4x2a A 2.0 BS03 3WL A 1 H127 M158 E173 I180 A181 H113 M144 E159 I166 A167 Q34 E100 H127 E173 Q20 E86 H113 E159 4.4.1.5 0004462,0005654,0005829,0005886,0006357,0006749,0008270,0009438,0016829,0019243,0030316,0043066,0046872 Ki=0.183uM Q9CPU0 26268338 203 TAFSCCSDPDPSTKDFLLQQTMLRIKDPKKSLDFYTRVLGLTLLQKLDFPAMKFSLYFLAYEDKNDIPKDKSEKTAWTFSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKIA 4x2a A 2.0 BS04 3WL B 1 Q34 F63 L70 F93 E100 Q20 F49 L56 F79 E86 Q34 E100 H127 E173 Q20 E86 H113 E159 4.4.1.5 0004462,0005654,0005829,0005886,0006357,0006749,0008270,0009438,0016829,0019243,0030316,0043066,0046872 Ki=0.183uM Q9CPU0 26268338 201 TAFSCCSDPDPSTKDFLLQQTMLRIKDPKKSLDFYTRVLGLTLLQKLDFPAMKFSLYFLAYEDKNDIPKDKSEKTAWTFSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKIA 4x2a B 2.0 BS03 3WL A 1 Q34 F63 F68 L70 F93 E100 Q27 F56 F61 L63 F86 E93 Q34 E100 H127 E173 Q27 E93 H120 E165 4.4.1.5 0004462,0005654,0005829,0005886,0006357,0006749,0008270,0009438,0016829,0019243,0030316,0043066,0046872 Ki=0.183uM Q9CPU0 26268338 203 SSGLTDETAFSCCSDPDPSTKDFLLQQTMLRIKDPKKSLDFYTRVLGLTLLQKLDFPAMKFSLYFLAYEDKNDIPKDKSEKTAWTFSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGMKGLAFIQDPDGYWIEILNPNKIATI 4x2a B 2.0 BS04 3WL B 1 H127 M158 E173 I180 I183 H120 M150 E165 I172 I175 Q34 E100 H127 E173 Q27 E93 H120 E165 4.4.1.5 0004462,0005654,0005829,0005886,0006357,0006749,0008270,0009438,0016829,0019243,0030316,0043066,0046872 Ki=0.183uM Q9CPU0 26268338 201 SSGLTDETAFSCCSDPDPSTKDFLLQQTMLRIKDPKKSLDFYTRVLGLTLLQKLDFPAMKFSLYFLAYEDKNDIPKDKSEKTAWTFSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGMKGLAFIQDPDGYWIEILNPNKIATI 6m2n A 2.198 BS01 3WL A 1 H41 C44 M49 N142 G143 C145 M165 H41 C44 M49 N142 G143 C145 M165 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0008233,0019082 Kd=4.03uM IC50=20nM, EC50=2940nM P0DTD1 32737471 401 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 6m2n B 2.198 BS01 3WL B 1 H41 C44 M49 N142 G143 C145 M165 E166 R188 Q189 H41 C44 M49 N142 G143 C145 M165 E166 R188 Q189 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0008233,0019082 Kd=4.03uM IC50=20nM, EC50=2940nM P0DTD1 32737471 401 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 6m2n C 2.198 BS01 3WL C 1 H41 M49 N142 G143 C145 M165 H41 M49 N142 G143 C145 M165 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0008233,0019082 Kd=4.03uM IC50=20nM, EC50=2940nM P0DTD1 32737471 401 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTF 6m2n D 2.198 BS01 3WL D 1 H41 C44 N142 G143 C145 M165 H41 C44 N142 G143 C145 M165 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0008233,0019082 Kd=4.03uM IC50=20nM, EC50=2940nM P0DTD1 32737471 401 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 7xax A 2.25 BS01 3WL A 1 H41 D48 L141 N142 G143 C145 H164 M165 Q189 H40 D47 L140 N141 G142 C144 H163 M164 Q188 2.1.1.-,2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0008233,0019082 P0C6X7 401 GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 8a0q A 2.048 BS01 3WL A 1 P13 F14 F107 L157 W161 I165 P11 F12 F105 L155 W159 I163 2.5.1.18 0004364,0005737,0006749,0016740,0046872 D2X9R3 36032685 301 DVKLHGSWVSPFNYRVIWALKLKGVEFEHIVEDLTNKSELLLKYNPVYKKIPVLVHGGKPIAESLVILEYIEETWPENPLLPTDPYERAMARFWIQYGATKTAAFGALFRASGEELEKAAKEVVEVLRVLEEQGLGDKKFFGGDSINLVDISFGLFTCWLEAIEEAAGVKVLEPSTLPRLHAWAQNFIEVPLIKENIPDYDKLLLHMKGVREKMM 8bzs A 2.25 BS02 3WL A 1 F285 E382 A610 G612 Y613 F268 E356 A584 G586 Y587 2.4.1.1 0000166,0004645,0005737,0005975,0005977,0005980,0008184,0016757,0030170,0098723,0102250,0102499 P00489 37277066 902 QISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPA 8imf B 2.4 BS01 3WL B 1 A247 R376 Y436 N482 F488 L490 A82 R200 Y260 N306 F312 L314 2.7.7.86 Q8N884 37666112 601 GASKLRAVLEKLKLSRDDSTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNENPLSQFLEGEILSASKMLSKFRKIIKEEINDIDVIMKRKGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFD