5dxt A 2.25 BS01 5H5 A 1 S774 W780 I800 Y836 I848 V851 S854 Q859 M922 F930 I932 D933 S621 W627 I647 Y683 I695 V698 S701 Q706 M759 F767 I769 D770 2.7.11.1,2.7.1.137,2.7.1.153 0001525,0001889,0001944,0004674,0005515,0005524,0005737,0005829,0005886,0005942,0005943,0005944,0006006,0006629,0006909,0007173,0008286,0010468,0010592,0010629,0014704,0014823,0014870,0016242,0016301,0016303,0016310,0030027,0030036,0030168,0030295,0030835,0031295,0032008,0032869,0035005,0035994,0036092,0038084,0040014,0043201,0043276,0043457,0043491,0043524,0043542,0043560,0044024,0046854,0046934,0048009,0048015,0048471,0048661,0050852,0051897,0055119,0060048,0060612,0071333,0071464,0071548,0086003,0097009,0106310,0110053,0141068,1903544,1905477,2000270,2000811 Ki=0.2nM -logKd/Ki=9.70, Ki=0.2nM Ki=0.350nM P42336 26741947 1101 NREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVDKQKYTLKINHDCVPEQVIAEAIRKKTRSMGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRTSTKSLWVINSALRIKILCATYVNVNIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHRERVPFVLTQDFLIVISKGAECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGW 5dxu A 2.64 BS01 5H5 A 1 M752 W760 I825 V828 D832 M900 F908 D911 M666 W674 I736 V739 D743 M799 F807 D810 2.7.1.137,2.7.1.153 0001779,0001819,0001938,0002250,0002551,0002679,0005515,0005524,0005737,0005829,0005886,0005942,0005943,0006468,0006629,0006935,0006954,0006955,0007165,0010595,0010628,0010818,0016301,0016303,0016310,0030101,0030154,0030183,0030217,0030335,0030593,0033031,0035005,0035747,0035754,0036092,0038084,0042110,0042113,0043303,0043491,0045087,0045766,0046854,0046934,0048015,0050852,0050853,0060374,0072672,1905278 -logKd/Ki=8.40, Ki=4nM Ki=6.94nM O00329 26741947 1101 NQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKAVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKDCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHEEEQLQLREILERYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKV