4wtu A 1.85 BS01 3UT A 1 G11 Q12 G13 L30 D32 S35 Y71 W76 F108 I118 R128 D228 G230 G13 Q14 G15 L32 D34 S37 Y73 W78 F110 I120 R130 D220 G222 D32 S35 N37 A39 Y71 D228 T231 D34 S37 N39 A41 Y73 D220 T223 3.4.23.46 0004190,0006508,0016020 ic50=0.3nM -logKd/Ki=9.52, IC50=0.3nM IC50=3.0nM P56817 25699151 407 FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 5ux4 A 2.805 BS01 3UT A 1 D33 I76 Y78 I129 D226 G228 D33 I76 Y78 I126 D223 G225 3.4.23.5 0000045,0004175,0004190,0005576,0005615,0005764,0005765,0006508,0008233,0010008,0016787,0030163,0031667,0031904,0038020,0042159,0042277,0042470,0043065,0045121,0060441,0070001,0070201,0098830,0098982,0099003,0099532,1901143 -logKd/Ki=7.05, IC50=0.09uM P24268 30108829 404 EPVSELLKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGYPFISVNNVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYLNVTRKAYWQVHMDQLEVGSELTLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMIPCEKVSSLPIITFKLGGQNYELHPEKYILKVSKTICLSGFMGMDIPPPSGPLWILGDVFIGCYYTVFDREYNRVGFAKAATL 5ux4 B 2.805 BS01 3UT B 1 D33 G35 S36 I76 Y78 I129 D226 G228 D33 G35 S36 I76 Y78 I126 D223 G225 3.4.23.5 0000045,0004175,0004190,0005576,0005615,0005764,0005765,0006508,0008233,0010008,0016787,0030163,0031667,0031904,0038020,0042159,0042277,0042470,0043065,0045121,0060441,0070001,0070201,0098830,0098982,0099003,0099532,1901143 P24268 30108829 403 EPVSELLKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGYPFISVNNVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYLNVTRKAYWQVHMDQLEVGSELTLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMIPCEKVSSLPIITFKLGGQNYELHPEKYILKVSQAGKTICLSGFMGMDIPPPSGPLWILGDVFIGCYYTVFDREYNRVGFAKAATL