4wr7 A 1.5 BS02 3TV A 1 F91 H94 H96 H119 A135 L198 T199 H200 F89 H92 H94 H117 A133 L196 T197 H198 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T197 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 Kd=0.002nM -logKd/Ki=11.70, Kd=0.002nM Kd=0.033nM P00915 26079542 302 PDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 4wr7 B 1.5 BS02 3TV B 1 F91 H94 H96 H119 A135 L198 T199 H200 F88 H91 H93 H116 A132 L195 T196 H197 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T196 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 Kd=0.002nM Kd=0.033nM P00915 26079542 302 DWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 4ww6 A 1.06 BS02 3TV A 1 H94 H119 V121 F131 V143 L198 T199 T200 H91 H116 V118 F127 V139 L194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=0.062nM -logKd/Ki=10.21, Kd=0.062nM Kd=0.91nM P00918 26079542 306 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4ww6 A 1.06 BS03 3TV A 2 H4 W5 H10 H15 D19 H1 W2 H7 H12 D16 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=0.062nM -logKd/Ki=10.21, Kd=0.062nM Kd=0.91nM P00918 26079542 307 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 5lln A 1.6 BS02 3TV A 1 Q94 H96 H98 H121 V123 L200 T201 V202 Q90 H92 H94 H117 V119 L196 T197 V198 H66 H96 H98 E108 H121 T201 H62 H92 H94 E104 H117 T197 4.2.1.1 0004089,0005515,0005737,0005829,0006730,0008270,0016829,0043209,0043231,0046872 Kd=0.53nM Q8N1Q1 303 LSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH 5lln B 1.6 BS02 3TV B 1 Q94 H96 H121 V123 F133 V145 L200 T201 V202 W211 Q89 H91 H116 V118 F128 V140 L195 T196 V197 W206 H66 H96 H98 E108 H121 T201 H61 H91 H93 E103 H116 T196 4.2.1.1 0004089,0005515,0005737,0005829,0006730,0008270,0016829,0043209,0043231,0046872 Kd=0.53nM Q8N1Q1 304 SWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH 5msa A 1.2 BS02 3TV A 1 H91 H117 V119 V141 L197 T198 T199 W208 H89 H115 V117 V139 L195 T196 T197 W206 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=19nM, koff=0.025s-1, kon=1300000M-1-s-1 O43570 302 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5msa B 1.2 BS02 3TV B 1 H91 H117 L197 T198 T199 H89 H115 L195 T196 T197 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=19nM, koff=0.025s-1, kon=1300000M-1-s-1 O43570 302 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5msa C 1.2 BS02 3TV C 1 H91 H117 V119 A129 V141 L197 T198 T199 H90 H116 V118 A128 V140 L196 T197 T198 H66 H91 H93 E104 H117 T198 H65 H90 H92 E103 H116 T197 4.2.1.1 0004089,0008270 Kd=19nM, koff=0.025s-1, kon=1300000M-1-s-1 O43570 302 SKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 5msa D 1.2 BS02 3TV D 1 H91 H117 L197 T198 T199 W208 H89 H115 L195 T196 T197 W206 H66 H91 H93 E104 H117 T198 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 Kd=19nM, koff=0.025s-1, kon=1300000M-1-s-1 O43570 302 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 6yha A 1.25 BS03 3TV A 1 H94 H96 H119 V121 S135 L198 T199 T200 H91 H93 H116 V118 S131 L194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=0.91nM P00918 33945229 305 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFKVEFDDSQDKAVLKGGPLDGTYRLTQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDAGKASQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLNECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 6yha A 1.25 BS04 3TV A 2 H4 W5 H10 H15 W16 D19 H1 W2 H7 H12 W13 D16 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=0.91nM P00918 33945229 306 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFKVEFDDSQDKAVLKGGPLDGTYRLTQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDAGKASQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLNECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7nzs A 1.5 BS02 3TV A 1 Q92 H94 H96 Y130 L197 T198 T199 Q89 H91 H93 Y127 L194 T195 T196 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 P00918 305 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNTGYLFQVEFDDSQDKAVLKGGPLDGTYRLKQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDYGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLTECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7nzs A 1.5 BS03 3TV A 2 H4 W5 H10 H15 D19 H1 W2 H7 H12 D16 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 P00918 306 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNTGYLFQVEFDDSQDKAVLKGGPLDGTYRLKQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDYGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLTECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK