4d2v A 2.45 BS01 45R A 1 I17 L27 A38 C70 L86 E87 Y88 C89 P90 I18 L28 A39 C68 L84 E85 Y86 C87 P88 D132 K134 E136 N137 D150 A171 D130 K132 E134 N135 D148 A154 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 Q14680 25589925 1334 HMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCGALAYAAPELIQGKGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2v B 2.45 BS01 45R B 1 I17 L27 K40 E57 L86 C89 P90 I149 D150 I16 L26 K39 E56 L85 C88 P89 I148 D149 D132 K134 E136 N137 D150 A171 D131 K133 E135 N136 D149 A164 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=7.43, IC50=0.037uM Q14680 25589925 1334 KDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDCGALAYAAPELIQGGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2v C 2.45 BS01 45R C 1 I17 V25 L27 A38 L86 E87 Y88 C89 P90 I17 V25 L27 A38 L82 E83 Y84 C85 P86 D132 K134 E136 N137 D150 A171 D128 K130 E132 N133 D146 A154 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=7.43, IC50=0.037uM Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2v D 2.45 BS01 45R D 1 I17 V25 A38 K40 E57 C70 L86 C89 I149 D150 I15 V23 A36 K38 E55 C68 L84 C87 I147 D148 D132 K134 E136 N137 D150 A171 D130 K132 E134 N135 D148 A161 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 Q14680 25589925 1334 DYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKFIHLDDDCVTELSVHHRNNRQTMISLWQYDHLTATYLLLLAKKARGKPVRLR 5twz A 2.631 BS01 45R A 1 I17 L27 A38 C70 L86 E87 C89 P90 L139 I149 I17 L24 A35 C67 L83 E84 C86 P87 L136 I146 D132 K134 E136 N137 D150 S171 D129 K131 E133 N134 D147 S151 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 Q14680 28926338 1000 SKDYDELLKYYELHETIGTAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR