2y03 A 2.85 BS04 5FW A 1 D121 S211 F306 F307 N329 D89 S179 F236 F237 N259 ? 0004930,0004935,0004940,0007186,0007189,0016020,0045823 P07700 21228877 601 AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLA 2y03 B 2.85 BS05 5FW B 1 D121 V122 S211 F306 F307 N329 D89 V90 S179 F246 F247 N269 ? 0004930,0004935,0004940,0007186,0007189,0016020,0045823 P07700 21228877 601 AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRKIDRASKRKTSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLA 4a7t A 1.45 BS01 5FW A 1 E21 K23 P28 K30 W32 E100 E21 K23 P28 K30 W32 E100 H46 H48 H63 H71 H80 D83 H120 R143 H46 H48 H63 H71 H80 D83 H120 R143 1.15.1.1 0000302,0000303,0001541,0001819,0001890,0001895,0002262,0004784,0005507,0005515,0005576,0005615,0005634,0005654,0005737,0005739,0005758,0005759,0005777,0005829,0005886,0006749,0006801,0006879,0006915,0006979,0007283,0007566,0007605,0007626,0008089,0008090,0008217,0008270,0008340,0009408,0009410,0010467,0016209,0016491,0019226,0019228,0019430,0030346,0031267,0031410,0032287,0032839,0032930,0032991,0033081,0035234,0040014,0042542,0042554,0042802,0042803,0043025,0043065,0043066,0043087,0043410,0043524,0045471,0046620,0046716,0046872,0048538,0048678,0050665,0050728,0050766,0051087,0051093,0051881,0060047,0060052,0060087,0060088,0070062,0072593,0099610,1902177,1904115,2000242 P00441 23612299 1000 ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCITGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 4a7t A 1.45 BS02 5FW A 2 K91 D92 K91 D92 H46 H48 H63 H71 H80 D83 H120 R143 H46 H48 H63 H71 H80 D83 H120 R143 1.15.1.1 0000302,0000303,0001541,0001819,0001890,0001895,0002262,0004784,0005507,0005515,0005576,0005615,0005634,0005654,0005737,0005739,0005758,0005759,0005777,0005829,0005886,0006749,0006801,0006879,0006915,0006979,0007283,0007566,0007605,0007626,0008089,0008090,0008217,0008270,0008340,0009408,0009410,0010467,0016209,0016491,0019226,0019228,0019430,0030346,0031267,0031410,0032287,0032839,0032930,0032991,0033081,0035234,0040014,0042542,0042554,0042802,0042803,0043025,0043065,0043066,0043087,0043410,0043524,0045471,0046620,0046716,0046872,0048538,0048678,0050665,0050728,0050766,0051087,0051093,0051881,0060047,0060052,0060087,0060088,0070062,0072593,0099610,1902177,1904115,2000242 P00441 23612299 1001 ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCITGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 4a7t F 1.45 BS01 5FW F 1 G130 N131 G130 N131 1.15.1.1 0000302,0000303,0001541,0001819,0001890,0001895,0002262,0004784,0005507,0005515,0005576,0005615,0005634,0005654,0005737,0005739,0005758,0005759,0005777,0005829,0005886,0006749,0006801,0006879,0006915,0006979,0007283,0007566,0007605,0007626,0008089,0008090,0008217,0008270,0008340,0009408,0009410,0010467,0016209,0016491,0019226,0019228,0019430,0030346,0031267,0031410,0032287,0032839,0032930,0032991,0033081,0035234,0040014,0042542,0042554,0042802,0042803,0043025,0043065,0043066,0043087,0043410,0043524,0045471,0046620,0046716,0046872,0048538,0048678,0050665,0050728,0050766,0051087,0051093,0051881,0060047,0060052,0060087,0060088,0070062,0072593,0099610,1902177,1904115,2000242 P00441 23612299 1000 ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCITGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 4a7t F 1.45 BS02 5FW F 2 E21 K23 K30 W32 E100 E21 K23 K30 W32 E100 1.15.1.1 0000302,0000303,0001541,0001819,0001890,0001895,0002262,0004784,0005507,0005515,0005576,0005615,0005634,0005654,0005737,0005739,0005758,0005759,0005777,0005829,0005886,0006749,0006801,0006879,0006915,0006979,0007283,0007566,0007605,0007626,0008089,0008090,0008217,0008270,0008340,0009408,0009410,0010467,0016209,0016491,0019226,0019228,0019430,0030346,0031267,0031410,0032287,0032839,0032930,0032991,0033081,0035234,0040014,0042542,0042554,0042802,0042803,0043025,0043065,0043066,0043087,0043410,0043524,0045471,0046620,0046716,0046872,0048538,0048678,0050665,0050728,0050766,0051087,0051093,0051881,0060047,0060052,0060087,0060088,0070062,0072593,0099610,1902177,1904115,2000242 P00441 23612299 1001 ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCITGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 5ytu A 1.9 BS01 5FW A 1 G12 P13 G13 P14 H46 H48 H63 H71 H80 D83 H120 R143 H47 H49 H64 H72 H81 D84 H121 R144 1.15.1.1 0000302,0000303,0001541,0001819,0001890,0001895,0002262,0004784,0005507,0005515,0005576,0005615,0005634,0005654,0005737,0005739,0005758,0005759,0005777,0005829,0005886,0006749,0006801,0006879,0006915,0006979,0007283,0007566,0007605,0007626,0008089,0008090,0008217,0008270,0008340,0009408,0009410,0010467,0016209,0016491,0019226,0019228,0019430,0030346,0031267,0031410,0032287,0032839,0032930,0032991,0033081,0035234,0040014,0042542,0042554,0042802,0042803,0043025,0043065,0043066,0043087,0043410,0043524,0045471,0046620,0046716,0046872,0048538,0048678,0050665,0050728,0050766,0051087,0051093,0051881,0060047,0060052,0060087,0060088,0070062,0072593,0099610,1902177,1904115,2000242 Kd=12uM -logKd/Ki=4.92, Kd=12uM P00441 29679384 201 MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 6h7j A 2.8 BS01 5FW A 1 W117 D121 V122 S211 S215 F306 F307 N329 Y333 W78 D82 V83 S172 S176 F239 F240 N262 Y266 ? 0004930,0004935,0004940,0007186,0007189,0016020,0045823 -logKd/Ki=8.62, Ki=2.4nM P07700 31072904 401 AAKVMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRASKRKTSRVMAMKEHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLL 6h7j B 2.8 BS02 5FW B 1 W117 D121 V122 S211 S215 F306 F307 N329 Y333 W79 D83 V84 S173 S177 F227 F228 N250 Y254 ? 0004930,0004935,0004940,0007186,0007189,0016020,0045823 P07700 31072904 402 AAAKVMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIMKEHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLAF 7dhr R 3.8 BS01 5FW R 1 D113 V117 S207 F290 N312 D84 V88 S177 F235 N257 ? 0004930,0004935,0004941,0006940,0007186,0007189,0016020,0097746 Ki=46nM, EC50=1.2nM, Kd=130nM, IC50=0.05nM P07550 601 EVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLAVADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIWTLVVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFLKEHKALKTLGIIMGTFTLAWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYSRSPDFRIAFQEL 7jjo R 2.6 BS01 5FW R 1 D121 F201 S211 S215 F306 N329 D82 F162 S172 S176 F228 N251 ? 0003796,0004930,0007186,0009253,0016020,0016998 P07700 32818430 401 WEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRFREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLL 7s0f R 2.96 BS01 5FW R 1 W117 D121 V125 F201 S211 F306 F307 N329 W74 D78 V82 F158 S168 F222 F223 N245 ? 0003796,0004930,0007186,0009253,0016020,0016998 P07700 34759376 401 MSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIFREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRL 7s0g R 3.86 BS01 5FW R 1 W117 D121 F201 S211 F306 Y333 W78 D82 F162 S172 F224 Y251 ? 0003796,0004930,0007186,0009253,0016020,0016998 P07700 34759376 401 WEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIEHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRL 7xjh R 3.3 BS01 5FW R 1 W113 D117 V121 F198 S208 S212 F308 N332 W78 D82 V86 F154 S164 S168 F224 N248 ? 0004930,0004935,0004939,0004993,0005886,0007186,0007187,0007189,0007198,0007268,0015052,0016020,0030425,0030594,0042803,0043235,0043410,0045202,0051378,0051380,0071880 O02662 34314699 401 AVALAGALLALEVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGRWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSEAQRCHSNPHCCAFASNIPYALLSSSVSFYLPLLVMLFVYARVFLVATRQLRLLRRELGRFPEHRALRTLGLIVGTFTLCWLPFFVANVMRALGGPSLVPSPALLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL