5afj A 2.2 BS01 42R A 1 L6 L10 L63 L6 L10 L63 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM -logKd/Ki=4.38, IC50=42uM P36544,P58154 25918415 1205 EFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj A 2.2 BS02 42R A 2 Y91 K141 Y91 K141 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM -logKd/Ki=4.38, IC50=42uM P36544,P58154 25918415 1206 EFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj B 2.2 BS01 42R A 2 L36 Q37 I165 L37 Q38 I166 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM -logKd/Ki=4.38, IC50=42uM P36544,P58154 25918415 1206 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj B 2.2 BS03 42R B 1 L6 E9 L10 L63 L7 E10 L11 L64 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM -logKd/Ki=4.38, IC50=42uM P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj B 2.2 BS04 42R B 2 Y91 N92 K141 Y184 Y92 N93 K142 Y185 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM -logKd/Ki=4.38, IC50=42uM P36544,P58154 25918415 1206 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj C 2.2 BS01 42R B 2 L36 Q37 W53 I165 L37 Q38 W54 I166 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM P36544,P58154 25918415 1206 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj C 2.2 BS03 42R C 1 L6 E9 L63 Y70 L7 E10 L64 Y71 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj C 2.2 BS04 42R C 2 Y91 N92 K141 Y92 N93 K142 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM P36544,P58154 25918415 1206 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj D 2.2 BS01 42R C 2 L36 I165 L37 I166 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM P36544,P58154 25918415 1206 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj D 2.2 BS03 42R D 1 L6 E9 L63 Y70 V107 L7 E10 L64 Y71 V108 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj D 2.2 BS04 42R D 2 Y91 N92 K141 Y92 N93 K142 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM P36544,P58154 25918415 1206 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj E 2.2 BS02 42R E 1 L6 L63 Y70 L7 L64 Y71 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afj E 2.2 BS03 42R E 2 Y91 N92 K141 R182 Y92 N93 K142 R183 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=42uM P36544,P58154 25918415 1206 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG