4y85 A 2.33 BS01 499 A 1 W132 F143 P145 V152 A165 K167 E208 G210 G213 S214 E217 V260 V269 D270 W52 F60 P62 V69 A82 K84 E125 G127 G130 S131 E134 V177 V186 D187 D253 K255 N258 D270 T290 D170 K172 N175 D187 T207 2.7.11.25 0004672,0005524,0006468 ic50=13nM -logKd/Ki=7.89, IC50=13nM P41279 25918157 401 LSSVRYGTVEDLLAFANHISNTPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNP 4y85 B 2.33 BS01 499 B 1 W132 F143 P145 V152 A165 K167 E208 G210 G213 S214 E217 V260 V269 D270 W51 F59 P61 V68 A81 K83 E124 G126 G129 S130 E133 V176 V185 D186 D253 K255 N258 D270 T290 D169 K171 N174 D186 T206 2.7.11.25 0004672,0005524,0006468 ic50=13nM P41279 25918157 401 LSSVRYGTVEDLLAFANHISNPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNP 4y85 C 2.33 BS01 499 C 1 W132 P145 V152 A165 K167 M207 E208 G210 G213 S214 E217 V260 V269 D270 W50 P58 V65 A78 K80 M120 E121 G123 G126 S127 E130 V173 V182 D183 D253 K255 N258 D270 T290 D166 K168 N171 D183 T203 2.7.11.25 0004672,0005524,0006468 ic50=13nM P41279 25918157 401 LSSVRYGTVEDLLAFANHISPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNP