2c47 A 2.4 BS01 5ID A 1 L60 E120 L121 L122 E169 L172 I187 L11 E71 L72 L73 E120 L123 I138 D165 K167 T215 D116 K118 T166 2.7.11.1 0004672,0005524,0006468 P78368 1300 PNFRVGKKIELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPI 2c47 B 2.4 BS01 5ID B 1 L60 L121 L122 E169 L172 I187 L12 L73 L74 E121 L124 I139 D165 K167 T215 D117 K119 T167 2.7.11.1 0004672,0005524,0006468 P78368 1300 PNFRVGKKIGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPI 2c47 C 2.4 BS01 5ID C 1 L60 L122 S125 E169 L172 I187 L9 L71 S74 E118 L121 I133 D165 K167 T215 D114 K116 T161 2.7.11.1 0004672,0005524,0006468 P78368 1300 FRVGKKIELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTP 2c47 D 2.4 BS01 5ID D 1 L60 L121 L122 E169 L172 I187 L14 L75 L76 E123 L126 I141 D165 K167 T215 D119 K121 T168 2.7.11.1 0004672,0005524,0006468 P78368 1300 MGPNFRVGKKIGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPTKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPI 2vuw A 1.8 BS01 5ID A 1 G491 A509 F605 F607 G608 D611 G653 L656 I686 G22 A40 F136 F138 G139 D142 G184 L187 I217 2.7.11.1 0004672,0005524,0006468 Q8TF76 19918057 1800 KGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK 2zoq A 2.39 BS01 5ID A 1 I48 E50 V56 A69 Q122 M125 S170 L173 I25 E27 V33 A46 Q99 M102 S147 L150 D166 K168 S170 N171 D184 T207 D143 K145 S147 N148 D161 T184 2.7.11.24 0000165,0001784,0004672,0004674,0004707,0005515,0005524,0005634,0005635,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005829,0005856,0005886,0005901,0005925,0006351,0006468,0006915,0006974,0008286,0009887,0010759,0014032,0014044,0016020,0016310,0019233,0019902,0030278,0030509,0030641,0030878,0031143,0031281,0031663,0032206,0032496,0032872,0033554,0034198,0035556,0038083,0038133,0042473,0042552,0042770,0042802,0043330,0045944,0048009,0048538,0050804,0051090,0051216,0051403,0051493,0060020,0060324,0060425,0060440,0061308,0070161,0070371,0070374,0070498,0070849,0071260,0071356,0072584,0090170,0098792,0098978,0106310,0120041,0140297,1904262,1904417,2000641 ic50=0.9uM -logKd/Ki=6.05, IC50=0.9uM P27361 18983981 382 VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGV 2zoq B 2.39 BS01 5ID B 1 I48 V56 A69 Q122 D123 M125 S170 L173 I25 V33 A46 Q99 D100 M102 S147 L150 D166 K168 S170 N171 D184 T207 D143 K145 S147 N148 D161 T184 2.7.11.24 0000165,0001784,0004672,0004674,0004707,0005515,0005524,0005634,0005635,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005829,0005856,0005886,0005901,0005925,0006351,0006468,0006915,0006974,0008286,0009887,0010759,0014032,0014044,0016020,0016310,0019233,0019902,0030278,0030509,0030641,0030878,0031143,0031281,0031663,0032206,0032496,0032872,0033554,0034198,0035556,0038083,0038133,0042473,0042552,0042770,0042802,0043330,0045944,0048009,0048538,0050804,0051090,0051216,0051403,0051493,0060020,0060324,0060425,0060440,0061308,0070161,0070371,0070374,0070498,0070849,0071260,0071356,0072584,0090170,0098792,0098978,0106310,0120041,0140297,1904262,1904417,2000641 ic50=0.9uM P27361 18983981 382 VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGV 3iq7 A 2.0 BS02 5ID A 1 I490 G491 A509 F605 F607 G608 D611 G653 L656 I686 I20 G21 A39 F135 F137 G138 D141 G183 L186 I216 2.7.11.1 0004672,0005524,0006468 Q8TF76 19918057 799 GPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK 3uwp A 2.05 BS01 5ID A 1 E129 G163 E186 K187 D222 F223 E126 G160 E183 K184 D219 F220 2.1.1.360 0031151,0051726 IC50=7000nM Q8TEK3 23250418 421 KLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRR 4ouc A 1.9 BS02 5ID A 1 I490 G491 E492 V498 A509 F605 F607 G608 D611 G653 L656 I686 I21 G22 E23 V29 A40 F136 F138 G139 D142 G184 L187 I217 2.7.11.1 0004672,0005524,0006468 Q8TF76 24732914 808 KGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK 5ax3 A 2.984 BS02 5ID A 1 I22 E24 A43 D97 L98 M99 D102 K105 L147 I22 E24 A41 D95 L96 M97 D100 K103 L145 D140 K142 S144 N145 D158 T181 D138 K140 S142 N143 D156 T170 2.7.11.24 0000165,0001784,0003677,0004672,0004674,0004707,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006935,0006974,0007165,0007166,0007268,0007507,0007611,0008286,0008353,0009887,0010759,0010800,0014032,0014044,0016020,0016301,0016310,0018105,0018107,0019858,0019902,0030278,0030521,0030641,0030878,0031143,0031647,0031663,0032206,0032496,0032872,0033554,0033598,0034198,0035094,0035556,0035578,0038127,0038133,0042473,0042552,0042802,0043330,0043401,0045202,0045542,0045596,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060291,0060324,0060425,0060440,0060716,0061308,0070161,0070371,0070849,0071356,0072584,0072686,0090170,0106310,0120041,1904813,2000641 -logKd/Ki=5.92, IC50=1.2uM Ki=530nM, IC50=1200nM P28482 26733474 401 GPEMVRGQVFDVGPRYTNLSYIGEYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAFLTEYVTRWYRAPEIMLGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGY 5od2 A 1.98 BS02 5ID A 1 T349 A383 S428 Y430 V431 P434 L440 I444 T344 A378 S423 Y425 V426 P429 L435 I439 2.7.1.146,2.7.1.147 0000287,0005737,0005975,0006000,0006096,0008443,0016301,0016310,0016773,0043843,0043844,0046835,0046872 Ki=0.74mM Q58999 29352744 502 EIKKFIETIKGTKLFTAYNTNVDAIKYLKDEDVQKLVDEFNHKDIIERMEEYPRIIEEPLDFVARLVHSIKTGKPAEVPIKDDKKLHEWFDRIKYDEERMGGQAGIVSNLMATLQIDKIIVYTPFLSKKQAEMFVDYDNLLYPLVENGNLVLKKVREAYRDDPIKINRIFEFKKGLKFKLNGEEITAKQSTRFIVASRPEALRIEIKDDVRKFLPKIGEAVDCAFLSGYQAIKEEYRDGKTAKYYFERAEEDIKLLKKNKNIKTHLEFASISNIEIRKMVVDYILSNVESVGMDETEIANVLHILGYDELSNNILKDSFIEDVIEGAKILLDKFKNLEVVQVHTIYYILFVCRADNPLSKEELEECLEFSTILASTKAKLGNIRAIDDLHEGLKIPHNKYGDLLKEIAEKFNDNNYKIALSPSRYVEKPKSTVGLGDTISSGAFVYYVSLLNKKRM 5od2 B 1.98 BS02 5ID B 1 H348 T349 A383 S428 Y430 V431 P434 L440 I444 H345 T346 A380 S425 Y427 V428 P431 L437 I441 2.7.1.146,2.7.1.147 0000287,0005737,0005975,0006000,0006096,0008443,0016301,0016310,0016773,0043843,0043844,0046835,0046872 Ki=0.74mM Q58999 29352744 502 IMEIKKFIETIKGTKLFTAYNTNVDAIKYLKDEDVQKLVDEFNHKDIIERMEEYPRIIEEPLDFVARLVHSIKTGKPAEVPIKDDKKLHEWFDRIKYDEERMGGQAGIVSNLMATLQIDKIIVYTPFLSKKQAEMFVDYDNLLYPLVENGNLVLKKVREAYRDDPIKINRIFEFKKGLKFKLNGEEITAKQSTRFIVASRPEALRIEIKDDVRKFLPKIGEAVDCAFLSGYQAIKEEYRDGKTAKYYFERAEEDIKLLKKNKNIKTHLEFASISNIEIRKMVVDYILSNVESVGMDETEIANVLHILGYDELSNNILKDSFIEDVIEGAKILLDKFKNLEVVQVHTIYYILFVCRADNPLSKEELEECLEFSTILASTKAKLGNIRAIDDLHEGLKIPHNKYGDLLKEIAEKFNDNNYKIALSPSRYVEKPKSTVGLGDTISSGAFVYYVSLLNKKRM 5od2 C 1.98 BS02 5ID C 1 T349 A379 A383 S428 Y430 V431 P434 L440 I444 T344 A374 A378 S423 Y425 V426 P429 L435 I439 2.7.1.146,2.7.1.147 0000287,0005737,0005975,0006000,0006096,0008443,0016301,0016310,0016773,0043843,0043844,0046835,0046872 Ki=0.74mM Q58999 29352744 502 EIKKFIETIKGTKLFTAYNTNVDAIKYLKDEDVQKLVDEFNHKDIIERMEEYPRIIEEPLDFVARLVHSIKTGKPAEVPIKDDKKLHEWFDRIKYDEERMGGQAGIVSNLMATLQIDKIIVYTPFLSKKQAEMFVDYDNLLYPLVENGNLVLKKVREAYRDDPIKINRIFEFKKGLKFKLNGEEITAKQSTRFIVASRPEALRIEIKDDVRKFLPKIGEAVDCAFLSGYQAIKEEYRDGKTAKYYFERAEEDIKLLKKNKNIKTHLEFASISNIEIRKMVVDYILSNVESVGMDETEIANVLHILGYDELSNNILKDSFIEDVIEGAKILLDKFKNLEVVQVHTIYYILFVCRADNPLSKEELEECLEFSTILASTKAKLGNIRAIDDLHEGLKIPHNKYGDLLKEIAEKFNDNNYKIALSPSRYVEKPKSTVGLGDTISSGAFVYYVSLLNKKRM 6c67 A 2.11 BS01 5ID A 1 S8 D12 G47 G48 N52 F102 F116 Q172 G254 D257 S7 D11 G38 G39 N43 F93 F107 Q163 G245 D248 2.7.1.20 0000287,0004001,0005515,0005524,0005525,0005886,0006166,0016301,0016310,0016772,0032567,0044209 Ki=210nM, IC50=1200nM P9WID5 31002508 401 TIAVTGSIATDHLMRFPGRFSEQVSLSFLVDDLVMHRGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAV 6c67 A 2.11 BS02 5ID A 2 G225 P226 V243 V244 E246 A284 V285 L288 G216 P217 V234 V235 E237 A275 V276 L279 2.7.1.20 0000287,0004001,0005515,0005524,0005525,0005886,0006166,0016301,0016310,0016772,0032567,0044209 Ki=210nM, IC50=1200nM P9WID5 31002508 402 TIAVTGSIATDHLMRFPGRFSEQVSLSFLVDDLVMHRGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAV 6c67 B 2.11 BS01 5ID B 1 S8 D12 G47 G48 N52 F102 F116 Q172 Q173 G254 D257 S7 D11 G39 G40 N44 F94 F108 Q164 Q165 G246 D249 2.7.1.20 0000287,0004001,0005515,0005524,0005525,0005886,0006166,0016301,0016310,0016772,0032567,0044209 Ki=210nM, IC50=1200nM P9WID5 31002508 401 TIAVTGSIATDHLMRFPGRFSEQLVSLSFLVDDLVMHRGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAV 6c67 B 2.11 BS02 5ID B 2 M110 G225 P226 V243 E246 A284 V285 L288 M102 G217 P218 V235 E238 A276 V277 L280 2.7.1.20 0000287,0004001,0005515,0005524,0005525,0005886,0006166,0016301,0016310,0016772,0032567,0044209 Ki=210nM, IC50=1200nM P9WID5 31002508 402 TIAVTGSIATDHLMRFPGRFSEQLVSLSFLVDDLVMHRGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAV 6g33 A 2.05 BS01 5ID A 1 G168 F172 V175 A189 F241 L244 E292 L295 G23 F27 V30 A44 F96 L99 E147 L150 D288 K290 N293 D325 T342 D143 K145 N148 D180 T197 2.7.12.1 0004672,0005524,0006468 Kd~7nM -logKd/Ki=8.15, Kd~7nM P49759 29601130 501 SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK 6g33 B 2.05 BS01 5ID B 1 G168 F172 V175 A189 F241 L244 E292 L295 G23 F27 V30 A44 F96 L99 E147 L150 D288 K290 N293 D325 T342 D143 K145 N148 D180 T197 2.7.12.1 0004672,0005524,0006468 Kd~7nM P49759 29601130 501 SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK 6g33 C 2.05 BS01 5ID C 1 F172 V175 A189 F241 L244 E292 L295 V324 F27 V30 A44 F96 L99 E147 L150 V179 D288 K290 N293 D325 T342 D143 K145 N148 D180 T197 2.7.12.1 0004672,0005524,0006468 Kd~7nM P49759 29601130 501 SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK 6g34 A 1.76 BS01 5ID A 1 I49 A68 F164 F166 G167 D170 G212 L215 I245 I19 A38 F134 F136 G137 D140 G182 L185 I215 2.7.11.1 0004672,0005524,0006468 Kd=5.7nM -logKd/Ki=8.24, Kd=5.7nM Q8TF76 29601130 401 PVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK 6g39 A 1.45 BS01 5ID A 1 I490 G491 V498 A509 Y605 F607 G608 D611 G653 L656 I686 I20 G21 V28 A39 Y135 F137 G138 D141 G183 L186 I216 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.34, Kd=4.6nM Q8TF76 29601130 802 GPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEYEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK 6g3a A 1.43 BS01 5ID A 1 I490 A509 I557 F607 G608 D611 G653 L656 I686 I20 A39 I87 F137 G138 D141 G183 L186 I216 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.38, Kd=4.2nM Q8TF76 29601130 805 GPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLETEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK 6jwa A 1.781 BS01 5ID A 1 V66 V116 M163 I174 V65 V115 M162 I173 D156 K158 N161 D175 S194 D155 K157 N160 D174 S193 2.7.11.1 0004672,0004674,0005524,0006468 ic50=10.9uM P68400 31282872 401 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 7w5o A 2.35 BS01 5ID A 1 A52 M108 D111 K114 S153 A42 M98 D101 K104 S143 2.7.11.24 0000165,0001784,0003677,0004672,0004674,0004707,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006935,0006974,0007165,0007166,0007268,0007507,0007611,0008286,0008353,0009887,0010759,0010800,0014032,0014044,0016020,0016301,0016310,0018105,0018107,0019858,0019902,0030278,0030521,0030641,0030878,0031143,0031647,0031663,0032206,0032496,0032872,0033554,0033598,0034198,0035094,0035556,0035578,0038127,0038133,0042473,0042552,0042802,0043330,0043401,0045202,0045542,0045596,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060291,0060324,0060425,0060440,0060716,0061308,0070161,0070371,0070849,0071356,0072584,0072686,0090170,0106310,0120041,1904813,2000641 P28482 35063772 401 PEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 7x4u A 1.98 BS01 5ID A 1 A52 Q105 M108 D111 K114 L156 A43 Q96 M99 D102 K105 L147 2.7.11.24 0000165,0001784,0003677,0004672,0004674,0004707,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006935,0006974,0007165,0007166,0007268,0007507,0007611,0008286,0008353,0009887,0010759,0010800,0014032,0014044,0016020,0016301,0016310,0018105,0018107,0019858,0019902,0030278,0030521,0030641,0030878,0031143,0031647,0031663,0032206,0032496,0032872,0033554,0033598,0034198,0035094,0035556,0035578,0038127,0038133,0042473,0042552,0042802,0043330,0043401,0045202,0045542,0045596,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060291,0060324,0060425,0060440,0060716,0061308,0070161,0070371,0070849,0071356,0072584,0072686,0090170,0106310,0120041,1904813,2000641 P28482 401 GPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYR 7xc1 A 2.09 BS01 5ID A 1 A52 Q105 M108 D111 K114 A43 Q96 M99 D102 K105 2.7.11.24 0000165,0001784,0003677,0004672,0004674,0004707,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006935,0006974,0007165,0007166,0007268,0007507,0007611,0008286,0008353,0009887,0010759,0010800,0014032,0014044,0016020,0016301,0016310,0018105,0018107,0019858,0019902,0030278,0030521,0030641,0030878,0031143,0031647,0031663,0032206,0032496,0032872,0033554,0033598,0034198,0035094,0035556,0035578,0038127,0038133,0042473,0042552,0042802,0043330,0043401,0045202,0045542,0045596,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060291,0060324,0060425,0060440,0060716,0061308,0070161,0070371,0070849,0071356,0072584,0072686,0090170,0106310,0120041,1904813,2000641 P28482 401 GPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 7xc1 B 2.09 BS02 5ID B 1 G32 A52 Q105 L107 M108 D111 K114 G21 A41 Q94 L96 M97 D100 K103 2.7.11.24 0000165,0001784,0003677,0004672,0004674,0004707,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006935,0006974,0007165,0007166,0007268,0007507,0007611,0008286,0008353,0009887,0010759,0010800,0014032,0014044,0016020,0016301,0016310,0018105,0018107,0019858,0019902,0030278,0030521,0030641,0030878,0031143,0031647,0031663,0032206,0032496,0032872,0033554,0033598,0034198,0035094,0035556,0035578,0038127,0038133,0042473,0042552,0042802,0043330,0043401,0045202,0045542,0045596,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060291,0060324,0060425,0060440,0060716,0061308,0070161,0070371,0070849,0071356,0072584,0072686,0090170,0106310,0120041,1904813,2000641 P28482 402 EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPG 8ov3 A 1.82 BS01 5ID A 1 D6897 L6898 D6912 C6913 M6929 Y6930 D99 L100 D114 C115 M131 Y132 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0004483 P0DTD1 7218 SSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNNEN 8zjv A 1.8 BS01 5ID A 1 I31 V39 A52 Q105 M108 D111 S153 L156 D167 I22 V30 A43 Q96 M99 D102 S144 L147 D158 2.7.11.24 0000165,0001784,0003677,0004672,0004674,0004707,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006935,0006974,0007165,0007166,0007268,0007507,0007611,0008286,0008353,0009887,0010759,0010800,0014032,0014044,0016020,0016301,0016310,0018105,0018107,0019858,0019902,0030278,0030521,0030641,0030878,0031143,0031647,0031663,0032206,0032496,0032872,0033554,0033598,0034198,0035094,0035556,0035578,0038127,0038133,0042473,0042552,0042802,0043330,0043401,0045202,0045542,0045596,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060291,0060324,0060425,0060440,0060716,0061308,0070161,0070371,0070849,0071356,0072584,0072686,0090170,0106310,0120041,1904813,2000641 P28482 401 GPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGY