4yp8 A 2.641 BS01 4GF A 1 M192 G193 E194 V200 A211 Y262 Y264 M265 P266 G268 S269 L318 M29 G30 E31 V37 A48 Y94 Y96 M97 P98 G100 S101 L150 D311 K313 A315 N316 D329 T351 D143 K145 A147 N148 D161 T179 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 -logKd/Ki=7.89, IC50=13nM IC50=13nM Q9NWZ3 26101573 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4yp8 B 2.641 BS01 4GF B 1 M192 G193 E194 V200 A211 Y262 V263 Y264 M265 P266 G268 S269 L318 M32 G33 E34 V40 A51 Y90 V91 Y92 M93 P94 G96 S97 L146 D311 K313 A315 N316 D329 T351 D139 K141 A143 N144 D157 T173 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=13nM Q9NWZ3 26101573 501 SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4yp8 C 2.641 BS01 4GF C 1 M192 E194 V200 A211 Y262 Y264 M265 P266 G268 S269 R273 L318 M29 E31 V37 A48 Y96 Y98 M99 P100 G102 S103 R107 L152 D311 K313 A315 N316 D329 T351 D145 K147 A149 N150 D163 T181 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=13nM Q9NWZ3 26101573 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 4yp8 D 2.641 BS01 4GF D 1 M192 G193 G195 V200 A211 Y262 Y264 M265 P266 G268 S269 R273 L318 M29 G30 G32 V37 A48 Y95 Y97 M98 P99 G101 S102 R106 L151 D311 K313 A315 N316 D329 T351 D144 K146 A148 N149 D162 T180 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=13nM Q9NWZ3 26101573 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA