4z16 A 2.9 BS01 4LH A 1 L828 A853 M902 Y904 L905 P906 G908 C909 R911 R953 L956 L15 A40 M84 Y86 L87 P88 G90 C91 R93 R135 L138 D949 A951 R953 N954 D967 D131 A133 R135 N136 D149 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=8.32, IC50=4.8nM IC50=4.8nM P52333 26258521 2000 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYELRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVRPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR 4z16 B 2.9 BS01 4LH B 1 L828 A853 M902 Y904 L905 P906 G908 C909 R911 R953 L956 L15 A40 M84 Y86 L87 P88 G90 C91 R93 R135 L138 D949 A951 R953 N954 D967 D131 A133 R135 N136 D149 2.7.10.2 0004672,0004713,0005524,0006468 IC50=4.8nM P52333 26258521 2000 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYELRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR 4z16 C 2.9 BS01 4LH C 1 L828 V836 A853 M902 Y904 L905 P906 G908 C909 R911 R953 L956 L15 V23 A40 M84 Y86 L87 P88 G90 C91 R93 R135 L138 D949 A951 R953 N954 D967 D131 A133 R135 N136 D149 2.7.10.2 0004672,0004713,0005524,0006468 IC50=4.8nM P52333 26258521 2000 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYELRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVRPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR 4z16 D 2.9 BS01 4LH D 1 L828 V836 A853 M902 Y904 L905 P906 G908 C909 R911 R953 L956 L15 V23 A40 M84 Y86 L87 P88 G90 C91 R93 R135 L138 D949 A951 R953 N954 D967 D131 A133 R135 N136 D149 2.7.10.2 0004672,0004713,0005524,0006468 IC50=4.8nM P52333 26258521 2000 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYELRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVRPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR