3ccz A 1.7 BS01 5HI A 1 R590 S661 S684 D690 K692 R150 S221 S244 D250 K252 E559 K691 D767 E119 K251 D327 1.1.1.34 0004420,0005789,0008299,0015936,0016616,0050661 Kd=51.7nM -logKd/Ki=7.29, Kd=51.7nM P04035 18540668 876 EPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLIETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAG 3ccz A 1.7 BS02 5HI B 1 E559 C561 A564 S565 K735 A751 L853 A856 E119 C121 A124 S125 K295 A311 L413 A416 E559 K691 D767 E119 K251 D327 1.1.1.34 0004420,0005789,0008299,0015936,0016616,0050661 Kd=51.7nM -logKd/Ki=7.29, Kd=51.7nM P04035 18540668 876 EPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLIETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAG 3ccz B 1.7 BS01 5HI A 1 E559 C561 A564 S565 K735 A751 L853 A856 E104 C106 A109 S110 K280 A296 L398 A401 E559 K691 D767 E104 K236 D312 1.1.1.34 0004420,0005789,0008299,0015936,0016616,0050661 Kd=51.7nM -logKd/Ki=7.29, Kd=51.7nM P04035 18540668 876 EPRPNEECLQILAKFLSDAEIIQLVNAKLIETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAG 3ccz B 1.7 BS02 5HI B 1 R590 S661 V683 S684 D690 K692 R135 S206 V228 S229 D235 K237 E559 K691 D767 E104 K236 D312 1.1.1.34 0004420,0005789,0008299,0015936,0016616,0050661 Kd=51.7nM -logKd/Ki=7.29, Kd=51.7nM P04035 18540668 876 EPRPNEECLQILAKFLSDAEIIQLVNAKLIETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAG 3ccz C 1.7 BS01 5HI C 1 R590 S661 V683 S684 D690 K692 R134 S205 V227 S228 D234 K236 E559 K691 D767 E103 K235 D311 1.1.1.34 0004420,0005789,0008299,0015936,0016616,0050661 Kd=51.7nM P04035 18540668 876 PNEECLQILGNGAKFLSDAEIIQLVETLIETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAG 3ccz C 1.7 BS02 5HI D 1 E559 C561 A564 S565 K735 A751 H752 L853 A856 E103 C105 A108 S109 K279 A295 H296 L397 A400 E559 K691 D767 E103 K235 D311 1.1.1.34 0004420,0005789,0008299,0015936,0016616,0050661 Kd=51.7nM P04035 18540668 876 PNEECLQILGNGAKFLSDAEIIQLVETLIETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAG 3ccz D 1.7 BS01 5HI C 1 E559 C561 A564 S565 K735 A751 N755 L853 A856 E93 C95 A98 S99 K269 A285 N289 L387 A390 E559 K691 D767 E93 K225 D301 1.1.1.34 0004420,0005789,0008299,0015936,0016616,0050661 Kd=51.7nM P04035 18540668 876 GAKFLSDAEIIQLVNETLIETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAG 3ccz D 1.7 BS02 5HI D 1 R590 S661 V683 S684 D690 K692 R124 S195 V217 S218 D224 K226 E559 K691 D767 E93 K225 D301 1.1.1.34 0004420,0005789,0008299,0015936,0016616,0050661 Kd=51.7nM P04035 18540668 876 GAKFLSDAEIIQLVNETLIETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAG