110 R111 F113 T219 E250 T253 L254 Q257 P491 K492 Q495 E102 R103 F105 T194 E216 T219 L220 Q223 P440 K441 Q444 D425 C459 R465 T466 Q506 D374 C408 R414 T415 Q455 3.1.3.48 0004725,0006470,0016311 IC50=70.0nM Q06124 29304282 601 RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLDVIELKYPLNCADPTSERWFHGHLSGAEKLLTEKGKHGSFLVREPGDFVLSVRTSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHVSDYINANIIMPPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 6cmr A 2.21 BS01 5OD A 1 E110 R111 F113 T219 E249 E250 T253 L254 Q257 P491 K492 Q495 E106 R107 F109 T212 E233 E234 T237 L238 Q241 P457 K458 Q461 3.1.3.48 0004725,0006470,0016311 -logKd/Ki=6.61, IC50=0.246uM IC50=70.0nM Q06124 30375376 601 TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLADLVQYYMEHHGQLKEDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDSNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHSDYINANIIMPEKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRR 6cms A 2.68 BS01 5OD A 1 R111 F113 T218 T219 T253 L254 Q257 P491 K492 Q495 R107 F109 T214 T215 T241 L242 Q245 P461 K462 Q465 3.1.3.48 0004725,0006470,0016311 -logKd/Ki=5.82, Kd=1.5uM IC50=70.0nM Q06124 30375376 601 TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHSDYINANIIMPEKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQR 6crg A 2.75 BS01 5OD A 1 R111 F113 T219 E250 T253 L254 Q257 P491 K492 Q495 R93 F95 T196 E218 T221 L222 Q225 P443 K444 Q447 3.1.3.48 0004725,0006470,0016311 IC50=70.0nM Q06124 30375388 601 RRWFHPNITGVEAENLLLTRGVDGSFLARPSDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGSNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGPVSDYINANIIMPKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 6crg B 2.75 BS01 5OD B 1 R111 F113 T219 E249 E250 T253 L254 Q257 P491 K492 Q495 R93 F95 T195 E216 E217 T220 L221 Q224 P428 K429 Q432 3.1.3.48 0004725,0006470,0016311 IC50=70.0nM Q06124 30375388 601 RRWFHPNITGVEAENLLLTGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLKFATLAKLVQYYMEHVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHVSDYINANIIMPKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 8wfy A 2.6 BS01 5OD A 1 E110 R111 F113 H114 T219 T253 Q257 Q495 E100 R101 F103 H104 T204 T230 Q234 Q454 3.1.3.48 0004725,0006470,0016311 Q06124 601 RRWFHPNITGVEAENLLLTRGVDGSFLARPSDLTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGSDYINANIIMPKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRSIYMAVQHYIETL 8wfy B 2.6 BS01 5OD B 1 E110 R111 F113 T219 E249 T253 Q257 P491 K492 Q495 E99 R100 F102 T198 E228 T232 Q236 P462 K463 Q466 3.1.3.48 0004725,0006470,0016311 Q06124 601 RRWFHPNITGVEAENLLLTRGVDGSFLARPSNPGDLTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRSIYMAVQHYIETL