4rx9 A 1.75 BS01 3YT A 1 L377 A400 M448 E449 A451 P455 R498 L501 D512 L15 A35 M78 E79 A81 P85 R128 L131 D142 D494 A496 R498 N499 D512 K533 D124 A126 R128 N129 D142 K162 2.7.10.2 0004672,0004713,0005524,0006468 ic50=13nM -logKd/Ki=7.89, IC50=13nM IC50=178nM P43405 25633741 702 VYLDRKLLTLEDKELGFGTVKKGYYQMKKVVKTVAVKILKPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVTDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNHHHH 5ut2 A 1.75 BS01 3YT A 1 L551 I559 L579 F628 V629 K630 G632 S633 L680 L16 I24 L44 F93 V94 K95 G97 S98 L145 N673 K677 N678 D699 N138 K142 N143 D164 2.7.10.2 0004672,0005524,0006468 IC50=1750nM O60674 28626521 903 VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSL 8uct A 2.93 BS01 3YT A 1 A169 M294 K295 R296 Y297 D298 D341 L344 D359 A48 M136 K137 R138 Y139 D140 D183 L186 D201 2.7.11.1 0004672,0005524,0006468 D6WMX4 604 KEEELEGVCAEIREAISKIKAQYYDIDESRFESNPITLNDLSLGKPIAKGTNGVVYSAKVKDDNKYPFALKMMFNYDIQSNSMEILKAMYRETVPARMYAWEIELANRRKHLPPHPNIVAIFSVFTDRNMSLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSAEMDKGGNTALMAPEIICQKPGTASVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNANYKEGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPEVAANVCQLFLWAPSTWLKPGLKVPTSGEILQWLLSLTTKVLCEGTYPEYLLISSFLCRAKLANVRNALHWIQENL 8x5k A 1.8 BS01 3YT A 1 L377 G378 A400 M448 E449 A451 G454 P455 R498 L501 D512 L15 G16 A37 M85 E86 A88 G91 P92 R135 L138 D149 2.7.10.2 0004672,0004713,0005524,0006468 P43405 701 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD