4mw5 B 2.347 BS01 415 B 1 I248 Y250 D287 H289 G290 Y472 V473 W474 D476 L478 F522 I17 Y19 D56 H58 G59 Y235 V236 W237 D239 L241 F285 H256 H259 S364 D367 S390 S393 K554 K557 H25 H28 S133 D136 S153 S156 K317 K320 6.1.1.10 0000166,0004812,0004825,0005524,0006418,0006431 Q38C91 24743796 909 GPGSMKVEKVFFVTSPIYYVNAAPHIGHVYSTLITDVIGRYHRVKGERVFALTGTDEHGQKVAEAAKQKQVSPYDFTTAVAGEFKKCFEQMDYSIDYFIRTTNEQHKAVVKELWTKLEQKGDIYLGRYEGWYSISDESFLTPQNITDGVDKVSLESGHVVTWVSEENYMFRLSAFRERLLEWYHANPGCIVPEFRRREVIRAVEKGLPDLSVSRARATLHNWAIPVPGNPDHCVYVWLDALTNYLTGSRLRVDESGKEVSLVDDFNELERFPADVHVIGKDILKFHAIYWPAFLLSAGLPLPKKIVAHGWWTKDRKKISKSLGNVFDPVEKAEEFGYDALKYFLLRESGFSDDGDYSDKNMIARLNGELADTLGNLVMRCTSAKINVNGEWPSPAAYTEEDESLIQLIKDLPGTADHYYLIPDIQKAIIAVFDVLRAINAYVTDMAPWKLVKTDPERLRTVLYITLEGVRVTTLLLSPILPRKSVVIFDMLGVPEVHRKGIENFEFGAVPPGTRLGPAVEGEVLFSKRST 5k0t A 2.6 BS01 415 A 1 I12 Y14 D51 H53 G54 Y228 V229 W230 A233 I265 F268 H269 I11 Y13 D50 H52 G53 Y227 V228 W229 A232 I264 F267 H268 I12 H20 H23 D51 S128 D131 G150 W230 I265 I11 H19 H22 D50 S127 D130 G149 W229 I264 6.1.1.10 0000166,0004812,0004825,0005524,0005737,0006412,0006418,0006431 -logKd/Ki=5.78, IC50=1.657uM P59078 27500735 601 SREKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTDEHGIKMLQSARKEGITPRDLADRNTSAFRRMAEVLNSSNDDYIRTSEERHYKASQAIWQAMVANGDIYKGGYAGWYSVRDEAYYGEEETEVRADGVRYGPQGTPVEWVEEESYFFRLSAYQDKLLDLYENNPGFIMPAERRNEIVSFVKSGLKDLSISRTTFDWGIPVPGDEKHVMYVWVDALTNYITALGYPDTTDERWAYWPANAHIIGKDISRFHAVYWPAFLMSAQLPLPKRVFAHGFLFNRIDPFELVERYGLDQLRYFLMREVPFGQDGSYSHEAIVNRTNADLANDLGNLAQRSLSMIAKNCEGKVPQPGAFSEADKAILDQADAALETARKAMDDQALHLALGAIFAVVAEANRYFAGQEPWALRKTDPARMGTVLYVTAEVLRRVGIMVQPFIPQSAEKLLDILAVPADKRQFADVLASPLAGGTDLPAPQPVFPRY 5k0t B 2.6 BS01 415 B 1 A11 I12 Y14 D51 H53 G54 F213 Y228 V229 W230 A233 L234 I265 H269 A10 I11 Y13 D50 H52 G53 F184 Y199 V200 W201 A204 L205 I236 H240 I12 H20 H23 D51 S128 W230 I265 I11 H19 H22 D50 S127 W201 I236 6.1.1.10 0000166,0004812,0004825,0005524,0005737,0006412,0006418,0006431 P59078 27500735 601 SREKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTDEHGIKMLQSARKEGITPRDLADRNTSAFRRMAEVLNSSNDDYIRTSEERHYKASQAIWQAMVANGDIYKGGYAGWYSEWVEEESYFFRLSAYQDKLLDLYENNPGFIMPAERRNEIVSFVKSGLKDLSISRTTFDWGIPVPGDEKHVMYVWVDALTNYITALGYPDTTDERWAYWPANAHIIGKDISRFHAVYWPAFLMSAQLPLPKRVFAHGFLFIDPFELVERYGLDQLRYFLMREVPFGQDGSYSHEAIVNRTNADLANDLGNLAQRSLSMIAKNCEGKVPQPGAFSEADKAILDQADAALETARKAMDDQALHLALGAIFAVVAEANRYFAGQEPWALRKTDPARMGTVLYVTAEVLRRVGIMVQPFIPQSAEKLLDILAVPADKRQFADVLASPLAGGTDLPAPQPVFPRYVE 5k0t C 2.6 BS01 415 C 1 A11 I12 Y14 D51 H53 G54 V229 W230 A233 L234 Y237 F268 H269 A11 I12 Y14 D51 H53 G54 V212 W213 A216 L217 Y220 F251 H252 I12 H20 H23 D51 S128 D131 W230 I265 I12 H20 H23 D51 S128 D131 W213 I248 6.1.1.10 0000166,0004812,0004825,0005524,0005737,0006412,0006418,0006431 P59078 27500735 601 MSREKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTDEHGIKMLQSARKEGITPRDLADRNTSAFRRMAEVLNSSNDDYIRTSEERHYKASQAIWQAMVANGDIYKGGYAGWYSVRDEAYQGTPVEWVEEESYFFRLSAYQDKLLDLYENNPGFIMPAERRNEIVSFVKSGLKDLSISRTTFDWGIPVPGDEKHVMYVWVDALTNYITALGYPDTTDERWAYWPANAHIIGKDISRFHAVYWPAFLMSAQLPLPKRVFAHGFLFNIDPFELVERYGLDQLRYFLMREVPFGQDGSYSHEAIVNRTNADLANDLGNLAQRSLSMIAKNCEGKVPQPGAFSEADKAILDQADAALETARKAMDDQALHLALGAIFAVVAEANRYFAGQEPWALRKTDPARMGTVLYVTAEVLRRVGIMVQPFIPQSAEKLLDILAVPADKRQFADVLASPLAGGTDLPAPQPVFPRYVE