1yvj A 2.55 BS01 4ST A 1 L828 G829 V836 A853 M902 Y904 L905 G908 R911 R953 L956 D967 L15 G16 V23 A40 M89 Y91 L92 G95 R98 R140 L143 D154 D949 A951 R953 N954 D967 D136 A138 R140 N141 D154 2.7.10.2 0004672,0004713,0005524,0006468 P52333 15831699 2000 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRPELRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR 2hz4 A 2.8 BS01 4ST A 1 W261 Y264 L266 K294 L302 W23 Y26 L28 K56 L64 D363 A365 R367 N368 D381 P402 D125 A127 R129 N130 D143 P164 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=5.47, IC50=3425nM P00519 17164530 501 KWEMERTDITMKHKLGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES 2hz4 A 2.8 BS02 4ST C 1 Y342 F497 Q498 S500 Y104 F259 Q260 S262 D363 A365 R367 N368 D381 P402 D125 A127 R129 N130 D143 P164 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=5.47, IC50=3425nM P00519 17164530 501 KWEMERTDITMKHKLGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES 2hz4 B 2.8 BS01 4ST B 1 L248 V256 A269 K271 F317 M318 R367 L370 D381 L16 V19 A32 K34 F80 M81 R130 L133 D144 D363 A365 R367 N368 D381 P402 D126 A128 R130 N131 D144 P165 2.7.10.2 0004672,0004713,0005524,0006468 P00519 17164530 501 DKWEMERTDITMKHKLGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 2hz4 C 2.8 BS01 4ST A 1 F497 Q498 S500 F256 Q257 S259 D363 A365 R367 N368 D381 P402 D122 A124 R126 N127 D140 P161 2.7.10.2 0004672,0004713,0005524,0006468 P00519 17164530 501 KWEMERTDITMKHKLGEVYEGVWKKYTVAVKTLKDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES 2hz4 C 2.8 BS02 4ST C 1 W235 Q300 W2 Q59 D363 A365 R367 N368 D381 P402 D122 A124 R126 N127 D140 P161 2.7.10.2 0004672,0004713,0005524,0006468 P00519 17164530 501 KWEMERTDITMKHKLGEVYEGVWKKYTVAVKTLKDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES 2j0j A 2.8 BS01 4ST A 1 I428 G429 V436 A452 K454 M499 L501 C502 E506 R550 L553 D564 I363 G364 V371 A387 K389 M434 L436 C437 E441 R485 L488 D499 D546 A548 R550 N551 D564 D481 A483 R485 N486 D499 2.7.10.2 0004672,0004713,0005524,0005856,0006468 Q00944 17574028 1687 RVLKVFHYFENSSEPTTWASIIRHGDATDVRGIIQKIVDCHKVKNVACYGLRLSHLQSEEVHWLHLDMGVSNVREKFELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKNDYMLEIADQVDQEIALKLGCLEIRRSYGEMRGNALEKKSNYEVLEKDVGLRRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGANPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPTDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKLQ 2j0k A 3.0 BS01 4ST A 1 I428 V436 A452 K454 E500 L501 C502 R550 L553 I355 V363 A379 K381 E427 L428 C429 R477 L480 D546 A548 R550 N551 D564 D473 A475 R477 N478 D491 2.7.10.2 0004672,0004713,0005524,0005856,0006468 Q00944 17574028 1687 RVLKVFHYFENSSEPTTWASIIRHGDATDVRGIIQKIVDCHKVKNVACYGLRLSHLQSEEVHWLHLDMGVSNVREKFELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKNDYMLEIADQVDQEIALKLGCLEIRRSYGEMRGNALEKKSNYEVLEKDVGLRRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGANPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPTDDYAEIIDETRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKLQ 2j0k B 3.0 BS01 4ST B 1 I428 A452 V484 E500 L501 C502 E506 R550 L553 D564 I368 A392 V424 E440 L441 C442 E446 R490 L493 D504 D546 A548 R550 N551 D564 D486 A488 R490 N491 D504 2.7.10.2 0004672,0004713,0005524,0005856,0006468 Q00944 17574028 1687 RVLKVFHYFENSSEPTTWASIIRHGDATDVRGIIQKIVDCHKVKNVACYGLRLSHLQSEEVHWLHLDMGVSNVREKFELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKNDYMLEIADQVDQEIALKLGCLEIRRSYGEMRGNALEKKSNYEVLEKDVGLRRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGANPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPGVRSHTDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKLQ 2j0m B 2.8 BS01 4ST B 1 I428 G429 V436 A452 K454 M499 E500 L501 C502 E506 R550 L553 D564 I15 G16 V23 A39 K41 M86 E87 L88 C89 E93 R137 L140 D151 D546 A548 R550 N551 D564 D133 A135 R137 N138 D151 2.7.10.2 0004672,0004713,0005524,0006468 Q00944 17574028 1687 DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKLQ