4ypq A 2.32 BS01 4F1 A 1 W317 L324 T325 I328 Q329 L483 Q484 Q487 A496 A497 F498 L505 F506 W53 L60 T61 I64 Q65 L219 Q220 Q223 A232 A233 F234 L241 F242 ? 0003677,0004879,0005634,0006355 ic50=7nM IC50=7.8nM, EC50=16nM P51449 26640126 601 ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 5c4o A 2.24 BS01 4F1 A 1 L324 T325 I328 Q329 L483 Q484 Q487 A496 A497 F498 L501 L505 F506 L58 T59 I62 Q63 L217 Q218 Q221 A230 A231 F232 L235 L239 F240 ? 0003677,0004879,0005634,0006355 ic50=6.1nM -logKd/Ki=8.21, IC50=6.1nM IC50=7.8nM, EC50=16nM P51449 26640126 601 LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 6t4i A 1.84 BS02 4F1 A 1 L324 T325 I328 Q329 K354 M358 L483 Q484 Q487 A496 A497 F498 Y502 L505 F506 L58 T59 I62 Q63 K88 M92 L217 Q218 Q221 A230 A231 F232 Y236 L239 F240 ? 0003677,0004879,0005634,0006355 IC50=7.8nM, EC50=16nM P51449 33536342 602 LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 6t4k A 1.89 BS02 4F1 A 1 L324 T325 I328 Q329 K354 L483 Q484 Q487 A496 A497 F498 Y502 L505 F506 L58 T59 I62 Q63 K88 L217 Q218 Q221 A230 A231 F232 Y236 L239 F240 ? 0003677,0004879,0005634,0006355 IC50=7.8nM, EC50=16nM P51449 33536342 602 LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 6t4u A 2.0 BS02 4F1 A 1 L324 T325 I328 Q329 K354 M358 L483 Q484 Q487 A496 A497 F498 L501 Y502 L505 F506 L57 T58 I61 Q62 K87 M91 L216 Q217 Q220 A229 A230 F231 L234 Y235 L238 F239 ? 0003677,0004879,0005634,0006355 IC50=7.8nM, EC50=16nM P51449 33536342 803 TEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 6t4y A 1.95 BS02 4F1 A 1 L324 T325 I328 Q329 K354 L483 Q484 Q487 A496 A497 F498 L501 L505 F506 L58 T59 I62 Q63 K88 L217 Q218 Q221 A230 A231 F232 L235 L239 F240 ? 0003677,0004879,0005634,0006355 IC50=7.8nM, EC50=16nM P51449 33536342 602 LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS 6tdc A 2.328 BS01 4F1 A 1 F310 C313 Q314 R316 I354 L358 M362 I369 S370 F391 M392 K395 F396 H477 F65 C68 Q69 R71 I109 L113 M117 I124 S125 F146 M147 K150 F151 H232 ? 0003677,0004879,0005634,0006355 IC50=130nM P37231 601 SHMESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY