5cfm A 1.994 BS01 4BW A 1 Y206 F276 R278 Y280 T303 P304 Y16 F86 R88 Y90 T113 P114 ? 0002218,0032481 Kd=50nM A7SLZ2 26300263 401 GSNVADGLAWSYYFGYLKFVLPELEKQIEKTSKFRSKEKFVKKMFILIPSNCFWDDKIPGSDYDPQNRITFEGNTEPLEKTRGGVFLRHYKHSVYEIKDGENEPWFCIMEYATPLLTLYDMSVAQPGELSREERDAQVVVFLRKLQDILEGDRACQGKYELVTFSPDRDLADVMLRKLKDSELEIGG 5cfm B 1.994 BS01 4BW A 1 Y206 F276 R278 T303 P304 Y16 F86 R88 T113 P114 ? 0002218,0032481 A7SLZ2 26300263 401 GSNVADGLAWSYYFGYLKFVLPELEKQIEKTSKFRSKEKFVKKMFILIPSNCFWDDKIPGSDYDPQNRITFEGNTEPLEKTRGGVFLRHYKHSVYEIKDGENEPWFCIMEYATPLLTLYDMSVAQPGELSREERDAQVVVFLRKLQDILEGDRACQGKYELVTFSPDRDLADVMLRKLKDSELEIGG 5vdt A 2.576 BS02 4BW A 1 D227 M229 P306 A307 T321 K362 R376 S378 S380 S434 Y436 D66 M68 P145 A146 T160 K201 R215 S217 S219 S273 Y275 2.7.7.86 -logKd/Ki=4.68, Kd=21uM Q8N884 28940468 602 MGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE 5vdt B 2.576 BS02 4BW B 1 D227 M229 P306 K362 R376 S378 S434 Y436 D59 M61 P138 K194 R208 S210 S266 Y268 2.7.7.86 Q8N884 28940468 602 MGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE 6ael A 1.9 BS01 4BW A 1 A238 F239 N259 K277 Y322 Y353 D358 H362 S514 G515 H517 A69 F70 N90 K108 Y153 Y184 D189 H193 S345 G346 H348 3.1.4.1,3.6.1.9 0003676,0016787,0046872 P06802 30356045 1007 KSWVEETCESIDTPECPAEFESPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPMYPTKAFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTDVPETYYSFNYEALAKNLSCREPNQHFRPYLKPFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNLFSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLGLIPAPNNGSHGSLNHLLKKPIYNPSHPKEEGFLSQCPIKSTSNDLGCTCDPWIVPIKDFEDDIYHMTVPYGRPRILLKQHRVCLLQQQQFLTGYSLDLLMPLWASYTFLSNDQFSRDDFSNCLYQDLRIPLSPVHKCSYYKSNSKLSYGFLTPPRLNRVSNHIYSEALLTSNIVPMYQSFQVIWHYLHDTLLQRYAHERNGINVVSGPVFDFDYDGRYDSLEILKQNSRVIRSQEILIPTHFFIVLTSCKQLSETPLECSALESSAYILPHRPDNIESCTHGKRESSWVEELLTLHRARVTDVELITGLSFYQDRQESVSELLRLKTHLPIFSQ 6ih7 A 2.25 BS01 4BW A 1 M28 Q31 L47 V48 R49 N95 L97 M182 G216 E218 G236 Y237 M8 Q11 L27 V28 R29 N75 L77 M162 G196 E198 G216 Y217 3.1.4.52 0000166,0046872 A0A0H3AJ04 31647518 301 SLDFDFTMAFQPIVNCRTKEIFGYEALVRGLNNESAYSVISRVNEDNRYLFDQMCRVKAIALAAKLGLTSKLSINFLPNAIYVPERCIRTTLEAAKRYQFPIENIMFEFTEAERVEDVNHIKRIVEYYKSLGFQTAIDDFGSGYSGLNLLADFQTNIVKVDMGLIRNIHADQVRQSIMKNCLKLFSDLNIQPLAEGVESHAEFAWLKAAGVELMQGYYFAKPGFESLPSVNPEFSEA 6ih7 B 2.25 BS01 4BW B 1 Q31 L47 V48 R49 A56 I60 C75 N95 M182 G216 V217 E218 G236 Y237 Q11 L27 V28 R29 A36 I40 C55 N75 M162 G196 V197 E198 G216 Y217 3.1.4.52 0000166,0046872 A0A0H3AJ04 31647518 301 SLDFDFTMAFQPIVNCRTKEIFGYEALVRGLNNESAYSVISRVNEDNRYLFDQMCRVKAIALAAKLGLTSKLSINFLPNAIYVPERCIRTTLEAAKRYQFPIENIMFEFTEAERVEDVNHIKRIVEYYKSLGFQTAIDDFGSGYSGLNLLADFQTNIVKVDMGLIRNIHADQVRQSIMKNCLKLFSDLNIQPLAEGVESHAEFAWLKAAGVELMQGYYFAKPGFESLPSVNPEFSEA 6wt4 A 1.78 BS01 4BW A 1 Y88 N91 F92 R153 L156 T157 N172 T173 Y10 N13 F14 R75 L78 T79 N94 T95 ? P0DUD7 32877915 301 SPAFALAVGYFKNFIFPAITQIKENGEVNPKICIYKPKHFDELTSTNIDMIKAELTNKKYNLSEINLSLKGARARDILTLNKKSKIHSYFDFPNTLLSLYSYVDSELKKKKFVELLIEQFYLKLNELIQENNLTNNITFCDKNLQGL 6wt4 B 1.78 BS01 4BW A 1 Y88 N91 F92 R153 L156 T157 N172 T173 Y10 N13 F14 R75 L78 T79 N94 T95 ? P0DUD7 32877915 301 SPAFALAVGYFKNFIFPAITQIKENGEVNPKICIYKPKHFDELTSTNIDMIKAELTNKKYNLSEINLSLKGARARDILTLNKKSKIHSYFDFPNTLLSLYSYVKKFVELLIEQFYLKLNELIQENNLTNNITFCDKNLQG 6ydz A 2.9 BS01 4BW A 1 S162 Y167 R238 Y240 T263 S9 Y14 R80 Y82 T105 ? 0002218,0032481 EC50=120nM, Kd=1040nM Q86WV6 33616279 401 NVAHGLAWSYYIGYLRLILPELQARIRTYNQHYGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPSSFSLSQEVLRHLRQEE 6yj9 A 1.5 BS01 4BW A 1 V24 A25 Y45 T46 A47 F115 I128 R132 V22 A23 Y43 T44 A45 F113 I126 R130 ? O31698 201 SLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTGYTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDPIMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSL 6yj9 B 1.5 BS01 4BW A 2 Y45 R132 Y36 R123 ? O31698 202 LEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTGYTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDPIMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRS 6yj9 B 1.5 BS02 4BW B 1 V24 A25 Y45 T46 A47 I48 F115 I128 R132 V15 A16 Y36 T37 A38 I39 F106 I119 R123 ? O31698 201 LEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTGYTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDPIMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRS 6yj9 B 1.5 BS03 4BW B 2 F17 M18 I19 K23 R132 K136 F8 M9 I10 K14 R123 K127 ? O31698 202 LEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTGYTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDPIMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRS 7una A 4.0 BS01 4BW A 1 Y161 F165 F236 P237 S262 T263 Y10 F14 F75 P76 S91 T92 3.2.2.5 0000166,0003953,0016787,0050135,0051607 A0A2T5Y4G4 35859168 401 LPSTALAIGYYNSFIKRVCEEIHGSECVEKIKVKSFRVDVVIPETLDDNGVGNFTTLYNKRYGLSKATTCTNRGFPFHFKPVDIHLLDIPSTLSTIVESLKLYLDMDYLEMRELENFAKVLKYLIGRNAATKGYVNVLTNVK 7una B 4.0 BS01 4BW A 1 F165 P237 D259 S262 F13 P75 D87 S90 3.2.2.5 0000166,0003953,0016787,0050135,0051607 A0A2T5Y4G4 35859168 401 PSTALAIGYYNSFIKRVCEEIHGSECVEKKIKVKSFRVDVVIPETLDDNGVGNFTTLYNKRYGLSKATTCTNGFPFHFKPVDIHLLDIPSTLSTIVESLKLYLDMDYLEMRELENFAKVLKYLIGRNAATKGYVNVLTNVK 7una C 4.0 BS01 4BW C 1 Y161 F165 F236 P237 D259 S262 T263 Y10 F14 F77 P78 D90 S93 T94 3.2.2.5 0000166,0003953,0016787,0050135,0051607 A0A2T5Y4G4 35859168 401 LPSTALAIGYYNSFIKRVCEEIHGSECVELKKIKVKSFRVDVVIPETLDDNGVGNFTTLYNKRYGLSKATTCTNRGFPFHFKPVDIHLLDIPSTLSTIVESLKLYFDMDYLEMRELENFAKVLKYLIGRNAATKGYVNVLTNV 7una D 4.0 BS01 4BW C 1 Y161 F165 T263 Y9 F13 T94 3.2.2.5 0000166,0003953,0016787,0050135,0051607 A0A2T5Y4G4 35859168 401 PSTALAIGYYNSFIKRVCEEIHGSECVELEGKKIKVKSFRVDVVIPETLDDNGVGNFTTLYNKRYGLSKATTCTNRGFPFHFKVDIHLLDIPSTLSTIVESLKLYDMDYLEMRELENFAKVLKYLIGRNAATKGYVNVLTNVK 7una E 4.0 BS01 4BW F 1 F165 F236 P237 S262 T263 F14 F73 P74 S89 T90 3.2.2.5 0000166,0003953,0016787,0050135,0051607 A0A2T5Y4G4 35859168 401 LPSTALAIGYYNSFIKRVCEEIHGSECVEKIKVKSFRVDVVIPETLDDNGVGNFTTLYNKRYGLSKATTCTGFPFHFKPVDIHLLDIPSTLSTIVESLKLYLDMDYLEMRELENFAKVLKYLIGRNAATKGYVNVLTNVK 7una F 4.0 BS01 4BW F 1 Y161 F165 F236 P237 T263 Y9 F13 F73 P74 T90 3.2.2.5 0000166,0003953,0016787,0050135,0051607 A0A2T5Y4G4 35859168 401 PSTALAIGYYNSFIKRVCEEIHGSECVELKKIKVKSFRVDVVIPETLDDNGVGNFTTLYNKRYGLSKATTCGFPFHFKPVDIHLLDIPSTLSTIVESLKLYLFDMDYLEMRELENFAKVLKYLIGRNAATKGYVNVLTNVK 7una G 4.0 BS01 4BW H 1 Y161 F165 F236 P237 S262 T263 Y10 F14 F75 P76 S91 T92 3.2.2.5 0000166,0003953,0016787,0050135,0051607 A0A2T5Y4G4 35859168 401 LPSTALAIGYYNSFIKRVCEEIHGSECVELKKIKVKSFRVDVVIPETLDDNGVGNFTTLYNKRYGLSKATTCTGFPFHFKPVDIHLLDIPSTLSTIVESLKLYDMDYLEMRELENFAKVLKYLIGRNAATKGYVNVLTNVK 7una H 4.0 BS01 4BW H 1 Y161 F165 F236 P237 T263 Y9 F13 F74 P75 T91 3.2.2.5 0000166,0003953,0016787,0050135,0051607 A0A2T5Y4G4 35859168 401 PSTALAIGYYNSFIKRVCEEIHGSECVELKKIKVKSFRVDVVIPETLDDNGVGNFTTLYNKRYGLSKATTCRGFPFHFKPVDIHLLDIPSTLSTIVESLKLYLDMDYLEMRELENFAKVLKYLIGRNAATKGYVNVLTNVK 7uq2 A 2.0 BS01 4BW A 1 Y8 K9 H11 K23 M75 F82 P84 Y9 K10 H12 K24 M76 F83 P85 ? 0000166 P13314 36848932 101 SMIEDIKGYKPHTEEKIGKVNAIKDAEVRLGLIFDALYDEFWEALDNCEDCEFAKNYAESLDQLTIAKTKLKEASMWACRAVFQPEEKY 7uq2 B 2.0 BS01 4BW B 1 Y8 K9 K23 M75 F82 P84 Y7 K8 K22 M74 F81 P83 ? 0000166 P13314 36848932 101 IEDIKGYKPHTEEKIGKVNAIKDAEVRLGLIFDALYDEFWEALDNCEDCEFAKNYAESLDQLTIAKTKLKEASMWACRAVFQPEEKY 7uq2 C 2.0 BS01 4BW C 1 Y8 K9 H11 K23 M75 F82 P84 Y7 K8 H10 K22 M74 F81 P83 ? 0000166 P13314 36848932 101 IEDIKGYKPHTEEKIGKVNAIKDAEVRLGLIFDALYDEFWEALDNCEDCEFAKNYAESLDQLTIAKTKLKEASMWACRAVFQPEEKY 7uq2 D 2.0 BS01 4BW B 1 Y8 K9 H11 K23 M75 R79 F82 P84 Y8 K9 H11 K23 M73 R77 F80 P82 ? 0000166 P13314 36848932 101 MIEDIKGYKPHTEEKIGKVNAIKDAEVRLGLIFDALYDEFWEALDNCCEFAKNYAESLDQLTIAKTKLKEASMWACRAVFQPEEKY 7uq2 E 2.0 BS01 4BW A 1 Y8 K9 H11 K23 M75 F82 P84 Y8 K9 H11 K23 M73 F80 P82 ? 0000166 P13314 36848932 101 MIEDIKGYKPHTEEKIGKVNAIKDAEVRLGLIFDALYDEFWEALDNCCEFAKNYAESLDQLTIAKTKLKEASMWACRAVFQPEEKY 7uq2 F 2.0 BS01 4BW C 1 Y8 K9 H11 K23 M75 F82 P84 Y7 K8 H10 K22 M74 F81 P83 ? 0000166 P13314 36848932 101 IEDIKGYKPHTEEKIGKVNAIKDAEVRLGLIFDALYDEFWEALDNCEDCEFAKNYAESLDQLTIAKTKLKEASMWACRAVFQPEEKY 8efn A 1.73 BS01 4BW D 1 N178 Y179 Y183 I247 R250 Y252 S275 N276 N9 Y10 Y14 I78 R81 Y83 S106 N107 ? 0002218,0032481 A0A2B4SES9 37379839 401 NVADGFAWNYYFGYLKLVLPRLEAQIAKSSEFRYKITKKKLYILVPKTCYVYDNIADADPRVTWAGDLTPCKINRGGIKERIYKQAVYRVAMTDKHEYFFILEYASNLMSLYDMSLHEDAPLSRQERDDQVVLFIRKLREILEGCKECRGKCEIVPISGDEKSKIADVLVAIHNA 8efn D 1.73 BS01 4BW D 1 N178 Y179 Y183 R250 Y252 K253 E272 S275 N276 N9 Y10 Y14 R81 Y83 K84 E103 S106 N107 ? 0002218,0032481 A0A2B4SES9 37379839 401 NVADGFAWNYYFGYLKLVLPRLEAQIAKSSEFRYKITKKKLYILVPKTCYVYDNIADADPRVTWAGDLTPCKINRGGIKERIYKQAVYRVAMTDKHEYFFILEYASNLMSLYDMSLHEDAPLSRQERDDQVVLFIRKLREILEGCKECRGKCEIVPISGDEKSKIADVLVAIHNA 8h2j A 2.4 BS01 4BW A 1 Y11 R12 M81 I84 A88 P90 Y10 R11 M80 I83 A87 P89 ? 0000166 A0A1C8HPQ3 36750095 101 DNQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8h2j B 2.4 BS01 4BW B 1 Y11 R12 M81 I84 R85 A88 P90 Y9 R10 M79 I82 R83 A86 P88 ? 0000166 A0A1C8HPQ3 36750095 101 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8h2j C 2.4 BS01 4BW D 1 Y11 R12 L14 M22 K26 M81 I84 A88 Q89 P90 Y9 R10 L12 M20 K24 M79 I82 A86 Q87 P88 ? 0000166 A0A1C8HPQ3 36750095 101 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8h2j D 2.4 BS01 4BW D 1 Q4 Y11 R12 L14 K26 M81 I84 R85 A88 P90 Q2 Y9 R10 L12 K24 M79 I82 R83 A86 P88 ? 0000166 A0A1C8HPQ3 36750095 101 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8h2j E 2.4 BS01 4BW E 1 Y11 R12 L14 M81 I84 A88 Y9 R10 L12 M79 I82 A86 ? 0000166 A0A1C8HPQ3 36750095 101 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8h2j F 2.4 BS01 4BW E 1 Y11 L14 M81 I84 A88 P90 Y9 L12 M79 I82 A86 P88 ? 0000166 A0A1C8HPQ3 36750095 101 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8wjc A 2.11 BS01 4BW A 1 R31 D34 L36 M40 V45 K46 S47 N85 R32 D35 L37 M41 V46 K47 S48 N86 A0A447EB45 201 SMTFGQALESLKRGHLVARKGWNGKGMFIFMRPEDSLPTNMIVNQVKSLPESFKRWVANNHGDSETDRIKFTAYLCMKAADGTIVNGWLASQTDMLANDWVIVE 8wjc B 2.11 BS01 4BW C 1 R31 L36 V45 K46 S47 F70 N85 R32 L37 V46 K47 S48 F71 N86 A0A447EB45 201 SMTFGQALESLKRGHLVARKGWNGKGMFIFMRPEDSLPTNMIVNQVKSLPESFKRWVANNHGDSETDRIKFTAYLCMKAADGTIVNGWLASQTDMLANDWVIVE 8wjc C 2.11 BS01 4BW C 1 R31 D34 L36 M40 V45 K46 S47 F70 N85 R32 D35 L37 M41 V46 K47 S48 F71 N86 A0A447EB45 201 SMTFGQALESLKRGHLVARKGWNGKGMFIFMRPEDSLPTNMIVNQVKSLPESFKRWVANNHGDSETDRIKFTAYLCMKAADGTIVNGWLASQTDMLANDWVIVE 8wjc D 2.11 BS01 4BW A 1 R31 L36 M40 V45 K46 S47 F70 N85 R32 L37 M41 V46 K47 S48 F71 N86 A0A447EB45 201 SMTFGQALESLKRGHLVARKGWNGKGMFIFMRPEDSLPTNMIVNQVKSLPESFKRWVANNHGDSETDRIKFTAYLCMKAADGTIVNGWLASQTDMLANDWVIVE