4y6m A 2.27 BS01 48Q A 1 I32 D34 G36 V78 T114 I123 Y192 D214 G216 T217 S218 I300 I32 D34 G36 V78 T114 I123 Y192 D214 G216 T217 S218 I300 D34 S37 N39 W41 Y77 D214 T217 D34 S37 N39 W41 Y77 D214 T217 3.4.23.39 0004190,0006508 -logKd/Ki=7.15, IC50=0.07uM P46925 26625296 501 SSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL 4y6m B 2.27 BS01 48Q B 1 M15 I32 D34 G36 V78 F111 I123 Y192 D214 G216 T217 S218 I300 M14 I31 D33 G35 V77 F110 I122 Y191 D213 G215 T216 S217 I299 D34 S37 N39 W41 Y77 D214 T217 D33 S36 N38 W40 Y76 D213 T216 3.4.23.39 0004190,0006508 P46925 26625296 501 SNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL 4y6m C 2.27 BS01 48Q A 1 D279 G281 D279 G281 D34 S37 N39 W41 Y77 D214 T217 D34 S37 N39 W41 Y77 D214 T217 3.4.23.39 0004190,0006508 P46925 26625296 501 SSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL 4y6m C 2.27 BS02 48Q C 1 M15 I32 D34 G36 F111 Y192 D214 G216 T217 S218 I300 M15 I32 D34 G36 F111 Y192 D214 G216 T217 S218 I300 D34 S37 N39 W41 Y77 D214 T217 D34 S37 N39 W41 Y77 D214 T217 3.4.23.39 0004190,0006508 P46925 26625296 501 SSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL