4zy6 A 2.15 BS01 4T6 A 1 A297 E345 Y346 L347 D393 N394 L396 A47 E87 Y88 L89 D135 N136 L138 N389 K391 D393 N394 D407 P416 T427 N131 K133 D135 N136 D149 P158 T169 2.7.11.1 0004672,0005524,0006468 Ki=5nM -logKd/Ki=8.30, Ki=5nM Q13153 26030457 601 EEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQPKKELIINEILVMRENKNPNIVNYLDSYLVELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK 4zy6 B 2.15 BS01 4T6 B 1 I276 V284 A297 E345 Y346 L347 G350 D393 N394 L396 T406 I22 V30 A43 E91 Y92 L93 G96 D139 N140 L142 T152 N389 K391 D393 N394 D407 T427 N135 K137 D139 N140 D153 T165 2.7.11.1 0004672,0005524,0006468 Ki=5nM Q13153 26030457 601 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFGFSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK 5bms A 2.903 BS01 4T6 A 1 I327 G328 V335 A348 F397 L398 G401 D444 L447 I29 G30 V37 A50 F99 L100 G103 D146 L149 D440 K442 D444 S445 D458 K467 T478 D142 K144 D146 S147 D160 K169 T180 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=6.34, Ki=455nM O96013 26030457 601 GSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR