4pdk A 2.8 BS01 3VV A 1 L101 L102 A103 R105 T106 I108 L208 Y212 V215 G216 Y219 R253 G256 S259 G260 L94 L95 A96 R98 T99 I101 L201 Y205 V208 G209 Y212 R246 G249 S252 G253 ? 0000062,0003677,0003700,0005737,0006355,0006631,0019217,0071072 -logKd/Ki=8.22, Kd=6nM Q9KQU8 25607896 301 PAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGLHILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLNKESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQHVKEDSEKDELKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVCQSGEREHLPQVIRQYGIASGHIWNQM 4pdk A 2.8 BS02 3VV A 2 N130 Y153 K156 Y184 M187 R191 F194 H195 I200 L203 N123 Y146 K149 Y177 M180 R184 F187 H188 I193 L196 ? 0000062,0003677,0003700,0005737,0006355,0006631,0019217,0071072 -logKd/Ki=8.22, Kd=6nM Q9KQU8 25607896 302 PAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGLHILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLNKESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQHVKEDSEKDELKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVCQSGEREHLPQVIRQYGIASGHIWNQM 4pdk A 2.8 BS03 3VV B 1 I111 R114 Y115 I104 R107 Y108 ? 0000062,0003677,0003700,0005737,0006355,0006631,0019217,0071072 -logKd/Ki=8.22, Kd=6nM Q9KQU8 25607896 301 PAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGLHILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLNKESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQHVKEDSEKDELKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVCQSGEREHLPQVIRQYGIASGHIWNQM 4pdk A 2.8 BS04 3VV B 2 P27 M75 P20 M68 ? 0000062,0003677,0003700,0005737,0006355,0006631,0019217,0071072 -logKd/Ki=8.22, Kd=6nM Q9KQU8 25607896 302 PAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGLHILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLNKESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQHVKEDSEKDELKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVCQSGEREHLPQVIRQYGIASGHIWNQM 4pdk B 2.8 BS01 3VV A 2 W21 I82 W14 I75 ? 0000062,0003677,0003700,0005737,0006355,0006631,0019217,0071072 -logKd/Ki=8.22, Kd=6nM Q9KQU8 25607896 302 PAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGLHILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLNKESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQHVKEDSEKDELKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVCQSGEREHLPQVIRQYGIASGHIWNQMKMTLPS 4pdk B 2.8 BS02 3VV B 1 L101 L102 A104 R105 T106 L208 Y212 V215 G216 Y219 R253 G256 I257 S259 G260 L94 L95 A97 R98 T99 L201 Y205 V208 G209 Y212 R246 G249 I250 S252 G253 ? 0000062,0003677,0003700,0005737,0006355,0006631,0019217,0071072 -logKd/Ki=8.22, Kd=6nM Q9KQU8 25607896 301 PAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGLHILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLNKESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQHVKEDSEKDELKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVCQSGEREHLPQVIRQYGIASGHIWNQMKMTLPS 4pdk B 2.8 BS03 3VV B 2 R126 N130 Y153 Y184 M187 R191 F194 L203 I204 L208 R119 N123 Y146 Y177 M180 R184 F187 L196 I197 L201 ? 0000062,0003677,0003700,0005737,0006355,0006631,0019217,0071072 -logKd/Ki=8.22, Kd=6nM Q9KQU8 25607896 302 PAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGLHILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLNKESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQHVKEDSEKDELKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVCQSGEREHLPQVIRQYGIASGHIWNQMKMTLPS 6p2j A 3.0 BS01 3VV A 1 W407 N415 Y417 W420 Y429 Y433 K445 F453 H460 W286 N294 Y296 W299 Y308 Y312 K324 F332 H339 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0033344,0034379,0034383,0034736,0042632,0042986 P35610 32433614 700 EQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCP 6p2j B 3.0 BS01 3VV B 1 W407 S414 N415 Y417 W420 N421 H425 Y429 Y433 K445 M449 F453 S456 H460 F476 F479 W286 S293 N294 Y296 W299 N300 H304 Y308 Y312 K324 M328 F332 S335 H339 F355 F358 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0033344,0034379,0034383,0034736,0042632,0042986 P35610 32433614 700 QGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCP 6p2p A 3.1 BS01 3VV A 1 N415 W420 Y429 Y433 H460 N294 W299 Y308 Y312 H339 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0033344,0034379,0034383,0034736,0042632,0042986 P35610 32433614 700 EQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCP 6p2p B 3.1 BS01 3VV B 1 N415 W420 N421 H425 Y433 K445 H460 F476 N294 W299 N300 H304 Y312 K324 H339 F355 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0033344,0034379,0034383,0034736,0042632,0042986 P35610 32433614 700 QGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHC 6p2p C 3.1 BS01 3VV C 1 N415 W420 Y429 Y433 H460 N294 W299 Y308 Y312 H339 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0033344,0034379,0034383,0034736,0042632,0042986 P35610 32433614 700 EQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCP 6p2p D 3.1 BS01 3VV D 1 N415 W420 N421 H425 Y433 K445 H460 F476 N294 W299 N300 H304 Y312 K324 H339 F355 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0033344,0034379,0034383,0034736,0042632,0042986 P35610 32433614 700 QGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHC 6vp0 C 3.1 BS03 3VV C 1 W334 F338 W374 Q375 W377 H382 I386 Y390 K400 R404 S411 H415 W257 F261 W297 Q298 W300 H305 I309 Y313 K323 R327 S334 H338 2.3.1.20,2.3.1.76 0003846,0004144,0005515,0005783,0005789,0005886,0006629,0006640,0006641,0008374,0016020,0016746,0019432,0019915,0034379,0035336,0035579,0042572,0042802,0043231,0046339,0046486,0050252,0055089 O75907 32433610 605 WELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNY 6vp0 E 3.1 BS02 3VV E 1 W334 F338 W374 Q375 W377 H382 I386 Y390 K400 R404 S411 H415 W257 F261 W297 Q298 W300 H305 I309 Y313 K323 R327 S334 H338 2.3.1.20,2.3.1.76 0003846,0004144,0005515,0005783,0005789,0005886,0006629,0006640,0006641,0008374,0016020,0016746,0019432,0019915,0034379,0035336,0035579,0042572,0042802,0043231,0046339,0046486,0050252,0055089 O75907 32433610 605 WELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNY 6vum B 3.67 BS01 3VV B 1 Y413 Y417 R418 H425 Y433 F453 S456 L478 F479 F486 D492 S506 G510 Y296 Y300 R301 H308 Y316 F336 S339 L361 F362 F369 D375 S389 G393 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0033344,0034379,0034383,0034736,0042632,0042986 P35610 32433613 702 QGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQ 6vum D 3.67 BS02 3VV D 1 Y413 Y417 R418 H425 Y433 F453 S456 L478 F479 F486 D492 S506 G510 Y296 Y300 R301 H308 Y316 F336 S339 L361 F362 F369 D375 S389 G393 2.3.1.26 0000062,0004772,0005515,0005783,0005789,0008203,0008374,0010742,0010878,0015485,0016020,0016746,0033344,0034379,0034383,0034736,0042632,0042986 P35610 32433613 702 QGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQ 6vz1 A 3.2 BS03 3VV A 1 W374 Q375 V381 H382 I386 Y390 R404 V407 S411 H415 Y476 W304 Q305 V311 H312 I316 Y320 R334 V337 S341 H345 Y406 2.3.1.20,2.3.1.76 0003846,0004144,0005515,0005783,0005789,0005886,0006629,0006640,0006641,0008374,0016020,0016746,0019432,0019915,0034379,0035336,0035579,0042572,0042802,0043231,0046339,0046486,0050252,0055089 O75907 32433611 503 WELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNY 6vz1 B 3.2 BS05 3VV B 1 P191 L195 Q375 H382 I386 Y390 R404 S411 H415 Y476 P128 L132 Q305 H312 I316 Y320 R334 S341 H345 Y406 2.3.1.20,2.3.1.76 0003846,0004144,0005515,0005783,0005789,0005886,0006629,0006640,0006641,0008374,0016020,0016746,0019432,0019915,0034379,0035336,0035579,0042572,0042802,0043231,0046339,0046486,0050252,0055089 O75907 32433611 503 WELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNY 6wf2 A 3.51 BS03 3VV A 1 N71 F142 Q143 N144 W149 R151 D152 H153 W180 L181 R184 K185 K190 G193 G194 Y250 T257 V260 N261 A288 N31 F102 Q103 N104 W109 R111 D112 H113 W140 L141 R144 K145 K150 G153 G154 Y210 T217 V220 N221 A248 1.14.19.1 0004768,0005506,0005783,0005789,0006629,0006633,0006636,0006641,0007584,0008610,0009617,0016020,0016215,0016491,0016717,0032896,0042632,0046872,0048733,0050830,0050872,0050873,0055088,0055092,0070542,0120162,1903699,1903966 P13516 32470559 403 DIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSSENLYFQ 6wf2 B 3.51 BS03 3VV B 1 N71 A108 I111 T112 H116 F142 Q143 N144 W149 R151 H153 W180 L181 R184 K185 V189 K190 G193 G194 Y250 T257 W258 V260 N261 A288 E291 N31 A68 I71 T72 H76 F102 Q103 N104 W109 R111 H113 W140 L141 R144 K145 V149 K150 G153 G154 Y210 T217 W218 V220 N221 A248 E251 1.14.19.1 0004768,0005506,0005783,0005789,0006629,0006633,0006636,0006641,0007584,0008610,0009617,0016020,0016215,0016491,0016717,0032896,0042632,0046872,0048733,0050830,0050872,0050873,0055088,0055092,0070542,0120162,1903699,1903966 P13516 32470559 403 DIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSH 7shn A 3.1 BS01 3VV A 1 S226 L229 L230 A232 A233 M335 W339 S340 M346 P350 I351 A388 L392 A396 S160 L163 L164 A166 A167 M269 W273 S274 M280 P284 I285 A313 L317 A321 3.1.2.-,7.6.2.- 0000038,0002082,0005324,0005515,0005524,0005737,0005739,0005764,0005765,0005777,0005778,0005783,0005789,0005829,0006635,0007031,0015607,0015910,0015916,0015919,0016020,0016787,0016887,0019899,0030497,0031966,0031998,0032000,0036109,0036113,0042626,0042758,0042760,0042802,0042803,0043217,0043531,0043651,0046982,0047617,0048471,0051900,0052817,0055085,0055089,0055092,0140359,1900016,1900407,1903427,1990535,2001280 P33897 34754073 800 MNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRIRGQVVDVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDQCTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAAAAAAAAAAAAAAAAAAAAA 7shn B 3.1 BS01 3VV B 1 L229 A232 M335 W339 M346 P350 E380 A388 R389 L392 A396 L163 A166 M269 W273 M280 P284 E305 A313 R314 L317 A321 3.1.2.-,7.6.2.- 0000038,0002082,0005324,0005515,0005524,0005737,0005739,0005764,0005765,0005777,0005778,0005783,0005789,0005829,0006635,0007031,0015607,0015910,0015916,0015919,0016020,0016787,0016887,0019899,0030497,0031966,0031998,0032000,0036109,0036113,0042626,0042758,0042760,0042802,0042803,0043217,0043531,0043651,0046982,0047617,0048471,0051900,0052817,0055085,0055089,0055092,0140359,1900016,1900407,1903427,1990535,2001280 P33897 34754073 801 MNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRKIRGQVVDVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDQCTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAAAAAAAAAAAAAAAAAAAAA 8fhi A 3.25 BS03 3VV A 1 F416 G417 P424 V427 K484 F487 F388 G389 P396 V399 K456 F459 ? 0005216,0005261,0005262,0005516,0005886,0006811,0006816,0016020,0016324,0035809,0042802,0046872,0051289,0055074,0055085,0070588,0098703 Q9XSM3 37735536 803 DWEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHD 8fhi B 3.25 BS04 3VV B 1 F416 G417 P424 V427 K484 F487 F388 G389 P396 V399 K456 F459 ? 0005216,0005261,0005262,0005516,0005886,0006811,0006816,0016020,0016324,0035809,0042802,0046872,0051289,0055074,0055085,0070588,0098703 Q9XSM3 37735536 803 DWEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHD 8fhi C 3.25 BS04 3VV C 1 F416 G417 P424 V427 K484 F487 F388 G389 P396 V399 K456 F459 ? 0005216,0005261,0005262,0005516,0005886,0006811,0006816,0016020,0016324,0035809,0042802,0046872,0051289,0055074,0055085,0070588,0098703 Q9XSM3 37735536 803 DWEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHD 8fhi D 3.25 BS04 3VV D 1 F416 G417 P424 V427 K484 F487 F388 G389 P396 V399 K456 F459 ? 0005216,0005261,0005262,0005516,0005886,0006811,0006816,0016020,0016324,0035809,0042802,0046872,0051289,0055074,0055085,0070588,0098703 Q9XSM3 37735536 804 DWEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHD 8ghe A 2.05 BS02 3VV A 1 A182 R290 E356 H360 L361 H365 I399 R402 A403 Q406 L407 G411 G412 I413 F414 K416 R585 L589 I593 H596 L597 I663 A181 R289 E355 H359 L360 H364 I398 R401 A402 Q405 L406 G410 G411 I412 F413 K415 R584 L588 I592 H595 L596 I662 1.13.11.-,1.13.11.31,1.13.11.33,3.3.2.- 0001676,0004052,0005506,0005515,0005737,0005829,0006629,0006631,0006690,0010656,0016020,0016165,0016702,0016787,0019369,0019372,0019395,0033559,0034440,0042383,0042554,0043651,0046872,0047977,0050473,0051122,0051213,0061436,0070062,0090331,1901751,2001303,2001306 P18054 37506345 702 GRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPSPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI 8ghe B 2.05 BS02 3VV A 1 R290 K416 R585 R289 K415 R584 1.13.11.-,1.13.11.31,1.13.11.33,3.3.2.- 0001676,0004052,0005506,0005515,0005737,0005829,0006629,0006631,0006690,0010656,0016020,0016165,0016702,0016787,0019369,0019372,0019395,0033559,0034440,0042383,0042554,0043651,0046872,0047977,0050473,0051122,0051213,0061436,0070062,0090331,1901751,2001303,2001306 P18054 37506345 702 GRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPSPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI