1pmv A 2.5 BS01 537 A 1 I70 A91 M146 L148 M149 D150 A151 V196 L206 I26 A47 M102 L104 M105 D106 A107 V152 L162 D189 K191 N194 D207 T226 D145 K147 N150 D163 T177 2.7.11.24 0004672,0004707,0005524,0006468 ic50=150nM -logKd/Ki=6.82, IC50=150nM IC50=190nM, Kd=22nM P53779 12954329 501 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLASFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQQLDEREHTIEEWKELIYKEVMN 1uki A 2.7 BS02 537 A 1 V40 A53 M108 E109 L110 M111 A113 V158 L168 V32 A45 M100 E101 L102 M103 A105 V150 L160 D151 K153 N156 D169 T188 D143 K145 N148 D161 T167 2.7.11.24 0004672,0004707,0005524,0006468 Kd=100nM, IC50=40nM P45983 15141161 0 NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIHTIEEWKELIYKEVMDL 2zmd A 2.88 BS01 537 A 1 I531 A551 I586 M602 E603 G605 L654 I16 A36 I71 M87 E88 G90 L139 N556 L565 D647 K649 N652 D664 A686 N41 L50 D132 K134 N137 D149 A162 2.7.12.1 0004672,0005524,0005975,0006468 -logKd/Ki=7.01, Kd=0.098uM IC50=98nM P33981 18480048 900 ECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMDSQVGAVNYMPPEAIKDMISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQT 4feu A 2.37 BS02 537 A 1 F53 P82 I101 I215 F35 P64 I83 I197 K55 D198 N203 D216 K37 D180 N185 D198 0005524,0016773,0046677 23758273 302 LDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4feu C 2.37 BS02 537 C 1 F53 I101 I205 I215 F44 I92 I196 I206 K55 D198 N203 D216 K46 D189 N194 D207 0005524,0016773,0046677 23758273 302 QRETSCSRPLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4feu E 2.37 BS02 537 E 1 F53 I101 I205 I215 F46 I94 I198 I208 K55 D198 N203 D216 K48 D191 N196 D209 0005524,0016773,0046677 23758273 302 RETSCSRPRLNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 5lvl A 1.4 BS01 537 A 1 L88 A109 S160 A162 G165 L212 L15 A36 S87 A89 G92 L139 D205 K207 E209 N210 D223 T245 D132 K134 E136 N137 D150 T172 2.7.11.1 0004672,0004674,0005524,0006468 Kd=1.25uM -logKd/Ki=5.90, Kd=1.25uM O15530 27693059 401 PRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEGLIFAKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLT