4y86 A 2.01 BS01 49D A 1 L420 L421 Y424 F441 A452 Q453 F456 L236 L237 Y240 F257 A268 Q269 F272 3.1.4.35 0004114,0004115,0004117,0005515,0005654,0005737,0005783,0005794,0005829,0005886,0007165,0008081,0010613,0016787,0019933,0032587,0042383,0042995,0043204,0046068,0046069,0046872,0047555,0048101,0048471,1900273,2000178 ic50=11nM IC50=6.00nM O76083 26316540 601 KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK 4y8c A 2.7 BS01 49D A 1 M365 L420 L421 Y424 M442 A452 Q453 F456 M181 L236 L237 Y240 M258 A268 Q269 F272 3.1.4.35 0004114,0004115,0004117,0005515,0005654,0005737,0005783,0005794,0005829,0005886,0007165,0008081,0010613,0016787,0019933,0032587,0042383,0042995,0043204,0046068,0046069,0046872,0047555,0048101,0048471,1900273,2000178 -logKd/Ki=7.96, IC50=11nM IC50=6.00nM O76083 26316540 601 KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK 4y8c B 2.7 BS01 49D B 1 L420 L421 Y424 F441 A452 Q453 F456 L240 L241 Y244 F261 A272 Q273 F276 3.1.4.35 0004114,0004115,0004117,0005515,0005654,0005737,0005783,0005794,0005829,0005886,0007165,0008081,0010613,0016787,0019933,0032587,0042383,0042995,0043204,0046068,0046069,0046872,0047555,0048101,0048471,1900273,2000178 IC50=6.00nM O76083 26316540 601 PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK