5acb C 2.7 BS01 5I1 C 1 I733 V741 A754 K756 F813 M816 D819 L866 Q1037 C1039 I18 V26 A39 K41 F98 M101 D104 L151 Q322 C324 D859 K861 S863 N864 D877 S889 T898 D144 K146 S148 N149 D162 S174 T183 2.7.11.22,2.7.11.23 0004672,0005524,0006468 -logKd/Ki=6.80, IC50=158nM Q9NYV4 27571479 2000 ESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCH 5acb D 2.7 BS01 5I1 D 1 I733 V741 A754 K756 F813 M816 D819 E825 Q1037 C1039 E1041 I16 V24 A37 K39 F92 M95 D98 E104 Q313 C315 E317 D859 K861 S863 N864 D877 T898 D138 K140 S142 N143 D156 T174 2.7.11.22,2.7.11.23 0004672,0005524,0006468 Q9NYV4 27571479 2000 DWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWS 7nxj A 2.36 BS01 5I1 A 1 I711 I765 F791 Y793 M794 E803 L844 Q1015 C1017 I17 I71 F93 Y95 M96 E105 L146 Q317 C319 D837 K839 S841 N842 D855 S867 T876 D139 K141 S143 N144 D157 S169 T178 2.7.11.22,2.7.11.23 0004672,0005524,0006468 Q14004 33945934 2000 IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSK 7nxj C 2.36 BS01 5I1 C 1 I708 I711 V719 K721 A732 K734 I765 F791 Y793 M794 H796 D797 L844 D855 C1017 I14 I17 V25 K27 A38 K40 I71 F97 Y99 M100 H102 D103 L150 D161 C323 D837 K839 S841 N842 D855 S867 T876 D143 K145 S147 N148 D161 S173 T182 2.7.11.22,2.7.11.23 0004672,0005524,0006468 Q14004 33945934 2000 IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDC