2qcf A 1.22 BS01 5FU A 1 S257 D259 K281 H283 N312 K314 M371 S372 P417 Q430 Y432 G450 R451 S35 D37 K59 H61 N90 K92 M149 S150 P195 Q208 Y210 G228 R229 2.4.2.10,4.1.1.23 0004590,0006207,0044205 -logKd/Ki=3.49, IC50=320uM Ki=98000nM P11172 18184586 501 MELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFENRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 2vp6 A 3.0 BS01 5FU A 1 E52 W57 Y70 F80 Q81 R105 A110 F114 E172 E41 W46 Y59 F69 Q70 R94 A99 F103 E161 E52 R105 E41 R94 2.7.1.145 0004136,0004137,0004138,0004797,0004849,0005524,0005737,0005739,0006139,0006170,0006222,0009157,0009224,0016301,0016310,0019136,0043174,0043771,0071897,1901293 Q9XZT6 18384378 1211 TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQRRPQSCKVLVLDAD 2vp6 B 3.0 BS01 5FU B 1 E52 W57 Y70 F80 Q81 R105 F114 E172 E41 W46 Y59 F69 Q70 R94 F103 E161 E52 R105 E41 R94 2.7.1.145 0004136,0004137,0004138,0004797,0004849,0005524,0005737,0005739,0006139,0006170,0006222,0009157,0009224,0016301,0016310,0019136,0043174,0043771,0071897,1901293 Q9XZT6 18384378 1210 TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQCKVLVLDAD 2vp6 C 3.0 BS01 5FU C 1 I29 E52 W57 Y70 Q81 F114 E172 I18 E41 W46 Y59 Q70 F103 E161 E52 R105 E41 R94 2.7.1.145 0004136,0004137,0004138,0004797,0004849,0005524,0005737,0005739,0006139,0006170,0006222,0009157,0009224,0016301,0016310,0019136,0043174,0043771,0071897,1901293 Q9XZT6 18384378 1210 TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQRRPQSCKVLVLDAD 2vp6 D 3.0 BS01 5FU D 1 E52 W57 L66 Y70 F80 Q81 R105 A110 F114 E172 E41 W46 L55 Y59 F69 Q70 R94 A99 F103 E161 E52 R105 E41 R94 2.7.1.145 0004136,0004137,0004138,0004797,0004849,0005524,0005737,0005739,0006139,0006170,0006222,0009157,0009224,0016301,0016310,0019136,0043174,0043771,0071897,1901293 Q9XZT6 18384378 1210 TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHCKVLVLDAD 2vp6 E 3.0 BS01 5FU E 1 I29 E52 W57 Y70 F80 Q81 R105 F114 E172 I18 E41 W46 Y59 F69 Q70 R94 F103 E161 E52 R105 E41 R94 2.7.1.145 0004136,0004137,0004138,0004797,0004849,0005524,0005737,0005739,0006139,0006170,0006222,0009157,0009224,0016301,0016310,0019136,0043174,0043771,0071897,1901293 Q9XZT6 18384378 1210 TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQCKVLVLDAD 2vp6 F 3.0 BS01 5FU F 1 E52 W57 Y70 F80 Q81 R105 A110 F114 E41 W46 Y59 F69 Q70 R94 A99 F103 E52 R105 E41 R94 2.7.1.145 0004136,0004137,0004138,0004797,0004849,0005524,0005737,0005739,0006139,0006170,0006222,0009157,0009224,0016301,0016310,0019136,0043174,0043771,0071897,1901293 Q9XZT6 18384378 1210 TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQCKVLVLDAD 2vp6 G 3.0 BS01 5FU G 1 I29 W57 L66 Y70 F80 Q81 R105 F114 E172 I18 W46 L55 Y59 F69 Q70 R94 F103 E161 E52 R105 E41 R94 2.7.1.145 0004136,0004137,0004138,0004797,0004849,0005524,0005737,0005739,0006139,0006170,0006222,0009157,0009224,0016301,0016310,0019136,0043174,0043771,0071897,1901293 Q9XZT6 18384378 1210 TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQCKVLVLDAD 2vp6 H 3.0 BS01 5FU H 1 I29 E52 W57 Y70 F80 Q81 R105 A110 F114 E172 I18 E41 W46 Y59 F69 Q70 R94 A99 F103 E161 E52 R105 E41 R94 2.7.1.145 0004136,0004137,0004138,0004797,0004849,0005524,0005737,0005739,0006139,0006170,0006222,0009157,0009224,0016301,0016310,0019136,0043174,0043771,0071897,1901293 Q9XZT6 18384378 1210 TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQCKVLVLDAD 3g1v A 1.3 BS01 5FU A 1 D20 K42 L123 M126 S127 P180 Q185 G202 R203 D10 K32 L113 M116 S117 P170 Q175 G192 R193 K42 G70 K72 D75 K32 G60 K62 D65 4.1.1.23 0004590,0005829,0006207,0006221,0016831,0044205 -logKd/Ki=3.19, Ki=645uM Ki=645000nM O26232 19435314 501 VMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKRFGCRIIAGFKVADIPETNEKICRATFKAGADAIIVHGFPGADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIK 3g1v A 1.3 BS02 5FU B 1 D75 I76 T79 D65 I66 T69 K42 G70 K72 D75 K32 G60 K62 D65 4.1.1.23 0004590,0005829,0006207,0006221,0016831,0044205 -logKd/Ki=3.19, Ki=645uM Ki=645000nM O26232 19435314 502 VMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKRFGCRIIAGFKVADIPETNEKICRATFKAGADAIIVHGFPGADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIK 3g1v B 1.3 BS01 5FU A 1 D75 I76 T79 D65 I66 T69 K42 G70 K72 D75 K32 G60 K62 D65 4.1.1.23 0004590,0005829,0006207,0006221,0016831,0044205 -logKd/Ki=3.19, Ki=645uM Ki=645000nM O26232 19435314 501 VMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKRFGCRIIAGFKVADIPETNEKICRATFKAGADAIIVHGFPGADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIK 3g1v B 1.3 BS02 5FU B 1 D20 K42 L123 M126 S127 P180 Q185 G202 R203 D10 K32 L113 M116 S117 P170 Q175 G192 R193 K42 G70 K72 D75 K32 G60 K62 D65 4.1.1.23 0004590,0005829,0006207,0006221,0016831,0044205 -logKd/Ki=3.19, Ki=645uM Ki=645000nM O26232 19435314 502 VMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKRFGCRIIAGFKVADIPETNEKICRATFKAGADAIIVHGFPGADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIK 3g3d A 1.7 BS01 5FU A 1 S68 D70 H94 K125 M182 S183 P228 Q241 Y243 G261 R262 S34 D36 H60 K91 M148 S149 P194 Q207 Y209 G227 R228 2.4.2.10,4.1.1.23 0004590,0006207,0044205 -logKd/Ki=4.74, Ki=18.2uM Ki=98000nM P11172 19260677 3000 ELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3g3d A 1.7 BS02 5FU B 1 D128 I129 T132 D94 I95 T98 2.4.2.10,4.1.1.23 0004590,0006207,0044205 -logKd/Ki=4.74, Ki=18.2uM Ki=98000nM P11172 19260677 3000 ELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3g3d B 1.7 BS01 5FU A 1 D128 I129 T132 D97 I98 T101 2.4.2.10,4.1.1.23 0004590,0006207,0044205 -logKd/Ki=4.74, Ki=18.2uM Ki=98000nM P11172 19260677 3000 APKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3g3d B 1.7 BS02 5FU B 1 S68 D70 H94 K125 M182 S183 P228 Q241 Y243 G261 R262 S37 D39 H63 K94 M151 S152 P197 Q210 Y212 G230 R231 2.4.2.10,4.1.1.23 0004590,0006207,0044205 -logKd/Ki=4.74, Ki=18.2uM Ki=98000nM P11172 19260677 3000 APKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3g3m A 1.4 BS01 5FU A 1 S68 D70 H94 K125 M182 S183 P228 Q241 Y243 G261 R262 S35 D37 H61 K92 M149 S150 P195 Q208 Y210 G228 R229 2.4.2.10,4.1.1.23 0004590,0006207,0044205 -logKd/Ki=5.96, Ki=1.1uM Ki=98000nM P11172 19260677 1000 KELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3mw7 A 2.32 BS01 5FU A 1 S68 D70 K92 H94 K125 M182 S183 P228 Q241 Y243 G261 R262 S37 D39 K61 H63 K94 M151 S152 P197 Q210 Y212 G230 R231 2.4.2.10,4.1.1.23 0004590,0006207,0044205 Ki=98000nM P11172 292 APKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3mw7 A 2.32 BS02 5FU B 1 D128 I129 T132 D97 I98 T101 2.4.2.10,4.1.1.23 0004590,0006207,0044205 Ki=98000nM P11172 292 APKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3mw7 B 2.32 BS01 5FU A 1 D128 T132 D94 T98 2.4.2.10,4.1.1.23 0004590,0006207,0044205 Ki=98000nM P11172 292 ELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3mw7 B 2.32 BS02 5FU B 1 S68 D70 K92 H94 K125 M182 S183 P228 Q241 Y243 G261 R262 S34 D36 K58 H60 K91 M148 S149 P194 Q207 Y209 G227 R228 2.4.2.10,4.1.1.23 0004590,0006207,0044205 Ki=98000nM P11172 292 ELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG 3sgu A 1.7 BS01 5FU A 1 D20 K72 L123 M126 S127 P180 Q185 G202 R203 D8 K60 L111 M114 S115 P168 Q173 G190 R191 K42 D70 K72 D75 K30 D58 K60 D63 4.1.1.23 0004590,0005829,0006207,0006221,0016831,0044205 Ki=645000nM O26232 1000 NRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFPGADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDL 3sw6 A 1.5 BS01 5FU A 1 D20 K72 L123 M126 S127 P180 Q185 G202 R203 D10 K62 L113 M116 S117 P170 Q175 G192 R193 K42 D70 K72 D75 K32 D60 K62 D65 4.1.1.23 0004590,0005829,0006207,0006221,0016831,0044205 Ki=645000nM O26232 1000 VMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFPGADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKD