1nhz A 2.3 BS01 486 A 1 M560 L563 N564 G567 Q570 M601 M604 F623 Q642 M646 L732 M31 L34 N35 G38 Q41 M72 M75 F94 Q113 M117 L203 ? -logKd/Ki=6.08, Ki=0.84uM IC50=1.1nM, Ki=1.2nM, EC50=872nM, Kd=15nM P04150 12686538 800 PTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNNIKKLLFHQ 2w8y A 1.8 BS01 486 A 1 L715 L718 N719 L721 G722 E723 Q725 W755 M756 M759 F794 L797 Y890 C891 M909 L33 L36 N37 L39 G40 E41 Q43 W73 M74 M77 F112 L115 Y208 C209 M227 ? -logKd/Ki=9.09, Ki=0.82nM IC50=0.300000nM, Ki=1.1nM, EC50=>10000nM P06401 19372222 1000 LIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHK 3h52 A 2.8 BS02 486 A 1 N564 G567 Q570 M601 F623 Q642 M752 N39 G42 Q45 M76 F98 Q117 M227 ? IC50=1.1nM, Ki=1.2nM, EC50=872nM, Kd=15nM P04150 19913032 3 HMLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPGNIKKLLFHQ 3h52 B 2.8 BS02 486 B 1 M560 L563 N564 G567 Q570 M604 Q642 M646 Y735 L753 M33 L36 N37 G40 Q43 M77 Q115 M119 Y208 L226 ? IC50=1.1nM, Ki=1.2nM, EC50=872nM, Kd=15nM P04150 19913032 1 LTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ 3h52 C 2.8 BS01 486 C 1 L563 G567 Q570 W600 F623 M639 L37 G41 Q44 W74 F97 M113 ? IC50=1.1nM, Ki=1.2nM, EC50=872nM, Kd=15nM P04150 19913032 4 MLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHEVVENLLNYCFQTFAEIITNQIPKYSNGNIKKLLFHQ 3h52 D 2.8 BS01 486 D 1 L563 N564 G567 Q570 M601 M639 Y735 C736 L753 L34 N35 G38 Q41 M72 M110 Y206 C207 L215 ? IC50=1.1nM, Ki=1.2nM, EC50=872nM, Kd=15nM P04150 19913032 2 PTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHEVVENLLNYCFQTFLEMLAEIITNQINGNIKKLLFHQ 3qt0 A 2.496 BS02 486 A 1 C285 R288 I326 Y327 L330 I341 F363 M364 H449 C75 R78 I116 Y117 L120 I131 F153 M154 H239 ? 0003677,0004879,0005634,0006355 P37231 21986665 4 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 4ltw A 2.045 BS02 486 A 1 L42 K50 Q63 M64 I67 Q68 M224 I228 L45 K53 Q66 M67 I70 Q71 M227 I231 24260475 302 SNAPSLISILQAIEPEVVYAGYDNTQPDTTNYLLSSLNRLAEKQLVSVVKWAKALPGFRNLHLDDQMTLIQYSWMGLMAFAMGWRSYKHTNGQMLYFAPDLIFNEQRMQQSAMYDLCQGMQQISQEFVRLQVTQEEFLCMKALLLLSTVPKEGLKSQASFDEMRMNYIKELNRAIAKKENNSAQNWQRFYQLTKLLDSMHDLVGGLLQFCFYTFVQSQALSVEFPEMLVEIISAQLPKVLAGMAKPLLFHK 4ltw A 2.045 BS03 486 A 2 F206 Y209 F209 Y212 24260475 303 SNAPSLISILQAIEPEVVYAGYDNTQPDTTNYLLSSLNRLAEKQLVSVVKWAKALPGFRNLHLDDQMTLIQYSWMGLMAFAMGWRSYKHTNGQMLYFAPDLIFNEQRMQQSAMYDLCQGMQQISQEFVRLQVTQEEFLCMKALLLLSTVPKEGLKSQASFDEMRMNYIKELNRAIAKKENNSAQNWQRFYQLTKLLDSMHDLVGGLLQFCFYTFVQSQALSVEFPEMLVEIISAQLPKVLAGMAKPLLFHK 5uc1 A 2.351 BS01 486 A 1 L559 N560 G563 G564 Q566 M600 R607 F619 M642 L40 N41 G44 G45 Q47 M81 R88 F98 M121 ? -logKd/Ki=7.85, Kd=14nM G5AQS2,P04150 29437838 801 TLPQLTPTLVSLLEVIEPEVLYAGYDGTVPDTTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQGNVLCFAPDLIINEQRMGLPYMYDQCKQMLFVSSELKRLQVSYEEYLCMKTLLLFSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHENVT 5uc1 B 2.351 BS01 486 B 1 L559 N560 G563 G564 Q566 M600 F619 M642 L40 N41 G44 G45 Q47 M81 F98 M121 ? -logKd/Ki=7.85, Kd=14nM G5AQS2,P04150 29437838 801 TLPQLTPTLVSLLEVIEPEVLYAGYDGTVPDTTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQGNVLCFAPDLIINEQRMGLPYMYDQCKQMLFVSSELKRLQVSYEEYLCMKTLLLFSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHENVT 5uc3 A 2.009 BS01 486 A 1 M560 L563 N564 G567 Q570 W600 M601 M604 F623 Q642 M646 C736 M35 L38 N39 G42 Q45 W75 M76 M79 F98 Q117 M121 C211 ? IC50=1.1nM, Ki=1.2nM, EC50=872nM, Kd=15nM P04150 801 PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLKPYCFQTFLDKTMSIGNIKKLLFHQ 5uc3 B 2.009 BS01 486 B 1 M560 G567 Q570 W600 F623 Q642 M646 L732 C736 M35 G42 Q45 W75 F97 Q116 M120 L206 C210 ? IC50=1.1nM, Ki=1.2nM, EC50=872nM, Kd=15nM P04150 801 PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLKPYCFQTFLDKTMSIGNIKKLLFHQ