5dxh A 3.0 BS01 5H2 A 1 M772 I800 Y836 I848 V851 S854 M922 I932 M725 I753 Y789 I801 V804 S807 M870 I880 2.7.11.1,2.7.1.137,2.7.1.153 0001525,0001889,0001944,0004674,0005515,0005524,0005737,0005829,0005886,0005942,0005943,0005944,0006006,0006629,0006909,0007173,0008286,0010468,0010592,0010629,0014704,0014823,0014870,0016242,0016301,0016303,0016310,0030027,0030036,0030168,0030295,0030835,0031295,0032008,0032869,0035005,0035994,0036092,0038084,0040014,0043201,0043276,0043457,0043491,0043524,0043542,0043560,0044024,0046854,0046934,0048009,0048015,0048471,0048661,0050852,0051897,0055119,0060048,0060612,0071333,0071464,0071548,0086003,0097009,0106310,0110053,0141068,1903544,1905477,2000270,2000811 -logKd/Ki=9.00, Ki=1nM Ki=1.000000nM P42336 26741947 1101 PPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSLRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHRVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAKMDWIFHTI 5dxh D 3.0 BS01 5H2 D 1 W780 I800 K802 Y836 I848 V850 V851 S854 Q859 M922 I932 D933 W728 I748 K750 Y784 I796 V798 V799 S802 Q807 M862 I872 D873 2.7.11.1,2.7.1.137,2.7.1.153 0001525,0001889,0001944,0004674,0005515,0005524,0005737,0005829,0005886,0005942,0005943,0005944,0006006,0006629,0006909,0007173,0008286,0010468,0010592,0010629,0014704,0014823,0014870,0016242,0016301,0016303,0016310,0030027,0030036,0030168,0030295,0030835,0031295,0032008,0032869,0035005,0035994,0036092,0038084,0040014,0043201,0043276,0043457,0043491,0043524,0043542,0043560,0044024,0046854,0046934,0048009,0048015,0048471,0048661,0050852,0051897,0055119,0060048,0060612,0071333,0071464,0071548,0086003,0097009,0106310,0110053,0141068,1903544,1905477,2000270,2000811 Ki=1.000000nM P42336 26741947 1101 PPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSTKSLWVINSALRIKILCATYVNVNIRIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSLRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAKMDWIFHTI