1a97 B 2.6 BS01 5GP B 1 R69 L90 D92 T93 T96 W134 I135 R67 L88 D90 T91 T94 W132 I133 D88 D89 D92 D86 D87 D90 2.4.2.-,2.4.2.22 0000287,0000310,0004422,0005829,0005886,0006166,0016757,0032263,0032264,0032265,0032991,0042802,0046872,0051289,0052657,0097216 P0A9M5 9743633 305 EKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVAISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMGVVFVPPIS 1a97 C 2.6 BS01 5GP C 1 R69 L90 D92 T93 G95 T96 W134 I135 R67 L88 D90 T91 G93 T94 W132 I133 D88 D89 D92 D86 D87 D90 2.4.2.-,2.4.2.22 0000287,0000310,0004422,0005829,0005886,0006166,0016757,0032263,0032264,0032265,0032991,0042802,0046872,0051289,0052657,0097216 P0A9M5 9743633 306 EKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVAISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMGVVFVPPIS 1ao0 A 2.8 BS03 5GP A 1 M238 Y242 S283 D345 D346 S347 V349 R350 G351 T352 T353 M234 Y238 S279 D341 D342 S343 V345 R346 G347 T348 T349 C1 G27 N102 G103 Y242 E300 K305 Q315 K423 C1 G27 N98 G99 Y238 E296 K301 Q311 K419 2.4.2.14 0000287,0004044,0006164,0006189,0006541,0009113,0016757,0046872,0051536,0051539 P00497 9271502 467 CGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGIVATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATGYENVQPLLFRSQNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKNSLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLREVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKMLAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQGVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHPCFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLACFTGKYPTEIYQDTVLPHVK 1ao0 B 2.8 BS04 5GP B 1 M238 Y242 S283 D345 D346 S347 V349 R350 G351 T352 T353 M234 Y238 S279 D341 D342 S343 V345 R346 G347 T348 T349 C1 G27 N102 G103 Y242 E300 K305 Q315 K423 C1 G27 N98 G99 Y238 E296 K301 Q311 K419 2.4.2.14 0000287,0004044,0006164,0006189,0006541,0009113,0016757,0046872,0051536,0051539 P00497 9271502 467 CGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGIVATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATGYENVQPLLFRSQNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKNSLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLREVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKMLAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQGVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHPCFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLACFTGKYPTEIYQDTVLPHVK 1ao0 C 2.8 BS03 5GP C 1 M238 Y242 S283 D345 D346 S347 V349 R350 G351 T353 M234 Y238 S279 D341 D342 S343 V345 R346 G347 T349 C1 G27 N102 G103 Y242 E300 K305 Q315 K423 C1 G27 N98 G99 Y238 E296 K301 Q311 K419 2.4.2.14 0000287,0004044,0006164,0006189,0006541,0009113,0016757,0046872,0051536,0051539 P00497 9271502 467 CGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGIVATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATGYENVQPLLFRSQNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKNSLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLREVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKMLAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQGVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHPCFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLACFTGKYPTEIYQDTVLPHVK 1ao0 D 2.8 BS04 5GP D 1 M238 Y242 S283 D345 D346 S347 V349 R350 G351 T353 M234 Y238 S279 D341 D342 S343 V345 R346 G347 T349 C1 G27 N102 G103 Y242 E300 K305 Q315 K423 C1 G27 N98 G99 Y238 E296 K301 Q311 K419 2.4.2.14 0000287,0004044,0006164,0006189,0006541,0009113,0016757,0046872,0051536,0051539 P00497 9271502 467 CGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGIVATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATGYENVQPLLFRSQNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKNSLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLREVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKMLAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQGVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHPCFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLACFTGKYPTEIYQDTVLPHVK 1c9k A 2.2 BS01 5GP A 1 Y28 A30 S32 I34 I43 H46 K47 R50 E58 E80 C81 Y28 A30 S32 I34 I37 H40 K41 R44 E52 E74 C75 2.7.1.156,2.7.7.62 0000166,0005524,0005525,0008820,0009236,0016301,0016310,0036428,0036429,0043752 Q05599 10529169 604 MILVTGGARSGKSRHAEALIGDAPQVLYIATSQIARIQHHKDGRPAHWRTAECWRHLDTLITADLAPDDAILLECITTMVTNLLFALDPEQWDYAAMERAIDDEIQILIAACQRCPAKVVLVTNEVGMGIVPENRLARHFRDIAGRVNQRLAAAADEVWLVVSGIGVKIK 1c9k B 2.2 BS01 5GP B 1 Y28 A30 S32 I43 H46 R50 E58 E80 Y28 A30 S32 I43 H46 R50 E58 E80 2.7.1.156,2.7.7.62 0000166,0005524,0005525,0008820,0009236,0016301,0016310,0036428,0036429,0043752 Q05599 10529169 605 MILVTGGARSGKSRHAEALIGDAPQVLYIATSQILDDEMAARIQHHKDGRPAHWRTAECWRHLDTLITADLAPDDAILLECITTMVTNLLFALGGENDPEQWDYAAMERAIDDEIQILIAACQRCPAKVVLVTNEVGMGIVPENRLARHFRDIAGRVNQRLAAAADEVWLVVSGIGVKIK 1c9k C 2.2 BS03 5GP C 1 Y28 A30 S32 K47 R50 E80 Y28 A30 S32 K38 R41 E68 2.7.1.156,2.7.7.62 0000166,0005524,0005525,0008820,0009236,0016301,0016310,0036428,0036429,0043752 Q05599 10529169 606 MILVTGGARSGKSRHAEALIGDAPQVLYIATSQILHHKDGRPAHWRTARHLDTLITADLAPDDAILLECITTMVTNLLFALGDPEQWDYAAMERAIDDEIQILIAACQRCPAKVVLVTNEVGMGIVPENRLARHFRDIAGRVNQRLAAAADEVWLVVSGIGVKIK 1ecb A 2.7 BS02 5GP A 1 Y74 Y258 D366 D367 V370 R371 G372 T374 Y74 Y258 D360 D361 V364 R365 G366 T368 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D438 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 505 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMPKSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFLDTL 1ecb A 2.7 BS03 5GP A 2 H25 Y258 A260 R261 R275 P302 E303 T304 K326 H25 Y258 A260 R261 R275 P302 E303 T304 K326 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D438 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 506 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMPKSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFLDTL 1ecb A 2.7 BS04 5GP B 2 V325 K326 R328 V325 K326 R328 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D438 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 506 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMPKSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFLDTL 1ecb B 2.7 BS01 5GP A 2 V325 K326 R328 V325 K326 R328 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D436 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 506 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFL 1ecb B 2.7 BS03 5GP B 1 Y258 D366 D367 S368 V370 R371 G372 T374 Y258 D358 D359 S360 V362 R363 G364 T366 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D436 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 505 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFL 1ecb B 2.7 BS04 5GP B 2 H25 Y258 A260 R261 R275 P302 E303 T304 K326 H25 Y258 A260 R261 R275 P302 E303 T304 K326 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D436 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 506 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFL 1ecb C 2.7 BS02 5GP C 1 Y74 Y258 D366 D367 V370 R371 G372 T374 Y74 Y258 D366 D367 V370 R371 G372 T374 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D444 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 505 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMPGQQLRRKSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFLDTLR 1ecb C 2.7 BS03 5GP C 2 H25 Y258 R261 P302 E303 T304 K326 H25 Y258 R261 P302 E303 T304 K326 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D444 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 506 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMPGQQLRRKSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFLDTLR 1ecb C 2.7 BS04 5GP D 2 V325 K326 R328 V325 K326 R328 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D444 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 506 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMPGQQLRRKSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFLDTLR 1ecb D 2.7 BS01 5GP C 2 V325 K326 R328 V325 K326 R328 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D436 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 506 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFLDTL 1ecb D 2.7 BS03 5GP D 1 Y74 Y258 D366 D367 V370 R371 G372 T374 Y74 Y258 D358 D359 V362 R363 G364 T366 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D436 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 505 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFLDTL 1ecb D 2.7 BS04 5GP D 2 H25 Y258 A260 R261 R275 P302 E303 T304 K326 H25 Y258 A260 R261 R275 P302 E303 T304 K326 C1 G27 N101 G102 Y258 R321 K326 M336 D444 C1 G27 N101 G102 Y258 R321 K326 M336 D436 2.4.2.14 0000287,0004044,0005737,0005829,0006164,0006189,0006541,0009113,0016757,0042802,0046872,0097216 P0AG16 9333323 506 CGIVGIAGVMPVNQSIYDALTVLQHRGQDAAGIITIDANNCFRLRKANGLVSDVFEARHMQRLQGNMGIGHVRYPTAGSSSASEAQPFYVNSPYGITLAHNGNLTNAHELRKKLFEEKRRHINTTSDSEILLNIFASELDNFRHYPLEADNIFAAIAATNRLIRGAYACVAMIIGHGMVAFRDPNGIRPLVLGKRDIDENRTEYMVASESVALDTLGFDFLRDVAPGEAIYITEEGQLFTRQCADNPVSNPCLFEYVYFARPDSFIDKISVYSARVNMGTKLGEKIAREWEDLDIDVVIPIPETSCDIALEIARILGKPYRQGFVKNRYVGRTFIMSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAKKVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEIRQIIGADGLIFQDLNDLIDAVRAENPDIQQFECSVFNGVYVTKDVDQGYLDFLDTL 1ex7 A 1.9 BS01 5GP A 1 S34 R38 R41 Y50 E69 F73 Y78 G79 S80 I99 D100 S34 R38 R41 Y50 E69 F73 Y78 G79 S80 I99 D100 2.7.4.8 0004385,0005524,0005634,0005737,0005829,0006163,0016301,0016310,0046037,0046711 P15454 11243817 187 SRPIVISGPSGTGKSTLLKKLFAEYPDSFGFSVSSTTRTPRAGEVNGKDYNFVSVDEFKSMIKNNEFIEWAQFSGNYYGSTVASVKQVSKSGKTCILDIDMQGVKSVKAIPELNARFLFIAPPSVEDLKKRLEGRGTETEESINKRLSAAQAELAYAETGAHDKVIVNDDLDKAYKELKDFIFAEK 1g7c A 2.05 BS01 5GP A 1 G19 S21 T22 N153 K154 D156 S192 W194 G16 S18 T19 N150 K151 D153 S189 W191 D17 K20 S21 T72 H95 D14 K17 S18 T69 H92 ? 0000329,0001933,0003746,0003779,0003924,0005515,0005525,0005737,0005739,0005829,0005840,0005853,0005856,0006409,0006412,0006414,0006417,0006469,0019003,0019901,0034198,0043022,0051015,0051017,1904408 P02994 11373622 507 EKSHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGVGEFEAGISKDGQTREHALLAFTLGVRQLIVAVNKMDSVKWDESRFQEIVKETSNFIKKVGYNPKTVPFVPISGWNGDNMIEATTNAPWYKGWEKETKAGVVKGKTLLEAIDAIEQPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKPGMVVTFAPAGVTTEVKSVEMHHEQLEQGVPGDNVGFNVKNVSVKEIRRGNVCGDAKNDPPKGCASFNATVIVLNHPGQISAGYSPVLDCHTAHIACRFDELLEKNDRRSGKKLEDHPKFLKSGDAALVKFVPSKPMCVEAFSEYPPLGRFAVRDMRQTVAVGVIKSVDKTE 1g9t A 2.8 BS01 5GP A 1 E103 D107 S108 G109 T111 L112 F156 V157 I162 E90 D94 S95 G96 T98 L99 F143 V144 I149 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032991,0042802,0046100,0046872,0051289,0052657,0097216 -logKd/Ki=3.28, Ki=526uM P0A9M2 12070315 190 MKHTVEVMIPEAEIKARIAELGRQITERYKDSGSDMVLVGLLRGSFMFMADLCREVQVSHEVDFMTASRDLKILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVGYGIDYAQRYRHLPYIGKVILL 1gky A 2.0 BS02 5GP A 1 S34 R38 R41 Y50 E69 Y78 G79 S80 I99 D100 S34 R38 R41 Y50 E69 Y78 G79 S80 I99 D100 2.7.4.8 0004385,0005524,0005634,0005737,0005829,0006163,0016301,0016310,0046037,0046711 P15454 1314905 187 SRPIVISGPSGTGKSTLLKKLFAEYPDSFGFSVSSTTRTPRAGEVNGKDYNFVSVDEFKSMIKNNEFIEWAQFSGNYYGSTVASVKQVSKSGKTCILDIDMQGVKSVKAIPELNARFLFIAPPSVEDLKKRLEGRGTETEESINKRLSAAQAELAYAETGAHDKVIVNDDLDKAYKELKDFIFAEK 1hgx A 1.9 BS01 5GP A 1 D103 I104 D106 T107 G108 T110 K134 Y156 I157 F162 D88 I89 D91 T92 G93 T95 K119 Y141 I142 F147 E102 D103 D106 Y156 R169 E87 D88 D91 Y141 R154 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 P51900 8679528 600 MDDLERVLYNQDDIQKRIRELAAELTEFYEDKNPVMICVLTGAVFFYTDLLKHLDFQLEPDYIICSSLTISKDLKTNIEGRHVLVVEDIIDTGLTMYQLLNNLQMRKPASLKVCTLCDKDIGKKAYDVPIDYCGFVVENRYIIGYGFDFHNKYRNLPVIGILKE 1hmp A 2.5 BS01 5GP A 1 K68 I135 D137 T138 G139 K140 T141 K165 F186 V187 K65 I132 D134 T135 G136 K137 T138 K162 F183 V184 E133 D134 D137 F186 R199 E130 D131 D134 F183 R196 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=5800nM P00492 8044844 300 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 1hmp B 2.5 BS01 5GP B 1 K68 I135 D137 T138 G139 T141 K165 F186 V187 K65 I127 D129 T130 G131 T133 K157 F178 V179 E133 D134 D137 F186 R199 E125 D126 D129 F178 R191 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=5800nM P00492 8044844 800 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYSTGDIKVIGGDDSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 1iyb A 1.5 BS01 5GP A 1 Q12 Y17 H39 W42 T78 L79 A80 F89 H92 E93 K96 H97 Q16 Y21 H43 W46 T82 L83 A84 F93 H96 E97 K100 H101 H39 W42 Y50 E93 K96 H97 H43 W46 Y54 E97 K100 H101 3.1.-.- 0003723,0033897 Q7XZV5 12484757 1295 YVEFAQDFDFFYFVQQWPGSYCDTKQSCCYPKTGKPASDFGIHGLWPNNNDGSYPSNCDSNSPYDQSQVSDLISRMQQNWPTLACPSGTGSAFWSHEWEKHGTCAENVFDQHGYFKKALDLKNQINLLEILQGAGIHPDGGFYSLNSIKNAIRSAIGYAPGIECNVDESGNSQLYQIYICVDGSGSNLIECPIFPRGKCGSSIEFPTF 1iyb B 1.5 BS01 5GP B 1 Q12 Y17 H39 W42 T78 L79 A80 F89 H92 E93 K96 H97 Q16 Y21 H43 W46 T82 L83 A84 F93 H96 E97 K100 H101 H39 W42 Y50 E93 K96 H97 H43 W46 Y54 E97 K100 H101 3.1.-.- 0003723,0033897 Q7XZV5 12484757 1296 YVEFAQDFDFFYFVQQWPGSYCDTKQSCCYPKTGKPASDFGIHGLWPNNNDGSYPSNCDSNSPYDQSQVSDLISRMQQNWPTLACPSGTGSAFWSHEWEKHGTCAENVFDQHGYFKKALDLKNQINLLEILQGAGIHPDGGFYSLNSIKNAIRSAIGYAPGIECNVDESGNSQLYQIYICVDGSGSNLIECPIFPRGKCGSSIEFPTF 1j1f A 1.6 BS01 5GP A 1 Q9 H34 T71 V72 L73 R74 F80 H83 E84 K87 Q10 H35 T72 V73 L74 R75 F81 H84 E85 K88 H34 W37 S44 E84 K87 H88 H35 W38 S45 E85 K88 H89 4.6.1.19 0003723,0004519,0004521,0005576,0006401,0016829,0033897 P23540 12731868 295 EFDSFWFVQQWPPAVCSFQKSGSCPGSGLRTFTIHGLWPQQSGTSLTNCPGSPFDITKISHLQSQLNTLWPTVLRANNQQFWSHEWTKHGTCSESTFNQAAYFKLAVDMRNNYDIIGALRPHAAGPNGRTKSRQAIKGFLKAKFGKFPGLRCRTDPQTKVSYLVEVVACFAQDGSTLIDCTRDTCGANFIF 1j1g A 1.6 BS01 5GP A 1 Q9 H34 S71 V72 L73 F80 H83 E84 K87 Q9 H34 S71 V72 L73 F80 H83 E84 K87 H34 W37 S44 E84 K87 H88 H34 W37 S44 E84 K87 H88 4.6.1.19 0003723,0004519,0004521,0005576,0006401,0016829,0033897 P23540 12731868 295 MDSFWFVQQWPPAVCSFQKSGSCPGSGLRTFTIHGLWPQQSGTSLTNCPGSPFDITKISHLQSQLNTLWPSVLRANNQQFWSHEWTKHGTCSESTFNQAAYFKLAVDMRNNYDIIGALRPHAAGPNGRTKSRQAIKGFLKAKFGKFPGLRCRTDPQTKVSYLVEVVACFAQDGSTLIDCTRDTCGANFIF 1j1g A 1.6 BS02 5GP A 2 S63 Q64 T67 N110 S63 Q64 T67 N110 H34 W37 S44 E84 K87 H88 H34 W37 S44 E84 K87 H88 4.6.1.19 0003723,0004519,0004521,0005576,0006401,0016829,0033897 P23540 12731868 296 MDSFWFVQQWPPAVCSFQKSGSCPGSGLRTFTIHGLWPQQSGTSLTNCPGSPFDITKISHLQSQLNTLWPSVLRANNQQFWSHEWTKHGTCSESTFNQAAYFKLAVDMRNNYDIIGALRPHAAGPNGRTKSRQAIKGFLKAKFGKFPGLRCRTDPQTKVSYLVEVVACFAQDGSTLIDCTRDTCGANFIF 1jxm A 2.0 BS01 5GP A 1 R568 R571 Y580 Y604 Y609 D629 R108 R111 Y120 Y144 Y149 D169 ? P31016 11779506 101 GFYIRALFDYCGFLSQALSFRFGDVLHVIDAGDEEWWQARRVGFIPSKRRVERREWSRLVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 1lvg A 2.1 BS02 5GP A 1 S37 R41 R44 Y53 E72 F76 Y81 G82 T83 D101 V102 D103 G106 R148 S33 R37 R40 Y49 E68 F72 Y77 G78 T79 D97 V98 D99 G102 R144 2.7.4.8 0001917,0004385,0005524,0005737,0005829,0006163,0006185,0006805,0016301,0016310,0046037,0046710 Q64520 12036965 1202 RPVVLSGPSGAGKSTLLKKLFQEHSSIFGFSVSHTTRNPRPGEEDGKDYYFVTREMMQRDIAAGDFIEHAEFSGNLYGTSKEAVRAVQAMNRICVLDVDLQGVRSIKKTDLCPIYIFVQPPSLDVLEQRLRLRNTETEESLAKRLAAARTDMESSKEPGLFDLVIINDDLDKAYATLKQALSEEIKKAQG 1pzm A 2.1 BS01 5GP A 1 I127 D129 S130 A131 T133 K157 F178 V179 D185 I95 D97 S98 A99 T101 K125 F146 V147 D153 E125 D126 D129 F178 R191 E93 D94 D97 F146 R159 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 Q9NJI5 17894860 301 YPMSARTLVTQEQVWAATAKCAKKIAADYKDFHLTADNPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASMLLDVRDSVENRHIMLVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVDVLVDYPVITIPRAFVIGYGMDFAESYRELRDICVLKKE 1pzm B 2.1 BS01 5GP B 1 D126 I127 D129 S130 A131 T133 K157 F178 V179 D185 D95 I96 D98 S99 A100 T102 K126 F147 V148 D154 E125 D126 D129 F178 R191 E94 D95 D98 F147 R160 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 Q9NJI5 17894860 302 YPMSARTLVTQEQVWAATAKCAKKIAADYKDFHLTADNPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICAVRMLLDVRDSVENRHIMLVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVDVLVDYPVITIPRAFVIGYGMDFAESYRELRDICVLKK 1qk3 A 1.65 BS01 5GP A 1 I148 D150 T151 G152 T154 K178 W199 I200 I148 D150 T151 G152 T154 K178 W199 I200 E146 D147 D150 W199 R212 E146 D147 D150 W199 R212 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Kd=7.1uM -logKd/Ki=5.15, Kd=7.1uM Q26997 10545170 300 MASKPIEDYGKGKGRIEPMYIPDNTFYNADDFLVPPHCKPYIDKILLPGGLVKDRVEKLAYDIHRTYFGEELHIICILKGSRGFFNLLIDYLATIQKYSGRESSVPPFFEHYVRLKSYQNDNSTGQLTVLSDDLSIFRDKHVLIVEDIVDTGFTLTEFGERLKAVGPKSMRIATLVEKRTDRSNSLKGDFVGFSIEDVWIVGCCYDFNEMFRDFDHVAVLSDAARKKF 1qk3 B 1.65 BS01 5GP B 1 K79 E146 I148 D150 G152 T154 K178 W199 I200 K82 E149 I151 D153 G155 T157 K181 W202 I203 E146 D147 D150 W199 R212 E149 D150 D153 W202 R215 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Kd=7.1uM -logKd/Ki=5.15, Kd=7.1uM Q26997 10545170 300 GSHMASKPIEDYGKGKGRIEPMYIPDNTFYNADDFLVPPHCKPYIDKILLPGGLVKDRVEKLAYDIHRTYFGEELHIICILKGSRGFFNLLIDYLATIQKYSGRESSVPPFFEHYVRLKSYQNDNSTGQLTVLSDDLSIFRDKHVLIVEDIVDTGFTLTEFGERLKAVGPKSMRIATLVEKRTDRSNSLKGDFVGFSIEDVWIVGCCYDFNEMFRDFDHVAVLSDAARKKF 1qk3 C 1.65 BS01 5GP C 1 E146 D147 I148 D150 T151 G152 T154 K178 W199 I200 E132 D133 I134 D136 T137 G138 T140 K164 W183 I184 E146 D147 D150 W199 R212 E132 D133 D136 W183 R196 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Kd=7.1uM Q26997 10545170 300 GSHMASKPIEDYGKGKGRIEPMYIPDNTFYNADDFLVPPHCKPYIDKILLPGGLVKDRVEKLAYDIHRTYFGEELHIICILKGSRGFFNLLIDYLATIQKYSGRESSVPPFFEHYVRLDLSIFRDKHVLIVEDIVDTGFTLTEFGERLKAVGPKSMRIATLVEKRTDRSLKGDFVGFSIEDVWIVGCCYDFNEMFRDFDHVAVLSDAARKKFE 1qk3 D 1.65 BS01 5GP D 1 E146 D147 I148 D150 T151 G152 T154 K178 W199 I200 E146 D147 I148 D150 T151 G152 T154 K178 W197 I198 E146 D147 D150 W199 R212 E146 D147 D150 W197 R210 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Kd=7.1uM Q26997 10545170 300 MASKPIEDYGKGKGRIEPMYIPDNTFYNADDFLVPPHCKPYIDKILLPGGLVKDRVEKLAYDIHRTYFGEELHIICILKGSRGFFNLLIDYLATIQKYSGRESSVPPFFEHYVRLKSYQNDNSTGQLTVLSDDLSIFRDKHVLIVEDIVDTGFTLTEFGERLKAVGPKSMRIATLVEKRTDRSLKGDFVGFSIEDVWIVGCCYDFNEMFRDFDHVAVLSDAARKKFE 1rnc A 1.5 BS01 5GP A 1 H12 N44 T45 K66 F120 D121 H12 N44 T45 K66 F120 D121 H12 K41 H119 F120 D121 H12 K41 H119 F120 D121 4.6.1.18 0003676,0004519,0004522,0004540,0005515,0005576,0016829,0050830 P61823 1548704 161 KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV 1t9s A 2.0 BS02 5GP A 1 H613 D654 D764 L765 Q817 F820 H80 D121 D232 L233 Q285 F288 3.1.4.35 0004114,0007165,0008081 O76074 15260978 859 EEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHPGVSNQFLINTNSELALMYNDESVLEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAE 1t9s B 2.0 BS02 5GP B 1 H613 H617 D654 D764 L765 Q817 F820 H80 H84 D121 D232 L233 Q285 F288 3.1.4.35 0004114,0007165,0008081 O76074 15260978 859 EEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHPGVSNQFLINTNSELALMYNDESVLEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAE 1vcz A 1.8 BS01 5GP A 1 W42 N44 W50 K96 H97 W42 N44 W50 K96 H97 H39 W42 W50 E93 K96 H97 H39 W42 W50 E93 K96 H97 3.1.27.1 0003723,0033897 Q9SSV1 295 AQDFDFFYFVQQWPASYCDTRRSCCYPTTGKPDEDFSIHGLWPNYENGKWPQNCDRESSLDESEISDLISTMEKNWPSLACPSSDGVRFWSHEWLKHGTCSALGERAYFQAALDFRKKSNLLENLKNAEITPRNGEHYTLESIKKAIEEGVGHSPYIECNVDTQGNHQIYQVYLCVDKTATDFIDCPIFPHGRGCGSKIEFPPF 1vcz A 1.8 BS02 5GP A 2 Q12 Y17 H39 W42 S78 L79 F89 H92 E93 K96 H97 Q12 Y17 H39 W42 S78 L79 F89 H92 E93 K96 H97 H39 W42 W50 E93 K96 H97 H39 W42 W50 E93 K96 H97 3.1.27.1 0003723,0033897 Q9SSV1 296 AQDFDFFYFVQQWPASYCDTRRSCCYPTTGKPDEDFSIHGLWPNYENGKWPQNCDRESSLDESEISDLISTMEKNWPSLACPSSDGVRFWSHEWLKHGTCSALGERAYFQAALDFRKKSNLLENLKNAEITPRNGEHYTLESIKKAIEEGVGHSPYIECNVDTQGNHQIYQVYLCVDKTATDFIDCPIFPHGRGCGSKIEFPPF 1waj A 2.8 BS01 5GP A 1 S36 F38 G84 D95 K374 K378 V379 I380 S36 F38 G84 D95 K374 K378 V379 I380 2.7.7.7,3.1.11.- 0000166,0003676,0003677,0003887,0004527,0006260,0006261,0008408,0039686,0039693,0046872 Q38087 9215631 904 MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYFDIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYEIKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFDLLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLMEYLNFWQQKTPVILTGWNVESFDIPYVYNRIKNIFGESTAKRLSPHRKTRVKVIENMYGSREIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNVGKLKYDGPISKLRESNHQRYISYNIIDVYRVLQIDAKRQFINLSLDMGYYAKIQIQSVFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPIPNRYKYVMSFDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERPSDVYSCSPNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGEIIKEALHNPNLSVDEPLDVDYRFDFSDEIKEKIKKLSAKSLNEMLFRAQRTEVAGMTAQINRKLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQWIERKVNEYLNEVCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVDFLDKFARERMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIGGFWTGKKRYALNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECIRRMLQEGEESLQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGFPGPKCPFHIRGILTYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIAWPSGTEITDLIKDDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKASLFDMFDF 1xz8 A 2.8 BS02 5GP A 1 V106 F108 T109 G110 R111 T112 R137 I161 V89 F91 T92 G93 R94 T95 R120 I144 2.4.2.9 0003723,0004845,0006353,0016757 P41007 15716449 200 MQKAVVMDEQAIRRALTRIAHEIIERNKGIDGCVLVGIKTRGIYLARRLAERIEQIEGASVPVGELDITLYRDVPFPVTERNVILVDDVLFTGRTVRAAMDAVMDLGRPARIQLAVLVDRGHRELPIRADFVGKNVPTSRSELIVVELSEVDGIDQVSIHEK 1znx A 2.35 BS01 5GP A 1 S53 R57 R60 Y69 E88 I92 S99 G100 S34 R38 R41 Y50 E69 I73 S80 G81 2.7.4.8 0000287,0004017,0004385,0005524,0005737,0005829,0006163,0016301,0016310,0019002,0019003,0046037,0046710,0046940 P9WKE9 16288457 300 VGRVVVLSGPSAVGKSTVVRCLRERIPNLHFSVSATTRAPRPGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGGLHRSGTLAQPVRAAAATGVPVLIEVDLAGARAIKKTMPEAVTVFLAPPSWQDLQARLIGRGTETADVIQRRLDTARIELAAQGDFDKVVVNRRLESACAELVSLLV 2a1y A 2.27 BS01 5GP A 1 A43 M45 G172 K173 C175 D207 M228 G230 S231 G256 A43 M45 G172 K173 C175 D207 M228 G230 S231 G253 1.7.1.7 0003824,0003920,0005829,0006163,0006207,0016491,0016627,1902560 Q81JJ9 1344 MGNVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAENNYFYIMHRFQPEKRISFIRDMQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDIAHGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTNGDVAKSIRFGATMVMIGSLFAGHEESPGETIEKLYKEYFGSFVEHKGSLEDTLIEMEQDLQSSISYAGGTKLDSIRTVDYVVVKNSIF 2a7r A 3.0 BS01 5GP A 1 M55 G183 S184 C186 D219 G220 G242 G243 G268 M269 S270 R286 S288 G290 M55 G183 S184 C186 D219 G220 G242 G243 G268 M269 S270 R286 S288 G290 1.7.1.7 0003824,0003920,0005515,0005829,0006144,0006163,0009117,0016491,0046037,0046872,1902560 Q9P2T1 16359702 500 MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQTYSGVPIIAANMDTVGTFEMAKVLCKFSLFTAVHKHYSLVQWQEFAGQNPDCLEHLAASSGTGSSDFEQLEQILEAIPQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQ 2a7r B 3.0 BS01 5GP B 1 M55 G183 S184 C186 D219 G220 G242 G243 G268 S270 R286 S288 G290 M55 G183 S184 C186 D219 G220 G242 G243 G268 S270 R286 S287 G289 1.7.1.7 0003824,0003920,0005515,0005829,0006144,0006163,0009117,0016491,0046037,0046872,1902560 Q9P2T1 16359702 500 MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQTYSGVPIIAANMDTVGTFEMAKVLCKFSLFTAVHKHYSLVQWQEFAGQNPDCLEHLAASSGTGSSDFEQLEQILEAIPQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYAGGVAEYRSEGKTVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQ 2a7r C 3.0 BS01 5GP C 1 M55 S184 C186 D219 G220 G242 G243 G268 M269 M55 S184 C186 D219 G220 G242 G243 G268 M269 1.7.1.7 0003824,0003920,0005515,0005829,0006144,0006163,0009117,0016491,0046037,0046872,1902560 Q9P2T1 16359702 500 MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQTYSGVPIIAANMDTVGTFEMAKVLCKFSLFTAVHKHYSLVQWQEFAGQNPDCLEHLAASSGTGSSDFEQLEQILEAIPQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYGKTVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQ 2anb A 2.9 BS01 5GP A 1 K17 S38 R42 R45 Y54 E73 V77 F78 Y82 G83 D102 I103 D104 R149 K16 S37 R41 R44 Y53 E72 V76 F77 Y81 G82 D101 I102 D103 R148 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0042802,0046037,0046710 P60546 16140325 301 AQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSVSHTTRQPRPGEVHGEHYFFVNHDEFKEMISRDAFLEHAEVFGNYYGTSREAIEQVLATGVDVFLDIDWQGAQQIRQKMPHARSIFILPPSKIELDRRLRGRGQDSEEVIAKRMAQAVAEMSHYAEYDYLIVNDDFDTALTDLKTIIRAERLRMSRQKQRHDALISKLLAD 2b8w A 2.22 BS03 5GP A 1 R48 T49 G50 K51 S52 G68 R183 D184 P241 L250 R43 T44 G45 K46 S47 G63 R163 D164 P221 L230 3.6.1.-,3.6.5.- 0003924,0005525 P32455 16511497 593 HMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGD 2b8w B 2.22 BS03 5GP B 1 R48 T49 G50 K51 S52 Y53 G68 R183 D184 P241 L250 R43 T44 G45 K46 S47 Y48 G63 R164 D165 P222 L231 3.6.1.-,3.6.5.- 0003924,0005525 P32455 16511497 593 HMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDL 2ble A 1.9 BS01 5GP A 1 M55 G183 S184 D219 G220 G221 L241 G242 G243 G268 M269 S270 R286 S288 G290 M55 G183 S184 D219 G220 G221 L241 G242 G243 G264 M265 S266 R280 S282 G284 K13 I48 P49 C186 T188 E289 K13 I48 P49 C186 T188 E283 1.7.1.7 0003824,0003920,0005515,0005829,0006144,0006163,0009117,0009409,0016491,0046872,1902560 P36959 1344 MPRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAVPQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVIRKLKLFYGMSSDTAMNKHGVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVTQQHNTV 2bwg A 2.4 BS01 5GP A 1 M55 G183 S184 D219 G220 G242 G243 G268 M269 S270 R286 S288 G290 M54 G182 S183 D218 G219 G241 G242 G267 M268 S269 R283 S285 G287 K13 I48 P49 K12 I47 P48 1.7.1.7 0003824,0003920,0005515,0005829,0006144,0006163,0009117,0009409,0016491,0046872,1902560 P36959 1340 PRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAVPQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVIERNGRKLKLFYGMSSDTAMNKHGVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVTQ 2bwg B 2.4 BS01 5GP B 1 M55 G183 S184 C186 D219 G220 G221 G243 G268 M269 S270 R286 S288 G290 M54 G182 S183 C185 D218 G219 G220 G242 G263 M264 S265 R278 S280 G282 K13 I48 P49 K12 I47 P48 1.7.1.7 0003824,0003920,0005515,0005829,0006144,0006163,0009117,0009409,0016491,0046872,1902560 P36959 1339 PRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAVPQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVIRKLKLFYGMSSDTAMNKHVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVT 2bwg C 2.4 BS01 5GP C 1 M55 G183 S184 C186 D219 G220 G242 G243 G268 M269 R286 S288 G290 M54 G182 S183 C185 D218 G219 G241 G242 G263 M264 R278 S280 G282 K13 I48 P49 K12 I47 P48 1.7.1.7 0003824,0003920,0005515,0005829,0006144,0006163,0009117,0009409,0016491,0046872,1902560 P36959 1339 PRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAVPQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVIRKLKLFYGMSSDTAMNKHVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVT 2bwg D 2.4 BS01 5GP D 1 M55 G183 S184 C186 D219 G220 G221 L241 G242 G243 G268 M269 R286 S288 G290 M54 G182 S183 C185 D218 G219 G220 L240 G241 G242 G263 M264 R277 S279 G281 K13 I48 P49 K12 I47 P48 1.7.1.7 0003824,0003920,0005515,0005829,0006144,0006163,0009117,0009409,0016491,0046872,1902560 P36959 1339 PRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAVPQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVIRKLKLFYGMSSDTAMNKHAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVT 2cnw C 2.39 BS03 5GP F 1 E274 K275 E271 K272 3.6.5.4 0003924,0005525,0006614,0016887,0048500 O07347 16780874 3001 QLSARLQEAIGRLRGRGRITEEDLKATLREIRRALMDADVNLEVARDFVERVREEALGKQVLESLTPAEVILATVYEALKEALGGEARLPVLKDRNLWFLVGLQGSGKTTTAAKLALYYKGKGRRPLLVAADTQRPAAREQLRLLGEKVGVPVLEVMDGESPESIRRRVEEKARLEARDLILVDTAGRLQIDEPLMGELARLKEVLGPDEVLLVLDAMTGQEALSVARAFDEKVGVTGLVLTKLDGDARGGAALSARHVTGKPIYFAGVSEKPEGLEPFYPERLAGRILG 2cnw D 2.39 BS04 5GP D 1 F141 L202 E205 F119 L180 E183 3.6.5.4 0003924,0005047,0005515,0005525,0005737,0005886,0006605,0006612,0006614,0016020,0016787,0016887 P83749 16780874 3001 AIPWGGNLEEVLEELEMALLAADVGLSATEEILQEVRASGRKDLKEAVKEKLVGMLEPDERRATLRKLGFQKPKPVEPKGRVVLVVGVNGVGKTTTIAKLGRYYQNLGKKVMFCAGDTFRAAGGTQLSEWGKRLSIPVIQGPEGTDPAALAYDAVQAMKARGYDLLFVDTAGRLHTKHNLMEELKKVKRAIAKADPEEPKEVWLVLDAVTGQNGLEQAKKFHEAVGLTGVIVTKLDGTAKGGVLIPIVRTLKVPIKFVGVGEGPDDLQPFDPEAFVEALLE 2cnw E 2.39 BS04 5GP E 1 F141 L202 E205 F117 L178 E181 3.6.5.4 0003924,0005047,0005515,0005525,0005737,0005886,0006605,0006612,0006614,0016020,0016787,0016887 P83749 16780874 3001 PWGGNLEEVLEELEMALLAADVGLSATEEILQEVRGRKDLKEAVKEKLVGMLEPDERRATLRKLGFNPQKPKPVEPKGRVVLVVGVNGVGKTTTIAKLGRYYQNLGKKVMFCAGDTFRAAGGTQLSEWGKRLSIPVIQGPEGTDPAALAYDAVQAMKARGYDLLFVDTAGRLHTKHNLMEELKKVKRAIAKADPEEPKEVWLVLDAVTGQNGLEQAKKFHEAVGLTGVIVTKLDGTAKGGVLIPIVRTLKVPIKFVGVGEGPDDLQPFDPEAFVEALLE 2cnw F 2.39 BS04 5GP F 1 F141 L202 E205 F98 L159 E162 3.6.5.4 0003924,0005047,0005515,0005525,0005737,0005886,0006605,0006612,0006614,0016020,0016787,0016887 P83749 16780874 3001 GNLEEVLEELEMALLAADVGLSATEEILQEVRASGRKDLKEAVKEKLVGMLEPPVEPKGRVVLVVGVNGVGKTTTIAKLGRYYQNLGKKVMFCAGDTFRAAGGTQLSEWGKRLSIPVIQGPEGTDPAALAYDAVQAMKARGYDLLFVDTAGRLHTKHNLMEELKKVKRAIAKADPEEPKEVWLVLDAVTGQNGLEQAKKFHEAVGLTGVIVTKLDGTAKGGVLIPIVRTLKVPIKFVGVGEGPDDLQPFDPEAFVEALLE 2d4h A 2.9 BS01 5GP A 1 R48 T49 G50 K51 S52 F65 S66 R183 D184 P241 R44 T45 G46 K47 S48 F61 S62 R166 D167 P224 3.6.1.-,3.6.5.- 0003924,0005525 P32455 16511497 593 IHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGSTVQKGIWMWCVPHPKKPGHILVLLDTEGLGDVENQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDESADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAV 2d4h B 2.9 BS01 5GP B 1 R48 T49 G50 K51 S52 F65 S66 R183 D184 P241 R43 T44 G45 K46 S47 F60 S61 R156 D157 P214 3.6.1.-,3.6.5.- 0003924,0005525 P32455 16511497 593 HMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGSKGIWMWCVPHPKKPGHILVLLDTEGLGQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPC 2fxv A 2.05 BS01 5GP A 1 V19 L20 F99 T100 F126 A128 N129 G130 Q131 A132 K156 V19 L20 F99 T100 F126 A128 N129 G130 Q131 A132 K156 2.4.2.22 0000310,0005737,0006166,0016757,0016763,0032265,0043101,0046110 Kd=4.5uM -logKd/Ki=5.35, Kd=4.5uM P42085 16716072 200 MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFASRFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQTESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQPGRDELVKLGYRVESLARIQSLEEGKVSFVQ 2fxv B 2.05 BS01 5GP B 1 V19 L20 F99 T100 D124 D125 F126 A128 N129 G130 Q131 A132 K156 V19 L20 F99 T100 D124 D125 F126 A128 N129 G130 Q131 A132 K156 2.4.2.22 0000310,0005737,0006166,0016757,0016763,0032265,0043101,0046110 Kd=4.5uM -logKd/Ki=5.35, Kd=4.5uM P42085 16716072 201 MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFASRFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQTESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQPGRDELVKLGYRVESLARIQSLEEGKVSFVQ 2j41 B 1.9 BS02 5GP B 1 K19 S39 R43 Y55 E74 Y78 Y83 G84 E103 I104 E105 K15 S35 R39 Y51 E70 Y74 Y79 G80 E99 I100 E101 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q5HGM3 17012781 1208 KGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSEVEMMNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEA 2j41 C 1.9 BS02 5GP C 1 K19 S39 R43 Y55 E74 Y78 Y83 G84 E103 I104 E105 K15 S35 R39 Y51 E70 Y74 Y79 G80 E99 I100 E101 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q5HGM3 17012781 1200 KGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSQSRINEARKEVEMMNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAK 2j41 D 1.9 BS03 5GP D 1 K19 S39 R43 Y55 E74 Y78 Y83 G84 E103 I104 E105 K15 S35 R39 Y51 E70 Y74 Y79 G80 E99 I100 E101 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q5HGM3 17012781 1210 KGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSEARKEVEMMNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAK 2jbh A 1.7 BS03 5GP A 1 D142 V143 G145 T146 G147 T149 K173 F194 V195 D201 D126 V127 G129 T130 G131 T133 K157 F177 V178 D184 E141 D142 G145 F194 R207 E125 D126 G129 F177 R190 2.4.2.8 0000166,0000287,0004422,0005515,0005829,0006166,0006178,0042803,0046038,0046872 Q9NRG1 21054786 1230 EAPDYGRGVVIMDDWPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNISRNSDRFVSMKVDFIRLKMQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTRSDGFRPDYAGFEIPNLFVVGYALDYNEYFRDLNHICVINEHGKEKYRV 2jbh B 1.7 BS03 5GP B 1 V143 G145 T146 G147 T149 K173 F194 V195 D201 V135 G137 T138 G139 T141 K165 F182 V183 D189 E141 D142 G145 F194 R207 E133 D134 G137 F182 R195 2.4.2.8 0000166,0000287,0004422,0005515,0005829,0006166,0006178,0042803,0046038,0046872 Q9NRG1 21054786 1230 PDYGRGVVIMDDWPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNISRNSDRFVSMKVDFIRLKSYRNDQSMGEMQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTGFRPDYAGFEIPNLFVVGYALDYNEYFRDLNHICVINEHGKEKYRV 2jky A 2.3 BS01 5GP A 1 Y69 K85 E111 V112 D114 T115 R116 T117 T118 K159 W188 Y189 Y191 E194 Y65 K78 E104 V105 D107 T108 R109 T110 T111 K152 W181 Y182 Y184 E187 2.4.2.8 0000166,0004422,0005634,0005737,0006166,0009058,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Q04178 22610485 300 DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEDLNSVGSEVGVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFI 2jky B 2.3 BS01 5GP B 1 D110 E111 V112 D114 T115 R116 T117 T118 K159 W188 Y189 Y191 E194 D98 E99 V100 D102 T103 R104 T105 T106 K147 W176 Y177 Y179 E182 2.4.2.8 0000166,0004422,0005634,0005737,0006166,0009058,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Q04178 22610485 300 DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEDLNVGVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFI 2jkz A 3.45 BS01 5GP A 1 E111 D114 T115 R116 T117 T118 K159 W188 Y189 Y191 E194 E95 D98 T99 R100 T101 T102 K143 W172 Y173 Y175 E178 2.4.2.8 0000166,0004422,0005634,0005737,0006166,0009058,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Q04178 22610485 300 DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEDVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIPEQ 2jkz B 3.45 BS02 5GP B 1 E111 V112 D114 T115 R116 T118 K159 W188 Y189 Y191 E194 E95 V96 D98 T99 R100 T102 K143 W172 Y173 Y175 E178 2.4.2.8 0000166,0004422,0005634,0005737,0006166,0009058,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Q04178 22610485 300 DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEDVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIPEQ 2jkz C 3.45 BS01 5GP C 1 E111 V112 D114 T115 R116 T117 T118 K159 W188 Y189 Y191 E194 E95 V96 D98 T99 R100 T101 T102 K143 W172 Y173 Y175 E178 2.4.2.8 0000166,0004422,0005634,0005737,0006166,0009058,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Q04178 22610485 300 DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEDVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIPEQ 2jkz D 3.45 BS02 5GP D 1 E111 D114 T115 R116 T117 T118 K159 W188 Y189 Y191 E194 E95 D98 T99 R100 T101 T102 K143 W172 Y173 Y175 E178 2.4.2.8 0000166,0004422,0005634,0005737,0006166,0009058,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Q04178 22610485 300 DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEDVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIPEQ 2klh A -1.00 BS01 5GP A 1 Y13 G16 S17 I18 Y28 H45 I65 Q68 A69 W72 E93 Y6 G9 S10 I11 Y21 H38 I58 Q61 A62 W65 E86 3.2.2.- 0009159,0070694 O35820 19822152 187 MRRSVYFCGSIRGGREDQALYARIVSRLRRYGKVLTEHVADAELEPLGEEAAGGDQFIHEQALNWLQQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRPQSGRVLSAMIRGAADGSRFQVWDYAEGEVETMLDRYFEAYLVEHHHHHH 2klh A -1.00 BS02 5GP B 1 S117 A118 M119 S110 A111 M112 3.2.2.- 0009159,0070694 O35820 19822152 187 MRRSVYFCGSIRGGREDQALYARIVSRLRRYGKVLTEHVADAELEPLGEEAAGGDQFIHEQALNWLQQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRPQSGRVLSAMIRGAADGSRFQVWDYAEGEVETMLDRYFEAYLVEHHHHHH 2klh B -1.00 BS01 5GP A 1 S117 A118 M119 S110 A111 M112 3.2.2.- 0009159,0070694 O35820 19822152 187 MRRSVYFCGSIRGGREDQALYARIVSRLRRYGKVLTEHVADAELEPLGEEAAGGDQFIHEQALNWLQQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRPQSGRVLSAMIRGAADGSRFQVWDYAEGEVETMLDRYFEAYLVEHHHHHH 2klh B -1.00 BS02 5GP B 1 Y13 G16 S17 I18 Y28 H45 I65 Q68 A69 W72 E93 Y6 G9 S10 I11 Y21 H38 I58 Q61 A62 W65 E86 3.2.2.- 0009159,0070694 O35820 19822152 187 MRRSVYFCGSIRGGREDQALYARIVSRLRRYGKVLTEHVADAELEPLGEEAAGGDQFIHEQALNWLQQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRPQSGRVLSAMIRGAADGSRFQVWDYAEGEVETMLDRYFEAYLVEHHHHHH 2ouq A 1.9 BS02 5GP A 1 H525 H563 D564 L635 D674 I692 F696 Q726 F729 H79 H117 D118 L189 D228 I246 F250 Q280 F283 3.1.4.17 0004114,0007165,0008081 Q9Y233 17389385 401 HMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETA 2p1d A 2.9 BS02 5GP A 1 K14 L17 N18 L20 F25 K29 S150 S151 P152 K8 L11 N12 L14 F19 K23 S144 S145 P146 2.1.1.56,2.1.1.57,2.7.7.48,3.4.21.91,3.6.1.15,3.6.4.13 0003968,0004482,0004483,0005524,0008168,0032259 P12823 12032088 912 ETLGEKWKSRLNALGKSEFQIYKKSGIQEVDRTLAKEGIKRGETDHHAVSRGSAKLRWFVERNLVTPEGKVVDLGCGRGGWSYYCGGLKNVREVKGLTKGGPGHEEPIPMSTYGWNLVRLQSGVDVFFIPPERCDTLLCDIGESSPNPTVEAGRTLRVLNLVENWLSNNTQFCVKVLNPYMSSVIEKMEALQRKHGGALVRNPLSRNSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDVDLGSGTRNI 2pnz A 2.14 BS02 5GP A 1 R89 K91 R81 K83 3.1.13.- 0000175,0000177,0000178,0004527,0005737,0006401,0016075,0016896 Q9V119 18353775 279 KLIDENGRRIDGRKKYELRPIKMEVGVLKNANGSAYIEWGKNKIIAAVYGPRELHPKHLQRPDRAILRVRYNMAPFSVEERKKPGPDRRSIEISKVIKGALEPALILEMFPRTAIDVFIEVLQADAGTRVAGITAASLALADAGIPMRDLVAACAAGKIEGEIVLDLNKEEDNYGEADVPVAIMPLKNDITLLQMDGYLTKDEFIEAVKLAIKGAKAVYQKQREALKEKYLKIAQE 2pnz B 2.14 BS01 5GP A 1 E69 T81 F137 E62 T74 F130 3.1.13.- 0000177,0000178,0005737,0006401,0016075 Q9V118 18353775 279 AGIMRDHIINLLKEGKRIDDRGFEDYRPIEIEVGVIEKAEGSALVKLGSTQVLVGIKTSLGEPFPDTPNMGVMTTNVELVPLASPTFEPGPPDERAIELARVIDRGIRESKALNLEKMVIVPGKIVRVVFIDVHVLDHDGNLMDAIGIAAIAALLNARVPKVRYNEETGEVETLDETEPLPVEKIPVPVTFAKIGNILVVDPSLDEELVMDGKITITTDETGHISAVQKSEGGAFKLEEVMYAVETAFKKAEEIRKLILEAVEKAKQ 2qor A 1.8 BS01 5GP A 1 S37 R41 Y53 E72 Y76 Y81 G82 T83 E101 M102 N103 R150 S37 R41 Y53 E72 Y76 Y81 G82 T83 E101 M102 N103 R150 2.7.4.8 0004385,0005524,0005829,0006163,0016301,0016310,0046037,0046710 A5K709 197 MARIPPLVVCGPSGVGKGTLIKKVLSEFPSRFRFSISCTTRNKREKETNGVDYYFVDKDDFERKLKEGQFLEFDKYANNFYGTLKSEYDLAVGEGKICLFEMNINGVKQLKESKHIQDGIYIFVKPPSIDILLGRLKNRNTEKPEEINKRMQELTREMDEADKVGFNYFIVNDDLARTYAELREYLLGSYPQLRGG 2vfa A 2.8 BS01 5GP A 1 D146 K174 F195 V196 Y203 D119 K147 F168 V169 Y176 E142 D143 D146 F195 R208 E115 D116 D119 F168 R181 2.4.2.22,2.4.2.8 0004422,0006166 P00492,P20035 18536021 1224 DPVFVKDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKK 2vfa B 2.8 BS01 5GP B 1 K77 K174 F195 V196 L201 D202 K65 K153 F174 V175 L180 D181 E142 D143 D146 F195 R208 E121 D122 D125 F174 R187 2.4.2.22,2.4.2.8 0004422,0006166 P00492,P20035 18536021 1227 AFDPVFVKDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKA 2w27 A 2.8 BS01 5GP A 1 Q19 N88 D210 E212 Y231 Q18 N87 D204 E206 Y225 P16 P15 ? O35014 19244251 501 LDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEIQSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESFLELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSNLDRIALLSPDLLKIDLQALSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQYAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFYKRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWIYQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLFIDLPYSYLYEQDGLI 2w27 A 2.8 BS02 5GP A 2 L35 G36 R37 S46 G48 F51 D65 N88 L34 G35 R36 S45 G47 F50 D64 N87 P16 P15 ? O35014 19244251 502 LDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEIQSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESFLELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSNLDRIALLSPDLLKIDLQALSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQYAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFYKRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWIYQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLFIDLPYSYLYEQDGLI 2w27 B 2.8 BS01 5GP B 1 Q19 N88 D210 E212 G230 Y231 Q19 N88 D206 E208 G226 Y227 P16 P16 ? O35014 19244251 501 MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEIQSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESFLELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSNLDRIALLSPDLLKIDLQALKSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQYAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFYKRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWIYQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLFIDLPYSY 2w27 B 2.8 BS02 5GP B 2 S46 G48 F51 S46 G48 F51 P16 P16 ? O35014 19244251 502 MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEIQSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESFLELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSNLDRIALLSPDLLKIDLQALKSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQYAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFYKRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWIYQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLFIDLPYSY 2xbu A 1.8 BS01 5GP A 1 V112 D114 T115 R116 T117 T118 K159 W188 Y189 Y191 E194 V95 D97 T98 R99 T100 T101 K142 W171 Y172 Y174 E177 2.4.2.8 0000166,0004422,0005634,0005737,0006166,0009058,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Q04178 22610485 1220 DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIPEQ 2xbu B 1.8 BS02 5GP B 1 V112 D114 T115 R116 T117 T118 K159 W188 Y189 Y191 E194 V97 D99 T100 R101 T102 T103 K144 W173 Y174 Y176 E179 2.4.2.8 0000166,0004422,0005634,0005737,0006166,0009058,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Q04178 22610485 1220 DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEDLVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKADLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIPEQ 2xjc A 2.0 BS01 5GP A 1 N52 M53 D54 F157 D206 H209 K215 T249 N250 S251 N50 M51 D52 F155 D204 H207 K213 T247 N248 S249 2.7.1.77,3.1.3.5,3.1.3.99 0000255,0005515,0005524,0005737,0005829,0006204,0008253,0009117,0016740,0016787,0042802,0046037,0046040,0046054,0046085,0046872,0050146,0050483,0050484,0050689,0061630,0070936,0106411 P49902 21396942 1489 TSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFNMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHES 3acc A 2.16 BS01 5GP A 1 D103 I104 D106 T107 G108 T110 K134 Y155 V156 D90 I91 D93 T94 G95 T97 K121 Y142 V143 E102 D103 D106 Y155 R168 E89 D90 D93 Y142 R155 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 Q5SLS3 20693661 817 GMFTPGNGPVQISAEAIKKRVEELGGEIARDYQGKTPHLICVLNGAFIFMADLVRAIPLPLTMDFIAISSYLLKDLRLPIHGRDVIVVEDIVDTGLTLSYLLDYLEARKPASVRVAALLSKPSRRQVEVPIHYLGFEIEDAYVYGYGLDRAQFDRNLPFITSIRPE 3b89 A 2.6 BS01 5GP A 1 S83 A111 D131 I132 Q156 D157 V158 S81 A109 D129 I130 Q154 D155 V156 2.1.1.179 0006364,0008168,0008649,0031167,0032259,0046677 Q763K9 500 NINDALTSILASKKYRALCPDTVRRILTEEWGRHKSPKQTVEAARTRLHGICGAVTPESLKAAAAALSAGDVKKALSLHASTKERLAELDTLYDFIFSAETPRRVLDIACGLNPLALYERGIASVWGCDIHQGLGDVITPFAREKDWDFTFALQDVLCAPPAEAGDLALIFKLLPLLEREQAGSAMALLQSLNTPRMAVSFPTRSEANYAAWFEGGLPAEFEIEDKKTIGTELIYLIKKN 3dy8 A 2.15 BS02 5GP A 1 H252 D293 M365 D402 I403 L420 Y424 Q453 F456 H75 D116 M188 D225 I226 L243 Y247 Q276 F279 3.1.4.35 0004114,0007165,0008081 O76083 18757755 900 GSHMTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQK 3dys A 2.3 BS03 5GP A 1 H252 H292 D293 M365 D402 I403 L420 Y424 Q453 F456 H71 H111 D112 M184 D221 I222 L239 Y243 Q272 F275 3.1.4.35 0004114,0007165,0008081 O76083 18757755 900 TYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQK 3gcm A 2.5 BS04 5GP C 1 F77 F78 F76 F77 2.7.7.8 0003723,0004654,0006396,0006402 A7ZS61 19327365 550 LNPIVRKFQYGQHTVTLETGMMARQATAAVMVSMDDTAVFVTVVGQKKAKPGQDFFPLTVNYQERTYAAGRIPGSFFRREGRPSEGETLIARLIDRPIRPLFPEGFVNEVQVIATVVSVNPQVNPDIVAMIGASAALSLSGIPFNGPIGAARVGYINDQYVLNPTQDELKESKLDLVVAGTEAAVLMVESEAELLSEDQMLGAVVFGHEQQQVVIQNINELVKEAGKPRWDWQPEPVNEALNARVAALAEARLSDAYRITDKQERYAQVDVIKSETIATLLAEDETLDENELGEILHAIEKNVVRSRVLAGEPRIDGREKDMIRGLDVRTGVLPRTHGSALFTRGETQALVTATLGTARDAQVLDELMGERTDTFLFHYNFPPYSVGETGMVGSPKRREIGHGRLAKRGVLAVMPDMDKFPYTVRVVSEITESNGSSSMASVCGASLALMDAGVPIKAAVAGIAMGLVKEGDNYVVLSDILGDEDHLGDMDFKVAGSRDGISALQMDIKIEGITKEIMQVALNQAKGARLHILGVMEQAINAPR 3kb8 A 2.09 BS02 5GP A 1 I101 D103 S104 G105 K131 F152 V153 I123 D125 S126 G127 K153 F174 V175 E99 D100 D103 F152 R165 E121 D122 D125 F174 R187 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 B9ZW32 266 MHHHHHHSSGVGTENLYFQSNAMMNQDIEKVLISEEQIQEKVLELGAIIAEDYKNTVPLAIGVLKGAMPFMADLLKRTDTYLEMDFMAVSSYGHSTVSTGEVKILKDLDTSVEGRDILIVEDIIDSGLTLSYLVDLFKYRKAKSVKIVTLLDKPTGRKVDLKADYVGFTVPHEFVVGYGLDYKEQYRNLPYVGVLKPSVYS 3kb8 B 2.09 BS01 5GP B 1 D100 I101 D103 S104 G105 K131 F152 V153 L158 D159 D109 I110 D112 S113 G114 K140 F161 V162 L167 D168 E99 D100 D103 F152 R165 E108 D109 D112 F161 R174 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 B9ZW32 267 ENLYFQSNAMMNQDIEKVLISEEQIQEKVLELGAIIAEDYKNTVPLAIGVLKGAMPFMADLLKRTDTYLEMDFMAVSSYGHSTVSTGEVKILKDLDTSVEGRDILIVEDIIDSGLTLSYLVDLFKYRKAKSVKIVTLLDKPTGRKVDLKADYVGFTVPHEFVVGYGLDYKEQYRNLPYVGVLKPSVYSN 3kia A 2.8 BS01 5GP A 1 P49 S50 R51 V80 A82 E102 G114 K115 A118 D135 A136 Y227 P36 S37 R38 V67 A69 E89 G101 K102 A105 D122 A123 Y207 P72 T231 Q248 E253 R254 P59 T211 Q228 E233 R234 2.4.1.266 0016757,0046872,0050504 B7SY86 21166895 336 AAEWFRQRSYDYGQFPPEDLARRKRELGLTVSAVLPSRNVADTVGGIIDEIHALNERAPLIDQILVVDADSEDGTAGVAASHGAEVYSENELMSGYGDAHGKGDAMWRALSVTRGDLVLYIDADTRDFRPQLAYGVLGPVLEVPGVRFVKAAYRRPEEDGGGRVTELTAKPLFNLFYPELAGFVQPLAGEFVADRELFCSIPFLTGYAVETGIMIDVLKKVGLGAMAQVDLGERQNRHQHLRDLSRMSYAVVRAVARRLRQEGRLQQLREPGLPESFFQLSDYLHAVATPEGLKLQEYVEELVERPPINEVLR 3kia C 2.8 BS01 5GP C 1 P49 S50 R51 E102 G114 K115 D135 A136 D137 Y227 P41 S42 R43 E94 G106 K107 D127 A128 D129 Y211 P72 T231 Q248 E253 R254 P64 T215 Q232 E237 R238 2.4.1.266 0016757,0046872,0050504 B7SY86 21166895 336 LGPASAAEWFRQRSYDYGQFPPEDLARRKRELGLTVSAVLPSRNVADTVGGIIDEIHALNERAPLIDQILVVDADSEDGTAGVAASHGAEVYSENELMSGYGDAHGKGDAMWRALSVTRGDLVLYIDADTRDFRPQLAYGVLGPVLEVPGVRFVKAAYRRPEDGGGRVTELTAKPLFNLFYPELAGFVQPLAGEFVADRELFCSIPFLTGYAVETGIMIDVLKKVGLGAMAQVDLGERQNRHLRDLSRMSYAVVRAVARRLRQEGRLQQLSFFQLSDYLHAVATPEGLKLQEYVEELVERPPINEVLR 3kyf A 2.1 BS01 5GP A 1 R127 H201 R120 H194 ? 0000166,0009288,0009425,0035438,0071945,0071973 -logKd/Ki=6.78, Kd=165.0nM Q88EQ6 20226196 501 PQPPKVLSTPLEIAANLRQLQESHDPLIITFHDRSHRFQSYVVHVDRESNTLALDEMIPRDGEKFIENGEHFRVEGFHDGVRIAWECDHALKISEVDGHRCYSGPLPQEVTYHQRRNAFRAALKLSQLVDIILDGAHLKGNGAMRGKLLDISATGCKLRFEGNVEDRLQLGQVYERFKAGNPLGLVDTMVELRHLHYEERINTTFAGVRFHNLSGQAQRKIESFVYQLQRE 3kyf A 2.1 BS02 5GP A 2 F84 G87 Q121 R122 R123 F77 G80 Q114 R115 R116 ? 0000166,0009288,0009425,0035438,0071945,0071973 -logKd/Ki=6.78, Kd=165.0nM Q88EQ6 20226196 502 PQPPKVLSTPLEIAANLRQLQESHDPLIITFHDRSHRFQSYVVHVDRESNTLALDEMIPRDGEKFIENGEHFRVEGFHDGVRIAWECDHALKISEVDGHRCYSGPLPQEVTYHQRRNAFRAALKLSQLVDIILDGAHLKGNGAMRGKLLDISATGCKLRFEGNVEDRLQLGQVYERFKAGNPLGLVDTMVELRHLHYEERINTTFAGVRFHNLSGQAQRKIESFVYQLQRE 3kyf A 2.1 BS03 5GP A 3 R127 D157 T161 G162 C163 K164 R200 H201 G214 V215 R216 R120 D150 T154 G155 C156 K157 R193 H194 G207 V208 R209 ? 0000166,0009288,0009425,0035438,0071945,0071973 -logKd/Ki=6.78, Kd=165.0nM Q88EQ6 20226196 503 PQPPKVLSTPLEIAANLRQLQESHDPLIITFHDRSHRFQSYVVHVDRESNTLALDEMIPRDGEKFIENGEHFRVEGFHDGVRIAWECDHALKISEVDGHRCYSGPLPQEVTYHQRRNAFRAALKLSQLVDIILDGAHLKGNGAMRGKLLDISATGCKLRFEGNVEDRLQLGQVYERFKAGNPLGLVDTMVELRHLHYEERINTTFAGVRFHNLSGQAQRKIESFVYQLQRE 3kyf A 2.1 BS04 5GP A 4 R122 R123 N124 R127 R115 R116 N117 R120 ? 0000166,0009288,0009425,0035438,0071945,0071973 -logKd/Ki=6.78, Kd=165.0nM Q88EQ6 20226196 504 PQPPKVLSTPLEIAANLRQLQESHDPLIITFHDRSHRFQSYVVHVDRESNTLALDEMIPRDGEKFIENGEHFRVEGFHDGVRIAWECDHALKISEVDGHRCYSGPLPQEVTYHQRRNAFRAALKLSQLVDIILDGAHLKGNGAMRGKLLDISATGCKLRFEGNVEDRLQLGQVYERFKAGNPLGLVDTMVELRHLHYEERINTTFAGVRFHNLSGQAQRKIESFVYQLQRE 3kyg A 2.1 BS01 5GP A 1 R136 R140 R169 N208 Q210 R116 R120 R149 N188 Q190 ? 0000166,0003674,0005515,0005575,0008150,0009288,0009425,0035438 -logKd/Ki=7.46, Kd=34.3nM Q9KNC3 20226196 501 SKTVSTINSTDALAMVEHSSELTLSITTPVGTKFVCRTPFIGTHTDKFLLVEMPKISADDLQYFFQEGFWMNIRAISPRGEGALIHFRSQLMHILQEPVPMAFLSIPNTMQVSQRRKEPRFELNLAGKVLFDEHRGDCELRDLSRSGCRFITPPLGKTYQVGDLVALEIFSDLRGTKTFPPLTGKICNLQRSLHHARYGLEFNEEGRNNAKNLLAQLKFNGTKLTLN 3kyg A 2.1 BS02 5GP A 2 R99 G100 Q134 R136 R79 G80 Q114 R116 ? 0000166,0003674,0005515,0005575,0008150,0009288,0009425,0035438 -logKd/Ki=7.46, Kd=34.3nM Q9KNC3 20226196 502 SKTVSTINSTDALAMVEHSSELTLSITTPVGTKFVCRTPFIGTHTDKFLLVEMPKISADDLQYFFQEGFWMNIRAISPRGEGALIHFRSQLMHILQEPVPMAFLSIPNTMQVSQRRKEPRFELNLAGKVLFDEHRGDCELRDLSRSGCRFITPPLGKTYQVGDLVALEIFSDLRGTKTFPPLTGKICNLQRSLHHARYGLEFNEEGRNNAKNLLAQLKFNGTKLTLN 3kyg A 2.1 BS03 5GP A 3 R140 D162 S164 G167 C168 R169 C207 N208 G219 L220 R120 D142 S144 G147 C148 R149 C187 N188 G199 L200 ? 0000166,0003674,0005515,0005575,0008150,0009288,0009425,0035438 -logKd/Ki=7.46, Kd=34.3nM Q9KNC3 20226196 503 SKTVSTINSTDALAMVEHSSELTLSITTPVGTKFVCRTPFIGTHTDKFLLVEMPKISADDLQYFFQEGFWMNIRAISPRGEGALIHFRSQLMHILQEPVPMAFLSIPNTMQVSQRRKEPRFELNLAGKVLFDEHRGDCELRDLSRSGCRFITPPLGKTYQVGDLVALEIFSDLRGTKTFPPLTGKICNLQRSLHHARYGLEFNEEGRNNAKNLLAQLKFNGTKLTLN 3kyg A 2.1 BS04 5GP A 4 E101 R135 R136 K137 R140 E81 R115 R116 K117 R120 ? 0000166,0003674,0005515,0005575,0008150,0009288,0009425,0035438 -logKd/Ki=7.46, Kd=34.3nM Q9KNC3 20226196 504 SKTVSTINSTDALAMVEHSSELTLSITTPVGTKFVCRTPFIGTHTDKFLLVEMPKISADDLQYFFQEGFWMNIRAISPRGEGALIHFRSQLMHILQEPVPMAFLSIPNTMQVSQRRKEPRFELNLAGKVLFDEHRGDCELRDLSRSGCRFITPPLGKTYQVGDLVALEIFSDLRGTKTFPPLTGKICNLQRSLHHARYGLEFNEEGRNNAKNLLAQLKFNGTKLTLN 3kyg B 2.1 BS01 5GP B 1 R136 R140 R169 N208 Q210 R116 R120 R149 N188 Q190 ? 0000166,0003674,0005515,0005575,0008150,0009288,0009425,0035438 -logKd/Ki=7.46, Kd=34.3nM Q9KNC3 20226196 501 SKTVSTINSTDALAMVEHSSELTLSITTPVGTKFVCRTPFIGTHTDKFLLVEMPKISADDLQYFFQEGFWMNIRAISPRGEGALIHFRSQLMHILQEPVPMAFLSIPNTMQVSQRRKEPRFELNLAGKVLFDEHRGDCELRDLSRSGCRFITPPLGKTYQVGDLVALEIFSDLRGTKTFPPLTGKICNLQRSLHHARYGLEFNEEGRNNAKNLLAQLKFNGTKLTLN 3kyg B 2.1 BS02 5GP B 2 R99 G100 Q134 R136 R79 G80 Q114 R116 ? 0000166,0003674,0005515,0005575,0008150,0009288,0009425,0035438 -logKd/Ki=7.46, Kd=34.3nM Q9KNC3 20226196 502 SKTVSTINSTDALAMVEHSSELTLSITTPVGTKFVCRTPFIGTHTDKFLLVEMPKISADDLQYFFQEGFWMNIRAISPRGEGALIHFRSQLMHILQEPVPMAFLSIPNTMQVSQRRKEPRFELNLAGKVLFDEHRGDCELRDLSRSGCRFITPPLGKTYQVGDLVALEIFSDLRGTKTFPPLTGKICNLQRSLHHARYGLEFNEEGRNNAKNLLAQLKFNGTKLTLN 3kyg B 2.1 BS03 5GP B 3 R140 D162 S164 G167 C168 R169 C207 N208 G219 E221 R120 D142 S144 G147 C148 R149 C187 N188 G199 E201 ? 0000166,0003674,0005515,0005575,0008150,0009288,0009425,0035438 -logKd/Ki=7.46, Kd=34.3nM Q9KNC3 20226196 503 SKTVSTINSTDALAMVEHSSELTLSITTPVGTKFVCRTPFIGTHTDKFLLVEMPKISADDLQYFFQEGFWMNIRAISPRGEGALIHFRSQLMHILQEPVPMAFLSIPNTMQVSQRRKEPRFELNLAGKVLFDEHRGDCELRDLSRSGCRFITPPLGKTYQVGDLVALEIFSDLRGTKTFPPLTGKICNLQRSLHHARYGLEFNEEGRNNAKNLLAQLKFNGTKLTLN 3kyg B 2.1 BS04 5GP B 4 E101 R135 R136 K137 E81 R115 R116 K117 ? 0000166,0003674,0005515,0005575,0008150,0009288,0009425,0035438 -logKd/Ki=7.46, Kd=34.3nM Q9KNC3 20226196 504 SKTVSTINSTDALAMVEHSSELTLSITTPVGTKFVCRTPFIGTHTDKFLLVEMPKISADDLQYFFQEGFWMNIRAISPRGEGALIHFRSQLMHILQEPVPMAFLSIPNTMQVSQRRKEPRFELNLAGKVLFDEHRGDCELRDLSRSGCRFITPPLGKTYQVGDLVALEIFSDLRGTKTFPPLTGKICNLQRSLHHARYGLEFNEEGRNNAKNLLAQLKFNGTKLTLN 3lnc A 1.95 BS01 5GP A 1 S39 R43 Y55 E74 Y83 G84 V85 V103 I104 D105 G108 S31 R35 Y47 E66 Y75 G76 V77 V95 I96 D97 G100 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q2GLF7 300 MLKSVGVILVLSSPSGTVANKLLENIVKSVSVTTRAARKGEKEGKDYYFVDREEFLRLCSNGEIIEHAEVFGNFYGVPRKNLEDNVDKGVSTLLVIDWQGAFKFMEMMREHVVSIFIMPPSMEELRRRRLKGAAFEISHCEAYDYVIVNEDIEETADRISNILRAEQMKTCRQVGLRELLESRFPIED 3lnc B 1.95 BS01 5GP B 1 S15 S39 R43 Y55 E74 V78 Y83 G84 V85 V103 I104 D105 G108 S16 S31 R35 Y47 E66 V70 Y75 G76 V77 V95 I96 D97 G100 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q2GLF7 300 SMLKSVGVILVLSSPSTVANKLLENIVKSVSVTTRAARKGEKEGKDYYFVDREEFLRLCSNGEIIEHAEVFGNFYGVPRKNLEDNVDKGVSTLLVIDWQGAFKFMEMMREHVVSIFIMPPSMEELRRRARLKGAAFEISHCEAYDYVIVNEDIEETADRISNILRAEQMKTCRQVGLRELLESRFPIE 3luh A 1.999 BS01 5GP A 1 Y529 K533 Q545 C546 K570 Y90 K94 Q106 C107 K131 3.1.26.n2 0003676 Kd=3.3mM Q9UKV8 20505670 3 KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLG 3luh B 1.999 BS01 5GP B 1 Y529 K533 Q545 C546 K570 Y90 K94 Q106 C107 K131 3.1.26.n2 0003676 Kd=3.3mM Q9UKV8 20505670 4 KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLG 3md7 A 1.27 BS03 5GP A 1 S18 P87 H88 A89 D90 H170 D188 H219 H241 S16 P85 H86 A87 D88 H168 D186 H217 H239 ? 0000166,0046872 Q2YQ74 21904058 303 SPRNCLRFTLLGCGSSPGVPRINGDWGKCDPKNPKNRRRRASLLVERYDAEGNNTVVVIDTGPDFRMQMIDSGVHMLDAAVYTHPHADHIHGIDDLRTYVVDNGRLMDVYANRLTRNRLYDTFGYCFETPVGSSYPPILSMHDIAPETPFSIEGAGGAIRFEPFSQVHGDIESLGFRIGSVVYCTDVSAFPEQSLQYIKDADVLIIGALQYRPHPSHFSLGEALEWIEKLSPKRAILTHMHVPLDYETVMRETPHHVEPGYDGLRFEVAV 3n1s A 1.45 BS01 5GP A 1 F29 D31 I32 L41 N88 E96 H101 H103 F29 D31 I32 L41 N88 E96 H101 H103 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 201 MAEETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIHMHLLGGRPLGPMLAHK 3n1s B 1.45 BS01 5GP B 1 F29 D31 I32 N88 E96 V97 H101 H103 F28 D30 I31 N87 E95 V96 H100 H102 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 200 AEETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIHMHLLGGRPLGPMLAHKGL 3n1s E 1.45 BS01 5GP E 1 I10 F29 D31 I32 L41 E96 V97 H101 H103 I10 F29 D31 I32 L41 E96 V97 H101 H103 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 203 MAEETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIHMHLLGGRPLGPMLA 3n1s F 1.45 BS01 5GP F 1 F29 D31 I32 N88 Q95 E96 H101 H103 F28 D30 I31 N87 Q94 E95 H100 H102 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 202 AEETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIHMHLLGGRPLGPMLAHKGL 3n1s I 1.45 BS01 5GP I 1 F29 D31 I32 N88 E96 V97 H101 H103 F28 D30 I31 N86 E94 V95 H99 H101 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 205 AEETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAIAEQEGIAEDGYRLIMNTNRHGGQEVYHIHMHLLGGRPLGPMLAH 3n1s J 1.45 BS01 5GP J 1 I10 F29 D31 I32 L41 N88 E96 V97 H101 H103 I10 F29 D31 I32 L41 N88 E96 V97 H101 H103 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 204 MAEETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIHMHLLGGRPLGPMLAHKGL 3n1s M 1.45 BS01 5GP M 1 F29 D31 I32 N88 Q95 E96 H101 H103 F28 D30 I31 N87 Q94 E95 H100 H102 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 207 AEETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIHMHLLGGRPLGPMLAH 3n1s N 1.45 BS01 5GP N 1 I10 F29 D31 I32 L41 N88 Q95 E96 H101 H103 I9 F28 D30 I31 L40 N87 Q94 E95 H100 H102 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 206 AEETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIHMHLLGGRPLGPMLAH 3n1t A 1.716 BS01 5GP A 1 I6 I10 D31 I32 L41 E96 V97 H103 I4 I8 D29 I30 L39 E94 V95 H101 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 200 EETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIAMHLLGGRPLGPMLAH 3n1t B 1.716 BS01 5GP B 1 I6 D31 I32 L41 E96 V97 H103 I5 D30 I31 L40 E95 V96 H102 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 200 AEETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIAMHLLGGRPLGPMLAHKG 3n1t E 1.716 BS01 5GP E 1 I6 D31 I32 E96 V97 H103 I3 D28 I29 E93 V94 H100 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 200 ETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIAMHLLGGRPLGPMLA 3n1t F 1.716 BS01 5GP F 1 I6 I10 D31 I32 L41 E96 V97 H103 I4 I8 D29 I30 L39 E94 V95 H101 3.9.1.- 0000166,0003824,0005737,0005829,0016787,0042803,0043530,0055130 P0ACE7 20934431 200 EETIFSKIIRREIPSDIVYQDDLVTAFRDISPQAPTHILIIPNILIPTVNDVSAEHEQALGRMITVAAKIAEQEGIAEDGYRLIMNTNRHGGQEVYHIAMHLLGGRPLGPMLAHK 3oxk A 1.55 BS02 5GP A 1 F29 D31 I32 L41 N86 Q93 T94 H99 H101 F31 D33 I34 L43 N88 Q95 T96 H101 H103 N86 H97 H99 H101 N88 H99 H101 H103 3.9.1.- 0000166,0003824,0005634,0005737,0016787,0043530 C4LYI2 25945711 125 GSMADSCIFCKIAQKQIPSTIVYEDDEIFAFKDINPIAPIHILVIPKQHIASLNEITEENEAFIGKVLYKVSLIGKKECPEGYRVVNNIGEDAGQTVKHIHFHILGGKKLAWDKL 3pen A 2.3005 BS02 5GP A 1 F221 V223 K234 S278 R280 A296 G298 F209 V211 K222 S266 R268 A284 G286 D19 K22 T23 H97 D18 K21 T22 H85 3.6.5.3 0000049,0001731,0003743,0003746,0003924,0005515,0005525,0006412,0006413,0006414,0016787,0046872 Q980A5 1 AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 3py6 A 1.7 BS03 5GP A 1 S18 H88 A89 D90 H170 D188 H219 H241 S16 H86 A87 D88 H168 D186 H217 H239 ? 0000166,0046872 Q2YQ74 21904058 303 SPRNCLRFTLLGCGSSPGVPRINGDWGKCDPKNPKNRRRRASLLVERYDAEGNNTVVVIDTGPDFRMQMIDSGVHMLDAAVYTHPHADHIHGIDDLRTYVVDNGRLMDVYANRLTRNRLYDTFGYCFETPVGSSYPPILSMHDIAPETPFSIEGAGGAIRFEPFSQVHGDIESLGFRIGSVVYCTDVSAFPEQSLQYIKDADVLIIGALQYRPHPSHFSLGEALEWIEKLSPKRAILTHMHVPLDYETVMRETPHHVEPGYDGLRFEVAV 3rhn A 2.1 BS01 5GP A 1 F41 D43 I44 N99 Q106 S107 V108 H112 H114 F30 D32 I33 N88 Q95 S96 V97 H101 H103 3.4.22.-,3.9.1.- 0000118,0000166,0003824,0005634,0005737,0006355,0006508,0006915,0008234,0009154,0016787,0016926,0016929,0043530,0072332 P80912 9164465 201 RPGGDTIFGKIIRKEIPAKIIFEDDQCLAFHDISPQAPTHFLVIPKKHISQISAAEDADESLLGHLMIVGKKCAADLGLKKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMNWPPG 3rl3 A 1.42 BS06 5GP A 1 H67 D86 N117 H118 F183 K225 I253 H254 E255 H57 D76 N107 H108 F168 K210 I238 H239 E240 3.1.-.- 0000166,0008081,0016208,0016787,0019002,0030145,0046872 ic50=67nM -logKd/Ki=7.17, IC50=67nM B1WBP0 21824479 951 VTITVDEYSSNPTQAFTHYNINQSRFQPPHVHMVDPIPYDTPKPAGHTRFVCISDTHSRTDGIQMPYGDILLHTGDFTELGLPSEVKKFNDWLGNLPYEYKIVIAGNHELTFDKEFMADLVRFPSVSKLKPEDFDNVQSLLTNSIYLQDSEVTVKGFRIYGAPWTPWFNGWGFNLPRGQSLLDKWNLIPEGTDILMTHGPPLGFRDWVPKELQRVGCVELLNTVQRRVRPKLHVFGGIHEGYGTMTDGYTTYINASTCTVSFQPTNPPIIFDLPNP 3rl4 A 1.29 BS06 5GP A 1 H67 D86 N117 H118 F183 E226 H252 H254 E255 H57 D76 N107 H108 F167 E210 H236 H238 E239 3.1.-.- 0000166,0008081,0016208,0016787,0019002,0030145,0046872 ic50=3800nM -logKd/Ki=5.42, IC50=3800nM B1WBP0 21824479 951 VTITVDEYSSNPTQAFTHYNINQSRFQPPHVHMVDPIPYDTPKPAGHTRFVCISDTHSRTDGIQMPYGDILLHTGDFTELGLPSEVKKFNDWLGNLPYEYKIVIAGNHELTFDKEFMADLVFPSVSKLKPEDFDNVQSLLTNSIYLQDSEVTVKGFRIYGAPWTPWFNGWGFNLPRGQSLLDKWNLIPEGTDILMTHGPPLGFRDWVPKELQRVGCVELLNTVQRRVRPKLHVFGHIHEGYGTMTDGYTTYINASTCTVSFQPTNPPIIFDLPNP 3tr0 A 1.851 BS01 5GP A 1 K17 S36 R40 Y52 E71 I75 Y80 G81 E100 I101 D102 K16 S35 R39 Y51 E70 I74 Y79 G80 E99 I100 D101 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q83EL7 26033498 205 NKANLFIISAPSGAGKTSLVRALVKALAEIKISISHTTRPKRPGDQEGVDYFFIDETRFQAMVKEGAFLEHATIYERHYGTEKDWVLRQLKAGRDVLLEIDWQGARQIRELFPPALSIFILPPSIEALRERLIKRRQDDTAIIEQRLALAREEMAHYKEFDYLVVNDNFDQAVQNLIHIISAERLQRDVQEKKLSRLLAEL 3w5w A 2.95 BS01 5GP A 1 R105 S289 R291 G308 G309 S315 G316 G317 R104 S286 R288 G305 G306 S312 G313 G314 ? 0046872 Q64PD9 23851074 401 LTKVIAQAHIDHFTKWFERADKIVIVSHVSPDGDAIGSSLGLYHFLDSQDKIVNVIVPNAFPDFLKWMPGSKDILLYDRYQEFADKLIMEADVICCLDFNALKRIDEMSDIVAASPGRKIMIDHHLYPEDFCRITISHPEISSTSELVFRLICRMGYFSDISKEGAECIYTGMMTDTGGFTYNSNNREIYFIISELLSKGIDKDDIYRKVYNTYSESRLRLMGYVLSNMKVYKDYNSALISLTKEEQGKFDYIKGDSEGFVNIPLSIKNVCFSCFLREDTEMIKISLRSVGKFPCNRLAAEFFNGGGHLNASGGEFYGTMEEAVKVFEQALEKYKPLLKE 3x02 A 2.45 BS01 5GP A 1 F139 N203 V204 F205 K214 L282 D369 F99 N163 V164 F165 K174 L241 D294 K150 D278 K110 D237 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 501 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPVNPEQYSKRFNEFMSNILT 3x02 A 2.45 BS02 5GP A 2 K96 Y98 S154 H161 R188 Y197 K65 Y67 S114 H121 R148 Y157 K150 D278 K110 D237 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 502 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPVNPEQYSKRFNEFMSNILT 3x02 A 2.45 BS03 5GP A 3 Q293 E297 Q252 E256 K150 D278 K110 D237 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 503 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPVNPEQYSKRFNEFMSNILT 3x02 B 2.45 BS01 5GP B 1 F139 V148 K150 N203 V204 F205 K214 L282 D369 F98 V107 K109 N162 V163 F164 K173 L240 D284 K150 D278 K109 D236 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 501 VKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPEQYSKRFNEFMSNILT 3x06 A 2.65 BS01 5GP A 1 F139 V148 K150 N203 V204 F205 K214 L282 F99 V108 K110 N163 V164 F165 K174 L242 K150 D278 K110 D238 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 501 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVMRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTVNPEQYSKRFNEFMSNILT 3x06 A 2.65 BS02 5GP A 2 Q293 E297 Q253 E257 K150 D278 K110 D238 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 502 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVMRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTVNPEQYSKRFNEFMSNILT 3x06 A 2.65 BS03 5GP A 3 K96 Y98 S154 H161 R188 Y197 K65 Y67 S114 H121 R148 Y157 K150 D278 K110 D238 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 504 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVMRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTVNPEQYSKRFNEFMSNILT 3x06 B 2.65 BS01 5GP B 1 F139 V148 K150 N203 V204 F205 L282 D369 F98 V107 K109 N162 V163 F164 L240 D284 K150 D278 K109 D236 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 501 VKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVMRNVFSHRLTVHRKYDLKGSVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPEQYSKRFNEFMSNIL 3x08 A 2.75 BS01 5GP A 1 K96 Y98 S154 H161 R188 Y197 K65 Y67 S114 H121 R148 Y157 K150 D278 K110 D238 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 501 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRAVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTTVNPEQYSKRFNEFMSNILT 3x08 A 2.75 BS02 5GP A 2 Q293 E297 Q253 E257 K150 D278 K110 D238 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 502 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRAVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTTVNPEQYSKRFNEFMSNILT 3x0a A 2.6 BS01 5GP A 1 F139 V148 N203 V204 L205 L282 D369 F99 V108 N163 V164 L165 L242 D296 K150 D278 K110 D238 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 501 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVLSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPVNPEQYSKRFNEFMSNILT 3x0a A 2.6 BS02 5GP A 2 K96 Y98 S154 A158 H161 R188 Y197 K65 Y67 S114 A118 H121 R148 Y157 K150 D278 K110 D238 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 502 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVLSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPVNPEQYSKRFNEFMSNILT 3x0a B 2.6 BS01 5GP B 1 F139 V148 N203 V204 L205 K214 T237 L282 D369 F98 V107 N162 V163 L164 K173 T194 L238 D282 K150 D278 K109 D234 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 501 VKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVLSHRLTVHRKYDLKGSAREASDKEKAKDLPTFKDNDFLNEGKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTNPEQYSKRFNEFMSNILT 3x0a B 2.6 BS02 5GP B 2 K96 Y98 S154 H161 R188 Y197 K64 Y66 S113 H120 R147 Y156 K150 D278 K109 D234 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 502 VKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVLSHRLTVHRKYDLKGSAREASDKEKAKDLPTFKDNDFLNEGKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTNPEQYSKRFNEFMSNILT 3x0c A 2.55 BS01 5GP A 1 F139 V148 K150 N203 V204 F205 K214 L282 F99 V108 K110 N163 V164 F165 K174 L242 K150 D278 K110 D238 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 501 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDGPGEFDPSVDVYAMKSHESSPKKEVYFMAIADILTTVNPEQYSKRFNEFMSNILT 3x0c A 2.55 BS02 5GP A 2 K96 Y98 S154 H161 R188 Y197 K65 Y67 S114 H121 R148 Y157 K150 D278 K110 D238 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 502 KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDGPGEFDPSVDVYAMKSHESSPKKEVYFMAIADILTTVNPEQYSKRFNEFMSNILT 3x0c B 2.55 BS01 5GP B 1 Y98 S154 A158 H161 R188 Y197 Y66 S113 A117 H120 R147 Y156 K150 D278 K109 D237 2.7.1.149 0005515,0005524,0005525,0005634,0005654,0005737,0005776,0005783,0005789,0005829,0005886,0006629,0007166,0010506,0016301,0016308,0016309,0016310,0042803,0046488,0046627,0046854,0052742,0061909,1902635,2000786 P78356 26774281 501 VKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIADILTPEQYSKRFNEFMSNILT 3zpg A 1.99 BS02 5GP A 1 L229 R231 P270 L271 A298 E302 L226 R228 P267 L268 A295 E299 1.1.1.193,3.5.4.26 0003824,0008270,0008703,0008835,0009231,0016491,0016787,0046872,0050661 D0CB74 23722836 1361 SELKQDQYWMQQAIELAKRGLYSTKPNPNVGCVIVKDDQLIGEGFHPKAGQPHAEVFALRQAGEQAQGATAYVTLEPCAHYGRTPPCAEALVKAQVKKVVVACPDPNPLVAGKGVQILKNAGIEVEIGICEDLAAKLNQGFLKAMSTGMPYVRLKVASSLDGRTAMASGESITGSAARQDVQHWRAISGAVITGIDTVIADDCQLNVRSLHNIDIETVAQPKRVILDRRGRLPLTAKILENPETVMVMGPYRQELADLGVIQLEIQPLKTLLQTLSKQYQIYDVLIEAGATLSSAFLQEGLIDEMISYVAPTLLGQSARAMFNADFEYMAQQLRFKLLDVIQLDQDIRLRLIPT 3zpg A 1.99 BS04 5GP A 2 K137 D183 H186 R351 R353 K136 D180 H183 R348 R350 1.1.1.193,3.5.4.26 0003824,0008270,0008703,0008835,0009231,0016491,0016787,0046872,0050661 D0CB74 23722836 1367 SELKQDQYWMQQAIELAKRGLYSTKPNPNVGCVIVKDDQLIGEGFHPKAGQPHAEVFALRQAGEQAQGATAYVTLEPCAHYGRTPPCAEALVKAQVKKVVVACPDPNPLVAGKGVQILKNAGIEVEIGICEDLAAKLNQGFLKAMSTGMPYVRLKVASSLDGRTAMASGESITGSAARQDVQHWRAISGAVITGIDTVIADDCQLNVRSLHNIDIETVAQPKRVILDRRGRLPLTAKILENPETVMVMGPYRQELADLGVIQLEIQPLKTLLQTLSKQYQIYDVLIEAGATLSSAFLQEGLIDEMISYVAPTLLGQSARAMFNADFEYMAQQLRFKLLDVIQLDQDIRLRLIPT 4ac9 B 3.03 BS03 5GP B 1 P96 K97 M104 L105 I139 T143 I288 L368 P84 K85 M92 L93 I127 T131 I276 L356 D15 K18 T19 T46 H69 D15 K18 T19 T34 H57 ? 0001514,0003723,0003746,0003924,0005525,0005737,0006414,0046872 Q8J307 15616587 1474 MDFKNINLGIFGHIDHGKTTLSKVLTEIAKRGITIDIGFSAFKLENYRITLVDAPGHADLIRAVVSAADIIDLALIVVDAKEGPKTQTGEHMLILDHFNIPIIVVITKSDNAGTEEIKRTEMIMKSILQSTHNLKNSSIIPISAKTGFGVDELKNLIITTLNNAEIIRNTESYFKMPLDHAFPIKGAGTVVTGTINKGIVKVGDELKVLPINMSTKVRSIQYFKESVMEAKAGDRVGMAIQGVDAKQIYRGCILTSKDTKLQTVDKIVAKIKISDIFKYNLTPKMKVHLNVGMLIVPAVAVPFKKVTFGKTEENIILNEVISGNECYCAFELEEKVLAEVGDRVLITRLDLPPTTLRICGHGLIEEFKPIKDLNIKKEVLREGKVKIDKGRTVIDGLAQSKVAAEKLIGEEISIEGKDIVGKIKGTFGTKGLLTAEFSGNVENRDKVILNRLRRWG 4aca B 3.15 BS02 5GP B 1 P96 K97 T98 L105 I139 T143 I288 P84 K85 T86 L93 I127 T131 I276 D15 K18 T19 T46 H69 D15 K18 T19 T34 H57 ? 0001514,0003723,0003746,0003924,0005525,0005737,0006414,0046872 Q8J307 15616587 1474 MDFKNINLGIFGHIDHGKTTLSKVLTEIAKRGITIDIGFSAFKLENYRITLVDAPGHADLIRAVVSAADIIDLALIVVDAKEGPKTQTGEHMLILDHFNIPIIVVITKSDNAGTEEIKRTEMIMKSILQSTHNLKNSSIIPISAKTGFGVDELKNLIITTLNNAEIIRNTESYFKMPLDHAFPIKGAGTVVTGTINKGIVKVGDELKVLPINMSTKVRSIQYFKESVMEAKAGDRVGMAIQGVDAKQIYRGCILTSKDTKLQTVDKIVAKIKISDIFKYNLTPKMKVHLNVGMLIVPAVAVPFKKVTFGKTEENIILNEVISGNECYCAFELEEKVLAEVGDRVLITRLDLPPTTLRICGHGLIEEFKPIKDLNIKKEVLREGKVKIDKGRTVIDGLAQSKVAAEKLIGEEISIEGKDIVGKIKGTFGTKGLLTAEFSGNVENRDKVILNRLRRWG 4acb B 3.34 BS03 5GP B 1 P96 K97 T98 M104 I139 T143 I288 P84 K85 T86 M92 I127 T131 I276 D15 K18 T19 T46 H69 D15 K18 T19 T34 H57 ? 0001514,0003723,0003746,0003924,0005525,0005737,0006414,0046872 Q8J307 15616587 1474 MDFKNINLGIFGHIDHGKTTLSKVLTEIAKRGITIDIGFSAFKLENYRITLVDAPGHADLIRAVVSAADIIDLALIVVDAKEGPKTQTGEHMLILDHFNIPIIVVITKSDNAGTEEIKRTEMIMKSILQSTHNLKNSSIIPISAKTGFGVDELKNLIITTLNNAEIIRNTESYFKMPLDHAFPIKGAGTVVTGTINKGIVKVGDELKVLPINMSTKVRSIQYFKESVMEAKAGDRVGMAIQGVDAKQIYRGCILTSKDTKLQTVDKIVAKIKISDIFKYNLTPKMKVHLNVGMLIVPAVAVPFKKVTFGKTEENIILNEVISGNECYCAFELEEKVLAEVGDRVLITRLDLPPTTLRICGHGLIEEFKPIKDLNIKKEVLREGKVKIDKGRTVIDGLAQSKVAAEKLIGEEISIEGKDIVGKIKGTFGTKGLLTAEFSGNVENRDKVILNRLRRWG 4dwq A 2.25 BS01 5GP A 1 N202 F204 E206 H329 P378 G379 S380 M381 H404 A406 G407 E446 Y451 K480 N202 F204 E206 H329 P378 G379 S380 M381 H404 A406 G407 E446 Y451 K480 3.1.-.-,6.5.1.8 0006396,0008452 O59245 22949672 501 MVVPLKRIDKIRWEIPKFDKRMRVPGRVYADEVLLEKMKNDRTLEQATNVAMLPGIYKYSIVMPDGHQGYGFPIGGVAAFDVKEGVISPGGIGYDINCGVRLIRTNLTEKEVRPRIKQLVDTLFKNVPSGVGSQGRIKLHWTQIDDVLVDGAKWAVDNGYGWERDLERLEEGGRMEGADPEAVSQRAKQRGAPQLGSLGSGNHFLEVQVVDKIFDPEVAKAYGLFEGQVVVMVHTGSRGLGHQVASDYLRIMERAIRKYRIPWPDRELVSVPFQSEEGQRYFSAMKAAANFAWANRQMITHWVRESFQEVFKQDPEGDLGMDIVYDVAHNIGKVEEHEVDGKRVKVIVHRKGATRAFPPGHEAVPRLYRDVGQPVLIPGSMGTASYILAGTEGAMKETFGSTCHGAGRVLSRKAATRQYRGDRIRQELLNRGIYVRAASMRVVAEEAPGAYKNVDNVVKVVSEAGIAKLVARMRPIGVAKG 4dwq B 2.25 BS01 5GP B 1 N202 F204 E206 H329 P378 G379 S380 M381 H404 A406 G407 Y451 K480 N202 F204 E206 H329 P378 G379 S380 M381 H404 A406 G407 Y451 K480 3.1.-.-,6.5.1.8 0006396,0008452 O59245 22949672 501 MVVPLKRIDKIRWEIPKFDKRMRVPGRVYADEVLLEKMKNDRTLEQATNVAMLPGIYKYSIVMPDGHQGYGFPIGGVAAFDVKEGVISPGGIGYDINCGVRLIRTNLTEKEVRPRIKQLVDTLFKNVPSGVGSQGRIKLHWTQIDDVLVDGAKWAVDNGYGWERDLERLEEGGRMEGADPEAVSQRAKQRGAPQLGSLGSGNHFLEVQVVDKIFDPEVAKAYGLFEGQVVVMVHTGSRGLGHQVASDYLRIMERAIRKYRIPWPDRELVSVPFQSEEGQRYFSAMKAAANFAWANRQMITHWVRESFQEVFKQDPEGDLGMDIVYDVAHNIGKVEEHEVDGKRVKVIVHRKGATRAFPPGHEAVPRLYRDVGQPVLIPGSMGTASYILAGTEGAMKETFGSTCHGAGRVLSRKAATRQYRGDRIRQELLNRGIYVRAASMRVVAEEAPGAYKNVDNVVKVVSEAGIAKLVARMRPIGVAKG 4egu A 0.95 BS01 5GP A 1 F30 D32 L33 N34 E97 H102 H104 F29 D31 L32 N33 E96 H101 H103 ? 0003824,0005737,0016787,0046872 Q182D4 201 ERMDCIFCKIANGEIPSTKVYEDDRVLAFNDLNPVAPYHILVVPKKHYDSLIDIPDKEMDIVSHIHVVINKIAKEKGFDQTGFRVINNCGSDGGQEVKHLHYHILAGKKLPNYEAGQN 4egu B 0.95 BS01 5GP B 1 F30 D32 L33 N34 N89 E97 V98 H102 H104 F30 D32 L33 N34 N89 E97 V98 H102 H104 ? 0003824,0005737,0016787,0046872 Q182D4 201 MERMDCIFCKIANGEIPSTKVYEDDRVLAFNDLNPVAPYHILVVPKKHYDSLIDIPDKEMDIVSHIHVVINKIAKEKGFDQTGFRVINNCGSDGGQEVKHLHYHILAGKKLPNYE 4ff2 A 2.0 BS04 5GP C 1 R424 K437 R440 F950 D951 R419 K432 R435 F945 D946 2.7.7.6 Q859P9 23235152 101 EELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQKSRTVGSEAPLKDVAQALSSRARYELFTEKETANPAFNGEVIKRYKELMEHGEGIADILRSRLAKFLNTKDVGKRFAQGTEANRWVGGKLLNIVEQDGDTFKYNEQLLQTAVLAGLQWRLTATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLTEAVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILAAFVESTDVVENIVDMSEIDPDNKKTIGLYTITELDSFDPINSFPTAIEEAVLVNPTEKMFFGDDIPPVANTQLRNPAVRNTPEQKAALKAEQATEFYVHTPMVQFYETLGKDRILELMGAGTLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQSEDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAILPTKATLDLSNQNNEDFSAFQLGLAQALDIKVHTMTREVMSDELTKLLEGNLKPAIDMMVEFNTTGSLPENAVDVLNTALGDRKSFVALMALMEYSRYLVAEDKSAFVTPLYVEADGVTNGPINAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRSTADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLLSLMDLFLPDINLGENGALELKRGIAKNPLTITIYGSGARGIAGKLVSSVTDAIYERMSDVLKARAKDPNISAAMAMFGKQAASEAHAEELLARFLKDMETLTSTVPVKRKGVLELQSTGTGAKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQTVGESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAKDPTWKKGDFLTQKELNDIQASLNNLAPMIETGSQTFYIAGSENAEVANQVLATNLDDRMRVPMSIYAPAQAGVAGIPFMTIGTGDGMMMQTLSTMKGAPKNTLKIFDGMNIGLNDITDASRKANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEALEAIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVDIRHKVLDKVNLSIDQMAAVGAPYQNNGKIDLSNMTPEQQADELNKLFREELEARKQ 4ff3 A 1.997 BS05 5GP C 1 R424 K437 R440 F950 D951 R419 K432 R435 F945 D946 2.7.7.6 Q859P9 23235152 101 EELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQKSRTVGSEAPLKDVAQALSSRARYELFTEKETANPAFNGEVIKRYKELMEHGEGIADILRSRLAKFLNTKDVGKRFAQGTEANRWVGGKLLNIVEQDGDTFKYNEQLLQTAVLAGLQWRLTATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLTEAVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILAAFVESTDVVENIVDMSEIDPDNKKTIGLYTITELDSFDPINSFPTAIEEAVLVNPTEKMFFGDDIPPVANTQLRNPAVRNTPEQKAALKAEQATEFYVHTPMVQFYETLGKDRILELMGAGTLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQSEDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAILPTKATLDLSNQNNEDFSAFQLGLAQALDIKVHTMTREVMSDELTKLLEGNLKPAIDMMVEFNTTGSLPENAVDVLNTALGDRKSFVALMALMEYSRYLVAEDKSAFVTPLYVEADGVTNGPINAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRSTADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLLSLMDLFLPDINLGENGALELKRGIAKNPLTITIYGSGARGIAGKLVSSVTDAIYERMSDVLKARAKDPNISAAMAMFGKQAASEAHAEELLARFLKDMETLTSTVPVKRKGVLELQSTGTGAKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQTVGESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAKDPTWKKGDFLTQKELNDIQASLNNLAPMIETGSQTFYIAGSENAEVANQVLATNLDDRMRVPMSIYAPAQAGVAGIPFMTIGTGDGMMMQTLSTMKGAPKNTLKIFDGMNIGLNDITDASRKANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEALEAIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVDIRHKVLDKVNLSIDQMAAVGAPYQNNGKIDLSNMTPEQQADELNKLFREELEARKQ 4ff4 A 2.026 BS05 5GP C 1 R424 K437 D951 R419 K432 D946 2.7.7.6 Q859P9 23235152 101 EELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQKSRTVGSEAPLKDVAQALSSRARYELFTEKETANPAFNGEVIKRYKELMEHGEGIADILRSRLAKFLNTKDVGKRFAQGTEANRWVGGKLLNIVEQDGDTFKYNEQLLQTAVLAGLQWRLTATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLTEAVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILAAFVESTDVVENIVDMSEIDPDNKKTIGLYTITELDSFDPINSFPTAIEEAVLVNPTEKMFFGDDIPPVANTQLRNPAVRNTPEQKAALKAEQATEFYVHTPMVQFYETLGKDRILELMGAGTLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQSEDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAILPTKATLDLSNQNNEDFSAFQLGLAQALDIKVHTMTREVMSDELTKLLEGNLKPAIDMMVEFNTTGSLPENAVDVLNTALGDRKSFVALMALMEYSRYLVAEDKSAFVTPLYVEADGVTNGPINAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRSTADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLLSLMDLFLPDINLGENGALELKRGIAKNPLTITIYGSGARGIAGKLVSSVTDAIYERMSDVLKARAKDPNISAAMAMFGKQAASEAHAEELLARFLKDMETLTSTVPVKRKGVLELQSTGTGAKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQTVGESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAKDPTWKKGDFLTQKELNDIQASLNNLAPMIETGSQTFYIAGSENAEVANQVLATNLDDRMRVPMSIYAPAQAGVAGIPFMTIGTGDGMMMQTLSTMKGAPKNTLKIFDGMNIGLNDITDASRKANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEALEAIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVDIRHKVLDKVNLSIDQMAAVGAPYQNNGKIDLSNMTPEQQADELNKLFREELEARKQ 4fwo A 2.9 BS02 5GP A 1 G205 N206 D278 L279 R280 E283 G326 I327 N330 G202 N203 D275 L276 R277 E280 G323 I324 N327 N11 R86 H175 R236 E381 N8 R83 H172 R233 E378 2.7.2.15 0005524,0005829,0006082,0006083,0008776,0008980,0016301,0016310,0016774,0046872,0070689 O06961 23747922 504 FPVVLVINCGSSSIKFSVLDVATCDVLMAGIADGMNTENAFLSINGDKPINLAHSNYEDALKAIAFELEKRDLTDSVALIGHRIAHGGELFTQSVIITDEIIDNIRRVSPLAPLHNYANLSGIDAARHLFPAVRQVAVFDTSFHQTLAPEAYLYGLPWEYFSSLGVRRYGFHGTSHRYVSRRAYELLDLDEKDSGLIVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVDFGAMAWIAKETGQTLSDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERARLAIKTFVHRIARHIAGHAASLHRLDGIIFTGGIGENSVLIRQLVIEHLGVLGLTLDVEMNKQPNSHGERIISANPSQVICAVIPTNEEKMIALDAIHLGNVKA 4g0z A 1.75 BS01 5GP A 1 N687 Y691 K695 Q707 C708 L710 K728 K732 N94 Y98 K102 Q114 C115 L117 K135 K139 ? 0003676 Kd=6.13mM -logKd/Ki=2.21, Kd=6.13mM O04379 22850669 801 SNKKMINGGTVNNWICINFSRQVQDNLARTFCQELAQMCYVSGMAFNPEPVLPPVSARPEQVEKVLKTRYHDATSKLSQGKEIDLLIVILPDNNGSLYGDLKRICETELGIVSQCCLTKHVFKMSKQYMANVALKINVKVGGRNTVL 4gty A 3.19 BS01 5GP A 1 T238 F239 N259 L272 K277 Y322 Y353 E355 D358 H517 T69 F70 N90 L103 K108 Y153 Y184 E186 D189 H348 3.1.4.1,3.1.4.39,3.6.1.9 0003676,0005044,0006955,0016787,0030247,0046872 P06802,Q9R1E6 23027977 1009 KSWVEETCESIDTPECPAEFESPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPMYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTDVPETYYSFNYEALAKNLSCREPNQHFRPYLKPFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNLFSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLGLIPAPNNGSHGSLNHLLKKPIYNPSHPKEEGFLSQCPIKSTSNDLGCTCDPEDDDIYHMTVPYGRPRILLKQHRVCLLQQQQFLTGYSLDLLMPLWASYTFLSNDSNCLYQDLRIPLSPVHKCSYYKSNSKLSYGFLTPPRLNHIYSEALLTSNIVPMYQSFQVIWHYLHDTLLQRYAHERNGINVVSGPVFDFDYDGRYDSLEILKQNSRVIRSQEILIPTHFFIVLTSCKQLSETPLECSALESSAYILPHRPDNIESCTHGKRESSWVEELLTLHRARVTDVELITGLSFYQDRQESVSELLRLKTHLPIFS 4gty B 3.19 BS01 5GP B 1 T238 F239 N259 L272 K277 Y322 Y353 E355 D358 H406 H517 T69 F70 N90 L103 K108 Y153 Y184 E186 D189 H237 H345 3.1.4.1,3.1.4.39,3.6.1.9 0003676,0005044,0006955,0016787,0030247,0046872 P06802,Q9R1E6 23027977 1005 KSWVEETCESIDTPECPAEFESPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPMYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTDVPETYYSFNYEALAKNLSCREPNQHFRPYLKPFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSYCGSGFHGSDNLFSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLGLIPAPNNGSHGSLNHLLKKPIYNPSHPKEEGFLSQCPIKSTSNDLGCTCDPDDDIYHMTVPYGRPRILLKQHRVCLLQQQQFLTGYSLDLLMPLWASYTFLSNDNCLYQDLRIPLSPVHKCSYYKLSYGFLTPPRLNHIYSEALLTSNIVPMYQSFQVIWHYLHDTLLQRYAHERNGINVVSGPVFDFDYDGRYDSLEILKQNSRVIRSQEILIPTHFFIVLTSCKQLSETPLECSALESSAYILPHRPDNIESCTHGKRESSWVEELLTLHRARVTDVELITGLSFYQDRQESVSELLRLKTHLPIFS 4h2w A 1.95 BS02 5GP A 1 L169 F172 M174 K235 A250 C251 G283 R286 L152 F155 M157 K218 A233 C234 G266 R269 C131 R159 E161 R168 E176 K235 A250 S253 C279 R286 C114 R142 E144 R151 E159 K218 A233 S236 C262 R269 6.2.1.n2 0000166,0004812,0005515,0005524,0006418,0016874,0046872 Q89VT8 23541895 403 DPLDHLADKLFHSMGSDGVYARTALYESIVERLAALITSHREAGTEALRFPPVMSRAQLEKSGYLKSFPNLLGCVCGLHGTEREINAAVSRFDAGGDWTTSLSPADLVLSPAACYPVYPIAASRGPLPKGGLRFDVAADCFRREPSKHLDRLQSFRMREYVCIGTPDDVSDFRERWMVRAQAIARDLGLTFRVDYASDPFFGRAGKMLANNQRDQQLKFELLIPLRSEEQPTACMSFNYHREHFGTTWGIQDANGEPAHTGCVAFGMDRLAVAMFHTHGTDLSAWPAKVRDILGL 4hiu A 3.3 BS02 5GP A 1 D64 V65 E66 A117 F118 N119 V120 D56 V57 E58 A109 F110 N111 V112 ? 0016020,0020002,0030430,0039660,0042802,0044423 P0C794 301 KHSYVELKDKVIVPGWPTLMLEIDFVNQFLNIPFLSVKEPLQLPAEKKLTDYFTIDVEPAGHSLVNIYFQIDDFLLLTLNSLSVYKDPIRKYMFLRLNKEQSKHAINAAFNVFSYRLRNIGVGPLGPDIRSS 4it0 A 2.4 BS05 5GP A 1 N202 F204 E206 H329 P378 G379 S380 M381 H404 A406 G407 Y451 K480 N201 F203 E205 H328 P377 G378 S379 M380 H403 A405 G406 Y450 K479 3.1.-.-,6.5.1.8 0006396,0008452 O59245 23560983 503 VVPLKRIDKIRWEIPKFDKRMRVPGRVYADEVLLEKMKNDRTLEQATNVAMLPGIYKYSIVMPDGHQGYGFPIGGVAAFDVKEGVISPGGIGYDINCGVRLIRTNLTEKEVRPRIKQLVDTLFKNVPSGVGSQGRIKLHWTQIDDVLVDGAKWAVDNGYGWERDLERLEEGGRMEGADPEAVSQRAKQRGAPQLGSLGSGNHFLEVQVVDKIFDPEVAKAYGLFEGQVVVMVHTGSRGLGHQVASDYLRIMERAIRKYRIPWPDRELVSVPFQSEEGQRYFSAMKAAANFAWANRQMITHWVRESFQEVFKQDPEGDLGMDIVYDVAHNIGKVEEHEVDGKRVKVIVHRKGATRAFPPGHEAVPRLYRDVGQPVLIPGSMGTASYILAGTEGAMKETFGSTCHGAGRVLSRKAATRQYRGDRIRQELLNRGIYVRAASMRVVAEEAPGAYKNVDNVVKVVSEAGIAKLVARMRPIGVAKG 4lm9 A 1.601 BS01 5GP A 1 F57 P61 Y63 S64 F66 S67 G68 R122 Y124 R164 A171 E189 F2 P6 Y8 S9 F11 S12 G13 R64 Y66 R106 A113 E131 ? 0003723,0019013 P33469 24564608 201 EFNVVPYYSWFSGITQFQKGKEFEFVEGQGVPIAPGVPATEAKGYWYRHNRRSFKTADGQLLPRWYFYYLGTGPHAKDQYGTDIDGVYWVASNQADVNTPADIVDRDPSSDEAIPTRFPPGTVLPQGYYIEG 4me4 B 2.55 BS04 5GP B 1 E185 H189 H277 D305 A309 L310 R314 E188 H192 H280 D308 A312 L313 R317 ? 0000166,0016787,0046872 C0QQ26 24176013 404 YQDPERKLKILLDYSSKIANEKDLRNVLLFLTDLAKEIMEADRASIFLYDDQKKTLWTIVAHGVDRIEIDADKGIAGYVFRTGEILNIPDAYKDPRFDRDIDKRTGYRTRTILAVPLFDRKQNIIGVFQVINKLTNSVFTEEDIELLRHISLYASSTIENAILYEKLKKAHEDVIYRLSHATKFKDPETQNHIIRVGLYAEILAREAGLDEEDVELVKLAAPMHDIGKVGIPDRVLLKPGKLNDEEWEIMKKHTIYGYEILKGGDSRLLQIAADIAIEHHERWDGTGYPFGKKGEEISIYGRMTSISDVFDALTSDRPYKKAWDMDRTVRFFKEQKGKHFDPFLTDIFLKNIDQMFSIKRELR 4o7z A 2.3 BS01 5GP A 1 R93 G98 S99 D173 K175 D195 C197 R198 R81 G86 S87 D161 K163 D183 C185 R186 6.3.2.6 0004639,0005524,0006164,0006189,0009236,0016874 O57978 301 AKMIPIDDDKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKLLEEHGIKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKNDELHDPMINYYHAKVLGISLDEIKKIEEIALKVNEILKDYLAKKGIILVDFKLEFGKDKNGDIVLADEISPDTCRFWDAKTKRSLDKDVFRFDKGDLIEAYKEIYERITGEKPEF 4o84 A 2.09 BS01 5GP A 1 E89 R93 G98 S99 D173 K175 C197 R198 R214 E78 R82 G87 S88 D162 K164 C186 R187 R203 6.3.2.6 0004639,0005524,0006164,0006189,0009236,0016874 O57978 308 AKKMIPIDDDKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKLLEEHGIKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKNDELHDPMINYYHAKVLGISLDEIKKIEEIALKVNEILKDYLAKKGIILVDFKLEFGKDKNGDIVLADEISPDTCRFWDAKTKRSLDKDVFRFDKGDLIEAYKEIYERITGEKPEF 4o84 B 2.09 BS01 5GP B 1 E89 R93 S99 D173 K175 D195 R198 R214 E78 R82 S88 D162 K164 D184 R187 R203 6.3.2.6 0004639,0005524,0006164,0006189,0009236,0016874 O57978 408 AKKMIPIDDDKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKLLEEHGIKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKNDELHDPMINYYHAKVLGISLDEIKKIEEIALKVNEILKDYLAKKGIILVDFKLEFGKDKNGDIVLADEISPDTCRFWDAKTKRSLDKDVFRFDKGDLIEAYKEIYERITGEKPEF 4ohf A 2.53 BS01 5GP A 1 R86 Y87 Y421 R82 Y83 Y414 ? 0008253,0016787,0042802,0046872 Q5ZZB6 24456211 501 KVFVNRIINMRKIKLIGLDMDHTLIRYNSKNFESLVYDLVKERLAESFHYPEEIKKFKFNFDDAIRGLVIDSKNGNILKLSRYGAIRLSYHGTKQISFSDQKKIYRSIYVDLGDPNYMAIDTSFSIAFCILYGQLVDLKDTNPDKMPSYQAIAQDVQYCVDKVHSDGTLKNIIIKNLKKYVIREKEVVEGLKHFIRYGKKIFILTNSEYSYSKLLLDYALSPFLDKGEHWQGLFEFVITLANKPRFFYDNLRFLSVNPENGTMTNVHGPIVPGVYQGGNAKKFTEDLGVGGDEILYIGDHIYGDILRLKKDCNWRTALVVEELGEEIASQIRALPIEKKIGEAMAIKKELEQKYVDLCTRSIDESYDQEIHDLQLQISTVDLQISRLLQEQNSFYNPKWERVFRAGAEESYFAYQVDRFACIYMEKLSDLLEHSPMTYFRANRRLLAHDIDILEH 4ohf B 2.53 BS01 5GP A 1 R86 Y421 R85 Y420 ? 0008253,0016787,0042802,0046872 Q5ZZB6 24456211 501 DTHKVFVNRIINMRKIKLIGLDMDHTLIRYNSKNFESLVYDLVKERLAESFHYPEEIKKFKFNFDDAIRGLVIDSKNGNILKLSRYGAIRLSYHGTKQISFSDQKKIYRSIYVDLGDPNYMAIDTSFSIAFCILYGQLVDLKDTNPDKMPSYQAIAQDVQYCVDKVHSDGTLKNIIIKNLKKYVIREKEVVEGLKHFIRYGKKIFILTNSEYSYSKLLLDYALSPFLDKGEHWQGLFEFVITLANKPRFFYDNLRFLSVNPENGTMTNVHGPIVPGVYQGGNAKKFTEDLGVGGDEILYIGDHIYGDILRLKKDCNWRTALVVEELGEEIASQIRALPIEKKIGEAMAIKKELEQKYVDLCTRSIDESSQQYDQEIHDLQLQISTVDLQISRLLQEQNSFYNPKWERVFRAGAEESYFAYQVDRFACIYMEKLSDLLEHSPMTYFRANRRLLAHDIDI 4ohf C 2.53 BS01 5GP C 1 R86 Y87 Y421 R82 Y83 Y401 ? 0008253,0016787,0042802,0046872 Q5ZZB6 24456211 501 KVFVNRIINMRKIKLIGLDMDHTLIRYNSKNFESLVYDLVKERLAESFHYPEEIKKFKFNFDDAIRGLVIDSKNGNILKLSRYGAIRLSYHGTKQISFSDQKKIYRSIYVDLGDPNYMAIDTSFSIAFCILYGQLVDLKDTNPDKMPSYQAIAQDVQYCVDKVHSDGTLKNIIIKNLKKYVIREKEVVEGLKHFIRYGKKIFILTNSEYSYSKLLLDYALSPFLDKGEHWQGLFEFVITLANKPRFFYDNLRFLSVNPENGTMTNVHGPIVPGVYQGGNAKKFTEDLGVGGDEILYIGDHIYGDILRLKKDCNWRTALVVEELGEEIASQIRALPIEKKIGEAMAIKKELEQKYVDLHDLQLQISTVDLQISRLLQEQNSFYNPKWERVFRAGAEESYFAYQVDRFACIYMEKLSDLLEHSPMTYFRANRRLLAHDID 4ohf D 2.53 BS01 5GP C 1 R86 Y87 Y421 R84 Y85 Y419 ? 0008253,0016787,0042802,0046872 Q5ZZB6 24456211 501 THKVFVNRIINMRKIKLIGLDMDHTLIRYNSKNFESLVYDLVKERLAESFHYPEEIKKFKFNFDDAIRGLVIDSKNGNILKLSRYGAIRLSYHGTKQISFSDQKKIYRSIYVDLGDPNYMAIDTSFSIAFCILYGQLVDLKDTNPDKMPSYQAIAQDVQYCVDKVHSDGTLKNIIIKNLKKYVIREKEVVEGLKHFIRYGKKIFILTNSEYSYSKLLLDYALSPFLDKGEHWQGLFEFVITLANKPRFFYDNLRFLSVNPENGTMTNVHGPIVPGVYQGGNAKKFTEDLGVGGDEILYIGDHIYGDILRLKKDCNWRTALVVEELGEEIASQIRALPIEKKIGEAMAIKKELEQKYVDLCTRSIDESSQQYDQEIHDLQLQISTVDLQISRLLQEQNSFYNPKWERVFRAGAEESYFAYQVDRFACIYMEKLSDLLEHSPMTYFRANRRLLAHDID 4ojx A 1.31 BS01 5GP A 1 H130 H213 V217 D244 H294 H326 K328 H124 H207 V211 D238 H288 H320 K322 3.1.4.17 0004114,0004115,0004118,0004119,0005575,0006198,0007189,0008081,0008270,0016787,0047555,1902660 P22434 25050706 402 MVVFEITILGANGGPTEYGTQCFILKPARTEDPELIAVDGGAGMYQLREMLVQGDDELVPSFYEHDREPIEFFIDSKLNIQKGLSKSLLQSLKRQGEHFESANTMKKTYEVFQGITDYYITHPHLDHISGLVVNSPSIYEQENSKKKTIWGLPHTIDVLQKHVFNDLIWPDLTAERSRKLKLKCLNPKEVQKCTIFPWDVIPFKVHHGIGVKTGAPVYSTFYIFRDRKSKDCIIVCGDVEQDRRESEESLLEEFWSYVAENIPLVHLKGILVECSCPLSSKPEQLYGHLSPIYLINELSNLNTLYNSSKGLSGLNVIVTHVKSTPAKRDPRLTILEELRFLAEERNLGDLRISIALEGHTLFL 4p86 A 1.93 BS01 5GP A 1 K40 D105 D106 V107 Y109 T110 G111 T113 R138 K161 V162 K38 D101 D102 V103 Y105 T106 G107 T109 R134 K157 V158 25525255 201 QKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGIYLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSTSNDEPLVKGADIPVDITDQKVILVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSEKVMVQLDEVDQNDLVAIYENE 4p86 B 1.93 BS01 5GP B 1 K40 D105 D106 V107 Y109 T110 G111 T113 R138 V162 K37 D99 D100 V101 Y103 T104 G105 T107 R132 V156 25525255 201 KAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGIYLAKRLAERIEQIEGNPVTVGEIDITLYRDDLTSNDEPLVKGADIPVDITDQKVILVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSEKVMVQLDEVDQNDLVAIYENE 4p86 B 1.93 BS02 5GP B 2 H140 P155 T156 S157 H134 P149 T150 S151 25525255 202 KAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGIYLAKRLAERIEQIEGNPVTVGEIDITLYRDDLTSNDEPLVKGADIPVDITDQKVILVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSEKVMVQLDEVDQNDLVAIYENE 4p86 C 1.93 BS01 5GP B 2 K4 E160 I177 K2 E154 I171 25525255 202 QKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGIYLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSNDEPLVKGADIPVDITDQKVILVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSEKVMVQLDEVDQNDLVAIYEN 4p86 C 1.93 BS02 5GP C 1 K4 H140 P155 T156 S157 E160 K2 H134 P149 T150 S151 E154 25525255 201 QKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGIYLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSNDEPLVKGADIPVDITDQKVILVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSEKVMVQLDEVDQNDLVAIYEN 4p86 C 1.93 BS03 5GP C 2 K40 D105 D106 V107 Y109 T110 G111 T113 R138 V162 K38 D99 D100 V101 Y103 T104 G105 T107 R132 V156 25525255 202 QKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGIYLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSNDEPLVKGADIPVDITDQKVILVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSEKVMVQLDEVDQNDLVAIYEN 4p86 D 1.93 BS01 5GP D 1 K40 D105 D106 V107 Y109 T110 G111 T113 R138 K161 V162 K38 D99 D100 V101 Y103 T104 G105 T107 R132 K155 V156 25525255 201 QKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGIYLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSNDEPLVKGADIPVDITDQKVILVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSEKVMVQLDEVDQNDLVAIYEN 4peg A 2.0 BS02 5GP A 1 N90 H91 D205 H230 M231 H232 N86 H87 D201 H226 M227 H228 3.1.4.- 0000375,0000398,0003723,0005506,0005634,0005737,0006397,0008270,0008419,0016787,0030145,0046872,0048471 C4M1P9 25123664 402 QIQHIAIVGCVHGKYREMYRQLSEYEKSTGKEISFVICTGDMQTLRYEADLVYLKVPPKYKQMGDFHLYYEGKEKAPYLTLFIGGNHESSNVLLHLYNGGFVCFNMYYLGVCSCININGLRIVGVSGIYKSFDEKKPYTYPPSPNDVVSLFHTRNYVIQMLSNLSQSSQIDISLSHDWPQGIVMKGNYKQLYRFQPGFKKDGASLGSPINKVILNTLKPKYWISGHMHCEYHAEEGPTHFIALGKIGYKNAISYLDLPLKQKTDLEYDKDWVCNLIMTWPAFSNKAQFPDLSYSISELLSKRTKELDKKIIELWEKYIGLKIIYDSDTFDIQFTSRRFYIEKIYNELNI 4peg B 2.0 BS02 5GP B 1 N90 H91 D205 L209 H230 M231 H232 N86 H87 D201 L205 H226 M227 H228 3.1.4.- 0000375,0000398,0003723,0005506,0005634,0005737,0006397,0008270,0008419,0016787,0030145,0046872,0048471 C4M1P9 25123664 402 QIQHIAIVGCVHGKYREMYRQLSEYEKSTGKEISFVICTGDMQTLRYEADLVYLKVPPKYKQMGDFHLYYEGKEKAPYLTLFIGGNHESSNVLLHLYNGGFVCFNMYYLGVCSCININGLRIVGVSGIYKSFDEKKPYTYPPSPNDVVSLFHTRNYVIQMLSNLSQSSQIDISLSHDWPQGIVMKGNYKQLYRFQPGFKKDGASLGSPINKVILNTLKPKYWISGHMHCEYHAEEGPTHFIALGKIGYKNAISYLDLPLKQKTDLEYDKDWVCNLIMTWPAFSNKAQFPDLSYSISELLSKRTKELDKKIIELWEKYIGLKIIYDSDTFDIQFTSRRFYIEKIYNELNI 4peg C 2.0 BS02 5GP C 1 N90 H91 G201 D205 H230 M231 H232 N86 H87 G197 D201 H226 M227 H228 3.1.4.- 0000375,0000398,0003723,0005506,0005634,0005737,0006397,0008270,0008419,0016787,0030145,0046872,0048471 C4M1P9 25123664 402 QIQHIAIVGCVHGKYREMYRQLSEYEKSTGKEISFVICTGDMQTLRYEADLVYLKVPPKYKQMGDFHLYYEGKEKAPYLTLFIGGNHESSNVLLHLYNGGFVCFNMYYLGVCSCININGLRIVGVSGIYKSFDEKKPYTYPPSPNDVVSLFHTRNYVIQMLSNLSQSSQIDISLSHDWPQGIVMKGNYKQLYRFQPGFKKDGASLGSPINKVILNTLKPKYWISGHMHCEYHAEEGPTHFIALGKIGYKNAISYLDLPLKQKTDLEYDKDWVCNLIMTWPAFSNKAQFPDLSYSISELLSKRTKELDKKIIELWEKYIGLKIIYDSDTFDIQFTSRRFYIEKIYNELNIN 4peg D 2.0 BS02 5GP D 1 N90 H91 D205 H230 M231 H232 N86 H87 D201 H226 M227 H228 3.1.4.- 0000375,0000398,0003723,0005506,0005634,0005737,0006397,0008270,0008419,0016787,0030145,0046872,0048471 C4M1P9 25123664 402 QIQHIAIVGCVHGKYREMYRQLSEYEKSTGKEISFVICTGDMQTLRYEADLVYLKVPPKYKQMGDFHLYYEGKEKAPYLTLFIGGNHESSNVLLHLYNGGFVCFNMYYLGVCSCININGLRIVGVSGIYKSFDEKKPYTYPPSPNDVVSLFHTRNYVIQMLSNLSQSSQIDISLSHDWPQGIVMKGNYKQLYRFQPGFKKDGASLGSPINKVILNTLKPKYWISGHMHCEYHAEEGPTHFIALGKIGYKNAISYLDLPLKQKTDLEYDKDWVCNLIMTWPAFSNKAQFPDLSYSISELLSKRTKELDKKIIELWEKYIGLKIIYDSDTFDIQFTSRRFYIEKIYNELNI 4peg E 2.0 BS02 5GP E 1 N90 H91 D205 H230 M231 H232 N86 H87 D201 H226 M227 H228 3.1.4.- 0000375,0000398,0003723,0005506,0005634,0005737,0006397,0008270,0008419,0016787,0030145,0046872,0048471 C4M1P9 25123664 402 QIQHIAIVGCVHGKYREMYRQLSEYEKSTGKEISFVICTGDMQTLRYEADLVYLKVPPKYKQMGDFHLYYEGKEKAPYLTLFIGGNHESSNVLLHLYNGGFVCFNMYYLGVCSCININGLRIVGVSGIYKSFDEKKPYTYPPSPNDVVSLFHTRNYVIQMLSNLSQSSQIDISLSHDWPQGIVMKGNYKQLYRFQPGFKKDGASLGSPINKVILNTLKPKYWISGHMHCEYHAEEGPTHFIALGKIGYKNAISYLDLPLKQKTDLEYDKDWVCNLIMTWPAFSNKAQFPDLSYSISELLSKRTKELDKKIIELWEKYIGLKIIYDSDTFDIQFTSRRFYIEKIYNELNI 4q9f A 1.75 BS01 5GP A 1 Y70 I71 G109 N110 Y111 I155 Y70 I71 G109 N110 Y111 I155 I71 E160 R163 I71 E160 R163 3.2.2.22 0000166,0016787,0017148,0030598,0035821,0090729 D9J2T9 802 DVSFRLSGADPSSYGMFIKDLRNALPHTEKVYNIPLLLPSVSGAGRYLLMHLFNYDGNTITVAVDVTNVYIMGYLALTTSYFFNEPAADLASQYVFRSARRKITLPYSGNYERLQIAAGKPREKIPIGLPALDTAISTLLHYDSTAAAGALLVLIQTTAEAARFKYIEQQIQERAYRDEVPSSATISLENSWSGLSKQIQLAQGNNGVFRTPTVLVDSKGNRVQITNVTSNVVTSNIQLLLNTKNI 4rht A 2.7633 BS02 5GP A 1 V124 K154 F175 V176 D182 V91 K121 F142 V143 D149 E122 D123 D126 F175 R188 E89 D90 D93 F142 R155 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006177,0006178,0006188,0016757,0032263,0032264,0043101,0046100,0046872,0052657 P9WHQ9 25915781 302 DIKSVLLTAEQIQARIAELGEQIGNDYRGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPR 4rht B 2.7633 BS02 5GP B 1 F175 V176 D182 F141 V142 D148 E122 D123 D126 F175 R188 E88 D89 D92 F141 R154 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006177,0006178,0006188,0016757,0032263,0032264,0043101,0046100,0046872,0052657 P9WHQ9 25915781 302 GDIKSVLLTAEQIQARIAELGEQIGNDYREQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRV 4rht C 2.7633 BS02 5GP C 1 V176 L181 V141 L146 E122 D123 D126 F175 R188 E88 D89 D92 F140 R153 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006177,0006178,0006188,0016757,0032263,0032264,0043101,0046100,0046872,0052657 P9WHQ9 25915781 302 KSVLLTAEQIQARIAELGEQIGNDYRTTGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTL 4rht D 2.7633 BS02 5GP D 1 V176 D182 V140 D146 E122 D123 D126 F175 R188 E89 D90 D93 F139 R152 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006177,0006178,0006188,0016757,0032263,0032264,0043101,0046100,0046872,0052657 P9WHQ9 25915781 302 DIKSVLLTAEQIQARIAELGEQIGNDYQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDP 4xba B 1.5 BS01 5GP B 1 L38 Y41 D63 M64 F65 H138 S142 M143 H147 H149 L6 Y9 D31 M32 F33 H106 S110 M111 H115 H117 3.6.1.71,3.6.1.72 0003824 O74859 26007660 301 SFRDNLKVYIESPESYKNVIYYDDDVVLVRDMFPKSKMHLLLMTRDPHLTHVHPLEIMMKHRSLVEKLVSYVQGDLSGLIFDEARNCLSQQLTNEALCNYIKVGFHAGPSMNNLHLHIMTLDHVSPSLKNSAHYISFTSPFFVKIDTPTSNLPTLFQEDLKCWRCGETFGRHFTKLKAHLQEEYDDWLDKSVS 4z0g A 1.25 BS01 5GP A 1 S74 M76 R325 G331 S332 I333 C334 T336 D367 G390 G391 Y414 G416 M417 G418 Q448 S70 M72 R206 G212 S213 I214 C215 T217 D248 G271 G272 Y294 G296 M297 G298 Q310 1.1.1.205 0003824,0003938,0006164,0016491 Ki=600uM Q756Z6 26558346 600 TYRDAATALEHLATYAEKDGLSVEQLMDRGGLTYNDFLVLPGKIDFPSSEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCTAEEQAEMVRRVKKYENDGPLASKSADTKQLLCGAAIGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQVIAGNVVTREQAASLIHAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTQFANQFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPGEYFFRGKRLKTYRGMGSIDAMQKVLVAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIGVRSLVEFREKVDSGSVRFEFRTPSAQLEGGVHNLHSYEKRLFD 4z0g B 1.25 BS01 5GP B 1 S74 M76 R325 G331 S332 I333 C334 T336 D367 G390 G391 Y414 G416 M417 G418 Q448 S72 M74 R208 G214 S215 I216 C217 T219 D250 G273 G274 Y296 G298 M299 G300 Q316 1.1.1.205 0003824,0003938,0006164,0016491 Ki=600uM Q756Z6 26558346 600 MTYRDAATALEHLATYAEKDGLSVEQLMDTRGGLTYNDFLVLPGKIDFPSSEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCTAEEQAEMVRRVKKYENDGPLASKSADTKQLLCGAAIGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQVIAGNVVTREQAASLIHAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTQFANQFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPGEYFFRGKRLKTYRGMGSIDAMQKTDVKVLVAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIGVRSLVEFREKVDSGSVRFEFRTPSAQLEGGVHNLHSYEKRLFD 4z0g B 1.25 BS02 5GP B 2 S283 V284 F285 S166 V167 F168 1.1.1.205 0003824,0003938,0006164,0016491 Ki=600uM Q756Z6 26558346 601 MTYRDAATALEHLATYAEKDGLSVEQLMDTRGGLTYNDFLVLPGKIDFPSSEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCTAEEQAEMVRRVKKYENDGPLASKSADTKQLLCGAAIGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQVIAGNVVTREQAASLIHAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTQFANQFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPGEYFFRGKRLKTYRGMGSIDAMQKTDVKVLVAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIGVRSLVEFREKVDSGSVRFEFRTPSAQLEGGVHNLHSYEKRLFD 4z87 A 2.25 BS01 5GP A 1 S74 M76 R325 G331 S332 I333 C334 T336 D367 G390 G391 Y414 G416 M417 G418 S72 M74 R323 G329 S330 I331 C332 T334 D365 G388 G389 Y412 G414 M415 G416 1.1.1.205 0000166,0003824,0003938,0005524,0005737,0006164,0006177,0006183,0016491,0046872 Q756Z6 26558346 601 HMTYRDAATALEHLATYAEKDGLSVEQLMDRGGLTYNDFLVLPGKIDFPSSEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCTAEEQAEMVRRVKKYENGFINAPVVVGPDATVADVRRMKNEFGFAGFPVTDDGKPTGKLQGIITSRDIQFVEDETLLVSEIMTKDVITGKQGINLEEANQILKNTKKGKLPIVDEAGCLVSMLSRTDLMKNQSYPLASKSADTKQLLCGAAIGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQVIAGNVVTREQAASLIHAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTQFANQFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPGEYFFRDGKRLKTYRGMGSIDAMQKVAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIGVRSLVEFREKVDSGSVRFEFRTPSAQLEGGVHNLHSYELFD 4z87 B 2.25 BS01 5GP B 1 S74 R325 G331 S332 C334 T336 D367 G390 G391 Y414 G416 M417 G418 Q448 S73 R324 G330 S331 C333 T335 D366 G389 G390 Y413 G415 M416 G417 Q426 1.1.1.205 0000166,0003824,0003938,0005524,0005737,0006164,0006177,0006183,0016491,0046872 Q756Z6 26558346 601 TYRDAATALEHLATYAEKDGLSVEQLMDSKTRGGLTYNDFLVLPGKIDFPSSEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCTAEEQAEMVRRVKKYENGFINAPVVVGPDATVADVRRMKNEFGFAGFPVTDDGKPTGKLQGIITSRDIQFVEDETLLVSEIMTKDVITGKQGINLEEANQILKNTKKGKLPIVDEAGCLVSMLSRTDLMKNQSYPLASKSADTKQLLCGAAIGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQVIAGNVVTREQAASLIHAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTQFANQFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPGEYFFRDGKRLKTYRGMGSIDAMQVAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIGVRSLVEFREKVDSGSVRFEFRTPSAQLEGGVHNLHSYELFD 4z87 C 2.25 BS01 5GP C 1 S74 R325 G331 S332 I333 C334 T336 D367 G390 G391 Y414 G416 M417 G418 S70 R320 G326 S327 I328 C329 T331 D362 G385 G386 Y408 G410 M411 G412 1.1.1.205 0000166,0003824,0003938,0005524,0005737,0006164,0006177,0006183,0016491,0046872 Q756Z6 26558346 601 TYRDAATALEHLATYAEKDGLSVEQLMDSGGLTYNDFLVLPGKIDFPSSEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCTAEEQAEMVRRVKKYENGFINAPVVVGPDATVADVRRMKNEFGFAGFPVTDDGKPGKLQGIITSRDIQFVEDETLLVSEIMTKDVITGKQGINLEEANQILKNTKKGKLPIVDEAGCLVSMLSRTDLMKNQSYPLASKSADTKQLLCGAAIGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQVIAGNVVTREQAASLIHAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTQFANQFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPGEYFFDGKRLKTYRGMGSIDAMQVLVAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIGVRSLVEFREKVDSGSVRFEFRTPSAQLEGGVHNLHSYEKLF 4z87 D 2.25 BS01 5GP D 1 S74 M76 R325 G331 S332 I333 C334 T336 D367 G390 G391 Y414 G416 M417 G418 Q448 S69 M71 R320 G326 S327 I328 C329 T331 D362 G385 G386 Y408 G410 M411 G412 Q415 1.1.1.205 0000166,0003824,0003938,0005524,0005737,0006164,0006177,0006183,0016491,0046872 Q756Z6 26558346 600 TYRDAATALEHLATYAEKDGLSVEQLMDGGLTYNDFLVLPGKIDFPSSEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCTAEEQAEMVRRVKKYENGFINAPVVVGPDATVADVRRMKNEFGFAGFPVTDDGKPTGKLQGIITSRDIQFVEDETLLVSEIMTKDVITGKQGINLEEANQILKNTKKGKLPIVDEAGCLVSMLSRTDLMKNQSYPLASKSADTKQLLCGAAIGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQVIAGNVVTREQAASLIHAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTQFANQFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPEYFFRDGKRLKTYRGMGSAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIGVRSLVEFREKVDSGSVRFEFRTPSAQLEGGVHNLHSYE 4zfn A 1.901 BS01 5GP A 1 F63 D97 T98 G99 T101 K125 W142 I143 D148 F61 D91 T92 G93 T95 K119 W136 I137 D142 D93 D94 D97 W142 D87 D88 D91 W136 2.4.2.- 0016757 Q97W22 201 EYHIPSWDEIEDAVFSIGEALVKSNYIPDVLIAVLTGGIIPAKLLSDLLDLKVIRYIDIKFYRSESKPVIRSVYTDSLEGKKVLVVDDVADTGETLEAVSNVITMFNPAKVMTAALYLKPWSKRIPDFYYKQIDKWIIFPWDKWDVVRENSNVPVDKKERFLNLYNQLLKIRK 4zfn B 1.901 BS01 5GP B 1 D93 D94 V95 A96 D97 T98 G99 E100 T101 K125 W142 I143 F145 D148 D93 D94 V95 A96 D97 T98 G99 E100 T101 K125 W142 I143 F145 D148 D93 D94 D97 W142 D93 D94 D97 W142 2.4.2.- 0016757 Q97W22 201 MVEYHIPSWDEIEDAVFSIGEALVKSNYIPDVLIAVLTGGIIPAKLLSDLLDLKVIRYIDIKFYRSVGKTESKPVIRSVYTDSLEGKKVLVVDDVADTGETLEAVSNVITMFNPAKVMTAALYLKPWSKRIPDFYYKQIDKWIIFPWDKWDVVRENSNVPVDKKERFLNLYNQLLKI 5esx A 2.71 BS01 5GP A 1 R76 D106 I107 D109 G110 G111 T113 K137 I161 D167 R77 D107 I108 D110 G111 G112 T114 K138 I162 D168 26968365 600 HMTIPDKIKAVYEKSTCLYTSNEVEAALDRMAIKIHETLQDKNPVIICVMVGGLVPLGNLLHRLDFPLEVDYVHATRYRGDLTGGDILWKVRPSSNLAGRTVLVVDDILDGGITLAAIINEIKAMGAAEVYSAVLVDKYRKRVPNGLQKADFVGLQVEDHYIFGYGMDYHEYLRNAPGIFIVHPDHE 5esx B 2.71 BS01 5GP B 1 R76 D106 I107 D109 G110 G111 T113 K137 I161 D167 R77 D107 I108 D110 G111 G112 T114 K138 I162 D168 26968365 601 HMTIPDKIKAVYEKSTCLYTSNEVEAALDRMAIKIHETLQDKNPVIICVMVGGLVPLGNLLHRLDFPLEVDYVHATRYRGDLTGGDILWKVRPSSNLAGRTVLVVDDILDGGITLAAIINEIKAMGAAEVYSAVLVDKYRKRVPNGLQKADFVGLQVEDHYIFGYGMDYHEYLRNAPGIFIVHPDH 5jv5 A 2.73 BS01 5GP A 1 I115 D117 K145 F166 V167 D173 I97 D99 K127 F148 V149 D155 E113 D114 D117 F166 R179 E95 D96 D99 F148 R161 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0020015,0031981,0032263,0032264,0046100,0046872,0052657,0097014 Q07010 27786284 301 HHMEPACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLRLCDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKEL 5jv5 B 2.73 BS01 5GP B 1 I115 D117 K145 F166 V167 D173 I94 D96 K124 F145 V146 D152 E113 D114 D117 F166 R179 E92 D93 D96 F145 R158 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0020015,0031981,0032263,0032264,0046100,0046872,0052657,0097014 Q07010 27786284 301 HHMEPACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKEL 5k1d A 1.94 BS01 5GP A 1 S65 L120 Q121 Y151 I292 L293 T313 G314 S315 I343 S67 L122 Q123 Y153 I294 L295 T313 G314 S315 I343 S65 K68 M107 E109 F122 Y151 G157 E272 K312 S315 S67 K70 M109 E111 F124 Y153 G159 E274 K312 S315 3.5.2.6 0000166,0008800,0016787,0017001,0030288,0046677,0046872 Ki=20.8uM -logKd/Ki=4.68, Ki=20.8uM Q99QC1 28242658 401 HHGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG 5km1 A 1.65 BS01 5GP A 1 I18 F41 D43 I44 N99 Q106 S107 H112 H114 I7 F30 D32 I33 N88 Q95 S96 H101 H103 3.4.22.-,3.9.1.- 0000118,0000166,0003824,0005080,0005515,0005634,0005654,0005737,0005829,0005856,0005886,0006355,0006508,0006915,0007165,0008234,0009154,0016787,0016926,0016929,0043530,0050850,0070062,0072332 -logKd/Ki=6.18, Kd=0.663uM P49773 28968488 201 RPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG 5o7f A 1.9 BS01 5GP A 1 R86 H105 H263 S265 R267 G283 G284 G285 H286 A290 G291 T293 R88 H107 H265 S267 R269 G285 G286 G287 H288 A292 G293 T295 ? 0000166,0003676,0046872 Q9X1T1 29107484 401 SGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVNASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATNTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEGVE 5o7f B 1.9 BS01 5GP B 1 R86 H105 H263 S265 R267 G283 G284 G285 H286 A290 G291 R88 H107 H265 S267 R269 G285 G286 G287 H288 A292 G293 ? 0000166,0003676,0046872 Q9X1T1 29107484 401 SGMDEIVKVLSQHDRILVVGHIMPDGDCVSSVLSLTLGLEKLGKEVKAAVDYKIPYVFEKFPYIDKIEENPNFDPELLVVVNASSPDRIGKFQDLLDKVPSVVIDHHSTNTNFGNWNWVDPSFAATAQMIFRINKALGVEYDSNLATLNYLGIATNTGFFRHSNADVRVFEDAYKLVKMGADAHFVAKEILENKRFEQFKLFAEVLERLQLLENGKIAYSYIDYDTYLRHNCTDEDSAGFVGELRSIRGVEVAVLFMEFPRGKIHVSMRSKDWFNVNEVAFELGGGGHPRAAGVTFEGKKIEEVIPRVINHLLKKFKEGV 5tc3 A 2.462 BS01 5GP A 1 S74 R325 G331 S332 C334 T336 D367 G418 Q448 S72 R323 G329 S330 C332 T334 D365 G410 Q416 1.1.1.205 0000166,0003824,0003938,0005524,0005737,0006164,0006177,0006183,0016491,0046872 Q756Z6 28572600 600 TYRDAATALEHLATYAEKDGLSVEQLMDSKTGGLTYNDFLVLPGKIDFPSSEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCTAEEQAEMVRRVKKYENGFINAPVVVGPDATVADVRRMKNEFGFAGFPVTDDGKPTGKLQGIITSRDIQFVEDETLLVSEIMTKDVITGKQGINLEEANQILKNTKKGKLPIVDEAGCLVSMLSRTDLMKNQSYPLASKSADTKQLLCGAAIGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQVIAGNVVTREQAASLIHAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTQFANQFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPGEYFRRLKTYRGSIDAAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIGVRSLVEFREKVDSGSVRFEFRTPSAQLEGGVHNLHSYELFD 5tc3 B 2.462 BS01 5GP B 1 S74 R325 G331 S332 C334 T336 D367 G390 G391 Y414 G418 S73 R324 G330 S331 C333 T335 D366 G389 G390 Y410 G412 1.1.1.205 0000166,0003824,0003938,0005524,0005737,0006164,0006177,0006183,0016491,0046872 Q756Z6 28572600 600 TYRDAATALEHLATYAEKDGLSVEQLMDSKTRGGLTYNDFLVLPGKIDFPSSEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCTAEEQAEMVRRVKKYENGFINAPVVVGPDATVADVRRMKNEFGFAGFPVTDDGKPTGKLQGIITSRDIQFVEDETLLVSEIMTKDVITGKQGINLEEANQILKNTKKGKLPIVDEAGCLVSMLSRTDLMKNQSYPLASKSADTKQLLCGAAIGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQVIAGNVVTREQAASLIHAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTQFANQFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPGEYFRDRLKTYRGSIDAMAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIGVRSLVEFREKVDSGSVRFEFRTPSAQLEGGVHNLHSLFD 5x71 A 2.568 BS01 5GP A 1 Q616 S702 G703 H704 W722 D746 W758 H759 Q611 S697 G698 H699 W717 D741 W753 H754 2.7.7.50 0003723,0004484,0005525,0006370,0016779,0030430,0044423 P14583 901 PDYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMSSGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQVMKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYGPTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKRIVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVINELVLKVKYVMHNPQIKLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILAFDPKITSDWTDAMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSVIDDTWVETDYEKFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHLLALLPQPYGASIREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQINTQKFMHCMITTVGDALKMDLDGGRAVIASYSLSNSSNSKERVLKFLSDANKAKAMVVFGAPNTHRLAYAKKVGLVLDSAIKMSKDLITFSNPTGRRWRDYGYSQSELYDAGYVEITIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPKWYVHKRMLMQDIRLSPAALVKCFTTLIRNICYVPHETYYRFRGILVDKYLRSKNVDPSQYSIVGSGSKTFTVLSHFEVPHECGPLVFEASTDVNISGHLLSLAIAAHFVASPMILWAEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQRWHSREEVLLAAEICESYAAMMLNNKHSPDIIGTLKSAINLVFKI 5x71 B 2.568 BS01 5GP B 1 Q616 P622 S702 G703 H704 W722 N747 W758 H759 Q610 P616 S696 G697 H698 W716 N741 W752 H753 2.7.7.50 0003723,0004484,0005525,0006370,0016779,0030430,0044423 P14583 901 DYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMSSGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQVMKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYGPTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKRIVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVINELVLKVKYVMHNPQIKLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILAFDPKITSDWTDAMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSVIDDTWVETDYEKFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHLLALLPQPYGASIREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQINTQKFMHCMITTVGDALKMDLDGGRAVIASYSLSNSSNSKERVLKFLSDANKAKAMVVFGAPNTHRLAYAKKVGLVLDSAIKMSKDLITFSNPTGRRWRDYGYSQSELYDAGYVEITIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPKWYVHKRMLMQDIRLSPAALVKCFTTLIRNICYVPHETYYRFRGILVDKYLRSKNVDPSQYSIVGSGSKTFTVLSHFEVPHECGPLVFEASTDVNISGHLLSLAIAAHFVASPMILWAEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQRWHSREEVLLAAEICESYAAMMLNNKHSPDIIGTLKSAINLVFKI 5xtk A 1.74 BS01 5GP A 1 R69 L90 D92 T93 T96 K115 W134 I135 R68 L89 D91 T92 T95 K114 W133 I134 2.4.2.-,2.4.2.22 0000287,0000310,0004422,0005829,0005886,0006166,0016757,0032263,0032264,0032265,0046872,0052657 Q8ZC05 302 NEKYVVTWDMLQIHARKLAQRLLPAEQWKGIIAVSRGGLVPAGILARELGIRYVDTVCISSYDHDNQRDLKVLKRAEGDGEGFIVIDDLVDTGGTATAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQNTWIEQPWDMAVTFVAPLSG 5y62 B 3.0 BS01 5GP B 1 R60 R175 H177 R23 R138 H140 ? -logKd/Ki=1.74, Kd=18.4mM Q9I4L4 28870806 600 RTSIEQRSNAVSQVLLGIFSYVRWPKEPAVLQLCVVGPTEYADGLLRGMVQANGRRVHAERRAVDNPDLGTLCNVIYLGVVDERERQQVFRSLAGHPVLSISERGTECSVGSMFCLNVGGPRITFEANLDSIARSGVRVHPSVLKLAR 6hgs A 1.55 BS01 5GP A 1 F26 R27 R67 D127 D128 L129 A131 T132 G133 T135 F24 R25 R65 D123 D124 L125 A127 T128 G129 T131 2.4.2.7 0002055,0003999,0005515,0005576,0005654,0005737,0005829,0006166,0006168,0007625,0016208,0016757,0032263,0032264,0034774,0044209,0046083,0070062 Ki=170uM P07741 31160323 200 DSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLGKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE 6hgs B 1.55 BS01 5GP B 1 F26 R27 R67 D127 D128 L129 A131 T132 G133 T135 F24 R25 R65 D120 D121 L122 A124 T125 G126 T128 2.4.2.7 0002055,0003999,0005515,0005576,0005654,0005737,0005829,0006166,0006168,0007625,0016208,0016757,0032263,0032264,0034774,0044209,0046083,0070062 Ki=170uM P07741 31160323 200 DSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE 6i0m A 2.567 BS01 5GP A 1 M70 R322 D364 S388 G415 M59 R308 D348 S372 G391 1.1.1.205 0000166,0003677,0003723,0003824,0003938,0005515,0005576,0005634,0005737,0005778,0005829,0006164,0006177,0006183,0007623,0016020,0016491,0034774,0046651,0046872,0070062,0071353,0097294,1904813 P12268 30664871 601 YVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGMGSLDAQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGG 6i0m B 2.567 BS01 5GP B 1 S68 R322 G328 T333 D364 G387 S388 S58 R303 G309 T312 D343 G366 S367 1.1.1.205 0000166,0003677,0003723,0003824,0003938,0005515,0005576,0005634,0005737,0005778,0005829,0006164,0006177,0006183,0007623,0016020,0016491,0034774,0046651,0046872,0070062,0071353,0097294,1904813 P12268 30664871 601 SYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDGRMGSRLVIISSRDIDFLEHDCFLEIMTKRLVVAPAGITLKEANEILQRSKKGKLPIVNEDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGKRLF 6j23 A 1.9 BS01 5GP A 1 H15 N17 F58 F61 H65 T97 T98 K100 G190 H217 E220 D296 H15 N17 F58 F61 H65 T97 T98 K100 G174 H201 E204 D280 3.5.4.- 0005737,0005829,0006401,0009117,0016787,0019239,0046872,0062154 Q8LPL7 31318636 401 MEWIQSLPKIELHAHLNGSIRDSTLLELARVLGEKGVIVFADVEHVIQKNDRSLVEVFKLFDLIHKLTTDHKTVTRITREVVEDFALENVVYLELRTTPKRSDSIGMSKRSYMEAVIQGLRSVSEVDIDFVRKKIYVRLLLSIDRRETTESAMETVKLALEMRDVGVVGIDLSGNPLVGEWSTFLPALQYAKDNDLHITLHCGEVPNPKEIQAMLDFKPHRIGHACFFKDEDWTKLKSFRIPVEICLTSNIVTKSISSIDIHHFADLYNAKHPLILCTNDFGVFSTSLSNEYALAVRSLGLSKSETFALARAAIDATFAEDEVKQQLRFIFDSASPEH 6jig A 1.903 BS01 5GP A 1 S52 G315 S316 I317 A318 T320 D351 G374 N375 G400 M401 A402 E428 S50 G313 S314 I315 A316 T318 D349 G372 N373 G398 M399 A400 E419 1.1.1.205 0003824,0003920,0003938,0005525,0005730,0005737,0006164,0006177,0006183,0016491,0020015,0046872 Q57ZS7 32296055 601 FNESASIPTGLTYDDVLIIPQHSRVTSRKEVNTTTRLSRNVKLSIPIVASNMDTVCEQRMAVAMAREGGIGILHRFCSIEEQCAMLREVKRAQSFLIESPRIILPHETAREAWEGLNWKGRVGGVGCLLVVNCKNERKLLGIITRHDLKLADESTTVESLMTPVDKMVVSTNTSISLEEVTHLMRKGRTANVPIVGQNGQLLYLVTLSDVVKLRKNKQASLDSRGRLLVGAAVGVKKDDMNRAIRLVEAGADVLVVDIAHGHSDLCINMVKRLKGDPRTASVDIIAGNIASAEAAEALIDAGADGLKIGVGPGSIAITRLVAGAGVPQLSAVLACTRVARRRGVPCIADGGLRTSGDISKAIGAGADTVMLGNMLAGTDEAPGRVLVKDGQKVKIIRGMAGFGANLSKAERERTSLVPEGVEGSVACKGPVGPIVRQLVGGLRSGMSYSGAKSIEEMQRRTRFVRMTGAGLRESGSHGVA 6jig A 1.903 BS02 5GP A 2 R93 Q95 I99 P102 R103 R123 V127 G128 C129 D211 R91 Q93 I97 P100 R101 R121 V125 G126 C127 D209 1.1.1.205 0003824,0003920,0003938,0005525,0005730,0005737,0006164,0006177,0006183,0016491,0020015,0046872 Q57ZS7 32296055 602 FNESASIPTGLTYDDVLIIPQHSRVTSRKEVNTTTRLSRNVKLSIPIVASNMDTVCEQRMAVAMAREGGIGILHRFCSIEEQCAMLREVKRAQSFLIESPRIILPHETAREAWEGLNWKGRVGGVGCLLVVNCKNERKLLGIITRHDLKLADESTTVESLMTPVDKMVVSTNTSISLEEVTHLMRKGRTANVPIVGQNGQLLYLVTLSDVVKLRKNKQASLDSRGRLLVGAAVGVKKDDMNRAIRLVEAGADVLVVDIAHGHSDLCINMVKRLKGDPRTASVDIIAGNIASAEAAEALIDAGADGLKIGVGPGSIAITRLVAGAGVPQLSAVLACTRVARRRGVPCIADGGLRTSGDISKAIGAGADTVMLGNMLAGTDEAPGRVLVKDGQKVKIIRGMAGFGANLSKAERERTSLVPEGVEGSVACKGPVGPIVRQLVGGLRSGMSYSGAKSIEEMQRRTRFVRMTGAGLRESGSHGVA 6low A 1.39 BS01 5GP A 1 V92 Y93 I94 G132 N133 Y134 I178 E183 R186 V69 Y70 I71 G109 N110 Y111 I155 E160 R163 3.2.2.22 0017148,0030598 P16094 32653369 302 DVSFRLSGADPRSYGMFIKDLRNALPFREKVYNIPLLLPSVSGAGRYLLMHLFNYDGKTITVAVDVTNVYIMGYLADTTSYFFNEPAAELASQYVFRDARRKITLPYSGNYERLQIAAGKPREKIPIGLPALDSAISTLLHYDSTAAAGALLVLIQTTAEAARFKYIEQQIQERAYRDEVPSLATISLENSWSGLSKQIQLAQGNNGIFRTPIVLVDNKGNRVQITNVTSKVVTSNIQLLLNTRNI 6mfu A 1.6 BS01 5GP A 1 S44 R48 R51 Y60 E79 F83 Y88 G89 T90 D106 I107 E108 R159 S43 R47 R50 Y59 E78 F82 Y87 G88 T89 D105 I106 E107 R158 2.7.4.8 0004385,0005524,0005829,0006163,0016301,0016310,0046037,0046710 J9VQ84 300 SRPINPDVVNRPLVICGPSGTGKSTLLKTLFESQPNTFGFSVSHTTRKPRPGEENGREYHFVTKEEFMEGVGKGEFLEWAEFGGNCYGTTFAALTALHPRRCILDIELQGVLQLKAKAPLQTPPLEPVFLFLSPPSISQLKSRLSGRGTETDASIRKRLDAAKEELRYAKEGKYDVYVVNDDLKVAGEKLEKVAMGWEGWKTCGDTLPELNLAELD 6mfu B 1.6 BS01 5GP B 1 S44 R48 R51 Y60 E79 F83 Y88 G89 T90 D106 I107 E108 R159 S42 R46 R49 Y58 E77 F81 Y86 G87 T88 D104 I105 E106 R157 2.7.4.8 0004385,0005524,0005829,0006163,0016301,0016310,0046037,0046710 J9VQ84 300 RPINPDVVNRPLVICGPSGTGKSTLLKTLFESQPNTFGFSVSHTTRKPRPGEENGREYHFVTKEEFMEGVGKGEFLEWAEFGGNCYGTTFAALTALHPRRCILDIELQGVLQLKAKAPLQTPPLEPVFLFLSPPSISQLKSRLSGRGTETDASIRKRLDAAKEELRYAKEGKYDVYVVNDDLKVAGEKLEKVAMGWEGWKTCGDTLPELNLAELD 6mfu C 1.6 BS01 5GP C 1 S44 R48 R51 Y60 E79 F83 Y88 G89 T90 D106 I107 E108 R159 S43 R47 R50 Y59 E78 F82 Y87 G88 T89 D105 I106 E107 R158 2.7.4.8 0004385,0005524,0005829,0006163,0016301,0016310,0046037,0046710 J9VQ84 300 SRPINPDVVNRPLVICGPSGTGKSTLLKTLFESQPNTFGFSVSHTTRKPRPGEENGREYHFVTKEEFMEGVGKGEFLEWAEFGGNCYGTTFAALTALHPRRCILDIELQGVLQLKAKAPLQTPPLEPVFLFLSPPSISQLKSRLSGRGTETDASIRKRLDAAKEELRYAKEGKYDVYVVNDDLKVAGEKLEKVAMGWEGWKTCGDTLPELNLAELD 6mfu D 1.6 BS01 5GP D 1 S44 R48 R51 Y60 E79 F83 Y88 G89 T90 D106 I107 E108 R159 S42 R46 R49 Y58 E77 F81 Y86 G87 T88 D104 I105 E106 R157 2.7.4.8 0004385,0005524,0005829,0006163,0016301,0016310,0046037,0046710 J9VQ84 300 RPINPDVVNRPLVICGPSGTGKSTLLKTLFESQPNTFGFSVSHTTRKPRPGEENGREYHFVTKEEFMEGVGKGEFLEWAEFGGNCYGTTFAALTALHPRRCILDIELQGVLQLKAKAPLQTPPLEPVFLFLSPPSISQLKSRLSGRGTETDASIRKRLDAAKEELRYAKEGKYDVYVVNDDLKVAGEKLEKVAMGWEGWKTCGDTLPELNLAELD 6mxc A 1.993 BS01 5GP A 1 D148 I149 D151 T152 G153 T155 K180 Y201 V202 E208 D132 I133 D135 T136 G137 T139 K164 Y185 V186 E192 E147 D148 D151 Y201 R214 E131 D132 D135 Y185 R198 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=2.73uM Q38CA1 31287615 301 PLKPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6mxc B 1.993 BS01 5GP B 1 D148 I149 D151 T152 G153 T155 K180 Y201 V202 E208 D131 I132 D134 T135 G136 T138 K163 Y184 V185 E191 E147 D148 D151 Y201 R214 E130 D131 D134 Y184 R197 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=2.73uM Q38CA1 31287615 301 PLKPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6mxc C 1.993 BS01 5GP C 1 D148 I149 D151 T152 G153 T155 K180 Y201 V202 E208 D134 I135 D137 T138 G139 T141 K166 Y187 V188 E194 E147 D148 D151 Y201 R214 E133 D134 D137 Y187 R200 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=2.73uM Q38CA1 31287615 301 KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYGTVQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6mxc D 1.993 BS01 5GP D 1 D148 I149 D151 T152 G153 T155 K180 Y201 V202 E208 D129 I130 D132 T133 G134 T136 K161 Y182 V183 E189 E147 D148 D151 Y201 R214 E128 D129 D132 Y182 R195 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=2.73uM Q38CA1 31287615 301 KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6mxc E 1.993 BS01 5GP E 1 D148 I149 D151 T152 G153 T155 K180 Y201 V202 E208 D130 I131 D133 T134 G135 T137 K162 Y183 V184 E190 E147 D148 D151 Y201 R214 E129 D130 D133 Y183 R196 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=2.73uM Q38CA1 31287615 301 KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITVQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6mxc F 1.993 BS01 5GP F 1 D148 I149 D151 T152 G153 T155 K180 Y201 V202 E208 D132 I133 D135 T136 G137 T139 K164 Y185 V186 E192 E147 D148 D151 Y201 R214 E131 D132 D135 Y185 R198 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=2.73uM Q38CA1 31287615 301 KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSTVQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6o3v A 3.5 BS01 5GP A 1 S573 H574 R577 Y588 R591 H612 N615 S573 H574 R577 Y588 R591 H612 N615 2.1.1.56,2.7.7.50,3.1.4.- 0003723,0004482,0004484,0005525,0006370,0008168,0016032,0016779,0016787,0019013,0019049,0032259,0044423,0052170,0106005 Q1WK45 32494598 901 MKVLALRHSVAQVYADTQIYTHDDTKDSYENAFLISNLTTHNILYFNYSARTLEILNKSGIAAIEIQSLEELFTLIRCNFTYDYENNVVYLHDYSYYTNNEIRTDQHWITKTNIEEYLLPGWKLTYVGYNGNDTRGHYNFSFTCQNAATDDDIIIEYIYSEALDFQNFMLRKIKERMTTSLPIARLSNRVFRDKLFPLLVKKHKRVVNVGPRNESMFTFLNFPSIRQFSNGPYLVKNTIKLKQERWLGKRVSQFDIGQYKNMLNVITTIYHYYNLYQEKPIIYMVGSAPSYWIYDVRQYSDFLFETWDPLDTPYSSIHHKELFFAKDIGKLKDNSILYIDIRTDRGNADWKEWRKVVELQTISNLNLAYQYLATGKSKVCCVKLTAMDLELPVSAKLLHHPTTEIRSEFYLLLDIWDVNNIKRFIPKGALYSFINNVITDNVFIQSPFKIRTSVSDYIVALYALSNDFNNREDIINLINNQKQSLITVRINNTFKDEPKVGFKSIYDWTFLPTDFETTNAIVTSYDGCLGIFGLSISLASKPTGNNHLFILNGTDKYYKLDQFANHTGISRRSHQVRFSESATSYSGYIFRDLSNSNFNLIGTNVENSVSGHVYNALIYYRYNYSFDLKRWIYLHSVEKYYEHAPIELIYACKSAKEFASLQDDLTVLRYANEIENYINKVYSITYADDPNYFIGIKFNNIPYIYDVKVPHLTFGVLYISDNMIPDVVKIMKSMKQELFGMDVTTSYTYMLSDGVYVANVSGVLATYFKMYNLFYKNQITFGQSRMFIPHITLSFSNNKTVRIETTKLRIKSIYLRKIRGDTVFDMPE 6o3v B 3.5 BS01 5GP B 1 H574 R577 Y588 R591 S610 H612 N615 H574 R577 Y588 R591 S610 H612 N615 2.1.1.56,2.7.7.50,3.1.4.- 0003723,0004482,0004484,0005525,0006370,0008168,0016032,0016779,0016787,0019013,0019049,0032259,0044423,0052170,0106005 Q1WK45 32494598 901 MKVLALRHSVAQVYADTQIYTHDDTKDSYENAFLISNLTTHNILYFNYSARTLEILNKSGIAAIEIQSLEELFTLIRCNFTYDYENNVVYLHDYSYYTNNEIRTDQHWITKTNIEEYLLPGWKLTYVGYNGNDTRGHYNFSFTCQNAATDDDIIIEYIYSEALDFQNFMLRKIKERMTTSLPIARLSNRVFRDKLFPLLVKKHKRVVNVGPRNESMFTFLNFPSIRQFSNGPYLVKNTIKLKQERWLGKRVSQFDIGQYKNMLNVITTIYHYYNLYQEKPIIYMVGSAPSYWIYDVRQYSDFLFETWDPLDTPYSSIHHKELFFAKDIGKLKDNSILYIDIRTDRGNADWKEWRKVVELQTISNLNLAYQYLATGKSKVCCVKLTAMDLELPVSAKLLHHPTTEIRSEFYLLLDIWDVNNIKRFIPKGALYSFINNVITDNVFIQSPFKIRTSVSDYIVALYALSNDFNNREDIINLINNQKQSLITVRINNTFKDEPKVGFKSIYDWTFLPTDFETTNAIVTSYDGCLGIFGLSISLASKPTGNNHLFILNGTDKYYKLDQFANHTGISRRSHQVRFSESATSYSGYIFRDLSNSNFNLIGTNVENSVSGHVYNALIYYRYNYSFDLKRWIYLHSVEKGGKYYEHAPIELIYACKSAKEFASLQDDLTVLRYANEIENYINKVYSITYADDPNYFIGIKFNNIPYIYDVKVPHLTFGVLYISDNMIPDVVKIMKSMKQELFGMDVTTSYTYMLSDGVYVANVSGVLATYFKMYNLFYKNQITFGQSRMFIPHITLSFSNNKTVRIETTKLRIKSIYLRKIRGDTVFDMPE 6o3v C 3.5 BS01 5GP C 1 S573 H574 R577 Y588 G611 H612 N615 S573 H574 R577 Y588 G611 H612 N615 2.1.1.56,2.7.7.50,3.1.4.- 0003723,0004482,0004484,0005525,0006370,0008168,0016032,0016779,0016787,0019013,0019049,0032259,0044423,0052170,0106005 Q1WK45 32494598 901 MKVLALRHSVAQVYADTQIYTHDDTKDSYENAFLISNLTTHNILYFNYSARTLEILNKSGIAAIEIQSLEELFTLIRCNFTYDYENNVVYLHDYSYYTNNEIRTDQHWITKTNIEEYLLPGWKLTYVGYNGNDTRGHYNFSFTCQNAATDDDIIIEYIYSEALDFQNFMLRKIKERMTTSLPIARLSNRVFRDKLFPLLVKKHKRVVNVGPRNESMFTFLNFPSIRQFSNGPYLVKNTIKLKQERWLGKRVSQFDIGQYKNMLNVITTIYHYYNLYQEKPIIYMVGSAPSYWIYDVRQYSDFLFETWDPLDTPYSSIHHKELFFAKDIGKLKDNSILYIDIRTDRGNADWKEWRKVVELQTISNLNLAYQYLATGKSKVCCVKLTAMDLELPVSAKLLHHPTTEIRSEFYLLLDIWDVNNIKRFIPKGALYSFINNVITDNVFIQSPFKIRTSVSDYIVALYALSNDFNNREDIINLINNQKQSLITVRINNTFKDEPKVGFKSIYDWTFLPTDFETTNAIVTSYDGCLGIFGLSISLASKPTGNNHLFILNGTDKYYKLDQFANHTGISRRSHQVRFSESATSYSGYIFRDLSNSNFNLIGTNVENSVSGHVYNALIYYRYNYSFDLKRWIYLHSVEKGKYYEHAPIELIYACKSAKEFASLQDDLTVLRYANEIENYINKVYSITYADDPNYFIGIKFNNIPYIYDVKVPHLTFGVLYISDNMIPDVVKIMKSMKQELFGMDVTTSYTYMLSDGVYVANVSGVLATYFKMYNLFYKNQITFGQSRMFIPHITLSFSNNKTVRIETTKLRIKSIYLRKIRGDTVFDMPE 6o6b A 2.7 BS01 5GP A 1 H574 R577 H612 H650 H574 R577 H612 H643 2.1.1.56,2.7.7.50,3.1.4.- 0003723,0004482,0004484,0005525,0006370,0008168,0016032,0016779,0016787,0019013,0019049,0032259,0044423,0052170,0106005 Q1WK45 901 MKVLALRHSVAQVYADTQIYTHDDTKDSYENAFLISNLTTHNILYFNYSARTLEILNKSGIAAIEIQSLEELFTLIRCNFTYDYENNVVYLHDYSYYTNNEIRTDQHWITKTNIEEYLLPGWKLTYVGYNGNDTRGHYNFSFTCQNAATDDDIIIEYIYSEALDFQNFMLRKIKERMTTSLPIARLSNRVFRDKLFPLLVKKHKRVVNVGPRNESMFTFLNFPSIRQFSNGPYLVKNTIKLKQERWLGKRVSQFDIGQYKNMLNVITTIYHYYNLYQEKPIIYMVGSAPSYWIYDVRQYSDFLFETWDPLDTPYSSIHHKELFFAKDIGKLKDNSILYIDIRTDRGNADWKEWRKVVELQTISNLNLAYQYLATGKSKVCCVKLTAMDLELPVSAKLLHHPTTEIRSEFYLLLDIWDVNNIKRFIPKGALYSFINNVITDNVFIQSPFKIRTSVSDYIVALYALSNDFNNREDIINLINNQKQSLITVRINNTFKDEPKVGFKSIYDWTFLPTDFETTNAIVTSYDGCLGIFGLSISLASKPTGNNHLFILNGTDKYYKLDQFANHTGISRRSHQVRFSESATSYSGYIFRDLSNSNFNLIGTNVENSVSGHVYNALIYYRYNYSFDLKRWIYLHSVEKYYEHAPIELIYACKSAKEFASLQDDLTVLRYANEIENYINKVYSITYADDPNYFIGIKFNNIPYIYDVKVPHLTFGVLYISDNMIPDVVKIMKSMKQELFGMDVTTSYTYMLSDGVYVANVSGVLATYFKMYNLFYKNQITFGQSRMFIPHITLSFSNNKTVRIETTKLRIKSIYLRKIRGDTVFDMPE 6o6b B 2.7 BS01 5GP B 1 H574 R577 H612 H650 H574 R577 H612 H643 2.1.1.56,2.7.7.50,3.1.4.- 0003723,0004482,0004484,0005525,0006370,0008168,0016032,0016779,0016787,0019013,0019049,0032259,0044423,0052170,0106005 Q1WK45 901 MKVLALRHSVAQVYADTQIYTHDDTKDSYENAFLISNLTTHNILYFNYSARTLEILNKSGIAAIEIQSLEELFTLIRCNFTYDYENNVVYLHDYSYYTNNEIRTDQHWITKTNIEEYLLPGWKLTYVGYNGNDTRGHYNFSFTCQNAATDDDIIIEYIYSEALDFQNFMLRKIKERMTTSLPIARLSNRVFRDKLFPLLVKKHKRVVNVGPRNESMFTFLNFPSIRQFSNGPYLVKNTIKLKQERWLGKRVSQFDIGQYKNMLNVITTIYHYYNLYQEKPIIYMVGSAPSYWIYDVRQYSDFLFETWDPLDTPYSSIHHKELFFAKDIGKLKDNSILYIDIRTDRGNADWKEWRKVVELQTISNLNLAYQYLATGKSKVCCVKLTAMDLELPVSAKLLHHPTTEIRSEFYLLLDIWDVNNIKRFIPKGALYSFINNVITDNVFIQSPFKIRTSVSDYIVALYALSNDFNNREDIINLINNQKQSLITVRINNTFKDEPKVGFKSIYDWTFLPTDFETTNAIVTSYDGCLGIFGLSISLASKPTGNNHLFILNGTDKYYKLDQFANHTGISRRSHQVRFSESATSYSGYIFRDLSNSNFNLIGTNVENSVSGHVYNALIYYRYNYSFDLKRWIYLHSVEKYYEHAPIELIYACKSAKEFASLQDDLTVLRYANEIENYINKVYSITYADDPNYFIGIKFNNIPYIYDVKVPHLTFGVLYISDNMIPDVVKIMKSMKQELFGMDVTTSYTYMLSDGVYVANVSGVLATYFKMYNLFYKNQITFGQSRMFIPHITLSFSNNKTVRIETTKLRIKSIYLRKIRGDTVFDMPE 6o6b C 2.7 BS01 5GP C 1 H574 R577 H612 H650 H574 R577 H612 H643 2.1.1.56,2.7.7.50,3.1.4.- 0003723,0004482,0004484,0005525,0006370,0008168,0016032,0016779,0016787,0019013,0019049,0032259,0044423,0052170,0106005 Q1WK45 901 MKVLALRHSVAQVYADTQIYTHDDTKDSYENAFLISNLTTHNILYFNYSARTLEILNKSGIAAIEIQSLEELFTLIRCNFTYDYENNVVYLHDYSYYTNNEIRTDQHWITKTNIEEYLLPGWKLTYVGYNGNDTRGHYNFSFTCQNAATDDDIIIEYIYSEALDFQNFMLRKIKERMTTSLPIARLSNRVFRDKLFPLLVKKHKRVVNVGPRNESMFTFLNFPSIRQFSNGPYLVKNTIKLKQERWLGKRVSQFDIGQYKNMLNVITTIYHYYNLYQEKPIIYMVGSAPSYWIYDVRQYSDFLFETWDPLDTPYSSIHHKELFFAKDIGKLKDNSILYIDIRTDRGNADWKEWRKVVELQTISNLNLAYQYLATGKSKVCCVKLTAMDLELPVSAKLLHHPTTEIRSEFYLLLDIWDVNNIKRFIPKGALYSFINNVITDNVFIQSPFKIRTSVSDYIVALYALSNDFNNREDIINLINNQKQSLITVRINNTFKDEPKVGFKSIYDWTFLPTDFETTNAIVTSYDGCLGIFGLSISLASKPTGNNHLFILNGTDKYYKLDQFANHTGISRRSHQVRFSESATSYSGYIFRDLSNSNFNLIGTNVENSVSGHVYNALIYYRYNYSFDLKRWIYLHSVEKYYEHAPIELIYACKSAKEFASLQDDLTVLRYANEIENYINKVYSITYADDPNYFIGIKFNNIPYIYDVKVPHLTFGVLYISDNMIPDVVKIMKSMKQELFGMDVTTSYTYMLSDGVYVANVSGVLATYFKMYNLFYKNQITFGQSRMFIPHITLSFSNNKTVRIETTKLRIKSIYLRKIRGDTVFDMPE 6o6b D 2.7 BS01 5GP D 1 H574 R577 H612 H650 H574 R577 H612 H643 2.1.1.56,2.7.7.50,3.1.4.- 0003723,0004482,0004484,0005525,0006370,0008168,0016032,0016779,0016787,0019013,0019049,0032259,0044423,0052170,0106005 Q1WK45 901 MKVLALRHSVAQVYADTQIYTHDDTKDSYENAFLISNLTTHNILYFNYSARTLEILNKSGIAAIEIQSLEELFTLIRCNFTYDYENNVVYLHDYSYYTNNEIRTDQHWITKTNIEEYLLPGWKLTYVGYNGNDTRGHYNFSFTCQNAATDDDIIIEYIYSEALDFQNFMLRKIKERMTTSLPIARLSNRVFRDKLFPLLVKKHKRVVNVGPRNESMFTFLNFPSIRQFSNGPYLVKNTIKLKQERWLGKRVSQFDIGQYKNMLNVITTIYHYYNLYQEKPIIYMVGSAPSYWIYDVRQYSDFLFETWDPLDTPYSSIHHKELFFAKDIGKLKDNSILYIDIRTDRGNADWKEWRKVVELQTISNLNLAYQYLATGKSKVCCVKLTAMDLELPVSAKLLHHPTTEIRSEFYLLLDIWDVNNIKRFIPKGALYSFINNVITDNVFIQSPFKIRTSVSDYIVALYALSNDFNNREDIINLINNQKQSLITVRINNTFKDEPKVGFKSIYDWTFLPTDFETTNAIVTSYDGCLGIFGLSISLASKPTGNNHLFILNGTDKYYKLDQFANHTGISRRSHQVRFSESATSYSGYIFRDLSNSNFNLIGTNVENSVSGHVYNALIYYRYNYSFDLKRWIYLHSVEKYYEHAPIELIYACKSAKEFASLQDDLTVLRYANEIENYINKVYSITYADDPNYFIGIKFNNIPYIYDVKVPHLTFGVLYISDNMIPDVVKIMKSMKQELFGMDVTTSYTYMLSDGVYVANVSGVLATYFKMYNLFYKNQITFGQSRMFIPHITLSFSNNKTVRIETTKLRIKSIYLRKIRGDTVFDMPE 6qsk D 3.394 BS01 5GP D 1 M98 S269 Y281 K289 M78 S230 Y242 K250 ? 0000139,0005458,0005739,0005783,0005789,0005794,0015297,0016020,0030659,0031410,0055085,1990570 P40107 31604945 401 ANSGPISILSYCGSSILMTVTNKFVVNLKDFNMNFVMLFVQSLVCTITLIILRILGFRSLNKTDAKNWFPISFLLVLMIYTSSKALQYLAVPIYTIFKNLTIILIAYGEVLFFGGSVTSMELSSFLLMVLSSVVATWGDQQFNPGYFWMFTNCITSALFVLIMRKRIKLTNFKDFDTMFYNNVLALPILLLFSFCVEDWSSVNLTNNFSNDSLTAMIISGVASVGISYCSGWCVRVTSSTTYSMVGALNKLPIALSGLIFFDAPRNFLSILSIFIGFLSGIIYAVAKQKKQQAQ 6qsk E 3.394 BS01 5GP E 1 M35 I265 S269 Y281 M18 I230 S234 Y246 ? 0000139,0005458,0005739,0005783,0005789,0005794,0015297,0016020,0030659,0031410,0055085,1990570 P40107 31604945 401 ANSGPISILSYCGSSILMTVTNKFVVNLKDFNMNFVMLFVQSLVCTITLIILRILGFRSLNKTDAKNWFPISFLLVLMIYTSSKALQYLAVPIYTIFKNLTIILIAYGEVLFFGGSVTSMELSSFLLMVLSSVVATWGDQQAVASFNPGYFWMFTNCITSALFVLIMRKRIKLTNFKDFDTMFYNNVLALPILLLFSFCVEDWSSVNLTNNFSNDSLTAMIISGVASVGISYCSGWCVRVTSSTTYSMVGALNKLPIALSGLIFFDAPRNFLSILSIFIGFLSGIIYAVAKQKKQQAQ 6rfu A 2.8 BS02 5GP A 1 I111 K113 K115 K133 L215 I109 K111 K113 K131 L213 1.1.1.205 0000166,0003824,0003938,0005737,0006164,0006177,0006183,0016491,0020015,0046872 P50098 32001697 602 NTNLRTKTLRDGTTAEELFSQDGLSFNDFIILPGFIDFDSSKVNVSGQFTKNILLHLPLVSSPMDTVTESSMARAMALMGGIGVIHNNCTVEQQARMVRSVKLYRNGFIMKPKSVSPDVPVSTIRNIKSEKGISGILVTEGGKYDGKLLGIVCTKDIDFVKDASAPVSQYMTRRENMTVERYPIKLEEAMDVLNRSRHGYLPVLNDKDEVVCLCSRRDAVRARDYPNSSLDRNGHLLCAAATSTREADKGRVAALSEAGIDVLVLDSSQGNTIYQVSFIRWVKKTYPHLEVVAGNVVTQDQAKNLIDAGADSLRIGMCGRPQATAIYKVARYAASRGVPCVADGGLRNVGDVCKALAVGANVAMLGSMIAGTSETPGEYFFKDGMRLKGGAVLDKGSVLKLLAYIHKGLQQSAQDIGEVSFDAIREKVYEGQVLFNRRTLTAQSE 6rfu B 2.8 BS03 5GP B 1 I111 K113 P114 K115 K133 I135 L215 I109 K111 P112 K113 K131 I133 L213 1.1.1.205 0000166,0003824,0003938,0005737,0006164,0006177,0006183,0016491,0020015,0046872 P50098 32001697 602 NTNLRTKTLRDGTTAEELFSQDGLSFNDFIILPGFIDFDSSKVNVSGQFTKNILLHLPLVSSPMDTVTESSMARAMALMGGIGVIHNNCTVEQQARMVRSVKLYRNGFIMKPKSVSPDVPVSTIRNIKSEKGISGILVTEGGKYDGKLLGIVCTKDIDFVKDASAPVSQYMTRRENMTVERYPIKLEEAMDVLNRSRHGYLPVLNDKDEVVCLCSRRDAVRARDYPNSSLDRNGHLLCAAATSTREADKGRVAALSEAGIDVLVLDSSQGNTIYQVSFIRWVKKTYPHLEVVAGNVVTQDQAKNLIDAGADSLRIGMGLACGRPQATAIYKVARYAASRGVPCVADGGLRNVGDVCKALAVGANVAMLGSMIAGTSETPGEYFFKDGMRLKGGAVLDKGSVLKLLAYIHKGLQQSAQDIGEVSFDAIREKVYEGQVLFNRRTLTAQSE 6wct A 2.1 BS01 5GP A 1 S23 S46 R50 R53 Y62 E81 V85 K90 G91 T92 E110 I111 D112 E164 S12 S35 R39 R42 Y51 E70 V74 K79 G80 T81 E99 I100 D101 E153 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 B2FT06 301 ARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEQMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRMRKRGQDSEAVIAQRLGAARDEMLHFNEFDYVIVNEVFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLTP 6wct B 2.1 BS01 5GP B 1 S46 R50 Y62 E81 V85 K90 G91 T92 E110 I111 D112 S36 R40 Y52 E71 V75 K80 G81 T82 E100 I101 D102 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 B2FT06 301 VARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEQMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRMEAVIAQRLGAARDEMLHFNEFDYVIVNEVFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLTP 6wct C 2.1 BS01 5GP C 1 S46 Y62 E81 V85 K90 G91 T92 E110 I111 D112 S35 Y51 E70 V74 K79 G80 T81 E99 I100 D101 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 B2FT06 301 ARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEQMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRMSEAVIAQRLGAARDEMLHFNEFDYVIVNEVFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLTPD 6wct D 2.1 BS01 5GP D 1 S46 R50 R53 Y62 E81 V85 H86 K90 G91 T92 I111 D112 S37 R41 R44 Y53 E72 V76 H77 K81 G82 T83 I102 D103 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 B2FT06 301 AVARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEQMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRMRKRGQDSEAVIAQRLGAARDEMLHFNEFDYVIVNEVFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLTPD 6yk9 B 1.7 BS01 5GP B 1 L9 G12 S65 D66 P67 P113 P114 D134 W147 L148 P149 I157 L8 G11 S64 D65 P66 P112 P113 D133 W146 L147 P148 I156 0019386,0047068 32061937 401 TIKKVAILGAGCYRTHSATGITNFARACEVAEMVGKPEIAMTHSTIAMAAELKYLAGIDNIVISDPSFAGEFTVVKDFDYNEVIKAHKENPETIMPKIREKVNELAKTVPKPPKGAIHFVHPEDLGLKVTTDDREAVRDADLIITWLPKGDMQKGIIEKFAGDIKQGAIITHACTIPTTLFYKIFEELGIADKVEVTSYHPGAVPEMKGQVYIAEGYASEEAINTIYELGKKARGHAFKLPAELIGPVCDMCAALTAITYAGLLVYRDAVMNILGAPAGFSQMMATESLEQITAYMKKVGIKNLEENLDPGVFLGTADSMNFGPIAEILPTVLKSLEKRAK 6yk9 C 1.7 BS01 5GP C 1 L9 G12 S65 D66 P67 P113 P114 D134 W147 L148 P149 I157 L8 G11 S64 D65 P66 P112 P113 D133 W146 L147 P148 I156 0019386,0047068 32061937 401 TIKKVAILGAGCYRTHSATGITNFARACEVAEMVGKPEIAMTHSTIAMAAELKYLAGIDNIVISDPSFAGEFTVVKDFDYNEVIKAHKENPETIMPKIREKVNELAKTVPKPPKGAIHFVHPEDLGLKVTTDDREAVRDADLIITWLPKGDMQKGIIEKFAGDIKQGAIITHACTIPTTLFYKIFEELGIADKVEVTSYHPGAVPEMKGQVYIAEGYASEEAINTIYELGKKARGHAFKLPAELIGPVCDMCAALTAITYAGLLVYRDAVMNILGAPAGFSQMMATESLEQITAYMKKVGIKNLEENLDPGVFLGTADSMNFGPIAEILPTVLKSLEKRAK 6ykb A 1.55 BS01 5GP A 1 L9 G12 S65 D66 P67 P113 P114 D134 W147 L148 P149 I157 L8 G11 S64 D65 P66 P112 P113 D133 W146 L147 P148 I156 0019386,0047068 32061937 401 TIKKVAILGAGCYRTHSATGITNFARACEVAEMVGKPEIAMTHSTIAMAAELKYLAGIDNIVISDPSFAGEFTVVKDFDYNEVIKAHKENPETIMPKIREKVNELAKTVPKPPKGAIHFVHPEDLGLKVTTDDREAVRDADLIITWLPKGDMQKGIIEKFAGDIKQGAIITHACTIPTTLFYKIFEELGIADKVEVTSYHPGAVPEMKGQVYIAEGYASEEAINTIYELGKKARGHAFKLPAELIGPVCDMCAALTAITYAGLLVYRDAVMNILGAPAGFSQMMATESLEQITAYMKKVGIKNLEENLDPGVFLGTADSMNFGPIAEILPTVLKSLEKRAK 6ykb C 1.55 BS01 5GP C 1 L9 G12 S65 D66 P67 P113 P114 D134 W147 L148 P149 I157 L8 G11 S64 D65 P66 P112 P113 D133 W146 L147 P148 I156 0019386,0047068 32061937 401 TIKKVAILGAGCYRTHSATGITNFARACEVAEMVGKPEIAMTHSTIAMAAELKYLAGIDNIVISDPSFAGEFTVVKDFDYNEVIKAHKENPETIMPKIREKVNELAKTVPKPPKGAIHFVHPEDLGLKVTTDDREAVRDADLIITWLPKGDMQKGIIEKFAGDIKQGAIITHACTIPTTLFYKIFEELGIADKVEVTSYHPGAVPEMKGQVYIAEGYASEEAINTIYELGKKARGHAFKLPAELIGPVCDMCAALTAITYAGLLVYRDAVMNILGAPAGFSQMMATESLEQITAYMKKVGIKNLEENLDPGVFLGTADSMNFGPIAEILPTVLKSLEKRAK 7bf4 A 1.55 BS01 5GP A 1 G46 G47 G48 I131 G45 G46 G47 I130 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- P0DTD1 33850605 201 MVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEM 7buj A 2.13 BS03 5GP A 1 K350 R364 C419 Y421 H467 F473 K204 R218 C273 Y275 H321 F327 2.7.7.86 Q8C6L5 32814054 605 PDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL 7buj B 2.13 BS03 5GP B 1 K350 R364 C419 Y421 H467 K205 R219 C274 Y276 H322 2.7.7.86 Q8C6L5 32814054 605 EPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL 7bum A 3.047 BS03 5GP A 1 D213 S291 I309 K350 R364 D67 S145 I163 K204 R218 2.7.7.86 0002218,0002221,0002230,0002637,0002753,0003677,0003682,0003690,0005515,0005524,0005525,0005546,0005634,0005654,0005694,0005737,0005829,0005886,0006281,0006974,0008289,0008340,0016604,0016779,0019933,0019934,0031491,0032479,0032481,0035861,0038001,0042803,0045087,0045738,0046872,0050776,0050863,0051607,0061501,0071360,0140693,0140896,0160004,0160049,2000042,2000774 Q8C6L5 32814054 603 PDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL 7bum B 3.047 BS03 5GP B 1 G290 S291 D307 K350 R364 G144 S145 D161 K204 R218 2.7.7.86 0002218,0002221,0002230,0002637,0002753,0003677,0003682,0003690,0005515,0005524,0005525,0005546,0005634,0005654,0005694,0005737,0005829,0005886,0006281,0006974,0008289,0008340,0016604,0016779,0019933,0019934,0031491,0032479,0032481,0035861,0038001,0042803,0045087,0045738,0046872,0050776,0050863,0051607,0061501,0071360,0140693,0140896,0160004,0160049,2000042,2000774 Q8C6L5 32814054 603 PDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL 7c4c A 2.265 BS10 5GP A 1 D80 E82 A83 L93 M206 W214 D34 E36 A37 L47 M160 W168 ? 0000166,0000175,0003676,0005739,0006139,0008270,0008408,0046872,1990923 Q38DE2 33332555 413 SSMILKYPYRVVDTHEKLKEAVTSLQGARSIALDIEAFCTTDQAKQLGRISLVQACSDAKPVVFLFDVLTLTPDVFVKDMQSLLSDREIRKLFFDCRRDVEALSCQLGVKPEGVLDLQVFFTAIQWKLRSVNRRSGMGYVLKSVAGLTRQEGDSAVQTAMTLGNRPVWDIRPLPDHFLEYAAGDVRHILLLSNYLVGNKDVPVDVVAVERLTAQYVEHYAVGKPVITEADATPAEVNRAWLERYIGPGGGCHFCGAKGHTEAECFKKQNGKAKCSFCGEVGHTARNCFKKHPQLLTCEKCGQLGHTGTSCFRTNPCKHCGGPHSSANCHKVI 7c4c A 2.265 BS11 5GP A 2 E325 H328 N332 C333 F334 E279 H282 N286 C287 F288 ? 0000166,0000175,0003676,0005739,0006139,0008270,0008408,0046872,1990923 Q38DE2 33332555 414 SSMILKYPYRVVDTHEKLKEAVTSLQGARSIALDIEAFCTTDQAKQLGRISLVQACSDAKPVVFLFDVLTLTPDVFVKDMQSLLSDREIRKLFFDCRRDVEALSCQLGVKPEGVLDLQVFFTAIQWKLRSVNRRSGMGYVLKSVAGLTRQEGDSAVQTAMTLGNRPVWDIRPLPDHFLEYAAGDVRHILLLSNYLVGNKDVPVDVVAVERLTAQYVEHYAVGKPVITEADATPAEVNRAWLERYIGPGGGCHFCGAKGHTEAECFKKQNGKAKCSFCGEVGHTARNCFKKHPQLLTCEKCGQLGHTGTSCFRTNPCKHCGGPHSSANCHKVI 7c4c A 2.265 BS12 5GP A 3 D141 Q164 D95 Q118 ? 0000166,0000175,0003676,0005739,0006139,0008270,0008408,0046872,1990923 Q38DE2 33332555 415 SSMILKYPYRVVDTHEKLKEAVTSLQGARSIALDIEAFCTTDQAKQLGRISLVQACSDAKPVVFLFDVLTLTPDVFVKDMQSLLSDREIRKLFFDCRRDVEALSCQLGVKPEGVLDLQVFFTAIQWKLRSVNRRSGMGYVLKSVAGLTRQEGDSAVQTAMTLGNRPVWDIRPLPDHFLEYAAGDVRHILLLSNYLVGNKDVPVDVVAVERLTAQYVEHYAVGKPVITEADATPAEVNRAWLERYIGPGGGCHFCGAKGHTEAECFKKQNGKAKCSFCGEVGHTARNCFKKHPQLLTCEKCGQLGHTGTSCFRTNPCKHCGGPHSSANCHKVI 7c4c A 2.265 BS13 5GP A 4 H305 E309 F311 H259 E263 F265 ? 0000166,0000175,0003676,0005739,0006139,0008270,0008408,0046872,1990923 Q38DE2 33332555 416 SSMILKYPYRVVDTHEKLKEAVTSLQGARSIALDIEAFCTTDQAKQLGRISLVQACSDAKPVVFLFDVLTLTPDVFVKDMQSLLSDREIRKLFFDCRRDVEALSCQLGVKPEGVLDLQVFFTAIQWKLRSVNRRSGMGYVLKSVAGLTRQEGDSAVQTAMTLGNRPVWDIRPLPDHFLEYAAGDVRHILLLSNYLVGNKDVPVDVVAVERLTAQYVEHYAVGKPVITEADATPAEVNRAWLERYIGPGGGCHFCGAKGHTEAECFKKQNGKAKCSFCGEVGHTARNCFKKHPQLLTCEKCGQLGHTGTSCFRTNPCKHCGGPHSSANCHKVI 7f4y A 2.2 BS06 5GP A 1 S36 F38 Y49 G84 M85 D95 F370 K374 K378 I380 S38 F40 Y51 G86 M87 D97 F372 K376 K380 I382 2.7.7.7,3.1.11.- 0000166,0003676,0003677,0003887,0004527,0006260,0006261,0008408,0039686,0039693,0046872 Q38087 34869578 1003 GSMKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYFDIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYEIKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFDLLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLMEYLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRVKVIENMYGSREIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNVGKLKYDGPISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYYAKIQIQSVFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPIPNRYKYVMSFDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERPSDVYSCSPNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGEIIKEALHNPNLSVDEPLDVDYRFDFSDEIKEKIKKLSAKSLNEMLFRAQRTEVAGMTAQINRKLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQWIERKVNEYLNEVCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVDFLDKFARERMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIGGFWTGKKRYALNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECIRRMLQEGEESLQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGFPGPKCPFHIRGILTYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIAWPSGTEITDLIKDDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKASL 7f4y B 2.2 BS04 5GP B 1 S36 F38 Y49 G84 M85 A91 D95 F370 K374 K378 V379 I380 S36 F38 Y49 G84 M85 A91 D95 F370 K374 K378 V379 I380 2.7.7.7,3.1.11.- 0000166,0003676,0003677,0003887,0004527,0006260,0006261,0008408,0039686,0039693,0046872 Q38087 34869578 1002 MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYFDIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYEIKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFDLLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLMEYLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRVKVIENMYGSREIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNVGKLKYDGPISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYYAKIQIQSVFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPIPNRYKYVMSFDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERPSDVYSCSPNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGEIIKEALHNPNLSVDEPLDVDYRFDFSDEIKEKIKKLSAKSLNEMLFRAQRTEVAGMTAQINRKLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQWIERKVNEYLNEVCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVDFLDKFARERMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIGGFWTGKKRYALNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECIRRMLQEGEESLQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGFPGPKCPFHIRGILTYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIAWPSGTEITDLIKDDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKASLFDMF 7lc7 A 1.58 BS02 5GP A 1 P12 D13 S117 K120 R165 Q166 N167 Y168 C169 P11 D12 S115 K118 R163 Q164 N165 Y166 C167 1.17.99.6 0006400,0008033,0008616,0016491,0046872,0051539,0052693 Q9WZJ0 302 GTVLIHVCCAPDLLTTIFHVRDAEFFFYNPNIQPLSEYEKRREAVDKVANHFSLNVRYGEYSTEEIRKWYTAVKDYKLGEGSKRCERCISFLLERTAQEARKRGHESFSTTLLASPRKNLPMIENIGKTIEEKYGVKFFFKNFRKGGAYQEGVRLSKELGIYRQNYCGCVFSLLERRE 7mpp A 2.0 BS01 5GP A 1 D25 T26 E27 T28 G30 L31 Q135 W139 Y151 D25 T26 E27 T28 G30 L31 Q135 W139 Y151 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 MTEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp A 2.0 BS03 5GP C 1 Y112 T113 D114 Y112 T113 D114 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 MTEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp A 2.0 BS04 5GP G 1 H79 K103 G117 Q135 H79 K103 G117 Q135 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 MTEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp C 2.0 BS01 5GP C 1 D25 E27 T28 G30 L31 Q135 W139 Y151 D24 E26 T27 G29 L30 Q134 W138 Y150 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp C 2.0 BS03 5GP I 1 Y112 T113 D114 Y111 T112 D113 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp C 2.0 BS04 5GP K 1 H79 K103 G117 Q135 H78 K102 G116 Q134 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp E 2.0 BS01 5GP A 1 Y112 D114 Y111 D113 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp E 2.0 BS02 5GP E 1 D25 T26 E27 T28 G30 L31 Q135 W139 Y151 D24 T25 E26 T27 G29 L30 Q134 W138 Y150 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp E 2.0 BS04 5GP M 1 H79 K103 G117 Q135 H78 K102 G116 Q134 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp G 2.0 BS01 5GP A 2 H79 K103 G117 L118 Q135 H78 K102 G116 L117 Q134 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 304 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp G 2.0 BS02 5GP G 2 D25 E27 T28 G30 L31 Q135 Y151 D24 E26 T27 G29 L30 Q134 Y150 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp G 2.0 BS04 5GP M 2 Y112 T113 D114 Y111 T112 D113 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp I 2.0 BS01 5GP E 1 Y112 D114 Y111 D113 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp I 2.0 BS02 5GP I 1 D25 T26 E27 T28 G30 L31 Q135 W139 Y151 D24 T25 E26 T27 G29 L30 Q134 W138 Y150 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp I 2.0 BS04 5GP O 1 H79 K103 G117 L118 Q135 H78 K102 G116 L117 Q134 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp K 2.0 BS01 5GP C 2 H79 K103 G117 L118 Q135 H78 K102 G116 L117 Q134 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 304 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp K 2.0 BS02 5GP G 2 Y112 D114 Y111 D113 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp K 2.0 BS03 5GP K 2 D25 T26 E27 T28 G30 L31 Q135 W139 Y151 D24 T25 E26 T27 G29 L30 Q134 W138 Y150 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp M 2.0 BS01 5GP E 2 H79 K103 G117 L118 H78 K102 G116 L117 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 304 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp M 2.0 BS02 5GP M 2 D25 E27 T28 G30 L31 Q135 W139 Y151 D24 E26 T27 G29 L30 Q134 W138 Y150 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp M 2.0 BS04 5GP O 2 Y112 D114 Y111 D113 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp O 2.0 BS01 5GP I 2 H79 K103 G117 L118 Q135 H78 K102 G116 L117 Q134 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 304 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp O 2.0 BS02 5GP K 2 Y112 T113 D114 Y111 T112 D113 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpp O 2.0 BS03 5GP O 2 D25 E27 T28 G30 L31 Q135 W139 Y151 D24 E26 T27 G29 L30 Q134 W138 Y150 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq A 2.35 BS01 5GP A 1 T26 E27 T28 G30 L31 Q135 W139 Y151 T26 E27 T28 G30 L31 Q135 W139 Y151 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 MTEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq A 2.35 BS02 5GP A 2 H79 F80 K103 G117 L118 H79 F80 K103 G117 L118 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 MTEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq A 2.35 BS05 5GP C 1 Y112 T113 D114 Y112 T113 D114 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 MTEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq C 2.35 BS01 5GP C 1 E27 T28 G30 L31 Q135 W139 Y151 E26 T27 G29 L30 Q134 W138 Y150 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq C 2.35 BS04 5GP I 1 Y112 D114 Y111 D113 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq C 2.35 BS05 5GP K 1 H79 F80 K103 G117 L118 H78 F79 K102 G116 L117 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq E 2.35 BS01 5GP A 1 Y112 T113 D114 Y111 T112 D113 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq E 2.35 BS02 5GP E 1 E27 T28 G30 L31 Q135 Y151 E26 T27 G29 L30 Q134 Y150 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq E 2.35 BS03 5GP E 2 H79 F80 K103 G117 L118 H78 F79 K102 G116 L117 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq G 2.35 BS04 5GP M 1 Y112 T113 D114 Y111 T112 D113 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq I 2.35 BS01 5GP E 1 Y112 T113 Y111 T112 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq I 2.35 BS02 5GP I 1 E27 T28 G30 L31 Q135 W139 Y151 E26 T27 G29 L30 Q134 W138 Y150 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq I 2.35 BS03 5GP I 2 H79 F80 F83 K103 G117 L118 H78 F79 F82 K102 G116 L117 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq K 2.35 BS02 5GP K 2 E27 T28 G30 L31 Q135 W139 Y151 E26 T27 G29 L30 Q134 W138 Y150 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq K 2.35 BS03 5GP K 3 H79 F80 F83 K103 G117 L118 H78 F79 F82 K102 G116 L117 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 303 TEIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq M 2.35 BS01 5GP M 1 E27 T28 G30 L31 Q135 W139 Y151 E25 T26 G28 L29 Q133 W137 Y149 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 EIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq M 2.35 BS02 5GP M 2 H79 F83 K103 G117 L118 H77 F81 K101 G115 L116 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 EIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq M 2.35 BS05 5GP O 1 Y112 T113 D114 Y110 T111 D112 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 EIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq O 2.35 BS01 5GP I 3 H79 F83 K103 G117 L118 H77 F81 K101 G115 L116 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 303 EIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq O 2.35 BS02 5GP K 2 Y112 T113 D114 Y110 T111 D112 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 302 EIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7mpq O 2.35 BS03 5GP O 1 E27 T28 G30 L31 Q135 Y151 E25 T26 G28 L29 Q133 Y149 ? 0003676,0004527,0006139,0008408 X5MEI1 34533457 301 EIRVHQGDLPNLDNYRIDAVAVDTETLGLQPHRDRLCVVQLSSGDGTADVIQIAKGQKSAPNLVRLLSDRDITKIFHFGRFDLAILAHTFGVMPDVVFCTKIASKLTRTYTDRHGLKEICGELLNVNISKQQQSSDWAAETLSRAQIEYAASDVLYLHRLKDIFEERLKREERESVAKACFQFLPMRANLDLLGWSEIDIFAHS 7p3b A 2.3 BS01 5GP A 1 N226 Y228 E230 H259 G402 G403 T404 M405 H428 A430 Y475 K504 N220 Y222 E224 H253 G396 G397 T398 M399 H422 A424 Y460 K489 6.5.1.8 0001701,0001890,0003723,0003972,0005515,0005525,0005634,0005635,0005654,0005737,0005789,0005829,0006388,0006396,0008033,0008452,0016874,0016886,0017166,0043231,0046872,0072669,0170057 Q9Y3I0 34854379 601 RSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG 7p3b B 2.3 BS01 5GP B 1 N226 Y228 E230 H259 H353 G402 G403 T404 M405 H428 A430 K504 N221 Y223 E225 H254 H348 G397 G398 T399 M400 H423 A425 K496 6.5.1.8 0001701,0001890,0003723,0003972,0005515,0005525,0005634,0005635,0005654,0005737,0005789,0005829,0006388,0006396,0008033,0008452,0016874,0016886,0017166,0043231,0046872,0072669,0170057 Q9Y3I0 34854379 601 RSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG 7r50 A 2.5 BS01 5GP A 1 M53 G300 A301 C303 D336 G359 S360 G386 M387 A388 R391 M52 G299 A300 C302 D335 G358 S359 G385 M386 A387 R390 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANCAGVDRFARVRDIALSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVAARTAGDSSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHP 7r50 B 2.5 BS01 5GP B 1 M53 G300 A301 M302 C303 D336 G338 G359 S360 M387 A388 R391 M52 G282 A283 M284 C285 D318 G320 G341 S342 M369 A370 R373 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEADFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHP 7r50 C 2.5 BS01 5GP C 1 M53 G300 A301 C303 D336 G359 S360 G386 M387 R391 E413 M52 G275 A276 C278 D311 G334 S335 G361 M362 R366 E383 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPLLHKRAHGAAVVVFEGRPIGLVTEANSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVGDSSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPLP 7r50 D 2.5 BS01 5GP D 1 G300 A301 C303 D336 G359 S360 G386 M387 A388 R391 E413 G299 A300 C302 D335 G358 S359 G385 M386 A387 R390 E404 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANCAGVDRFARVRDIALSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPLPA 7r50 E 2.5 BS01 5GP E 1 M53 G300 A301 C303 D336 G337 G338 G359 S360 G386 M387 A388 R391 E413 M52 G299 A300 C302 D335 G336 G337 G358 S359 G385 M386 A387 R390 E405 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANCAGVDRFARVRDIALSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVASFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPLP 7r50 F 2.5 BS01 5GP F 1 M53 G300 A301 C303 D336 G337 G338 M357 G359 S360 A388 R391 M52 G272 A273 C275 D308 G309 G310 M329 G331 S332 A360 R363 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPNALLHKRAHGAAVVVFEGRPIGLVTALSDFVTAPVGTDPREVFDLLEDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPLP 7r50 G 2.5 BS01 5GP G 1 A51 M53 G300 A301 C303 D336 G337 G359 S360 R391 A50 M52 G264 A265 C267 D300 G301 G323 S324 R355 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVANALLHKRAHGAAVVPIGLVTEDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVSSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAA 7r50 H 2.5 BS01 5GP H 1 M53 G300 A301 C303 D336 G337 G338 V339 G359 S360 G386 M387 A388 R391 M52 G299 A300 C302 D335 G336 G337 V338 G358 S359 G385 M386 A387 R390 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANCAGVDRFARVRDIALSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVSSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPLP 7r50 I 2.5 BS01 5GP I 1 G300 C303 D336 G337 G338 G359 S360 G386 M387 A388 R391 G296 C299 D332 G333 G334 G355 S356 G382 M383 A384 R387 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANCAGVDRFARVRDIAFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVASSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPLP 7r50 J 2.5 BS01 5GP J 1 M53 G300 A301 C303 D336 G337 G338 G359 S360 G386 M387 A388 R391 M52 G275 A276 C278 D311 G312 G313 G334 S335 G361 M362 A363 R366 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVAASSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFA 7r50 K 2.5 BS01 5GP K 1 A51 M53 G300 A301 C303 T305 D336 G337 G338 G359 S360 G386 M387 A388 A50 M52 G290 A291 C293 T295 D326 G327 G328 G349 S350 G376 M377 A378 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEARVRDIALSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVFDRARKGLFRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPLP 7r50 L 2.5 BS01 5GP L 1 G300 A301 C303 D336 G337 G338 G359 S360 G386 M387 A388 R391 G299 A300 C302 D335 G336 G337 G358 S359 G385 M386 A387 R390 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANCAGVDRFARVRDIALSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHP 7r50 M 2.5 BS01 5GP M 1 M53 G300 A301 C303 D336 G338 G359 S360 G386 M387 A388 R391 M52 G299 A300 C302 D335 G337 G358 S359 G385 M386 A387 R390 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANCAGVDRFARVRDIALSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVAASSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPLPA 7r50 N 2.5 BS01 5GP N 1 M53 G300 A301 C303 D336 G359 S360 G386 M387 R391 E413 M52 G292 A293 C295 D328 G351 S352 G378 M379 R383 E398 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANCDRFARVLSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVSSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPLP 7r50 O 2.5 BS01 5GP O 1 M53 G300 A301 C303 D336 G337 G359 S360 G386 A388 R391 M52 G285 A286 C288 D321 G322 G344 S345 G371 A373 R376 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANLSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVSSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPLPA 7r50 P 2.5 BS01 5GP P 1 M53 G300 A301 C303 D336 G337 G338 M357 G359 S360 G386 A388 R391 E413 M52 G299 A300 C302 D335 G336 G337 M356 G358 S359 G385 A387 R390 E403 1.7.1.7 0003824,0003920,0003938,0005829,0006164,0006166,0016491,0032264 A0QYE8 35338694 501 VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPVTLSPEDSVSDANALLHKRAHGAAVVVFEGRPIGLVTEANCAGVDRFARVRDIALSDFVTAPVGTDPREVFDLLEHAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFAEGHPL 7s5e A 2.4 BS01 5GP A 1 K27 S46 R50 R53 Y62 E81 V85 H86 K90 G91 E110 I111 D112 K16 S35 R39 R42 Y51 E70 V74 H75 K79 G80 E99 I100 D101 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 B2FT06 301 ARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEQMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRMRKRGQDSEAVIAQRLGAARDEMLHFNEFDYVIVNEVFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLT 7s5e B 2.4 BS01 5GP B 1 S46 R50 Y62 E81 V85 K90 G91 T92 E110 I111 D112 S36 R40 Y52 E71 V75 K80 G81 T82 E100 I101 D102 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 B2FT06 301 VARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEQMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRDSEAVIAQRLGAARDEMLHFNEFDYVIVNEVFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLT 7s5e D 2.4 BS01 5GP D 1 S46 R50 R53 Y62 E81 V85 K90 G91 E110 I111 D112 S37 R41 R44 Y53 E72 V76 K81 G82 E101 I102 D103 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 B2FT06 301 AVARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEQMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRMRKRGQDSEAVIAQRLGAARDEMLHFNEFDYVIVNEVFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLTPD 7s5e E 2.4 BS01 5GP E 1 K27 S46 R50 R53 Y62 E81 V85 H86 K90 G91 E110 I111 D112 K16 S35 R39 R42 Y51 E70 V74 H75 K79 G80 E99 I100 D101 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 B2FT06 301 ARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEQMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRMRKRGQDSEAVIAQRLGAARDEMLHFNEFDYVIVNEVFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLT 7s5e F 2.4 BS01 5GP F 1 S46 R50 Y62 E81 V85 K90 G91 T92 E110 I111 D112 S36 R40 Y52 E71 V75 K80 G81 T82 E100 I101 D102 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 B2FT06 301 VARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEQMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRDSEAVIAQRLGAARDEMLHFNEFDYVIVNEVFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLT 7s5e H 2.4 BS01 5GP H 1 S46 R50 R53 Y62 E81 V85 K90 G91 E110 I111 D112 S37 R41 R44 Y53 E72 V76 K81 G82 E101 I102 D103 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 B2FT06 301 AVARGTLYIVAAPSGAGKSSIVNATLARDPQIALSISFTSRAMRPGEVNGQHYHFVSAEKFEQMIAAGDFFEHAWVHGDWKGTARQSVEPQLAAGQDVLLEIDWQGAQQVRQLVPGTVTVFILPPSKQALQDRMRKRGQDSEAVIAQRLGAARDEMLHFNEFDYVIVNEVFDTAVDELCAIFTASRLRREAQKVRHAGLIQALLTPD 7u5f A 2.0 BS01 5GP A 1 A14 G15 K16 S35 R39 Y51 E70 Y79 G80 I100 D101 A13 G14 K15 S34 R38 Y50 E69 Y78 G79 I99 D100 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 300 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLAG 7u5f B 2.0 BS01 5GP B 1 A14 K16 S35 R39 Y51 E70 Y79 G80 I100 D101 A13 K15 S34 R38 Y50 E69 Y78 G79 I99 D100 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 300 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLAG 7u5f C 2.0 BS01 5GP C 1 S12 K16 S35 R39 Y51 E70 Y79 G80 I100 D101 G104 S11 K15 S34 R38 Y50 E69 Y78 G79 I99 D100 G103 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 300 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLA 7u5f D 2.0 BS01 5GP D 1 S12 G15 K16 S35 R39 Y51 E70 Y79 G80 I100 D101 S11 G14 K15 S34 R38 Y50 E69 Y78 G79 I99 D100 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 300 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLAG 7v1g A 1.38 BS03 5GP A 1 K13 L16 N17 C19 K21 F24 R28 S151 P152 S216 K8 L11 N12 C14 K16 F19 R23 S146 P147 S211 3.4.21.91,3.6.1.15,3.6.4.13 0004482,0004483,0008168,0032259 C4TPE0 35758665 304 MTLGDLWKRRLNNCTKEEFFAYRRTGILETERDKARELLRKGETNMGLAVSRGTAKLAWLEERGYVNLKGEVVDLGCGRGGWSYYAASRPAVMGVKAYTIGGKGHEAPKMVTSLGWNLIKFRAGMDVFTMQPHRADTVMCDIGESSPDAAIEGERTRKVILLMEQWKNRNPSASCVFKVLAPYRPEVIEALHRFQLQWGGGLVRTPFSRNSTHEMYYSTAISGNIVNSVNVQSRKLLARFGDQRGPIRVPEMDLGVGTR 7va2 A 2.3 BS01 5GP A 1 E13 M14 L17 W60 N61 H65 E13 M14 L17 W60 N61 H65 3.1.15.- 0000175,0003676,0004527,0005737,0006259,0016896 P57665 203 MQNPQNLIWIALEMTGLDPDRDVIIEMATIVTDSDLNTLAEGPVIAIHQPEEILAGMDEWNTRQHGQSGLTQRVRESTVSMAEAEAQTLAFLEQWVPKRSSPICGNSICQDRRFLYRHMPRLEGYFHYRNLDVSTLKELAARWAPQVRESFKKGNTHLALDDIRESIAELRHYRDHFIKL 7xxk A 2.0 BS01 5GP A 1 R259 T282 W330 R4 T27 W75 ? 0003723,0019013 P0DTC9 402 KKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFP 7xxk B 2.0 BS01 5GP A 2 R259 W330 R2 W73 ? 0003723,0019013 P0DTC9 403 PRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFP 7xxk C 2.0 BS01 5GP C 1 M317 A336 I337 K338 M61 A80 I81 K82 ? 0003723,0019013 P0DTC9 402 KPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTF 8dcg A 2.35 BS02 5GP A 1 C98 F204 E206 H234 H329 P378 G379 S380 M381 H404 A406 G407 Y451 K480 C98 F204 E206 H234 H329 P378 G379 S380 M381 H404 A406 G407 Y451 K480 3.1.-.-,6.5.1.8 0006396,0008452 O59245 36130078 501 MVVPLKRIDKIRWEIPKFDKRMRVPGRVYADEVLLEKMKNDRTLEQATNVAMLPGIYKYSIVMPDGHQGYGFPIGGVAAFDVKEGVISPGGIGYDINCGVRLIRTNLTEKEVRPRIKQLVDTLFKNVPSGVGSQGRIKLHWTQIDDVLVDGAKWAVDNGYGWERDLERLEEGGRMEGADPEAVSQRAKQRGAPQLGSLGSGNHFLEVQVVDKIFDPEVAKAYGLFEGQVVVMVHTGSRGLGHQVASDYLRIMERAIRKYRIPWPDRELVSVPFQSEEGQRYFSAMKAAANFAWANRQMITHWVRESFQEVFKQDPEGDLGMDIVYDVAHNIGKVEEHEVDGKRVKVIVHRKGATRAFPPGHEAVPRLYRDVGQPVLIPGSMGTASYILAGTEGAMKETFGSTCHGAGRVLSRKAATRQYRGDRIRQELLNRGIYVRAASMRVVAEEAPGAYKNVDNVVKVVSEAGIAKLVARMRPIGVAKG 8dcg B 2.35 BS02 5GP B 1 C98 N202 F204 E206 H234 H329 P378 G379 S380 M381 H404 A406 G407 Y451 K480 C98 N202 F204 E206 H234 H329 P378 G379 S380 M381 H404 A406 G407 Y451 K480 3.1.-.-,6.5.1.8 0006396,0008452 O59245 36130078 501 MVVPLKRIDKIRWEIPKFDKRMRVPGRVYADEVLLEKMKNDRTLEQATNVAMLPGIYKYSIVMPDGHQGYGFPIGGVAAFDVKEGVISPGGIGYDINCGVRLIRTNLTEKEVRPRIKQLVDTLFKNVPSGVGSQGRIKLHWTQIDDVLVDGAKWAVDNGYGWERDLERLEEGGRMEGADPEAVSQRAKQRGAPQLGSLGSGNHFLEVQVVDKIFDPEVAKAYGLFEGQVVVMVHTGSRGLGHQVASDYLRIMERAIRKYRIPWPDRELVSVPFQSEEGQRYFSAMKAAANFAWANRQMITHWVRESFQEVFKQDPEGDLGMDIVYDVAHNIGKVEEHEVDGKRVKVIVHRKGATRAFPPGHEAVPRLYRDVGQPVLIPGSMGTASYILAGTEGAMKETFGSTCHGAGRVLSRKAATRQYRGDRIRQELLNRGIYVRAASMRVVAEEAPGAYKNVDNVVKVVSEAGIAKLVARMRPIGVAKG 8egl A 2.35 BS02 5GP A 1 K16 S35 R39 Y51 E70 Y79 G80 E99 I100 D101 K15 S34 R38 Y50 E69 Y78 G79 E98 I99 D100 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLA 8egl B 2.35 BS02 5GP B 1 S35 Y51 E70 V74 Y79 G80 E99 I100 D101 R146 S34 Y50 E69 V73 Y78 G79 E98 I99 D100 R136 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRRRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLA 8egl C 2.35 BS02 5GP C 1 K16 S35 R39 R42 Y51 E70 V74 Y79 G80 E99 I100 D101 R146 K15 S34 R38 R41 Y50 E69 V73 Y78 G79 E98 I99 D100 R145 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLAG 8egl D 2.35 BS02 5GP D 1 K16 S35 R39 R42 Y51 E70 Y79 G80 E99 I100 D101 R146 K15 S34 R38 R41 Y50 E69 Y78 G79 E98 I99 D100 R145 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLA 8egl E 2.35 BS02 5GP E 1 K16 S35 R39 Y51 E70 V74 Y79 G80 E99 I100 D101 R146 K15 S34 R38 Y50 E69 V73 Y78 G79 E98 I99 D100 R145 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLAG 8egl F 2.35 BS02 5GP F 1 K16 S35 R39 R42 Y51 E70 Y79 G80 E99 I100 D101 R146 K15 S34 R38 R41 Y50 E69 Y78 G79 E98 I99 D100 R145 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLA 8egl G 2.35 BS02 5GP G 1 K16 S35 R39 R42 Y51 E70 Y79 G80 E99 I100 D101 R146 K15 S34 R38 R41 Y50 E69 Y78 G79 E98 I99 D100 R145 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLAG 8egl H 2.35 BS02 5GP H 1 S35 Y51 E70 V74 Y79 G80 E99 I100 D101 S34 Y50 E69 V73 Y78 G79 E98 I99 D100 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLAG 8egl I 2.35 BS02 5GP I 1 K16 S35 R39 R42 Y51 E70 Y79 G80 E99 I100 D101 R146 K15 S34 R38 R41 Y50 E69 Y78 G79 E98 I99 D100 R145 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLA 8egl J 2.35 BS02 5GP J 1 K16 S35 R39 Y51 E70 Y79 G80 E99 I100 D101 K15 S34 R38 Y50 E69 Y78 G79 E98 I99 D100 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLA 8egl K 2.35 BS02 5GP K 1 K16 S35 R39 R42 Y51 E70 Y79 G80 T81 E99 I100 D101 G104 R146 K14 S33 R37 R40 Y49 E68 Y77 G78 T79 E97 I98 D99 G102 R144 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 GTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLA 8egl L 2.35 BS02 5GP L 1 S35 E70 Y79 G80 T81 E99 I100 D101 S34 E55 Y60 G61 T62 E80 I81 D82 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Q9HTM2 302 SGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTEVDGVNYHFFLAMLERNEHAEVYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLAG 8odo A 2.2 BS01 5GP A 1 Y228 E230 H259 G402 G403 T404 M405 H428 A430 G431 Y475 K504 Y226 E228 H257 G400 G401 T402 M403 H426 A428 G429 Y473 K502 6.5.1.8 0001701,0001890,0003723,0003972,0005515,0005525,0005634,0005635,0005654,0005737,0005789,0005829,0006388,0006396,0008033,0008452,0016874,0016886,0017166,0043231,0046872,0072669,0170057 Q9Y3I0 38493148 601 RSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG 8odo C 2.2 BS01 5GP C 1 N226 Y228 E230 H259 G402 G403 T404 M405 H428 A430 G431 Y475 K504 N224 Y226 E228 H257 G400 G401 T402 M403 H426 A428 G429 Y473 K502 6.5.1.8 0001701,0001890,0003723,0003972,0005515,0005525,0005634,0005635,0005654,0005737,0005789,0005829,0006388,0006396,0008033,0008452,0016874,0016886,0017166,0043231,0046872,0072669,0170057 Q9Y3I0 38493148 601 RSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG 8odo E 2.2 BS01 5GP E 1 N226 Y228 E230 H259 H353 G402 G403 T404 M405 H428 A430 G431 Y475 K504 N224 Y226 E228 H257 H351 G400 G401 T402 M403 H426 A428 G429 Y473 K502 6.5.1.8 0001701,0001890,0003723,0003972,0005515,0005525,0005634,0005635,0005654,0005737,0005789,0005829,0006388,0006396,0008033,0008452,0016874,0016886,0017166,0043231,0046872,0072669,0170057 Q9Y3I0 38493148 601 RSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG 8odo G 2.2 BS01 5GP G 1 N226 Y228 E230 H259 G402 G403 T404 M405 H428 A430 G431 Y475 K504 N224 Y226 E228 H257 G400 G401 T402 M403 H426 A428 G429 Y473 K502 6.5.1.8 0001701,0001890,0003723,0003972,0005515,0005525,0005634,0005635,0005654,0005737,0005789,0005829,0006388,0006396,0008033,0008452,0016874,0016886,0017166,0043231,0046872,0072669,0170057 Q9Y3I0 38493148 601 RSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG 8pkz A -1.00 BS01 5GP A 1 K167 L168 G169 L183 L187 Q190 L197 Q218 K11 L12 G13 L27 L31 Q34 L41 Q62 Q72H73 336 GSSGEGQKDLKLGELLLQKGWISREALEEALVEQEKTGDLLGRILVRKGLPEEALYRALAEQKGLEFLESTEGIVPDPSAALLLLRSDALRYGAVPIGFQNGEVEVVLSDPRHKEAVAQLLNRPARFYLALPQAWEELFRRAYPQK 8pkz A -1.00 BS02 5GP A 2 L168 Q190 L196 L197 G198 R199 L211 L215 Q218 L12 Q34 L40 L41 G42 R43 L55 L59 Q62 Q72H73 337 GSSGEGQKDLKLGELLLQKGWISREALEEALVEQEKTGDLLGRILVRKGLPEEALYRALAEQKGLEFLESTEGIVPDPSAALLLLRSDALRYGAVPIGFQNGEVEVVLSDPRHKEAVAQLLNRPARFYLALPQAWEELFRRAYPQK 8qjo A 1.85 BS04 5GP A 1 Y89 N91 H151 K158 G159 N161 H175 Y63 N65 H125 K132 G133 N135 H149 405 WGAQGHRLVAEVADARLNPTARAEVDRLLATEPDATLASIAPWADQLRAKDPGLGRRSAGWHYVNIAEDNCHYEAPKHCRNGNCIVEALKAQSTILGDRSLTDGERLQALKFVVHLVGDIHQPMHAGYAHDKGGNDFQLQFGNRGTNLHSLWDSGMLNTRKLDDAGYLPLLQSQRAPKLARQSNPQRDPQTWAEASCRISMQAGVYPATRKIGDEYTERYRPLAEAQLRLAGENLAQLLNRVLGA 8qjo B 1.85 BS04 5GP B 1 R74 Y89 N91 H151 K158 G159 N161 H175 R48 Y63 N65 H125 K132 G133 N135 H149 405 WGAQGHRLVAEVADARLNPTARAEVDRLLATEPDATLASIAPWADQLRAKDPGLGRRSAGWHYVNIAEDNCHYEAPKHCRNGNCIVEALKAQSTILGDRSLTDGERLQALKFVVHLVGDIHQPMHAGYAHDKGGNDFQLQFGNRGTNLHSLWDSGMLNTRKLDDAGYLPLLQSQRAPKLARQSNPQRDPQTWAEASCRISMQAGVYPATRKIGDEYTERYRPLAEAQLRLAGENLAQLLNRVLGARLE 8vr0 A 2.25 BS01 5GP A 1 W152 G229 G230 H333 E387 F389 W150 G227 G228 H331 E385 F387 1.2.1.8 0000166,0008802,0016491,0016620,0019285,0046872 A0A0H3FPU4 501 RMAEQQLYIHGKFVAATSGKTFETINPATGEVLATVQAAGREDVDRAVKSAQQGQKVWAAMSAMARSRILRKAVDILRERNDELARLETLDTGKPLSETAAVDIVTGADVLEYYAGLIPALEGSQIPLRDSSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYREAGLPDGVFNVLPGIGAETGQYLTEHPDIAKISFTGGVASGKKVMANSAASSLKEVTMELGGKSPLIIAEDANLDLAADIAMMANFYSSGQVCTNGTRVFVPAKFKAEFEHKILERVGRIRAGDLFADDTNFGPLVSFPHRQNVLRYIESGKSEGARLLCGGDVLKGEGFDNGAWVAPTVFTDCTDDMTIVREEIFGPVMSILSYDDEAEVIRRANATEYGLAAGVVTPDLNRAHRIIHQLEAGICWINSWGESPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQVEMGPFQSIF 8vr0 B 2.25 BS01 5GP B 1 W152 G229 G230 F389 W150 G227 G228 F387 1.2.1.8 0000166,0008802,0016491,0016620,0019285,0046872 A0A0H3FPU4 501 RMAEQQLYIHGKFVAATSGKTFETINPATGEVLATVQAAGREDVDRAVKSAQQGQKVWAAMSAMARSRILRKAVDILRERNDELARLETLDTGKPLSETAAVDIVTGADVLEYYAGLIPALEGSQIPLRDSSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYREAGLPDGVFNVLPGIGAETGQYLTEHPDIAKISFTGGVASGKKVMANSAASSLKEVTMELGGKSPLIIAEDANLDLAADIAMMANFYSSGQVCTNGTRVFVPAKFKAEFEHKILERVGRIRAGDLFADDTNFGPLVSFPHRQNVLRYIESGKSEGARLLCGGDVLKGEGFDNGAWVAPTVFTDCTDDMTIVREEIFGPVMSILSYDDEAEVIRRANATEYGLAAGVVTPDLNRAHRIIHQLEAGICWINSWGESPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQVEMGPFQSIF 8vr0 C 2.25 BS01 5GP C 1 W152 G229 G230 E387 F389 W150 G227 G228 E385 F387 1.2.1.8 0000166,0008802,0016491,0016620,0019285,0046872 A0A0H3FPU4 501 RMAEQQLYIHGKFVAATSGKTFETINPATGEVLATVQAAGREDVDRAVKSAQQGQKVWAAMSAMARSRILRKAVDILRERNDELARLETLDTGKPLSETAAVDIVTGADVLEYYAGLIPALEGSQIPLRDSSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYREAGLPDGVFNVLPGIGAETGQYLTEHPDIAKISFTGGVASGKKVMANSAASSLKEVTMELGGKSPLIIAEDANLDLAADIAMMANFYSSGQVCTNGTRVFVPAKFKAEFEHKILERVGRIRAGDLFADDTNFGPLVSFPHRQNVLRYIESGKSEGARLLCGGDVLKGEGFDNGAWVAPTVFTDCTDDMTIVREEIFGPVMSILSYDDEAEVIRRANATEYGLAAGVVTPDLNRAHRIIHQLEAGICWINSWGESPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQVEMGPFQSIF