2n27 A -1.00 BS04 4DY A 1 L32 M76 M109 L32 M76 M109 V35 V35 ? 0000086,0000922,0002027,0005509,0005513,0005515,0005576,0005634,0005654,0005737,0005813,0005819,0005829,0005856,0005876,0005886,0007186,0008076,0010800,0010801,0010856,0010880,0010881,0016020,0016240,0019855,0019901,0021762,0030017,0031432,0031514,0031954,0031982,0032465,0032516,0032991,0034704,0035307,0035458,0043209,0043539,0044305,0044325,0046427,0046872,0048306,0050848,0051343,0051592,0055117,0060314,0060315,0060316,0071346,0071902,0072542,0097225,0098901,0099523,0140056,0140238,1901020,1901842,1901844,1902494,1905913,1990456 -logKd/Ki=6.55, Kd=280nM P0DP23 27339229 205 ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK 7lpa A 3.37 BS03 4DY A 1 Y511 S512 F543 T550 N551 Y379 S380 F411 T418 N419 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 905 DRRSIFDAVAQSNCQELESLLPFLQRSETGKTCLLKAMLNLHNGQNDTIALLLDVARKTKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGAVQAAANGDFFKRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpa B 3.37 BS04 4DY B 1 Y511 S512 F543 T550 N551 Y379 S380 F411 T418 N419 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 907 DRRSIFDAVAQSNCQELESLLPFLQRSETGKTCLLKAMLNLHNGQNDTIALLLDVARKTKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGAVQAAANGDFFKRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpa C 3.37 BS04 4DY C 1 Y511 S512 F543 T550 N551 Y379 S380 F411 T418 N419 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 907 DRRSIFDAVAQSNCQELESLLPFLQRSETGKTCLLKAMLNLHNGQNDTIALLLDVARKTKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGAVQAAANGDFFKRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpa D 3.37 BS04 4DY D 1 Y511 S512 F543 T550 N551 Y379 S380 F411 T418 N419 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 906 DRRSIFDAVAQSNCQELESLLPFLQRSETGKTCLLKAMLNLHNGQNDTIALLLDVARKTKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGAVQAAANGDFFKRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpb A 3.54 BS03 4DY A 1 Y511 T550 Y554 Y377 T416 Y420 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 3000 DRRSIFDAVAQSNCQELESLLPFLQRSETGKTCLLKAMLNLHNGQNDTIALLLDVARKTKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENVQAAANGDFFKRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpb B 3.54 BS05 4DY B 1 Y511 T550 Y554 Y377 T416 Y420 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 3000 DRRSIFDAVAQSNCQELESLLPFLQRSETGKTCLLKAMLNLHNGQNDTIALLLDVARKTKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENVQAAANGDFFKRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpb C 3.54 BS05 4DY C 1 Y511 T550 Y554 Y377 T416 Y420 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 3000 DRRSIFDAVAQSNCQELESLLPFLQRSETGKTCLLKAMLNLHNGQNDTIALLLDVARKTKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENVQAAANGDFFKRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpb D 3.54 BS05 4DY D 1 Y511 T550 Y554 Y377 T416 Y420 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 3000 DRRSIFDAVAQSNCQELESLLPFLQRSETGKTCLLKAMLNLHNGQNDTIALLLDVARKTKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENVQAAANGDFFKRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpd A 3.55 BS02 4DY A 1 Y511 S512 L515 F543 T550 N551 Y280 S281 L284 F312 T319 N320 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 904 ALHIAIERRNMTLVTLLVEGFYFGELPLSLAACTNQLAIVKFLLQNSARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpd B 3.55 BS02 4DY B 1 Y511 S512 L515 F543 T550 N551 Y280 S281 L284 F312 T319 N320 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 904 ALHIAIERRNMTLVTLLVEGFYFGELPLSLAACTNQLAIVKFLLQNSARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpd C 3.55 BS02 4DY C 1 Y511 S512 L515 F543 T550 N551 Y280 S281 L284 F312 T319 N320 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 904 ALHIAIERRNMTLVTLLVEGFYFGELPLSLAACTNQLAIVKFLLQNSARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpd D 3.55 BS02 4DY D 1 Y511 S512 L515 F543 T550 N551 Y280 S281 L284 F312 T319 N320 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 903 ALHIAIERRNMTLVTLLVEGFYFGELPLSLAACTNQLAIVKFLLQNSARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe A 3.72 BS03 4DY A 1 Y511 S512 T550 Y554 R557 Y269 S270 T308 Y312 R315 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 1003 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe B 3.72 BS03 4DY B 1 Y511 S512 T550 Y554 R557 Y269 S270 T308 Y312 R315 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 1003 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe C 3.72 BS03 4DY C 1 Y511 S512 T550 Y554 R557 Y269 S270 T308 Y312 R315 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 1003 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lpe D 3.72 BS03 4DY D 1 Y511 S512 T550 Y554 R557 Y269 S270 T308 Y312 R315 ? 0000122,0001659,0001660,0001774,0002024,0002790,0003085,0004888,0005216,0005230,0005231,0005261,0005262,0005515,0005516,0005524,0005886,0006629,0006811,0006816,0007204,0008289,0008324,0009268,0009408,0009897,0010459,0010917,0014047,0014832,0015276,0015278,0016020,0017081,0019233,0019722,0030425,0032591,0034220,0034605,0035091,0042802,0042995,0043005,0043025,0043065,0043434,0045202,0045211,0045429,0046872,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0051289,0055085,0060079,0060083,0070588,0071312,0071318,0071345,0071356,0071363,0071468,0071502,0090212,0097603,0098703,0098982,1901594,1990090 EC50=300nM, Ki=2000nM, IC50=19nM O35433 34239123 1003 HIAIERRNMTLVTLLYFGELPLSLAACTNQLAIVKFLLQSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW 7lr0 A 3.81 BS01 4DY A 1 S514 L517 F545 T552 L555 Y556 S404 L407 F435 T442 L445 Y446 ? 0000122,0001659,0001660,0002024,0002790,0005216,0005230,0005261,0005262,0005516,0005524,0005886,0006629,0006811,0006816,0009268,0009408,0014832,0016020,0019233,0032591,0034220,0034605,0043005,0045211,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0055085,0060083,0070588,0071468,0097603,0098703,0098982,1901594 I3LZN5 33846324 903 LKLYDRRSIFDAVAQNNCQELESLLPFLQKSRKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTISLLLDIARQTDSLKEFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELINKKGLTPLALAASSGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIVFTTAAYYRPVDGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFLRGIQYFLQRRPSMKTLFVDSYSEMLFFVQSLFMLGSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFS 7lr0 A 3.81 BS02 4DY D 1 F593 L671 F483 L539 ? 0000122,0001659,0001660,0002024,0002790,0005216,0005230,0005261,0005262,0005516,0005524,0005886,0006629,0006811,0006816,0009268,0009408,0014832,0016020,0019233,0032591,0034220,0034605,0043005,0045211,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0055085,0060083,0070588,0071468,0097603,0098703,0098982,1901594 I3LZN5 33846324 904 LKLYDRRSIFDAVAQNNCQELESLLPFLQKSRKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTISLLLDIARQTDSLKEFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELINKKGLTPLALAASSGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIVFTTAAYYRPVDGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFLRGIQYFLQRRPSMKTLFVDSYSEMLFFVQSLFMLGSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFS 7lr0 B 3.81 BS01 4DY A 1 F593 L671 F483 L539 ? 0000122,0001659,0001660,0002024,0002790,0005216,0005230,0005261,0005262,0005516,0005524,0005886,0006629,0006811,0006816,0009268,0009408,0014832,0016020,0019233,0032591,0034220,0034605,0043005,0045211,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0055085,0060083,0070588,0071468,0097603,0098703,0098982,1901594 I3LZN5 33846324 903 LKLYDRRSIFDAVAQNNCQELESLLPFLQKSRKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTISLLLDIARQTDSLKEFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELINKKGLTPLALAASSGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIVFTTAAYYRPVDGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFLRGIQYFLQRRPSMKTLFVDSYSEMLFFVQSLFMLGSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFS 7lr0 B 3.81 BS02 4DY B 1 S514 L517 F545 T552 L555 Y556 S404 L407 F435 T442 L445 Y446 ? 0000122,0001659,0001660,0002024,0002790,0005216,0005230,0005261,0005262,0005516,0005524,0005886,0006629,0006811,0006816,0009268,0009408,0014832,0016020,0019233,0032591,0034220,0034605,0043005,0045211,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0055085,0060083,0070588,0071468,0097603,0098703,0098982,1901594 I3LZN5 33846324 903 LKLYDRRSIFDAVAQNNCQELESLLPFLQKSRKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTISLLLDIARQTDSLKEFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELINKKGLTPLALAASSGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIVFTTAAYYRPVDGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFLRGIQYFLQRRPSMKTLFVDSYSEMLFFVQSLFMLGSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFS 7lr0 C 3.81 BS01 4DY B 1 F593 L671 F483 L539 ? 0000122,0001659,0001660,0002024,0002790,0005216,0005230,0005261,0005262,0005516,0005524,0005886,0006629,0006811,0006816,0009268,0009408,0014832,0016020,0019233,0032591,0034220,0034605,0043005,0045211,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0055085,0060083,0070588,0071468,0097603,0098703,0098982,1901594 I3LZN5 33846324 903 LKLYDRRSIFDAVAQNNCQELESLLPFLQKSRKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTISLLLDIARQTDSLKEFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELINKKGLTPLALAASSGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIVFTTAAYYRPVDGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFLRGIQYFLQRRPSMKTLFVDSYSEMLFFVQSLFMLGSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFS 7lr0 C 3.81 BS02 4DY C 1 S514 L517 F545 T552 L555 Y556 S404 L407 F435 T442 L445 Y446 ? 0000122,0001659,0001660,0002024,0002790,0005216,0005230,0005261,0005262,0005516,0005524,0005886,0006629,0006811,0006816,0009268,0009408,0014832,0016020,0019233,0032591,0034220,0034605,0043005,0045211,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0055085,0060083,0070588,0071468,0097603,0098703,0098982,1901594 I3LZN5 33846324 903 LKLYDRRSIFDAVAQNNCQELESLLPFLQKSRKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTISLLLDIARQTDSLKEFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELINKKGLTPLALAASSGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIVFTTAAYYRPVDGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFLRGIQYFLQRRPSMKTLFVDSYSEMLFFVQSLFMLGSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFS 7lr0 D 3.81 BS01 4DY C 1 F593 L671 F483 L539 ? 0000122,0001659,0001660,0002024,0002790,0005216,0005230,0005261,0005262,0005516,0005524,0005886,0006629,0006811,0006816,0009268,0009408,0014832,0016020,0019233,0032591,0034220,0034605,0043005,0045211,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0055085,0060083,0070588,0071468,0097603,0098703,0098982,1901594 I3LZN5 33846324 903 LKLYDRRSIFDAVAQNNCQELESLLPFLQKSRKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTISLLLDIARQTDSLKEFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELINKKGLTPLALAASSGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIVFTTAAYYRPVDGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFLRGIQYFLQRRPSMKTLFVDSYSEMLFFVQSLFMLGSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFS 7lr0 D 3.81 BS02 4DY D 1 S514 L517 F545 T552 L555 Y556 S404 L407 F435 T442 L445 Y446 ? 0000122,0001659,0001660,0002024,0002790,0005216,0005230,0005261,0005262,0005516,0005524,0005886,0006629,0006811,0006816,0009268,0009408,0014832,0016020,0019233,0032591,0034220,0034605,0043005,0045211,0048265,0048266,0050909,0050954,0050955,0050960,0050965,0050968,0051219,0055085,0060083,0070588,0071468,0097603,0098703,0098982,1901594 I3LZN5 33846324 904 LKLYDRRSIFDAVAQNNCQELESLLPFLQKSRKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTISLLLDIARQTDSLKEFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEELINKKGLTPLALAASSGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIVFTTAAYYRPVDGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFLRGIQYFLQRRPSMKTLFVDSYSEMLFFVQSLFMLGSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFS 7vek B 2.6 BS02 4DY B 1 L155 V158 R159 L190 P191 V194 L206 A393 E394 Y397 L143 V146 R147 L178 P179 V182 L194 A359 E360 Y363 2.4.1.- 0008194,0016757,0035251,0046527 B5MGN9 35234151 501 QQLHVVFFPIMAHGHMIPTLDIARLFAARNVRATIITTPLNAHTFTKAISPTIHLELFKFPAQDVGLPEGCENLEQALGSSLIEKFFKGVGLLREQLEAYLEKTRPNCLVADMFFPWATDSAAKFNIPRLVFHGTSFFSLCALEVVRLYEPHKNVSSDEELFSLPLFPHDIKMMRLQLPEDVWKHEKAEGKTRLKLIKESELKSYGVIVNSFYELEPNYAEFFRKELGRRAWNIGPVSLCNRSTEHECLKWLNSKKKNSVIYICFGSTAHQIAPQLYEIAMALEASGQEFIWVVRNDSWLPRGFEQRVEGKGLIIRGWAPQVLILEHEAIGAFVTHCGWNSTLEGITAGVPMVTWPIFAEQFYNEKLVNQILKIGVPVGANKWSRETSIEDVIKKDAIEKALREIMVGDEAEERRSRAKKLKEMAWKAVEEGGSSYSDLSALIEELRGYHA