4zji A 1.99 BS01 4OQ A 1 E315 V318 M319 N322 I327 V328 F379 N383 H387 L405 T406 A412 E57 V60 M61 N64 I69 V70 F121 N125 H129 L147 T148 A154 D389 K391 D393 N394 D407 P416 T427 D131 K133 D135 N136 D149 P158 T163 2.7.11.1 0004672,0005524,0006468 Kd=340nM -logKd/Ki=6.47, Kd=340nM Kd=340nM, IC50=323nM Q13153 26191365 601 LEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK 4zji B 1.99 BS01 4OQ B 1 E315 M319 N322 I327 V328 F379 N383 H387 L405 T406 A412 E57 M61 N64 I69 V70 F121 N125 H129 L147 T148 A154 D389 K391 D393 N394 D407 P416 T427 D131 K133 D135 N136 D149 P158 T163 2.7.11.1 0004672,0005524,0006468 Kd=340nM Kd=340nM, IC50=323nM Q13153 26191365 601 LEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA 4zji C 1.99 BS01 4OQ C 1 E315 V318 M319 N322 I327 V328 F379 N383 V385 H387 L405 T406 A412 E60 V63 M64 N67 I72 V73 F124 N128 V130 H132 L150 T151 A157 D389 K391 D393 N394 D407 T427 D134 K136 D138 N139 D152 T167 2.7.11.1 0004672,0005524,0006468 Kd=340nM Kd=340nM, IC50=323nM Q13153 26191365 601 DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDATGQEVAIKQMNKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT 4zji D 1.99 BS01 4OQ D 1 E315 M319 N322 I327 V328 F379 N383 V385 H387 L405 T406 A412 E58 M62 N65 I70 V71 F122 N126 V128 H130 L148 T149 A154 D389 K391 D393 N394 D407 T427 D132 K134 D136 N137 D150 T166 2.7.11.1 0004672,0005524,0006468 Kd=340nM Kd=340nM, IC50=323nM Q13153 26191365 601 ILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFAQITSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT