2i6a A 2.2 BS01 5I5 A 1 N14 D18 I39 G64 S65 C123 L134 F170 N12 D16 I37 G62 S63 C121 L132 F168 R132 G297 A298 G299 D300 R130 G295 A296 G297 D298 2.7.1.20 0003723,0004001,0004136,0005524,0005634,0005654,0005737,0005829,0005886,0006144,0006166,0006175,0006753,0009156,0016301,0016310,0032263,0034654,0044209,0046872,0106383 ic50=0.9nM -logKd/Ki=9.05, IC50=0.9nM IC50=9.0nM P55263 17154503 500 SVRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH 2i6a B 2.2 BS01 5I5 B 1 N14 L16 D18 I39 G64 S65 F170 N296 N12 L14 D16 I37 G62 S63 F168 N294 R132 G297 A298 G299 D300 R130 G295 A296 G297 D298 2.7.1.20 0003723,0004001,0004136,0005524,0005634,0005654,0005737,0005829,0005886,0006144,0006166,0006175,0006753,0009156,0016301,0016310,0032263,0034654,0044209,0046872,0106383 ic50=0.9nM IC50=9.0nM P55263 17154503 500 SVRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH 2i6a C 2.2 BS01 5I5 C 1 N14 D18 Q38 I39 G64 S65 A136 F170 N12 D16 Q36 I37 G62 S63 A134 F168 R132 G297 A298 G299 D300 R130 G295 A296 G297 D298 2.7.1.20 0003723,0004001,0004136,0005524,0005634,0005654,0005737,0005829,0005886,0006144,0006166,0006175,0006753,0009156,0016301,0016310,0032263,0034654,0044209,0046872,0106383 ic50=0.9nM IC50=9.0nM P55263 17154503 500 SVRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH 2i6a D 2.2 BS01 5I5 D 1 N14 D18 I39 C123 A136 F170 N296 D300 N12 D16 I37 C121 A134 F168 N294 D298 R132 G297 A298 G299 D300 R130 G295 A296 G297 D298 2.7.1.20 0003723,0004001,0004136,0005524,0005634,0005654,0005737,0005829,0005886,0006144,0006166,0006175,0006753,0009156,0016301,0016310,0032263,0034654,0044209,0046872,0106383 ic50=0.9nM IC50=9.0nM P55263 17154503 500 SVRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH