4z7h A 2.9 BS01 4L5 A 1 L577 K599 I642 C645 H692 L695 D711 L16 K38 I81 C84 H131 L134 D150 D688 K690 N693 D711 T734 D127 K129 N132 D150 T168 2.7.11.1,3.1.26.- 0004521,0004540,0004672,0004674,0005524,0006397,0006468,0030968 -logKd/Ki=6.66, IC50=218nM EC50=143nM, IC50=1180nM O75460 25968568 1001 SVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSPGTEGWIAPEMLSNPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFH 4z7h B 2.9 BS01 4L5 B 1 L577 G578 K599 C645 L695 D711 L16 G17 K38 C84 L134 D150 D688 K690 N693 D711 T734 D127 K129 N132 D150 T166 2.7.11.1,3.1.26.- 0004521,0004540,0004672,0004674,0005524,0006397,0006468,0030968 EC50=143nM, IC50=1180nM O75460 25968568 1001 SVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHVPGTEGWIAPEMLSPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYF